1. An Updated Review of the Epigenetic Mechanism Underlying the Pathogenesis of Age-related Macular Degeneration
- Author
-
Mingwei Zhao, Shikun He, and Xiaohua Li
- Subjects
0301 basic medicine ,genetic structures ,Single-nucleotide polymorphism ,Review Article ,Pathology and Forensic Medicine ,Pathogenesis ,03 medical and health sciences ,single nucleotide polymorphisms ,0302 clinical medicine ,medicine ,Epigenetics ,age-related macular degeneration ,Genetic association ,Genetics ,biology ,epigenetics ,RNA ,Cell Biology ,Macular degeneration ,medicine.disease ,eye diseases ,030104 developmental biology ,Histone ,DNA methylation ,biology.protein ,Neurology (clinical) ,sense organs ,Geriatrics and Gerontology ,030217 neurology & neurosurgery - Abstract
Epigenetics has been recognized to play an important role in physiological and pathological processes of the human body. Accumulating evidence has indicated that epigenetic mechanisms contribute to the pathogenesis of age-related macular degeneration (AMD). Although the susceptibility related to genetic variants has been revealed by genome-wide association studies, those genetic variants may predict AMD risk only in certain human populations. Other mechanisms, particularly those involving epigenetic factors, may play an important role in the pathogenesis of AMD. Therefore, we briefly summarize the most recent reports related to such epigenetic mechanisms, including DNA methylation, histone modification, and non-coding RNA, and the interplay of genetic and epigenetic factors in the pathogenesis of AMD.
- Published
- 2020