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Saudi Arabia is known for its dry climate. This arid climate of the region makes its ecosystems highly susceptible, with limited water resources and vulnerable agricultural fields. Therefore, it is crucial to comprehend the public's awareness and perceptions of environmental issues and climate change that have an impact on their health and immune system. This study employed a cross-sectional survey to examine the knowledge, attitudes, and practices (KAP) and related health impact of environmental pollutants and climate change in Saudi Arabia. The participants were chosen randomly from various regions across the kingdom. In this study, a total of 437 respondents were selected using convenience sampling (80.78% female and 19.22% male). Participants have fair knowledge on immunological and health effect of environmental pollution and climate change (94.3% and 87.5%, respectively). Participants are well aware of influence of environmental pollutants and climate change on spread of infectious diseases 51–94%. Significant correlation exists between participants of private sector in attitude domain of KAP (P = 0.003, χ2 = 5.139). Significant correlation exists between participants of private sector in attitude domain of KAP (P = 0.003, χ2 = 5.139. Participants are well aware of influence of environmental pollutants and climate change on spread of infectious diseases (51–94%). In conclusion, the health mission in Saudi Arabia has integrated order to manage the diseases that are related to climate change. It is crucial to enhance the knowledge and skills of general public regarding climate change and its impact on health. [ABSTRACT FROM AUTHOR]