1. Sesquiterpenes and Steroids from an Endophytic Eutypella scoparia .
- Author
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Zhang W, Lu X, Huo L, Zhang S, Chen Y, Zou Z, and Tan H
- Subjects
- Anti-Bacterial Agents isolation & purification, Cell Line, Tumor, China, Humans, Methicillin-Resistant Staphylococcus aureus drug effects, Microbial Sensitivity Tests, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Plant Leaves chemistry, Sesquiterpenes isolation & purification, Staphylococcus aureus drug effects, Steroids isolation & purification, Terpenes isolation & purification, Anti-Bacterial Agents pharmacology, Ascomycota chemistry, Sesquiterpenes pharmacology, Steroids pharmacology
- Abstract
A chemical investigation on the EtOAc extract of the endophytic fungus Eutypella scoparia SCBG-8 led to the isolation of eight new sesquiterpenes eutyscoparins A-H ( 1-8 ), one C-28 steroid eutyscoparene A ( 9 ), one triterpenoid eutyscoparene B ( 10 ), six known terpenoids, and two known steroids. Their structures including absolute configurations were established on the basis of spectroscopic data analysis, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) calculations. Compound 7 displayed antibacterial activity against S. aureus and MRSA (methicillin-resistant Staphylococcus aureus ) with MIC values of 6.3 μg/mL.
- Published
- 2021
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