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Your search keyword '"Meaghan O’Neill"' showing total 2 results
Start Over Author "Meaghan O’Neill" Topic sars-cov-2
2 results on '"Meaghan O’Neill"'

1. Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome

Author

Meghan H. Shilts, Christian Rosas-Salazar, Britton A. Strickland, Kyle S. Kimura, Mohammad Asad, Esha Sehanobish, Michael H. Freeman, Bronson C. Wessinger, Veerain Gupta, Hunter M. Brown, Helen H. Boone, Viraj Patel, Mali Barbi, Danielle Bottalico, Meaghan O’Neill, Nadeem Akbar, Seesandra V. Rajagopala, Simon Mallal, Elizabeth Phillips, Justin H. Turner, Elina Jerschow, and Suman R. Das

Subjects
SARS-CoV-2, COVID-19, upper respiratory tract, microbiome, mild, moderate, Microbiology, QR1-502
Abstract

BackgroundThe upper respiratory tract (URT) is the portal of entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with the URT microbiome. However, understanding of the associations between the URT microbiome and the severity of coronavirus disease 2019 (COVID-19) is still limited.ObjectiveOur primary objective was to identify URT microbiome signature/s that consistently changed over a spectrum of COVID-19 severity.MethodsUsing data from 103 adult participants from two cities in the United States, we compared the bacterial load and the URT microbiome between five groups: 20 asymptomatic SARS-CoV-2-negative participants, 27 participants with mild COVID-19, 28 participants with moderate COVID-19, 15 hospitalized patients with severe COVID-19, and 13 hospitalized patients in the ICU with very severe COVID-19.ResultsURT bacterial load, bacterial richness, and within-group microbiome composition dissimilarity consistently increased as COVID-19 severity increased, while the relative abundance of an amplicon sequence variant (ASV), Corynebacterium_unclassified.ASV0002, consistently decreased as COVID-19 severity increased.ConclusionsWe observed that the URT microbiome composition significantly changed as COVID-19 severity increased. The URT microbiome could potentially predict which patients may be more likely to progress to severe disease or be modified to decrease severity. However, further research in additional longitudinal cohorts is needed to better understand how the microbiome affects COVID-19 severity.

Published
2022
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2. COVID-19-Induced Anosmia and Ageusia Are Associated With Younger Age and Lower Blood Eosinophil Counts

Author

Mali Barbi, Mohammad Asad, Ruth Eisenberg, Thomas J. Ow, Denise Sanchez Tejera, Mahendra Rangareddy, Alexandre Peshansky, Nadeem Akbar, Viraj V. Patel, Meaghan O’Neill, Danielle M. Bottalico, Valerie Fong, Avindra Nath, Bryan Smith, Mimi Y. Kim, Golda Hudes, Meryl Kravitz, Cynthia Matsumura, Denisa Ferastraoaru, Elina Jerschow, Merhunisa Karagic, and Esha Sehanobish

Subjects
Male, 2019-20 coronavirus outbreak, Younger age, Coronavirus disease 2019 (COVID-19), Anosmia, Olfaction Disorders, 03 medical and health sciences, 0302 clinical medicine, Disease severity, medicine, Humans, Immunology and Allergy, 030212 general & internal medicine, 030223 otorhinolaryngology, Blood eosinophil, SARS-CoV-2, business.industry, COVID-19, Infant, Original Articles, General Medicine, Ageusia, Eosinophil, Eosinophils, medicine.anatomical_structure, Otorhinolaryngology, Immunology, medicine.symptom, business
Abstract

Background Anosmia and ageusia are symptoms commonly associated with COVID-19, but the relationship with disease severity, onset and recovery are unclear. Objective To examine factors associated with anosmia and ageusia and the recovery from these symptoms in an ethnically diverse cohort. Methods Individuals tested for SARS-CoV-2 between March and April 2020 were eligible for the study. Randomly selected participants answered a telephone questionnaire on COVID-19 symptoms with a focus on anosmia and ageusia. Additionally, relevant past medical history and data on the COVID-19 clinical course were obtained from electronic medical records. 486 patients were in the COVID-19 group and 103 were COVID-19-negative. Results Patients who were younger were more likely to report anosmia and/or ageusia (odds ratio (OR) for anosmia per 1-year increase in age: 0·98, 95%CI:0–97-0·99, p = 0·003; for ageusia: 0·98, 95%CI:0·97-0·99, p = 0·005) as were patients with lower eosinophil counts (OR for anosmia per 0.1-K/μL increase in eosinophils: 0·02, 95%CI:0·001-0·46, p = 0·01, for ageusia 0·10, 95%CI:0·01-0·97, p = 0·047). Male gender was independently associated with a lower probability of ageusia (OR:0·56, 95%CI:0·38-0·82, p = 0·003) and earlier sense of taste recovery (HR:1·44, 95%CI:1·05-1·98, p = 0·02). Latinos showed earlier sense of taste recovery than white patients (HR:1·82, 95%CI:1·05-3·18, p = 0·03). Conclusion Anosmia and ageusia were more common among younger patients and those with lower blood eosinophil counts. Ageusia was less commonly reported among men, and time to taste recovery was earlier among both men and Latinos.

Published
2021
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