1. Evolutionary history of Salmonella typhi.
- Author
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Roumagnac P, Weill FX, Dolecek C, Baker S, Brisse S, Chinh NT, Le TA, Acosta CJ, Farrar J, Dougan G, and Achtman M
- Subjects
- Adaptation, Physiological, Africa, Alleles, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Asia, DNA Gyrase genetics, Drug Resistance, Bacterial, Drug Resistance, Multiple, Bacterial, Fluoroquinolones pharmacology, Fluoroquinolones therapeutic use, Genetic Variation, Haplotypes, Humans, Molecular Sequence Data, Mutation, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Salmonella typhi drug effects, Selection, Genetic, Typhoid Fever drug therapy, Biological Evolution, Carrier State microbiology, Genes, Bacterial, Salmonella typhi genetics, Typhoid Fever microbiology
- Abstract
For microbial pathogens, phylogeographic differentiation seems to be relatively common. However, the neutral population structure of Salmonella enterica serovar Typhi reflects the continued existence of ubiquitous haplotypes over millennia. In contrast, clinical use of fluoroquinolones has yielded at least 15 independent gyrA mutations within a decade and stimulated clonal expansion of haplotype H58 in Asia and Africa. Yet, antibiotic-sensitive strains and haplotypes other than H58 still persist despite selection for antibiotic resistance. Neutral evolution in Typhi appears to reflect the asymptomatic carrier state, and adaptive evolution depends on the rapid transmission of phenotypic changes through acute infections.
- Published
- 2006
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