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Purpose: To report a case of a tractional epiretinal membrane that rapidly progressed after intrascleral intraocular lens (IOL) fixation (Yamane technique).Case summary: A 59-year-old male presented with acute-onset decreased visual acuity in the left eye, which occurred 2 days previously. He was diagnosed with IOL dislocation, and underwent vitrectomy and intrascleral IOL fixation following dislocated IOL removal. Choroidal detachment related to ocular hypotony was checked for 1 day after surgery, but there were no signs of leakage at the wound. Two months after the surgery, a tractional epiretinal membrane was present in the superior arcade. and cystoid macular edema was seen on fundoscopy. The best corrected visual acuity had deteriorated to 0.6. Vessel tortuosity and cystoid macular edema deteriorated due to progressive tractional epiretinal membrane 3 months after the surgery, while visual acuity decreased to 0.2. The tractional epiretinal membrane and internal limiting membrane were removed through secondary vitrectomy. Visual acuity recovered to 0.6 1 month after the surgery, and remained stable thereafter.Conclusions: We report this case because there have been no previously reported cases of rapidly progressing tractional epiretinal membrane after application of the Yamane technique.

Purpose: To investigate the changes in peripapillary and macular vessel density in ethambutol-induced optic neuropathy using optical coherence tomography angiography (OCTA).Methods: The medical records of patients diagnosed with ethambutol-induced optic neuropathy were analyzed retrospectively. Patient age, sex, daily dose (mg/day/kg), treatment duration, best-corrected visual acuity (logMAR), color vision (Ishihara color plate tests), and mean deviation of visual field test were evaluated in non-pathological individuals with age and sex controlled as the normal control group. Peripapillary retinal nerve fiber layer (RNFL) thickness, macular ganglion cell/inner plexiform layer (GC/IPL) thickness, radial peripapillary capillary (RPC) density, and macular superficial capillary plexus (SCP) density were also compared between the patient and control groups.Results: The study included 22 patient eyes and 31 control group eyes. Comparing the OCTA results between the groups, there were no significant differences in peripapillary RNFL thickness, but the temporal RPC density was significantly (p = 0.025) lower in the patient group (48.00 ± 8.23%) than in controls (52.39 ± 5.58%). For macular structures, the mean GC/IPL thickness and whole SCP density were lower in the patients (p = 0.001 and p = 0.008, respectively). In the patients, the changes in peripapillary RNFL thickness and RPC density were significantly positively correlated (r = 0.811, p < 0.001), as were the mean macular GC/IPL thickness and whole SCP density (r = 0.445, p = 0.037).Conclusions: Patients with ethambutol-induced optic neuropathy had significantly lower temporal RPC and macular SCP densities. Ethambutol toxicity may affect not only axonal degeneration but also peripapillary and macular vascular function.