1. Genital tract sequestration of SIV following acute infection.
- Author
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Whitney JB, Hraber PT, Luedemann C, Giorgi EE, Daniels MG, Bhattacharya T, Rao SS, Mascola JR, Nabel GJ, Korber BT, and Letvin NL
- Subjects
- Animals, DNA, Viral genetics, Gene Flow, Macaca mulatta, Male, Polymerase Chain Reaction, Simian Acquired Immunodeficiency Syndrome blood, Simian Immunodeficiency Virus genetics, Vaccination, Viral Load, Viremia prevention & control, Virus Replication, Gene Products, env genetics, Genitalia, Male virology, Semen virology, Simian Acquired Immunodeficiency Syndrome prevention & control, Simian Acquired Immunodeficiency Syndrome virology, Simian Immunodeficiency Virus pathogenicity
- Abstract
We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.
- Published
- 2011
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