1. FSH acts on the proliferation of type A spermatogonia via Nur77 that increases GDNF expression in the Sertoli cells.
- Author
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Ding LJ, Yan GJ, Ge QY, Yu F, Zhao X, Diao ZY, Wang ZQ, Yang ZZ, Sun HX, and Hu YL
- Subjects
- Animals, Cells, Cultured, Glial Cell Line-Derived Neurotrophic Factor genetics, Humans, Male, Mice, Nuclear Receptor Subfamily 4, Group A, Member 1 genetics, Spermatogonia metabolism, Transcription, Genetic, Transcriptional Activation, Cell Proliferation, Follicle Stimulating Hormone physiology, Glial Cell Line-Derived Neurotrophic Factor biosynthesis, Nuclear Receptor Subfamily 4, Group A, Member 1 biosynthesis, Sertoli Cells metabolism, Spermatogonia cytology
- Abstract
The molecular mechanism responsible for the regulation of GDNF in Sertoli cells remains largely unknown. In the present study, FSH induced the expression of Nur77 and GDNF in mouse testis tissue and human fetal Sertoli cells. Moreover, FSH increased the number of A spermatogonia co-cultured with Sertoli cells. In the additional assays, Nur77 was observed to directly regulate GDNF transcription. Furthermore, overexpression of Nur77 and siRNA-mediated knockdown of Nur77 affected levels of GDNF mRNA and protein in primary human fetal Sertoli cells. These results indicate that FSH-induced Nur77 regulates the expression of GDNF in Sertoli cells to stimulate the proliferation of A spermatogonia in vitro., (Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.)
- Published
- 2011
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