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Your search keyword '"Serotonin and Noradrenaline Reuptake Inhibitors chemistry"' showing total 2 results
Start Over Descriptor "Serotonin and Noradrenaline Reuptake Inhibitors chemistry" Topic selective serotonin reuptake inhibitors
2 results on '"Serotonin and Noradrenaline Reuptake Inhibitors chemistry"'

1. Recent advances in liquid chromatographic methods for the determination of selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors.

Author

Jia E and Bartlett MG

Subjects
Humans, Chromatography, Liquid methods, Selective Serotonin Reuptake Inhibitors blood, Selective Serotonin Reuptake Inhibitors chemistry, Selective Serotonin Reuptake Inhibitors urine, Serotonin and Noradrenaline Reuptake Inhibitors blood, Serotonin and Noradrenaline Reuptake Inhibitors chemistry, Serotonin and Noradrenaline Reuptake Inhibitors urine
Abstract

Depression is now the second largest public health burden throughout the world. Selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) have replaced older antidepressants to become first-line medications to treat this disease with increased remission rates and markedly decreased incidence of severe adverse events. Traditional and modern bioanalytical strategies for SSRI and SNRI determination are being continuously improved. There has also been a recent increase in the use of unconventional sample preparation methods. This review critically evaluates the development of SSRI and SNRI liquid chromatographic analytical methods published between 2014 and mid-2019, with special attention to novel sample preparation methods., (© 2019 John Wiley & Sons, Ltd.)

Published
2020
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2. Design and synthesis of 4-benzylpiperidine carboxamides as dual serotonin and norepinephrine reuptake inhibitors.

Author

Paudel S, Cao Y, Guo S, An B, Kim KM, and Cheon SH

Subjects
Amides chemical synthesis, Amides metabolism, HEK293 Cells, Humans, Norepinephrine Plasma Membrane Transport Proteins chemistry, Norepinephrine Plasma Membrane Transport Proteins metabolism, Piperidines chemistry, Protein Binding, Serotonin Plasma Membrane Transport Proteins chemistry, Serotonin Plasma Membrane Transport Proteins metabolism, Selective Serotonin Reuptake Inhibitors chemistry, Selective Serotonin Reuptake Inhibitors metabolism, Serotonin and Noradrenaline Reuptake Inhibitors chemistry, Serotonin and Noradrenaline Reuptake Inhibitors metabolism, Structure-Activity Relationship, Amides chemistry, Drug Design, Selective Serotonin Reuptake Inhibitors chemical synthesis, Serotonin and Noradrenaline Reuptake Inhibitors chemical synthesis
Abstract

A series of 4-benzylpiperidine carboxamides were designed and synthesized, and tested for their dual (serotonin and norepinephrine) reuptake inhibition. The synthesis of 4-benzylpiperidine carboxamides involved two main steps: amidation and substitution. Derivatives with 3 carbon linker displayed better activity than with 2 carbon linker. 4-Biphenyl- and 2-naphthyl-substituted derivatives 7e and 7j showed greater dual reuptake inhibition than standard drug venlafaxine HCl., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Published
2015
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