1. SARS-CoV-2: lessons from both the history of medicine and from the biological behavior of other well-known viruses.
- Author
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Fiorino S, Tateo F, Biase D, Gallo CG, Orlandi PE, Corazza I, Budriesi R, Micucci M, Visani M, Loggi E, Hong W, Pica R, Lari F, and Zippi M
- Subjects
- Antiviral Agents therapeutic use, COVID-19 epidemiology, COVID-19 transmission, Climate, Disease Reservoirs virology, Genome, Viral, History, 19th Century, History, 20th Century, History, 21st Century, Humans, Mutation, RNA Viruses pathogenicity, RNA Viruses physiology, Reinfection epidemiology, Reinfection history, Reinfection transmission, Reinfection virology, Respiratory Tract Infections drug therapy, Respiratory Tract Infections epidemiology, Respiratory Tract Infections history, Respiratory Tract Infections transmission, Virus Replication, COVID-19 Drug Treatment, COVID-19 history, Pandemics history, SARS-CoV-2 pathogenicity, SARS-CoV-2 physiology
- Abstract
SARS-CoV-2 is the etiological agent of the current pandemic worldwide and its associated disease COVID-19. In this review, we have analyzed SARS-CoV-2 characteristics and those ones of other well-known RNA viruses viz. HIV, HCV and Influenza viruses, collecting their historical data, clinical manifestations and pathogenetic mechanisms. The aim of the work is obtaining useful insights and lessons for a better understanding of SARS-CoV-2. These pathogens present a distinct mode of transmission, as SARS-CoV-2 and Influenza viruses are airborne, whereas HIV and HCV are bloodborne. However, these viruses exhibit some potential similar clinical manifestations and pathogenetic mechanisms and their understanding may contribute to establishing preventive measures and new therapies against SARS-CoV-2.
- Published
- 2021
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