1. Structurally related immunological effects of triterpenoid saponins.
- Author
-
Bernhardt M, Sturm C, Shaker KH, Paper DH, Franz G, and Seifert K
- Subjects
- Animals, Cell Division drug effects, Cell Line, Cells, Cultured, Female, In Vitro Techniques, Lymphocyte Activation drug effects, Macrophages drug effects, Mice, Mice, Inbred DBA, Phagocytosis drug effects, Plants, Medicinal chemistry, Spleen cytology, Spleen drug effects, Spleen immunology, Structure-Activity Relationship, Tetrazolium Salts, Thiazoles, Immunity, Cellular drug effects, Saponins chemistry, Saponins immunology, Triterpenes chemistry, Triterpenes immunology
- Abstract
The influence of the triterpenoid saponins 1-10 has been investigated on murine spleenocytes in the lymphocyte transformation test and on murine macrophages in an phagocytosis assay. The lymphocyte transformation test and the phagocytosis assay showed that the tested compounds have no stimulating effect. However, a significant inhibition of lymphocyte proliferation by the triterpenoid saponins 2, 6 and 10 was demonstrated.
- Published
- 2001