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Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Andrew P. Rothstein, Casandra W. Philipson, Birgitte B. Simen, and Robert C. Morfino own Ginkgo Bioworks employee stocks or restricted stock unit grants. Ezra T. Ernst owns XWELL employee stocks or restricted stock unit grants. No other potential conflicts of interest were disclosed.

Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Robert C. Morfino, Benjamin H. Rome, Andrew P. Rothstein, Siyao Lisa Li, and Thomas W. S. Aichele report Ginkgo Bioworks employee stocks or restricted stock units (RSU) grants. Aaron Bivins reports grants from the U.S. Environmental Protection Agency, Louisiana Water Resources Research Institute, and Louisiana State University, payments from BioRad Laboratories, and equipment or materials from Ceres Nanosciences. Ezra T. Ernst reports XWELL employee stocks or RSU grants. No other potential conflicts of interest were disclosed.

The article reports that Predeparture testing of international travelers has been identified as a key measure for reducing the transmission of SARS-CoV-2 during air travel. Topics include using genomic surveillance data, a new study examined the effect of predeparture testing on postarrival SARS-CoV-2 test positivity among international travelers; and provides real-world evidence supporting predeparture testing as a tool for reducing travel-associated SARS-CoV-2 transmission.

The article reports that Wastewater surveillance in airports and on aircraft can enable detection of emerging SARS-CoV-2 variants. Topics include Aircraft wastewater samples from selected international flights were collected and tested for SARS-CoV-2 by Reverse transcriptase polymerase chain reaction and whole genome sequencing; and monitor SARS-CoV-2 variants without direct traveler involvement or disruption to airport operations and can complement traveler-based surveillance.