1. [The new aspects of treatment of severe sepsis and septic shock].
- Author
-
Adukauskiene D, Rimdeika R, Vitkauskiene A, Pilvinis V, and Cicinskaite I
- Subjects
- APACHE, Adrenal Cortex Hormones administration & dosage, Adrenal Cortex Hormones therapeutic use, Adult, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use, Anti-Infective Agents administration & dosage, Anti-Infective Agents therapeutic use, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Blood Glucose analysis, Blood Transfusion, Cardiotonic Agents administration & dosage, Cardiotonic Agents therapeutic use, Fluid Therapy, Humans, Meta-Analysis as Topic, Protein C therapeutic use, Randomized Controlled Trials as Topic, Recombinant Proteins therapeutic use, Sepsis diagnosis, Sepsis drug therapy, Sepsis mortality, Sepsis physiopathology, Shock, Septic diagnosis, Shock, Septic drug therapy, Shock, Septic mortality, Shock, Septic physiopathology, Time Factors, Vasoconstrictor Agents administration & dosage, Vasoconstrictor Agents therapeutic use, Sepsis therapy, Shock, Septic therapy
- Abstract
The mortality rate of infection-induced organ dysfunction or hypoperfusion abnormalities due to severe sepsis and septic shock remains unacceptably high. The adequacy and speed of treatment administered in the first hours after syndrome develops influence outcome. Initial resuscitation, appropriate antimicrobial treatment, selection of optimal control methods, properties of fluid therapy, use of vasopressors and inotropic therapy, proper corticosteroid administration, value of the use of recombinant human activated protein C, and glucose control are the most important points newly evaluated for severe and septic shock management.
- Published
- 2006