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Start Over Descriptor "Ha-CoV-2" Topic sars-cov
2 results on '"Ha-CoV-2"'

1. A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro.

Author

Hetrick, Brian, Yu, Dongyang, Olanrewaju, Adeyemi A., Chilin, Linda D., He, Sijia, Dabbagh, Deemah, Alluhaibi, Ghaliah, Ma, Yuan-Chun, Hofmann, Lewis A., Hakami, Ramin M., and Wu, Yuntao

Subjects
*SARS disease, *SARS-CoV-2, *COVID-19 pandemic, *PANDEMICS, *INFLUENZA viruses, *INFLUENZA A virus
Abstract

Background: The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has resulted in the infection of over 128 million people and has caused over 2.8 million deaths as of April 2021 in more than 220 countries and territories. Currently, there is no effective treatment for COVID-19 to reduce mortality. We investigated the potential anti-coronavirus activities from an oral liquid of traditional medicine, Respiratory Detox Shot (RDS), which contains mostly herbal ingredients traditionally used to manage lung diseases. Results: Here we report that RDS inhibited the infection of target cells by lenti-SARS-CoV, lenti-SARS-CoV-2, and hybrid alphavirus-SARS-CoV-2 (Ha-CoV-2) pseudoviruses, and by infectious SARS-CoV-2 and derived Ha-CoV-2 variants including B.1.1.7, B.1.351, P.1, B.1.429, B.1.2, B.1.494, B.1.1.207, B.1.258, and B.1.1.298. We further demonstrated that RDS directly inactivates the infectivity of SARS-CoV-2 virus particles. In addition, we found that RDS can also block the infection of target cells by Influenza A virus. Conclusions: These results suggest that RDS may broadly inhibit the infection of respiratory viruses. [ABSTRACT FROM AUTHOR]

Published
2021
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2. A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro

Author

Lewis A. Hofmann, Linda D. Chilin, Brian Hetrick, Yuan-Chun Ma, Ghaliah Alluhaibi, Sijia He, Dongyang Yu, Adeyemi A. Olanrewaju, Deemah Dabbagh, Yuntao Wu, and Ramin M. Hakami

Subjects
0301 basic medicine, QH301-705.5, viruses, Influenza A, QD415-436, Antiviral therapy, medicine.disease_cause, Biochemistry, General Biochemistry, Genetics and Molecular Biology, Virus, 03 medical and health sciences, 0302 clinical medicine, Traditional Chinese medicine, Respiratory detox shot, Pandemic, medicine, Influenza A virus, Respiratory system, Biology (General), Coronavirus, Infectivity, Lung, Traditional medicine, business.industry, SARS-CoV-2, Research, SARS-CoV-2 pseudovirus, virus diseases, COVID-19, SARS-CoV, respiratory system, In vitro, respiratory tract diseases, 030104 developmental biology, medicine.anatomical_structure, Ha-CoV-2, 030220 oncology & carcinogenesis, business, TP248.13-248.65, Biotechnology
Abstract

Background The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has resulted in the infection of over 128 million people and has caused over 2.8 million deaths as of April 2021 in more than 220 countries and territories. Currently, there is no effective treatment for COVID-19 to reduce mortality. We investigated the potential anti-coronavirus activities from an oral liquid of traditional medicine, Respiratory Detox Shot (RDS), which contains mostly herbal ingredients traditionally used to manage lung diseases. Results Here we report that RDS inhibited the infection of target cells by lenti-SARS-CoV, lenti-SARS-CoV-2, and hybrid alphavirus-SARS-CoV-2 (Ha-CoV-2) pseudoviruses, and by infectious SARS-CoV-2 and derived Ha-CoV-2 variants including B.1.1.7, B.1.351, P.1, B.1.429, B.1.2, B.1.494, B.1.1.207, B.1.258, and B.1.1.298. We further demonstrated that RDS directly inactivates the infectivity of SARS-CoV-2 virus particles. In addition, we found that RDS can also block the infection of target cells by Influenza A virus. Conclusions These results suggest that RDS may broadly inhibit the infection of respiratory viruses.

Published
2021

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