1. Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin.
- Author
-
Escobar B, Montenegro I, Villena J, Werner E, Godoy P, Olguín Y, and Madrid A
- Subjects
- Antifungal Agents chemical synthesis, Antifungal Agents classification, Antifungal Agents pharmacology, Catechols chemical synthesis, Catechols pharmacology, Inorganic Chemicals chemical synthesis, Inorganic Chemicals chemistry, Inorganic Chemicals pharmacology, Microbial Sensitivity Tests, Mycelium pathogenicity, Saprolegnia pathogenicity, Spores, Fungal pathogenicity, Catechols chemistry, Mycelium drug effects, Saprolegnia drug effects, Spores, Fungal drug effects
- Abstract
An efficient synthesis of a series of 4'-oxyalkyl-isocordoin analogues ( 2 - 8 ) is reported for the first time. Their structures were confirmed by ¹H-NMR,
13 C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis . The entire series of isocordoin derivatives (except compound 7 ) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4'-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents., Competing Interests: The authors declare no conflict of interest.- Published
- 2017
- Full Text
- View/download PDF