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The new virus called severe acute respiratory syndrome coronavirus 2 (SARSCov-2) causing Coronavirus disease 2019 (COVID-19) has spread quickly in several countries and it has become pandemic. Different types of clinical manifestations are attributed to this infection. Some mechanisms related to the infection regarding the immune response are not still elucidated. Herein we reported a case of a 66-years-old patient affected by myelodysplasia who was referred to our hospital because of clinical and radiological manifestations of viral pneumonia. The clinical course has become complicated due to bacterial secondary over-infection by Pseudomonas aeruginosa during stay in internal medicine unit whilst a persistent positive oral and naso-pharyngeal swab test was reported up to 100 days of admission. The patient had a fast clinical and radiological worsening that led her to be admitted to an intensive care unit. Despite intubation and mechanical ventilation she died in a few days., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Emerging literature evidence shows that the manifestations of the coronavirus disease 2019 (COVID‐19), which is the disease caused by SARS‐CoV‐2, encompass alterations of the pulmonary, cardiovascular, gastrointestinal, and neurological system. Moreover, hematologic and dermatologic manifestations have been documented. The aim of this review is to summarize the dermatologic manifestations of COVID‐19 involving the hair and nails in a narrative way. A total of 1136 patients have been reported to have de novo hair loss following COVID‐19. Notably, 958 patients experienced telogen effluvium (TE) (female/male ratio = 3,86:1), two female patients experienced anagen effluvium, and 176 people had alopecia areata (female/male ratio of 19:3). Ten patients were reported to have ungual changes following the infection with the novel coronavirus: The individuals affected were 6 women and 4 men. COVID‐19 can be associated with hair and ungual manifestations. This review summarizes the evidence regarding the hair and ungual manifestations of COVID‐19, which could be harnessed to better understand the clinical implications and pathophysiology of this disease that has been burdening society globally since December 2019. [ABSTRACT FROM AUTHOR]

COPD influences survival in patients affected by COVID-19, comparison between subjects admitted to an internal medicine unit, and subjects admitted to an intensive care unit: An Italian experience Keywords: COPD; SARS-Cov-2; survival; comorbidities EN COPD SARS-Cov-2 survival comorbidities 1239 1241 3 01/30/21 20210301 NES 210301 In December 2019 a new viral infectious disease caused by severe acute syndrome coronavirus 2 (SARS-CoV-2) broke out causing coronavirus disease 2019 (COVID-19), emerging in China.1-3 The disease spread in Europe including Italy since February 2020. Notably comorbidities, such as diabetes, hypertension and COPD were more present in patients admitted to an intensive care unit. [Extracted from the article]

The most frequent dermatologic pictures are macular-papular exanthemas, pernio-like lesions, papules-vesicles, urticarial lesions, and livedo reticularis. Bullous dermatosis on the hands following SARS-CoV-2 infection Dear Editor, The novel coronavirus SARS-CoV-2, which causes Coronavirus disease 2019 (COVID-19), can lead to heterogeneous symptoms which range from interstitial pneumonia to generalized disturbances characterized by severe immune responses and aberrant inflammation, which may be associated to various dermatologic manifestations.1,2 A 77-year-old male patient was admitted to our hospital for bilateral pneumonia and symptomatic SARS-CoV-2 infection, which was confirmed with a positive oropharyngeal swab. [Extracted from the article]

Transverse orange nail lesions following SARS-CoV-2 infection Neri et al2 reported the case of a COVID-19 patient who developed the "red half-moon" sign, which consists in "distally convex half-moon-shaped red bands surrounding the distal margin of the lunula". However, unlike the evidence that we found in the literature, the nail lesions of our patient were located distally in the nails. [Extracted from the article]

COVID-19 presents with a wide range of clinical neurological manifestations. It has been recognized that SARS-CoV-2 infection affects both the central and peripheral nervous system, leading to smell and taste disturbances; acute ischemic and hemorrhagic cerebrovascular disease; encephalopathies and seizures; and causes most surviving patients to have long lasting neurological symptoms. Despite this, typical neuropathological features associated with the infection have still not been identified. Studies of post-mortem examinations of the cerebral cortex are obtained with difficulty due to laboratory safety concerns. In addition, they represent cases with different neurological symptoms, age or comorbidities, thus a larger number of brain autoptic data from multiple institutions would be crucial. Histopathological findings described here are aimed to increase the current knowledge on neuropathology of COVID-19 patients. We report post-mortem neuropathological findings of ten COVID-19 patients. A wide range of neuropathological lesions were seen. The cerebral cortex of all patients showed vascular changes, hyperemia of the meninges and perivascular inflammation in the cerebral parenchyma with hypoxic neuronal injury. Perivascular lymphocytic inflammation of predominantly CD8-positive T cells mixed with CD68-positive macrophages, targeting the disrupted vascular wall in the cerebral cortex, cerebellum and pons were seen. Our findings support recent reports highlighting a role of microvascular injury in COVID-19 neurological manifestations. [ABSTRACT FROM AUTHOR]

Why carry out this study?. • People vaccinated against SARS-CoV-2 are daily increasing, and several cases of varicella zoster virus reactivation have been reported. • The real extend of reactivation risk has not been still elucidated. What was learned from the study?. • Varicella zoster virus reactivation among SARS-CoV-2 vaccinated or infected adults predominantly was a mild herpes zoster rash. Near 90% were non-serious. No pneumonia or death was reported. • The manifestations appeared predominantly within 10 days following the first dose or infection. • Our findings support that COVID-19 vaccination is safe and remains strongly recommended. Varicella zoster virus (VZV) reactivation has been reported following vaccination for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the real extent remains unknown. We conducted a systematic review to summarize evidence of VZV reactivation or infection following SARS-CoV-2 vaccination. Episodes after coronavirus disease-2019 (COVID-19) were also identified. Related articles were identified in PubMed and EMBASE databases till December 31, 2021 using the terms "varicella zoster" and "COVID-19″. PROSPERO Register Number: CRD42021289399. The search revealed 314 articles, of which 55 met the inclusion criteria. VZV manifestations were documented in 179 (82.1%) subjects following SARS-CoV-2 vaccination and in 39 (17.9%) patients with COVID-19. Among the vaccinated, median (IQR) age was 56.5 (42–70) years, and 56.8% were female. Twenty-one (16.8%) were immunosuppressed. The median (IQR) latency time after vaccination was 6 (3–10) days, and 84.4% received mRNA vaccines. VZV reactivation occurred following a first dose (68.2%), a second dose (12.8%) or a booster (0.6%). The most important VZV manifestation was dermatome herpes zoster rash, which accounted for 86.4% of events in vaccinated subjects. Twenty patients (11.3%) presented serious VZV events after vaccination, with Herpes Zoster ophthalmicus (5.6%) and post-herpetic neuralgia (3.4%) predominating. No VZV pneumonia or deaths were recorded. Antiviral prescriptions were made in 96.2% of vaccinated subjects. No significant differences between vaccinated and infected subjects were found. This study indicates that the occurrence of VZV reactivation is clinically relevant. However, our findings suggest that COVID-19 vaccination is safe, and remains strongly recommended. [ABSTRACT FROM AUTHOR]