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1. Chromatin topology is coupled to Polycomb group protein subnuclear organization

Author

Ajazul H. Wani, Alistair N. Boettiger, Patrick Schorderet, Ayla Ergun, Christine Münger, Ruslan I. Sadreyev, Xiaowei Zhuang, Robert E. Kingston, and Nicole J. Francis

Subjects
Science
Abstract

Polycomb Group (PcG) proteins regulate gene expression and genome architecture. Using super-resolution microscopy and molecular simulations, Waniet al. describe the organization of PcG proteins into hundreds of nano-scale protein clusters and suggest these clusters shape genome architecture.

Published
2016
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