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14 results on '"Bagolan, P."'

1. What do pediatric surgeons think about sexual issues in dealing with patients with anorectal malformations? The ARM-Net consortium members’ opinion

Author

Amerstorfer, Ee, Grano, C, Verhaak, C, Garcia-Vasquez, A, Miserez, M, Radleff-Schlimme, A, Schwarzer, N, Haanen, M, de Blaauw, I, Jenetzky, E, van der Steeg, A, van Rooij, Ialm, Aminoff, D, Bagolan, P, Iacobelli, B, Broens, P, Deluggi, S, Ludwiczek, J, Fanjul, M, Fascetti-Leon, F, Gamba, P, Gine, C, Giuliani, S, Goseman, J, Lacher, M, Grasshoff-Derr, S, Holland-Cunz, S, Leva, E, Morandi, A, Lisi, G, Madadi-Sanjan, O, Makedonsky, I, Marcelis, C, Midrio, P, Ozen, O, Piniprato, A, Reck-Burneo, C, Reutter, H, Rohleder, S, Samuk, I, Schmiedeke, E, Sloots, P, van der Steeg, H, Stenstrom, P, Till, H, Volk, P, and Wester, T

Subjects
Male, Human sexuality, Anorectal malformation, sexuality, sexual functioning, adolescence, training, ARM-Net, Pediatrics, DISEASE, 0302 clinical medicine, QUALITY-OF-LIFE, Surveys and Questionnaires, Pediatric surgery, Child, Referral and Consultation, General Medicine, Middle Aged, Anorectal Malformations, 3. Good health, Adolescence, Europe, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], 030211 gastroenterology & hepatology, Original Article, Female, HEALTH, Life Sciences & Biomedicine, Sexuality, Sexual functioning, medicine.medical_specialty, Attitude of Health Personnel, Multidisciplinary team, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 030225 pediatrics, medicine, Training, Humans, Surgeons, Science & Technology, business.industry, Metabolic Disorders Radboud Institute for Health Sciences [Radboudumc 6], Pediatric Surgeon, ADULTS, CARE, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Family medicine, Pediatrics, Perinatology and Child Health, Settore MED/20, Surgery, business
Abstract

PURPOSE: Since pediatric surgeons aim to follow their patients with anorectal malformations (ARM) into adulthood the aim of this study was to investigate how pediatric surgeons deal with sexual issues related to ARM. METHODS: In 2018, a questionnaire was developed by the working group "Follow-up and sexuality" of the ARM-Net consortium and sent to all consortium-linked pediatric surgeons from 31 European pediatric surgical centers. Obtained data were statistically analyzed. RESULTS: Twenty-eight of 37 pediatric surgeons (18 males/10 females) answered the questionnaire. The majority of pediatric surgeons (82%) think they should talk about sexual issues with their patient. More than 50% of pediatric surgeons do not feel at all or only moderately confident discussing the topic of sexuality. Most pediatric surgeons require more support (96%) and wish to be trained in sexuality and sexual issues (78%) to feel confident towards their ARM-patients/parents. For optimal care, sexual issues with ARM-patients should be managed by a multidisciplinary team. CONCLUSIONS: Pediatric surgeons feel that sexuality is an important issue for their ARM-patients, which they are primarily responsible of but should be managed in concert with a multidisciplinary team. A training in sexuality is wished to feel more confident about this specific issue. ispartof: PEDIATRIC SURGERY INTERNATIONAL vol:35 issue:9 pages:935-943 ispartof: location:Germany status: published

Published
2019

3. Meconium ileus

Author

Conforti, A and Bagolan, P

Subjects
Settore MED/20
Published
2018

5. Tethered cord in patients affected by anorectal malformations: a survey from the ARM-Net Consortium

Author

Fanjul, Marã­a, Samuk, I., Bagolan, P., Leva, E., Sloots, C., Ginã©, C., Aminoff, D., Midrio, P., Aminoff, Dalia, Bagolan, Piero, De Blaauw, Ivo, Deluggi, Stefan, Fascetti Leon, Francesco, Garcã­a, Araceli, Ginã©, Carles, Giuliani, Stefano, Grano, Caterina, Grasshoff-derr, Sabine, Haanen, Michel, Holland-cunz, Stephan, Jenetzky, Ekkehart, Lacher, Martin, Leva, Ernesto, Lisi, Grabiele, Makedonsky, Igor, Marcelis, Carlos, Midrio, Paola, Miserez, Marc, Ozen, Onur, Percin, Ferda, Reutter, Heiko, Rohleder, Stephan, Samuk, Inbal, Schmiedeke, Eberhard, Schwarzer, Nicole, Sloots, Pim, Stenstrã¶m, Pernilla, Till, Holger, Van Der Steeg, Lideke, Van Rooij, Iris, Volk, Patrick, Wester, Tomas, Zwink, Nadine, and Pediatric Surgery

Subjects
Male, medicine.medical_specialty, Pediatrics, Neurosurgery, Survey result, Diagnostic tools, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Arm-Net Consortium, 030225 pediatrics, Pediatric surgery, medicine, Humans, Screening tool, In patient, Neural Tube Defects, Tethered Cord, Societies, Medical, Ultrasonography, Tethered cord, medicine.diagnostic_test, business.industry, Incidence, Infant, Newborn, Infant, Magnetic resonance imaging, General Medicine, Perinatology and Child Health, Anorectal malformation, Magnetic Resonance Imaging, Anorectal Malformations, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Child, Preschool, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Settore MED/20, Female, business, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract

Item does not contain fulltext PURPOSE: The goal of this study was to determine the degree of consensus in the management of spinal cord tethering (TC) in patients with anorectal malformation (ARM) in a large cohort of European pediatric centers. METHODS: A survey was sent to pediatric surgeons (one per center) members of the ARM-Net Consortium. RESULTS: Twenty-four (86%) from ten different countries completed the survey. Overall prevalence of TC was: 21% unknown, 46% below 15, and 29% between 15 and 30%. Ninety-six agreed on screening all patients for TC regardless the type of ARM and 79% start screening at birth. Responses varied in TC definition and diagnostic tools. Fifty percent of respondents prefer ultrasound (US), 21% indicate either US or magnetic resonance (MRI) based on a pre-defined risk of presenting TC, and 21% perform both. Discrepancy exists in complementary test: 82% carry out urodynamic studies (UDS) and only 37% perform somatosensory-evoked potentials (SSEP). Prophylactic untethering is performed in only two centers (8%). CONCLUSIONS: Survey results support TC screening in all patients with ARM and conservative management of TC. There is discrepancy in the definition of TC, screening tools, and complementary test. Protocols should be developed to avoid such variability in management.

Published
2017

6. Standardized Postnatal Management of Infants with Congenital Diaphragmatic Hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update

Author

Snoek, Kitty G., Reiss, Irwin K M, Greenough, Anne, Capolupo, Irma, Urlesberger, Berndt, Wessel, Lucas, Storme, Laurent, Deprest, Jan, Schaible, Thomas, Van Heijst, Arno, Tibboel, Dick, Allegaert, K., Debeer, A., Keijzer, R., Benachi, A., Tissieres, P., Kipfmueller, F., Schaible, T., Breatnach, C., Patel, N., Leva, E., Ciralli, F., Bagolan, P., Dotta, A., Morini, F., Di Pede, A., Emblem, R., Ertesvag, K., Migdal, M., Piotrowski, A., Frenckner, B., Mesas, C., Elorza, D., Martinez, L., Scharbatke, H., Cohen-Overbeek, T., Eggink, A. J., Kraemer, U. S., Tibboel, D., Wijnen, R. M H, Deprest, J., De Coppi, P., Eaton, S., Davenport, M., Debeer, Anne, Allegaert, Karel, De Coppi, Paolo, Pediatric Surgery, and Pediatrics

Subjects
Postnatal Care, medicine.medical_specialty, Pediatrics, Consensus, Hypertension, Pulmonary, Standardized treatment, MEDLINE, Congenital diaphragmatic hernia, Sildenafil Citrate, law.invention, Randomized controlled trial, Clinical Protocols, law, medicine, Humans, Hernia, Intensive care medicine, Expert Testimony, Monitoring, Physiologic, business.industry, High mortality, Infant, Newborn, Infant, Postnatal treatment, Patient data, medicine.disease, Respiration, Artificial, Europe, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Settore MED/20, Pediatrics, Perinatology and Child Health, Practice Guidelines as Topic, business, Hernias, Diaphragmatic, Congenital, Developmental Biology
Abstract

Contains fulltext : 168576.pdf (Publisher’s version ) (Open Access) In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized neonatal treatment protocol. Five years later, the number of participating centers has been raised from 13 to 22. In this article the relevant literature is updated, and consensus has been reached between the members of the CDH EURO Consortium. Key updated recommendations are: (1) planned delivery after a gestational age of 39 weeks in a high-volume tertiary center; (2) neuromuscular blocking agents to be avoided during initial treatment in the delivery room; (3) adapt treatment to reach a preductal saturation of between 80 and 95% and postductal saturation >70%; (4) target PaCO2 to be between 50 and 70 mm Hg; (5) conventional mechanical ventilation to be the optimal initial ventilation strategy, and (6) intravenous sildenafil to be considered in CDH patients with severe pulmonary hypertension. This article represents the current opinion of all consortium members in Europe for the optimal neonatal treatment of CDH.

Published
2016
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8. Score for Neonatal Acute Physiology-II Predicts Outcome in Congenital Diaphragmatic Hernia Patients∗

Author

Snoek, Kg, Capolupo, I, Morini, F, Van Rosmalen, J, Greenough, A, Van Heijst, A, Reiss, Ikm, Ijsselstijn, H, Tibboel, D, Di Pede, A, Dotta, A, Bagolan, P, Kraemer, U, Reiss, I, Wijnen, R, Pinto, C, Gorett Silva, M, Saldanha, J, Bhat, P, Schaible, T, Wessel, L, Allegaert, K, Debeer, A, Pediatric Surgery, Epidemiology, and Pediatrics

Subjects
Male, Pediatrics, medicine.medical_specialty, medicine.medical_treatment, Diaphragmatic breathing, Score for Neonatal Acute Physiology-II, Critical Care and Intensive Care Medicine, Severity of Illness Index, congenital diaphragmatic hernia, law.invention, Decision Support Techniques, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, 030225 pediatrics, Severity of illness, bronchopulmonary dysplasia, medicine, Extracorporeal membrane oxygenation, Humans, Prospective Studies, Prospective cohort study, 030219 obstetrics & reproductive medicine, business.industry, Infant, Newborn, Congenital diaphragmatic hernia, prediction, extracorporeal membrane oxygenation, medicine.disease, Prognosis, Respiration, Artificial, mortality, Logistic Models, Multicenter study, Bronchopulmonary dysplasia, Pediatrics, Perinatology and Child Health, Multivariate Analysis, Settore MED/20, prediction-II, Female, business, Hernias, Diaphragmatic, Congenital
Abstract

Objective: Accurate and validated predictors of outcome for infants with congenital diaphragmatic hernia are needed. Score for Neonatal Acute Physiology-II has been validated to predict mortality in newborns. We investigated whether Score for Neonatal Acute Physiology-II scores in congenital diaphragmatic hernia could predict mortality, need for extracorporeal membrane oxygenation (in patients born in a center with extracorporeal membrane oxygenation availability), and development of bronchopulmonary dysplasia (oxygen dependency beyond 28 d after birth) in survivors. Design: Data were obtained from a prospective, multicenter randomized controlled trial of initial ventilation strategy carried out by the Congenital Diaphragmatic Hernia EURO Consortium (NTR 1310). Setting: ICUs of level III university children's hospitals. Patients: Congenital diaphragmatic hernia infants without severe chromosomal anomalies or severe cardiac anomalies born between November 2008 and December 2013. Interventions: Randomization for initial ventilation strategy (high-frequency oscillation/ conventional mechanical ventilation. Measurements and Main Results: Logistic regression analyses were used to evaluate associations between Score for Neonatal Acute Physiology-II and outcome parameters. Of the 171 included patients, 46 died (26.9%), 40 of 108 (37.0%) underwent extracorporeal membrane oxygenation, and 39 of 125 survivors (31.2%) developed bronchopulmonary dysplasia. In nonsurvivors, the median Score for Neonatal Acute Physiology-II was 42.5 (interquartile range, 33.5-53.8) and 16.5 (interquartile range, 9.0-27.5) in survivors (p

Published
2016
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12. Invasive candida infections in neonates after major surgery: Current evidence and new directions

Author

Domenico Umberto De Rose, Alessandra Santisi, Maria Paola Ronchetti, Ludovica Martini, Lisa Serafini, Pasqua Betta, Marzia Maino, Francesco Cavigioli, Ilaria Cocchi, Lorenza Pugni, Elvira Bonanno, Chryssoula Tzialla, Mario Giuffrè, Jenny Bua, Benedetta Della Torre, Giovanna Nardella, Danila Mazzeo, Paolo Manzoni, Andrea Dotta, Pietro Bagolan, Cinzia Auriti, on behalf of Study Group of Neonatal Infectious Diseases, De Rose D.U., Santisi A., Ronchetti M.P., Martini L., Serafini L., Betta P., Maino M., Cavigioli F., Cocchi I., Pugni L., Bonanno E., Tzialla C., Giuffre M., Bua J., Della Torre B., Nardella G., Mazzeo D., Manzoni P., Dotta A., Bagolan P., and Auriti C.

Subjects
0301 basic medicine, Microbiology (medical), Antifungal, medicine.medical_specialty, medicine.drug_class, Invasive Candida infections, 030106 microbiology, lcsh:Medicine, Invasive Candida infection, Candida infections, 03 medical and health sciences, Broad spectrum, Neonatal surgery, invasive Candida infections, 0302 clinical medicine, Invasive fungal infection, Invasive fungal infections, Intensive care, Epidemiology, Fungal colonization, Immunology and Allergy, Medicine, Antifungal prophylaxi, 030212 general & internal medicine, Molecular Biology, Newborns, General Immunology and Microbiology, business.industry, lcsh:R, Impaired immune responses, Newborn, Surgery, Infectious Diseases, Settore MED/20, Antifungal prophylaxis, business
Abstract

Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, as well as the roles of different Candida spp., the epidemiology and costs of ICIs, diagnosis of ICIs, and antifungal prophylaxis and treatment.

Published
2021

13. The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design

Author

Buffin-Meyer, Bénédicte, Klein, Julie, van der Zanden, Loes F M, Levtchenko, Elena, Moulos, Panogiotis, Lounis, Nadia, Conte-Auriol, Françoise, Hindryckx, An, Wühl, Elke, Persico, Nicola, Oepkes, Dick, Schreuder, Michiel F, Tkaczyk, Marcin, Ariceta, Gema, Fossum, Magdalena, Parvex, Paloma, Feitz, Wout, Olsen, Henning, Montini, Giovanni, Decramer, Stéphane, Schanstra, Joost P, De Catte, Luc, Vayssieres, Christophe, Sartor, Agnès, Groussolles, Marion, Plard, Christelle, Guerby, Paul, Connan, Laure, Morin, Mathieu, Simon, Elizabeth, Breaud, Jean, Saliou, Anne-Hélène, De Parscau, Loic, Jay, Nadine, Germouty, Isabelle, Le Bouar, Gwenaelle, Ryckewaert, Amelie, Manca-Pellissier, Marie-Christine, Merrot, Thierry, Laurichesse, Helene, Gallot, Denis, Bessenay, Lucie, Bidat, Laurent, Boize, Philippe, Winer, Norbert, Allain-Launey, Emma, Le Vaillant, Claudine, Prieur, Fabienne, Lavocat, Marie-Pierre, Coatleven, Frederic, Debromez, Eric, Harembat, Jérôme, Llanas, Brigitte, Favre, Romain, Moog, Raphael, Zaloszyc, Ariane, Massardier, Jérôme, Demede, Delphine, Perrotin, Franck, Cloarec, Sylvie, Vequeau-Goua, Valérie, Descombes, Emmanuelle, Boulot, Pierre, Morin, Denis, Fuchs, Florent, Tenenbaum, Julie, Ville, Yves, Blanc, Thomas, Heidet, Laurence, Paris, Anne, Dobremez, Eric, Froute, Marie-Françoise, Gondry, Jean, Muszynski, Charles, Haraux, Elodie, Lobelle, Fabienne, Chevreau, Julien, Rosenblatt, Jonathan, Baudoin, Véronique, Deschenes, Georges, Guigue, Virginie, Amblard, Florence, Bourdat-Michel, Guylhène, Schaefer, Franz, Elsässer, Michael, Rossi, Federica, Manzoni, Gianantonio, De Marco, Erika A, Capone, Valentina, Caforio, Leonardo, Zaccara, Antonio, Innocenzi, Michele, Bagolan, Pietro, Capozza, Nicola, Castagnetti, Marco, Mancini, Mariangela, van Scheltema, Phebe Adama, Kortmann, Barbara, Schreuder, Michiel, Stańczyk, Małgorzata, Szaflik, Krzysztof, Wojtera, Justyna, Krzeszowski, Waldemar, Talar, Tomasz, Pawłowska, Barbara, Fortecka-Piestrzeniewicz, Katarzyna, Olejniczak, Dariusz, Arevalo, Silvia, Rodo, Carlota, Lindgren, Peter, Chehade, Hassib, ANTENATAL Consortium, Hindryckx, A., De Catte, L., Vayssieres, C., Sartor, A., Groussolles, M., Plard, C., Guerby, P., Connan, L., Morin, M., Simon, E., Breaud, J., Saliou, A.H., De Parscau, L., Jay, N., Germouty, I., Le Bouar, G., Ryckewaert, A., Manca-Pellissier, M.C., Merrot, T., Laurichesse, H., Gallot, D., Bessenay, L., Bidat, L., Boize, P., Winer, N., Allain-Launey, E., Le Vaillant, C., Prieur, F., Lavocat, M.P., Coatleven, F., Debromez, E., Harembat, J., Llanas, B., Favre, R., Moog, R., Zaloszyc, A., Massardier, J., Demede, D., Perrotin, F., Cloarec, S., Vequeau-Goua, V., Descombes, E., Boulot, P., Morin, D., Fuchs, F., Tenenbaum, J., Ville, Y., Blanc, T., Heidet, L., Paris, A., Dobremez, E., Froute, M.F., Gondry, J., Muszynski, C., Haraux, E., Lobelle, F., Chevreau, J., Rosenblatt, J., Baudoin, V., Deschenes, G., Guigue, V., Amblard, F., Bourdat-Michel, G., Wühl, E., Schaefer, F., Elsässer, M., Persico, N., Rossi, F., Manzoni, G., De Marco, E.A., Montini, G., Capone, V., Caforio, L., Zaccara, A., Innocenzi, M., Bagolan, P., Capozza, N., Castagnetti, M., Mancini, M., Oepkes, D., van Scheltema, P.A., Feitz, W., Kortmann, B., Schreuder, M., Tkaczyk, M., Stańczyk, M., Szaflik, K., Wojtera, J., Krzeszowski, W., Talar, T., Pawłowska, B., Fortecka-Piestrzeniewicz, K., Olejniczak, D., Ariceta, G., Arevalo, S., Rodo, C., Fossum, M., Lindgren, P., Parvex, P., Chehade, H., Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Radboud University Medical Center [Nijmegen], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), HybridStat Predictive Analytics [Athens, Greece], Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospitals Leuven [Leuven], Heidelberg University Hospital [Heidelberg], University of Milan, Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico [Milan, Italy], Leiden University Medical Center (LUMC), Radboud Institute for Molecular Life Sciences [Nijmegen, the Netherlands], Polish Mother’s Memorial Hospital Research Institute [Lodz] (ICZMP), Pediatric Nephrology [Barcelona, Spain] (Vall d’Hebron Hospital), Universitat Autònoma de Barcelona (UAB)-Vall d'Hebron University Hospital [Barcelona], Karolinska University Hospital [Stockholm], Karolinska Institutet [Stockholm], Geneva University Hospital (HUG), Aarhus University Hospital, Aarhus University [Aarhus], Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, ANTENATAL Consortium: An Hindryckx, Luc De Catte, Christophe Vayssieres, Agnès Sartor, Marion Groussolles, Christelle Plard, Paul Guerby, Laure Connan, Mathieu Morin, Elizabeth Simon, Jean Breaud, Anne-Hélène Saliou, Loic De Parscau, Nadine Jay, Isabelle Germouty, Gwenaelle Le Bouar, Amelie Ryckewaert, Marie-Christine Manca-Pellissier, Thierry Merrot, Helene Laurichesse, Denis Gallot, Lucie Bessenay, Laurent Bidat, Philippe Boize, Norbert Winer, Emma Allain-Launey, Claudine Le Vaillant, Fabienne Prieur, Marie-Pierre Lavocat, Frederic Coatleven, Eric Debromez, Jérôme Harembat, Brigitte Llanas, Romain Favre, Raphael Moog, Ariane Zaloszyc, Jérôme Massardier, Delphine Demede, Franck Perrotin, Sylvie Cloarec, Valérie Vequeau-Goua, Emmanuelle Descombes, Pierre Boulot, Denis Morin, Florent Fuchs, Julie Tenenbaum, Yves Ville, Thomas Blanc, Laurence Heidet, Anne Paris, Eric Dobremez, Marie-Françoise Froute, Jean Gondry, Charles Muszynski, Elodie Haraux, Fabienne Lobelle, Julien Chevreau, Jonathan Rosenblatt, Véronique Baudoin, Georges Deschenes, Virginie Guigue, Florence Amblard, Guylhène Bourdat-Michel, Elke Wühl, Franz Schaefer, Michael Elsässer, Nicola Persico, Federica Rossi, Gianantonio Manzoni, Erika A De Marco, Giovanni Montini, Valentina Capone, Leonardo Caforio, Antonio Zaccara, Michele Innocenzi, Pietro Bagolan, Nicola Capozza, Marco Castagnetti, Mariangela Mancini, Dick Oepkes, Phebe Adama van Scheltema, Wout Feitz, Barbara Kortmann, Michiel Schreuder, Marcin Tkaczyk, Małgorzata Stańczyk, Krzysztof Szaflik, Justyna Wojtera, Waldemar Krzeszowski, Tomasz Talar, Barbara Pawłowska, Katarzyna Fortecka-Piestrzeniewicz, Dariusz Olejniczak, Gema Ariceta, Silvia Arevalo, Carlota Rodo, Magdalena Fossum, Peter Lindgren, Paloma Parvex, Hassib Chehade., Schanstra, Joost, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Università degli Studi di Milano = University of Milan (UNIMI)

Subjects
Posterior urethral valve, medicine.medical_specialty, Urinary system, [SDV]Life Sciences [q-bio], kidney disease, prenatal biomarkers, Renal function, Prenatal care, 030204 cardiovascular system & hematology, DIAGNOSIS, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Medicine, obstructive uropathy, Obstructive uropathy, development, 030304 developmental biology, RISK, 0303 health sciences, Transplantation, Kidney, ddc:618, Science & Technology, business.industry, Obstetrics, Original Articles, prediction, Urology & Nephrology, Omics, medicine.disease, 6. Clean water, 3. Good health, [SDV] Life Sciences [q-bio], Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], medicine.anatomical_structure, Nephrology, embryonic structures, Settore MED/20, URINARY-TRACT OBSTRUCTION, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business, Life Sciences & Biomedicine, Kidney disease
Abstract

Altres ajuts: The study is partially made possible by support of the 'Programme Hospitalier de Recherche Clinique and 'La Foundation de la Recherche Médicale (grant number DEQ20170336759, France). M.T. was supported by the Polish Mothers Memorial Hospital Research Institute (internal grant number 2016/IV/54-GW. LvdZ is supported by a Kolff grant from the Dutch Kidney Foundation (13OKJ36) and a ZonMW-VENI grant from the Netherlands Organisation for Scientific Research (91618036). This project has been supported by ERN ERKNet and ERN eUROGEN, which are partly co-funded by the European Union within the framework of the Third Health Programme 'ERN-2016-Framework Partnership Agreement 2017-2021'. Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management of PUV is prenatal prediction of postnatal renal function. Fetal ultrasound and fetal urine biochemistry are currently employed for this prediction, but clearly lack precision. We previously developed a fetal urine peptide signature that predicted in utero with high precision postnatal renal function in fetuses with PUV. We describe here the objectives and design of the prospective international multicentre ANTENATAL (multicentre validation of a fetal urine peptidome-based classifier to predict postnatal renal function in posterior urethral valves) study, set up to validate this fetal urine peptide signature. Participants will be PUV pregnancies enrolled from 2017 to 2021 and followed up until 2023 in >30 European centres endorsed and supported by European reference networks for rare urological disorders (ERN eUROGEN) and rare kidney diseases (ERN ERKNet). The endpoint will be renal/patient survival at 2 years postnatally. Assuming α = 0.05, 1-β = 0.8 and a mean prevalence of severe renal outcome in PUV individuals of 0.35, 400 patients need to be enrolled to validate the previously reported sensitivity and specificity of the peptide signature. In this largest multicentre study of antenatally detected PUV, we anticipate bringing a novel tool to the clinic. Based on urinary peptides and potentially amended in the future with additional omics traits, this tool will be able to precisely quantify postnatal renal survival in PUV pregnancies. The main limitation of the employed approach is the need for specialized equipment. Accurate risk assessment in the prenatal period should strongly improve the management of fetuses with PUV.

Published
2020
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14. A cross-sectional nationwide survey on esophageal atresia and tracheoesophageal fistula

Author

Ernesto Leva, P.L. Lelli Chiesa, S. Caterino, A. Pini Prato, M. Andermarcher, S. Cacciaguerra, F. Bartoli, Vincenzo Jasonni, Bruno Noccioli, Fabio Rossi, Vito Briganti, Mario Lima, Gloria Pelizzo, C. Manzoni, L. Mascia, Mario Messina, Piergiorgio Gamba, P. Andriolo, A. Rizzo, M. Nobili, Daniela Codrich, A. Cacciari, E. De Grazia, V. Di Benedetto, F. Caccia, D. A. Cozzi, G. Perrino, E. Clemente, Francesco Saverio Camoglio, Pietro Bagolan, Juergen Schleef, Ciro Esposito, S. De Pascale, Silvana Federici, D. Salerno, Giovanna Riccipetitoni, Diego Falchetti, Antonino Tramontano, G. Piazza, G. Paradies, A. Franchella, Francesco Vaccarella, S. Licciardi, F. Caravaggi, M. Bernardi, M.G.R. Aceti, L. Liotta, Girolamo Mattioli, Carmelo Romeo, Marcello Carlucci, D. Alberti, Antonino Appignani, F.S. Chiarenza, Ascanio Martino, M. Ubertazzi, Pini Prato, A, Carlucci, M., Bagolan, P., Gamba, P.G., Bernardi, M., Leva, E., Paradies, G., Manzoni, C., Noccioli, B., Tramontano, A., Jasonni, V., Vaccarella, F., De Pascale, S., Alberti, D., Riccipetitoni, G., Falchetti, D., Caccia, F., Pelizzo, G., Schleef, J., Lima, M., Andriolo, P., Franchella, A., Cacciari, A., Caravaggi, F., Federici, S., Andermarcher, M., Perrino, G., Codrich, D., Camoglio, F.S., Chiarenza, F.S., Martino, A., Appignani, A., Briganti, V., Caterino, S., Cozzi, D., Messina, M., Rizzo, A., Liotta, L., Salerno, D., Aceti, M.G.R., Bartoli, F., Romeo, C., Esposito, C., Lelli Chiesa, P.L., Clemente, E., Mascia, L., Cacciaguerra, S., Di Benedetto, V., Licciardi, S., De Grazia, E., Ubertazzi, M., Piazza, G., Mattioli, G., Rossi, F., and Nobili, M.

Subjects
Male, Prenatal Diagnosi, Pediatrics, Cross-sectional, Diagnosis, Esophageal atresia, Management, Mortality, Nationwide survey, Adult, Cross-Sectional Studies, Diagnosis-Related Groups, Esophageal Atresia, Female, Humans, Incidence, Infant, Newborn, Italy, Pregnancy, Tracheoesophageal Fistula, Young Adult, Prenatal Diagnosis, Surveys and Questionnaires, Cross-sectional study, Tracheoesophageal fistula, Pediatric surgery, Epidemiology, Esophageal atresia, Management, Mortality, Nationwide survey, Adult, Cross-Sectional Studies, Surveys and Questionnaire, Incidence (epidemiology), Mortality rate, Medicine (all), Diagnosis-Related Group, General Medicine, Place of birth, Perinatology and Child Health, Diagnosi, Human, medicine.medical_specialty, Key words Esophageal atresia, Pediatrics, Perinatology and Child Health, Surgery, medicine, Cross-Sectional Studie, business.industry, Infant, medicine.disease, Newborn, Atresia, Settore MED/20, business
Abstract

Background Our study aims at disclosing epidemiology and most relevant clinical features of esophageal atresia (EA) pointing to a model of multicentre collaboration. Methods A detailed questionnaire was sent to all Italian Units of pediatric surgery in order to collect data of patients born with EA between January and December 2012. The results were crosschecked by matching date and place of birth of the patients with those of diagnosis-related group provided by the Italian Ministry of Health (MOH). Results A total of 146 questionnaires were returned plus a further 32 patients reported in the MOH database. Basing on a total of 178 patients with EA born in Italy in 2012, the incidence of EA was calculated in 3.33 per 10,000 live births. Antenatal diagnosis was suspected in 29.5% patients. 55.5% showed associated anomalies. The most common type of EA was Gross type C (89%). Postoperative complications occurred in 37% of type C EA and 100% of type A EA. A 9.5% mortality rate was reported. Conclusions This is the first Italian cross-sectional nationwide survey on EA. We can now develop shared guidelines and provide more reliable prognostic expectations for our patients.

Published
2015

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