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Background: Randomised controlled trials (RCTs) provide the most reliable information to inform clinical practice and patient care. We aimed to map global clinical research publication activity through RCT-related articles in high-impact-factor medical journals over the past five decades.Methods: We conducted a cross-sectional analysis of articles published in the highest ranked medical journals with an impact factor > 10 (according to Journal Citation Reports published in 2017). We searched PubMed/MEDLINE (from inception to December 31, 2017) for all RCT-related articles (e.g. primary RCTs, secondary analyses and methodology papers) published in high-impact-factor medical journals. For each included article, raw metadata were abstracted from the Web of Science. A process of standardization was conducted to unify the different terms and grammatical variants and to remove typographical, transcription and/or indexing errors. Descriptive analyses were conducted (including the number of articles, citations, most prolific authors, countries, journals, funding sources and keywords). Network analyses of collaborations between countries and co-words are presented.Results: We included 39,305 articles (for the period 1965-2017) published in forty journals. The Lancet (n = 3593; 9.1%), the Journal of Clinical Oncology (n = 3343; 8.5%) and The New England Journal of Medicine (n = 3275 articles; 8.3%) published the largest number of RCTs. A total of 154 countries were involved in the production of articles. The global productivity ranking was led by the United States (n = 18,393 articles), followed by the United Kingdom (n = 8028 articles), Canada (n = 4548 articles) and Germany (n = 4415 articles). Seventeen authors who had published 100 or more articles were identified; the most prolific authors were affiliated with Duke University (United States), Harvard University (United States) and McMaster University (Canada). The main funding institutions were the National Institutes of Health (United States), Hoffmann-La Roche (Switzerland), Pfizer (United States), Merck Sharp & Dohme (United States) and Novartis (Switzerland). The 100 most cited RCTs were published in nine journals, led by The New England Journal of Medicine (n = 78 articles), The Lancet (n = 9 articles) and JAMA (n = 7 articles). These landmark contributions focused on novel methodological approaches (e.g. the "Bland-Altman method") and trials on the management of chronic conditions (e.g. diabetes control, hormone replacement therapy in postmenopausal women, multiple therapies for diverse cancers, cardiovascular therapies such as lipid-lowering statins, antihypertensive medications, and antiplatelet and antithrombotic therapy).Conclusions: Our analysis identified authors, countries, funding institutions, landmark contributions and high-impact-factor medical journals publishing RCTs. Over the last 50 years, publication production in leading medical journals has increased, with Western countries leading in research but with low- and middle-income countries showing very limited representation. [ABSTRACT FROM AUTHOR]

The article presents a scientific research on patients with multiple sclerosis (MS) by analyzing data on the bibliographic analysis of articles published from 2003 to 2012. Mentioned is the use of Science Citation Index-Expanded (SCI-E) database from online Web of Science (WOS) platform. Data from "Multiple Sclerosis and Multiple Sclerosis Journal" is also evaluated.

Objective: Reproductive biology is a highly productive area. By analyzing papers published in the major journals in the period 2003–2005, the collaborative patterns were characterized. Design: Original research papers published in 2004 in the journals included in the first quartile of the category “Reproductive Biology” of the Journal Citation Reports (2005) were selected. A bibliometric analysis was carried out with the information obtained, thus building up the networks of coauthorship and institutional collaboration. Result(s): A total of 4,702 papers were analyzed, 96.75% signed in collaboration by two or more authors, the authors per paper index being 5.24; 73.73% of the papers were collaborations between institutions. The U.S.A. and the U.K. headed the absolute productivity ranking in number of papers, and adapting the data with respect to the population, Israel, Australia, and other European countries, such as Finland, Belgium, Sweden, and The Netherlands, had notable contributions. Conclusion(s): We identified the networks of authors who publish in the journals with the greatest impact factor. Only some of the most productive institutions have consolidated collaborative relationships with other institutions. We identified the scientific “isolation” of some countries which, although their productivity is high, have a small number of international collaborations. [Copyright &y& Elsevier]

Objective: To characterize global research on the effectiveness of drug use prevention policies, plans, programs and projects, based on the analysis of research articles published and indexed in scientific databases. Material and methods: Articles on this topic contained in the Web of Science Core Collection database were downloaded and transferred to a Microsoft Access database using a broad search profile that has already been successfully applied in other works. To characterize the scientific production, methods and indicators from the field of bibliometrics were used, as well as social network analysis. Results: The number of published articles (1266) increased, only diminished in the first years of the epidemic by Covid-19. The subject areas with the highest number of papers were Substance Abuse (435), Public Environmental & Occupational Health (394), Psychiatry (163) and Psychology Clinical (157). Articles published by institutions in the United States, United Kingdom, Australia and Canada predominated. The most studied topics were those related to alcohol abuse, smoking, opioids and cannabis. Conclusions: A progressive increase in the number of articles on the analyzed topic and institutional collaboration has been confirmed, which is indicative of its health and scientific interest. Alcoholism and smoking are the two most studied addictions in these papers, and the most frequent and most cited topics deal with prevention in adolescence, therapeutic compliance, the effectiveness of harm reduction programs and prevention from primary care. [ABSTRACT FROM AUTHOR]

Objective To study the most important metrics of publication in the field of reproductive medicine over the decade 2003–2012 to aid in discerning the clinical, social, and epidemiologic implications of this relatively new but rapidly emerging area in medical sciences. Design Bibliometric analysis of most-cited publications from Web of Science databases. Setting Not applicable. Patient(s) None. Intervention(s) None. Main Outcome Measure(s) Most productive and frequently cited investigators, institutions, and countries and specific areas of research, scientific collaborations, and comparison of the growth of reproductive medicine research compared with other areas of medical investigation such as obstetrics and gynecology and related science categories. Result(s) We found that 90 investigators with more than 1,000 citations had jointly published 4,010 articles. A continued rise in the impact factor of reproductive medicine journals was seen. The number of publications in reproductive medicine grew more rapidly compared with other science categories. Presently 22% of highly cited articles in reproductive medicine research are published in journals belonging to science categories outside reproductive medicine. The most-cited study groups are situated in the Netherlands, Belgium, Spain, the United States, and the United Kingdom, and collaborative studies have been increasing. Conclusion(s) Reproductive medicine research and subsequent clinical development have attained scientific growth and maturity. High-quality research is increasingly being published in high-impact journals. The increase in (inter)national collaborations seems to be key to the field's success. [ABSTRACT FROM AUTHOR]

Purpose: To characterize the global research trend in radiology departments based on bibliometric indicators.Material and Method: As a source of information, Science Citation Index Expanded and Journal Citation Reports from Web of Science Core Collection (WoSCC) were used. Annual trends, journals of publication, subject categories of journals, collaboration indexes between authors and institutions, network of cowords and most cited papers were identified and analysed. The period of study was 2009-2018.Results: 283,587 downloaded papers were analysed. The number of articles was increasing, as well as the percentage of funded works. Papers were published in 7314 different journals, being the most productive Plos One (5077), followed by American Journal of Roentgenology (4602) and European Radiology (3644). Most productive subject categories of journals were Radiology, Nuclear Medicine & Medical Imaging (86,568 papers), Clinical Neurology (29,722) and Surgery (23,564). International collaboration has increased more than 5 points, from 15.2% in 2009 to 20.7% in 2018.Conclusions: Most cited articles were published in high impact journals outside the scope of diagnostic imaging. Most influential topics included technical innovations within imaging modalities. MRI replaced conventional radiography and CT as the imaging technique of choice in imaging research. [ABSTRACT FROM AUTHOR]