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Your search keyword '"Borstnik, Kristina"' showing total 2 results
Start Over Author "Borstnik, Kristina" Topic sesquiterpenes
2 results on '"Borstnik, Kristina"'

1. Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.

Author

Borstnik K, Paik IH, Shapiro TA, and Posner GH

Subjects
Animals, Drug Design, Antimalarials pharmacology, Artemisinins pharmacology, Bridged Bicyclo Compounds, Heterocyclic pharmacology, Peroxides, Plasmodium drug effects, Sesquiterpenes pharmacology
Abstract

Mechanism-based rational design and gram-scale chemical synthesis have produced some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarises recent achievements in this area of peroxide drug development for malaria chemotherapy.

Published
2002
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2. New chemical and biological aspects of artemisinin-derived trioxane dimers.

Author

Posner GH, Northrop J, Paik IH, Borstnik K, Dolan P, Kensler TW, Xie S, and Shapiro TA

Subjects
Dimerization, Magnetic Resonance Spectroscopy, Mass Spectrometry, Molecular Structure, Artemisinins, Sesquiterpenes chemistry, Sesquiterpenes pharmacology
Abstract

Joining two 10-deoxoartemisinin trioxane units via a p-diacetylbenzene linker produces new C-10 non-acetal dimers and. 1H NMR spectroscopy allows unambiguous assignment of the stereochemistry at C-10 in these dimers. Successful replacement of both carbonyl oxygen atoms in these diketone dimers by fluorine atoms produces new tetrafluorinated dimers and. Each dimer was evaluated in vitro for antimalarial, antiproliferative, and antitumor activities; ketone dimers and, more than fluorinated dimers and, are promising for chemotherapy of both malaria and cancer.

Published
2002
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