The Γ-type combined structure is an unconventional high-rise long-span structure, and there is no research literature about the influence of traveling wave effect on such structure at present. This study established an accuracy equivalent simplified model for such structure, employed the modified large mass method to carry out a time history analysis on the seismic response such as the shear force, axial force, and bending moment of the model affected by the traveling wave effect, and summarized the corresponding laws through the analysis results of different working conditions such as time difference, mass ratio, and stiffness ratio. The results demonstrate that, with the increase in the input time difference of seismic wave, the bending moment of the control section increases gradually, while the shear force and axial force decrease first and then increase, and traveling wave effect response within a certain range of time difference is weaker than the uniform excitation response. The differences of traveling wave effect responses due to the change of mass ratio between the vertical and horizontal parts of the structure are less than 10%, while the differences due to the change of stiffness ratio are greater than 20%. [ABSTRACT FROM AUTHOR]