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We report the chemistry and biological activities of a Cameroonian Citrus clementina Hort. Ex Tanaka, a vegetatively propagated species. The compounds isolated from this plant were determined to be the known 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone ( 1 ), tangerine ( 3 ), nobilletin ( 4 ), 5,7,8,4'-tetramethoxyflavone ( 5 ), citracridone I ( 6 ), 5-hydroxynoracronycine ( 7 ), citracridone III ( 8 ), xanthyletin ( 10 ), suberosin ( 9 ), E -suberenol ( 11 ), E -methoxysuberenol ( 13 ), 6-formylumbelliferone ( 12 ), aurantiamide acetate ( 2 ), limonin ( 14 ), stigmasterol, β -sitosterol and β -sitosterol-3- O - β -D-glucoside. The structures of the compounds were established on the basis of their NMR spectroscopic data and comparison with published data. Methanol leaf extract and compounds 1 , 2 , 4 , 6 , 7 and 10 were evaluated for their anti-inflammatory, antioxidant, urease and anti-diabetic effects. Compound 10 showed antioxidant activity, anti-inflammatory effect, urease activity and anti-diabetic activity with IC 50 values of 47.3 µM, 33.5 µM, 25.2 µM and 33.9 µM respectively, values that were comparable to the respective positive standards.