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Your search keyword '"Contrast media -- Chemical properties"' showing total 7 results
Start Over Descriptor "Contrast media -- Chemical properties" Topic science and technology
7 results on '"Contrast media -- Chemical properties"'

1. Calcium-sensitive MRI contrast agents based on superparamagnetic iron oxide nanoparticles and calmodulin

Author

Atanasijevic, Tatjana, Shusteff, Maxim, Fam, Peter, and Jasanoff, Alan

Subjects
Contrast media -- Chemical properties, Ferric oxide -- Chemical properties, Nanoparticles -- Chemical properties, Calmodulin -- Chemical properties, Diagnostic imaging -- Methods, Science and technology
Abstract

We describe a family of calcium indicators for magnetic resonance imaging (MRI), formed by combining a powerful iron oxide nanoparticle-based contrast mechanism with the versatile calcium-sensing protein calmodulin and its targets. Calcium-dependent protein--protein interactions drive particle clustering and produce up to 5-fold changes in T2 relaxivity, an indication of the sensors' potency. A variant based on conjugates of wild-type calmodulin and the peptide M13 reports concentration changes near 1 [micro]M [Ca.sup.2+], suitable for detection of elevated intracellular calcium levels. The midpoint and cooperativity of the response can be tuned by mutating the protein domains that actuate the sensor. Robust MRI signal changes are achieved even at nanomolar particle concentrations ( magnetic resonance | T2 relaxation | signal transduction | molecular imaging | neuroimaging

Published
2006

2. Responsive MRI agents for sensing metabolism in vivo

Author

De Leon-Rodriguez, Luis M., Lubag, Angelo Josue M., Malloy, Craig R., Martinez, Gary V., Gillies, Robert J., and Sherry, A. Dean

Subjects
Contrast media -- Chemical properties, Contrast media -- Optical properties, Gadolinium -- Chemical properties, Gadolinium -- Optical properties, Magnetic resonance imaging -- Analysis, Chemistry, Science and technology
Published
2009

4. Bioresponsive, cell-penetrating, and multimeric MR contrast agents

Author

Major, Jody L. and Meade, Thomas J.

Subjects
Contrast media -- Chemical properties, Contrast media -- Optical properties, Gadolinium -- Chemical properties, Gadolinium -- Optical properties, Magnetic resonance imaging -- Analysis, Chemistry, Science and technology
Published
2009

6. Recent Findings from Gazi University Provide New Insights into Science (Unusual radiographic images of radiopaque contrast media incidentally observed in intracranial region: two case reports)

Subjects
Contrast media -- Chemical properties, Radiography -- Methods, Editors, Health, Science and technology
Abstract

2019 MAR 8 (NewsRx) -- By a News Reporter-Staff News Editor at Science Letter -- Investigators discuss new findings in Science. According to news reporting from Ankara, Turkey, by NewsRx [...]

Published
2019

7. New findings reported from University of California, Department of Radiology describe advances in biomacromolecules

Subjects
University of California, Ethylene glycol -- Chemical properties, Contrast media -- Chemical properties, Health, Science and technology, Chemical properties
Abstract

A new study, "Cascade polymeric MRI contrast media derived from poly(ethylene glycol) cores: initial syntheses and characterizations," is now available. "Diagnostic contrast media for magnetic resonance imaging (MRI) are often [...]

Published
2007

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