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Multiple hematopoietic progenitor cell (HPC) transplantation options for patients with sickle cell disease (SCD) are currently under investigation. Patients with SCD have a high rate of alloimmunization to red blood cell antigens, often complicating transfusion support. Transfusion reactions, including acute and delayed hemolytic reactions, have been observed despite immunosuppressive regimens. Allogeneic donor transplants have been shown to carry a risk of prolonged reticulocytopenia and acute hemolysis with severe anemia in nonmyeloablative regimens. We discuss our experience providing transfusion support to patients with SCD undergoing HPC transplantation, propose an outline for a complete pretransplantation evaluation, and discuss donor/recipient compatibility issues and their implications. [ABSTRACT FROM AUTHOR]

B. Extensive bone marrow necrosis evident on histological sections taken from the autopsy gl Marrow sections from autopsy showed ill-defined necrotic cells with amorphous eosinophilic necrotic debris (Figure 1(B)), consistent with marrow necrosis. Bone marrow necrosis and fat embolism syndrome in sickle cell disease: Increased susceptibility of patients with non-SS genotypes and a possible association with human parvovirus B19 infection. Fat embolism syndrome secondary to bone marrow necrosis in patients with hemoglobinopathies. [Extracted from the article]