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LEBANON, NEW HAMPSHIRE -- Near the Vermont-New Hampshire border, where highway signs warn of occasional moose crossings, the Dartmouth-Hitchcock Medical Center looms like a mountain behind a wall of fir [...]

BOSTON AND CAMBRIDGE, MASSACHUSETTS -- At 34, David Sinclair is a rising star. His spacious ninth-floor office at Harvard Medical School boasts a panoramic Boston view. His rapidly growing lab [...]

Just when scientists thought they had deciphered the roles played by the cell's leading actors, a familiar performer has turned up in a stunning variety of guises. RNA, long upstaged by its more glamorous sibling, DNA, is turning out to have star qualities of its own., #1 The Winner Small RNAs Make Big Splash For decades, RNA molecules were dismissed as little more than drones, taking orders from DNA and converting genetic information into proteins. But [...]

Twenty years ago, a curious new agent emerged from obscurity to join the cast of biology's villains. Dubbed prions, these infectious proteins have been fingered for causing an array of [...]

On a typical day, at least 150 women undergo mammography at the California Pacific Medical Center in San Francisco, and for the last year, most have agreed to take part [...]

How does a scientist hit a home run in the drug business? For Kenneth Koe and Willard Welch, it took curiosity, determination, and a series of lucky breaks. The payoff [...]

The idea gelled at the Havana Club in New York City, over Cuban food and heated conversation. Gathered at the Manhattan restaurant were trustees of a patient advocacy group, the [...]

For those who trust government-approved drugs, 2004 was not a banner year. Merck, the maker of the anti-inflammatory medicine Vioxx, pulled the drug off the global market in September after [...]

A disparate group of researchers banded together in 1999 to explore novel therapies in immunology. Five years later, the Immune Tolerance Network has 'turned the corner' on management problems, leaders say, and clinical results are starting to appear, It was touch and go when immunologist Jeffrey Bluestone finally handed off his precious cargo 5 years ago: an 800-page tome he hoped would transform medicine. An overnight courier drove [...]

Cardiologist Richard Schatz is tired of watching his patients die. They face daily anguish--as do millions of other people--because their hearts are pocked with dead muscle, undersupplied by blood, and [...]

HOUSTON, TEXAS -- If statistics were a religion, Donald Berry would be among its most dogged proselytizers. Head of biostatistics at the M. D. Anderson Cancer Center here, he's dropped [...]

Gleevec demonstrated the power of targeted cancer drugs, but applying similar strategies to the treatment of common cancers hasn't been easy, Physicians treating lung cancer grasp at every straw of optimism they can find, as the straws are few and far between: Many patients are diagnosed when their disease has spread [...]

Autoimmune disease and transplant researchers are teaming up in their search for ways to make the immune system tolerate tissue it's attacking., The immune system is a shifty character, displaying the faces of Dr. Jekyll and Mr. Hyde. Most people encounter only its benevolent side, charged with protecting against disease. But in [...]

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A fertilized egg has hoop after hoop to jump through during its upcoming 9 months of gestation. 'We pass more biological milestones before we are born than we'll ever pass [...]

A select group of proteins are known contortionists; they bend and fold and stick together, contributing to neurodegenerative diseases such as Alzheimer's. Now researchers report the startling news that all [...]

Normally, we associate evolution with organisms growing more complex as they acquire new genes over time. But as a new analysis of the genome sequences of two 5 bacteria shows, [...]

For crystallographers, some of the more challenging proteins are those found on cell membranes. Often large and insoluble, membrane proteins are difficult to induce to form crystals. Even when that [...]

Since the COX-2 inhibitor Vioxx was yanked off the market more than a year ago, the remaining anti-inflammatory painkillers have been under a cloud of suspicion. Which are the safest, [...]

A cancer drug that chemist Robert Holton invented has reaped more than $350 million in royalties. But his efforts to transform part of that windfall into an expanded chemistry program [...]

For Frank Slack, the story began when his worms exploded through their vulvas. It was 1997, and the developmental biologist, now at Yale, had been tinkering with microRNAs (miRNAs), tiny [...]

The U.S. Food and Drug Administration (FDA) promised a decision on the emergency contraceptive Plan B early last summer. But on 26 August, after more than 2 years of deliberation, [...]

The U.S. Food and Drug Administration (FDA), buffeted by scandals from the Vioxx withdrawal to the morning-after pill Plan B, endured more turbulence last week after its commissioner of 2 [...]

A protein named after the Greek goddess who spins life's thread has joined the short list of ways to extend a mouse's natural life span. Whereas lab mice can live [...]

The U.S. Department of Veterans Affairs (VA) is quietly moving forward with plans for a national gene bank that would link DNA donated by up to 7 million veterans and [...]

MONTREAL, CANADA -- 'Alice in Blunderland' is how biochemist Rose Johnstone describes her 1970s investigations into curious, lipid-encased particles burped out by the sheep red blood cells she was studying. [...]

The House of Representatives has told the Department of Veterans Affairs (VA) to spend $100 million more on research into the mental health of veterans. But it didn't give the [...]

How many people does obesity kill? That question has turned into a headache for the Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia: In the past year, its [...]