1. Mediators of youth anxiety outcomes 3 to 12 years after treatment.
- Author
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Makover HB, Kendall PC, Olino T, Carper MM, Albano AM, Piacentini J, Peris T, Langley AK, Gonzalez A, Ginsburg GS, Compton S, Birmaher B, Sakolsky D, Keeton C, and Walkup J
- Subjects
- Adaptation, Psychological drug effects, Adolescent, Child, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Male, Treatment Outcome, Anxiety psychology, Anxiety therapy, Anxiety Disorders psychology, Anxiety Disorders therapy, Cognitive Behavioral Therapy, Selective Serotonin Reuptake Inhibitors therapeutic use, Sertraline therapeutic use
- Abstract
Objective: Test changes in perceived coping efficacy, negative self-statements, and interpretive biases to threat during treatment as potential mediators of the relationship between randomly assigned treatment conditions and long-term anxiety follow-ups. Age at randomization was also tested as a moderator of mediational relationships., Method: Participants included 319 youth (ages 7-17) from the Child/Adolescent Multimodal Study (CAMS) who participated in a naturalistic follow-up beginning an average of 6.5 years after the end of the CAMS intervention. The intervention conditions included cognitive behavioral therapy (CBT; Coping Cat), pharmacotherapy (sertraline), combined CBT and sertraline, and pill placebo. Putative mediators were measured four times during the intervention phase. Follow-up consisted of four annual assessments of current anxiety., Results: Reductions on a measure of interpretive bias to threat over the course of the combined condition intervention, as compared to the placebo condition, mediated anxiety outcomes at the first follow-up visit. This mediated effect was not significant for the CBT-only or sertraline-only conditions when compared to the placebo condition. No other significant mediated effects were found for putative mediators. Age did not significantly moderate any mediated effects., Conclusion: Changes in youth-reported interpretive biases to threat over the course of combined youth anxiety interventions, as compared to a placebo intervention, may be associated with lower anxiety an average of 6.5 years following treatment., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2020
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