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Shruti Singh,1 Nirav Nimavat,2 Amarjeet Kumar Singh,3 Shamshad Ahmad,4 Nishi Sinha2 1Department of Pharmacology, AIIMS, Patna, Bihar, India; 2Department of Community Medicine, SBKS MIRC, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India; 3Department of Anaesthesia, AIIMS, Patna, Bihar, India; 4Department of Community and Family Medicine, AIIMS, Patna, Bihar, IndiaCorrespondence: Nirav NimavatDepartment of Community Medicine, SBKS MIRC, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, IndiaEmail nkniraj1529@gmail.comBackground: The world is facing the most challenging pandemic in the 21st century. The developed and developing countries are facing the burden equally and no proven treatment options available. Recent studies suggest the plausibility of vitamin D therapy and prophylaxis for COVID-19, in the setting where the deficiency is more prevalent. Though evaluation of vitamin D status is not a routine in India, the present study focuses on the level of Vitamin d among COVID-19 patients.Methods: The study was a hospital-based cross-sectional to find the status of vitamin D among COVID-19 patients in a tertiary care hospital, Patna, Bihar, India. The demographic, comorbidity data were taken, and the level of vitamin D was measured by a chemiluminescence-based immunoassay analyzer. The analysis compared the level of deficiency and insufficiency among different groups of COVID-19 patients. The role of DM and HTN as risk factors for mortality was compared.Results: Among the total study participants (156), 42.31% were obese and 17.31% were severe as per clinical severity. The total prevalence of vitamin D deficiency was 58.97% and insufficiency was 89.1%. The prevalence was found high among male (61.02%), overweight (65.52%), and severe (62.96%) patients. The severity increases with advanced age (p< 0.05) and important risk factors for mortality are DM, HTN, and advanced age.Conclusion: The level of vitamin D can be assessed for the prognosis of COIVD-19 patients and help to modify the treatment protocol. Appropriate therapeutic/preventive intervention of vitamin D can alter the course and severity of COVID-19.Keywords: Vitamin D, COVID-19, SARS-CoV-2, low level of Vitamin D