1. Supramolecular Isoguanosine Assemblies Form Hydrogels with Excellent Long-Term Stability.
- Author
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Zhao, Hang, Schäfer, Andreas H., and Seela, Frank
- Subjects
- *
NUCLEOSIDE oxidase , *HYDROGELS , *COLLOIDAL gels , *GUANOSINE phosphates , *DRUG delivery devices - Abstract
Supramolecular nucleoside-based hydrogels have the potential to be utilized in drug delivery, regenerative medicine and for the construction of nanoscopic devices. Isoguanosine, its 2′-deoxyribonucleoside and the 2′-deoxy-2′-fluororibonucleoside form hydrogels in alkali metal salt solutions. Gel stability depends on the metal ions used (Li+, Na+, K+, Rb+, Cs+). All isoguanosine gels show long-term stability of several months, whereas guanosine gels collapse within minutes or hours. Rheological data confirm a 15 times higher hydrogel stability for isoguanosine compared to guanosine. Isoguanosine gel stability covers a broad pH range (pH 3–10), and the stability at physiological Na+ ion concentration is striking. SEM images reveal that isoguanosine self-assembles into helical stacked fibers that are interconnected whereas guanosine forms discrete ribbons. Moreover, isoguanosine gels display excellent loading and release ability for small molecules. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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