8 results on '"Borges, Lysandro Pinto"'
Search Results
2. SARS-CoV-2 has been circulating in northeastern Brazil since February 2020: evidence for antibody detection in asymptomatic patients.
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Gurgel RQ, de Sá LC, Souza DRV, Martins AF, Matos ILS, Lima AGA, Vieira SCF, Neto JMR, Cuevas LE, and Borges LP
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- Antibodies, Viral, Brazil epidemiology, Humans, Immunoglobulin G, Immunoglobulin M, COVID-19, SARS-CoV-2
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We screened stored samples collected before COVID-19 had been reported in Brazil. 989 samples were tested for SAR-CoV-2 antibodies using two different methods; 16 (1.6%) were positive (7 (43.8%) IgM, 3 (18.8%) IgG and 6 (37.5%) IgG/IgM positive), suggesting SARS-CoV-2 had circulated before the first reported COVID-19 case in Brazil., (Copyright © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.)
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- 2021
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3. COVID-19 Crisis in Brazil: Post-Vaccination Seroprevalence and Infection in More and Less Vaccinated Municipalities in a Northeastern State.
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Santos, Ronaldy Santana, Barreto, Marina dos Santos, Silva, Eloia Emanuelly Dias, Silva, Beatriz Soares da, Jesus, Pamela Chaves de, Silva, Deise Maria Rego Rodrigues, Moura, Pedro Henrique Macedo, Souza, Jessiane Bispo de, Santos, Leticia Milena Machado dos, Guimarães, Adriana Gibara, Santana, Lucas Alves da Mota, and Borges, Lysandro Pinto
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COVID-19 pandemic ,SARS-CoV-2 Omicron variant ,VACCINATION ,VACCINATION coverage ,CITIES & towns - Abstract
Background: Given the impact of the pandemic in Brazil, vaccination is essential to prevent illness and death. Thus, this study sought to compare, after vaccination, the circulation of SARS-CoV-2 and the response to vaccination in the least and most vaccinated municipalities of a Brazilian state during the height of the pandemic when the Omicron variant was dominant. Methods: We tested for the SARS-CoV-2 antigen and confirmed infection using an RT-qPCR and measured IgM and IgG antibodies in fully vaccinated participants from municipalities with higher and lower vaccination rates. Results: We showed that participants from the least vaccinated municipalities were more likely to have detectable IgM antibodies and a positive antigen/RT-qPCR result for SARS-CoV-2 than participants from the most vaccinated municipalities. There were no differences between the vaccines used (BNT162b2, Ad26.COV2.S, AZD1222, and CoronaVac) and antibody production. Conclusions: Our study evaluated municipal vaccination coverage and its effects on mortality, infections, and anti-SARS-CoV-2 antibodies during a critical phase of the pandemic. The results suggest that higher vaccination coverage reduces acute cases and confers higher memory antibody levels against SARS-CoV-2. Even with a full vaccination schedule, individuals living in places with low vaccination rates are more susceptible to infection. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Impacto da estrutura de detenção na ocorrência de infecção por SARS-CoV-2 em jovens detentos
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Borges, Lysandro Pinto, Guimarães, Adriana Gibara, Souza, Daniela Raguer Valadão de, Martins, Aline Fagundes, Rezende Neto, José Melquiades de, Santos, Aryanne Araujo, Invenção, Grazielly Bispo da, Matos, Igor Leonardo Santos, Santos, Kezia Alves dos, Souza, Nicolas Alessandro Alves, Walker, Cristiani Isabel Banderó, Jesus, Pamela Chaves, Oliveira, Lylyan Gleyze Brito, and Oliveira, Makson Gleydson Brito de
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Unidades socioeducativas ,Ensayos de inmunofluorescencia ,SARS-CoV-2 ,COVID-19 ,Immunofluorescence assays ,Ensaios de imunofluorescência ,Socio-educational units - Abstract
Considering that COVID-19 is a respiratory disease transmitted by contact and places of incarceration are an environment that imposes additional risks for viral spread, this study sought to identify cases of SARS-CoV-2 infection in socio-educational units. We evaluated the seroprevalence of IgM and IgG for SARS-CoV-2 in workers and adolescents confined in five socio-educational units. Adolescents and workers tested positive for IgM (n=8, each), IgG (n=26; n=6) and both (n=13; n=6), with a greater chance of detecting IgG (OR: 2.16, p = 0.03) and both (OR: 68.59, p
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- 2022
5. Mapping the technological landscape of SARS, MERS, and SARS-CoV-2 vaccines.
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Nascimento Júnior, José Adão Carvalho, Santos, Anamaria Mendonça, Cavalcante, Rafael Ciro Marques, Quintans-Júnior, Lucindo José, Walker, Cristiani Isabel Banderó, Borges, Lysandro Pinto, Frank, Luiza Abrahão, and Serafini, Mairim Russo
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COVID-19 ,SARS-CoV-2 ,MIDDLE East respiratory syndrome ,SARS disease ,COVID-19 vaccines ,GENETIC vectors - Abstract
The last two decades have seen the emergence of several viral outbreaks. Some of them are the severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and severe acute respiratory syndrome 2 (SARS-CoV2) – the cause of the coronavirus disease 2019 (COVID-19). Ever, vaccines for emergency use have been authorized for the control and prevention of COVID-19. Currently, there is an urgent need to develop a vaccine for prophylaxis of COVID-19 and for other future epidemics. This review describes patented vaccines for SARS and MERS-CoV and vaccines developed and approved for emergency use against the new coronavirus (COVID-19). The European Patent Office and the World Intellectual Property Organization were the patent databases used using specific terms. In addition, another search was carried out in the Clinical Trials in search of ongoing clinical studies focused on the COVID-19 vaccine. The patent search showed that most vaccines are based on viral vector platforms, nucleic acids, or protein subunits. The review also includes an overview of completed and ongoing clinical trials for SARS-CoV-2 in several countries. The information provided here lists vaccines for other types of coronavirus that have been used in the development of vaccines for COVID-19. [ABSTRACT FROM AUTHOR]
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- 2021
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6. Rapid diagnosis of COVID-19 in the first year of the pandemic: A systematic review.
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Borges, Lysandro Pinto, Martins, Aline Fagundes, Silva, Breno de Mello, Dias, Bruna de Paula, Gonçalves, Ricardo Lemes, Souza, Daniela Raguer Valadão de, Oliveira, Makson Gleydson Brito de, Jesus, Pamela Chaves de, Serafini, Mairim Russo, Quintans, Jullyana Souza Siqueira, Coutinho, Henrique Douglas Melo, Martins, Natália, and Júnior, Lucindo José Quintans
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COVID-19 testing , *COVID-19 , *PANDEMICS , *POINT-of-care testing , *DISEASE outbreaks , *SCIENCE publishing - Abstract
• Most tests analyzed were not adequately validated; • For the extensive use of these rapid tests the validation should be immediate; • More studies are needed to determine cross reactivity in these tests.. COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health threat and remains a challenge for modern medicine. Rapid and accurate diagnosis of COVID-19 is vital for proper disease and outbreak management. Our review aimed to analyze scientific articles published in the literature addressing the rapid tests available for COVID-19 diagnosis at the first year of the pandemic. Methods: A systematic review was performed from October 22 to 27, 2020, searching data published in PubMed and Google Scholar databases, using subject headings or keywords related to point of care and rapid test diagnostic for SARS-CoV-2 and COVID-19. Results: The first survey identified 403 articles, but only 23 met the defined criteria for the systematic analysis. The sensitivity and specificity parameters were assessed in 19 studies, and the data suggested that there was lower sensitivity in the period 1 to 7 days after the emergence of symptoms (∼38%) higher sensitivity at 8 to 14 days (∼90%), and the highest at 15 to 39 days (∼98%). Accuracy was reported in six studies, reporting values above 50%. Only three studies reported a possible cross-reaction. Conclusions: Our findings indicate that the rapid tests used in the first year of the pandemic were tested with a small number of samples and not adequately validated. And the studies that described them were conducted with little scientific rigor. [ABSTRACT FROM AUTHOR]
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- 2021
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7. Does In-Person Visiting Affect the Number of COVID-19 Cases in Prisons?
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Borges, Lysandro Pinto, Martins, Aline Fagundes, de Souza, Daniela Raguer Valadão, de Rezende Neto, José Melquiades, Santos, Aryanne Araujo, Oliveira, Brenda Morais, Matos, Igor Leonardo Santos, da Invenção, Grazielly Bispo, dos Santos, Kezia Alves, Souza, Nicolas Alessandro Alves, de Jesus, Pamela Chaves, dos Santos, Cliomar Alves, de Oliveira Goes, Marco Aurélio, de Souza, Mércia Simone Feitosa, de Carvalho Barreto, Ikaro Daniel, Guimarães, Adriana Gibara, and Quintans-Júnior, Lucindo José
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COVID-19 pandemic , *COVID-19 , *SARS-CoV-2 , *PRISONS , *VACCINATION , *IMMUNOGLOBULIN M - Abstract
Even with the current advances that have been made in regard to COVID-19, such as a better understanding of the disease and the steady growth in the number of vaccinated individuals, it remains a challenge for humanity. Dealing with the disease in prison settings has been particularly difficult. This study sought to discover whether in-person visiting affected the number of cases of SARS-CoV-2 infection in the penitentiaries in the state of Sergipe (Brazil). We conducted a two-phase study (when visiting was suspended and after it recommenced) in seven penitentiaries in Sergipe using immunochromatography and nasopharyngeal swab testing to evaluate whether visiting affects the number of COVID-19 cases. In the first phase (n = 778), 57.6% of inmates reported risk factors and 32.5% were positive for COVID-19 (18.9% IgM, 24.2% IgG, 1% antigen). In the second phase, 19.6% tested positive (13.9% IgM, 7.9% IgG, 0.2% antigen). The occurrence of positive cases of COVID-19 and positive results (IgM and IgG) were significantly higher in the first phase. In the second phase, 56.7% of inmates had received visits and 18.7% were positive for COVID-19 (14% IgM, 7% IgG). Among those who had not received visits, 20.9% tested positive (13.8% IgM, 9.2% IgG, 0.5% antigen). There was no significant difference in positive cases/results between inmates that had and had not received visits. These findings suggest that, under the conditions assessed, visiting does not seem to affect the number of COVID-19 cases in prisons and reinforces the importance of sanitary measures to control dissemination. [ABSTRACT FROM AUTHOR]
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- 2021
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8. Rapid antigen detection of severe acute respiratory syndrome coronavirus-2 in stray cats: A cross-sectional study.
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Santos, Ronaldy Santana, Braga Lee, Daniel Antônio, Barreto, Marina dos Santos, Dias Silva, Eloia Emanuelly, de Jesus, Pamela Chaves, Macedo Moura, Pedro Henrique, Rego Rodrigues Silva, Deise Maria, de Souza, Jessiane Bispo, Bezerra, Taynar Lima, Meira Santos, Patricia Oliveira, Guimarães, Adriana Gibara, da Mota Santana, Lucas Alves, Prudencio, Carlos Roberto, and Borges, Lysandro Pinto
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SARS-CoV-2 , *ANIMAL disease control , *CATS , *ANIMAL populations , *ANTIGEN analysis - Abstract
Background and Aim: Although reverse zoonotic transmission events from humans to domestic cats have been described, there is currently little evidence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) circulation in stray cats. Due to the evidence of natural and experimental infections in cats and the capacity to disseminate the virus among them, this study aimed to identify the SARS-CoV-2 antigen in stray cats from the Federal University of Sergipe in Brazil. Materials and Methods: One hundred twenty six stray cats from the university were screened for SARS-CoV-2 antigens by random sampling. Throat swab samples were tested for the virus using rapid antigen detection tests. Results: Of the 126 animals tested, 30 (23.60%) were positive for SARS-CoV-2 antigens. To our knowledge, for the first time, this study detected the SARS-CoV-2 antigen in stray cats and confirmed the presence of SARS-CoV-2 infections in Brazil's stray cat population. Conclusion: The detection of SARS-CoV-2 in stray cats poses a risk for infected and healthy animals and possibly for humans who attend the university daily. As a limitation of the study, the small sample size necessitates caution when interpreting the results. This underscores the need for further research in this area to help control diseases in stray animals during potential pandemics. This highlights the need for monitoring and controlling the spread of the virus in stray animal populations. [ABSTRACT FROM AUTHOR]
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- 2024
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