1. Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection – Surveillance for Emerging Threats to Mothers and Babies Network, 22 state, local, and territorial health departments, March 29, 2020 -March 5, 2021
- Author
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Galang, Romeo R, Newton, Suzanne M, Woodworth, Kate R, Griffin, Isabel, Oduyebo, Titilope, Sancken, Christina L, Olsen, Emily O'Malley, Aveni, Kathryn, Wingate, Heather, Shephard, Hanna, Fussman, Chris, Alaali, Zahra S, Silcox, Kristin, Siebman, Samantha, Halai, Umme-Aiman, Lopez, Camille Delgado, Lush, Mamie, Sokale, Ayomide, Barton, Jerusha, Chaudhary, Ifrah, Patrick, Paul H, Schlosser, Levi, Reynolds, Bethany, Gaarenstroom, Nicole, Chicchelly, Sarah, Read, Jennifer S, de Wilde, Leah, Mbotha, Deborah, Azziz-Baumgartner, Eduardo, Hall, Aron J, Tong, Van T, Ellington, Sascha, and Gilboa, Suzanne M
- Subjects
Adult ,SARS-CoV-2 ,COVID-19 ,Mothers ,macromolecular substances ,AcademicSubjects/MED00290 ,illness severity ,Pregnancy ,Risk Factors ,Humans ,Supplement Article ,Female ,Pregnant Women ,Pregnancy Complications, Infectious ,Aged - Abstract
Background Pregnant women with coronavirus disease 2019 (COVID-19) are at increased risk for severe illness compared with nonpregnant women. Data to assess risk factors for illness severity among pregnant women with COVID-19 are limited. This study aimed to determine risk factors associated with COVID-19 illness severity among pregnant women with SARS-CoV-2 infection. Methods Pregnant women with SARS-CoV-2 infection confirmed by molecular testing were reported during March 29, 2020–March 5, 2021 through the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET). Criteria for illness severity (asymptomatic, mild, moderate-to-severe, or critical) were adapted from National Institutes of Health and World Health Organization criteria. Crude and adjusted risk ratios for moderate-to-severe or critical COVID-19 illness were calculated for selected demographic and clinical characteristics. Results Among 7,950 pregnant women with SARS-CoV-2 infection, moderate-to-severe or critical COVID-19 illness was associated with age 25 years and older, healthcare occupation, pre-pregnancy obesity, chronic lung disease, chronic hypertension, and pregestational diabetes mellitus. Risk of moderate-to-severe or critical illness increased with the number of underlying medical or pregnancy-related conditions. Conclusions Older age and having underlying medical conditions were associated with increased risk of moderate-to-severe or critical COVID-19 illness among pregnant women. This information might help pregnant women understand their risk for moderate-to-severe or critical COVID-19 illness and inform targeted public health messaging.
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- 2021