1. Ginsenoside Rg1 enhances lymphatic transport of intrapulmonary silica via VEGF-C/VEGFR-3 signaling in silicotic rats.
- Author
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Yu J, Mao L, Guan L, Zhang Y, and Zhao J
- Subjects
- Animals, Biological Transport, Active drug effects, Disease Models, Animal, Lung drug effects, Lung metabolism, Lung pathology, Lymphangiogenesis drug effects, Lymphatic Vessels drug effects, Lymphatic Vessels metabolism, Lymphatic Vessels pathology, Male, Panax, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Rats, Sprague-Dawley, Receptors, Cell Surface genetics, Signal Transduction drug effects, Silicosis pathology, Up-Regulation drug effects, Drugs, Chinese Herbal therapeutic use, Ginsenosides therapeutic use, Phytotherapy, Silicon Dioxide pharmacokinetics, Silicosis drug therapy, Silicosis metabolism, Vascular Endothelial Growth Factor C metabolism, Vascular Endothelial Growth Factor Receptor-3 metabolism
- Abstract
Ginsenoside Rg1, extracted mainly from Panax ginseng, has been shown to exert strong pro-angiogenic activities in vivo. But it is unclear whether ginsenoside Rg1 could promote lung lymphangiogenesis to improve lymphatic transport of intrapulmonary silica in silicotic rats. Here we investigated the effect of ginsenoside Rg1 on lymphatic transport of silica during experimental silicosis, and found that ginsenoside Rg1 treatment significantly raised the silicon content in tracheobronchial lymph nodes and serum to reduce the silicon level in lung interstitium, meanwhile increased pulmonary lymphatic vessel density by enhancing the protein and mRNA expressions of vascular endothelial growth factor-C (VEGF-C) and vascular endothelial growth factor receptor-3 (VEGFR-3). The stimulative effect of ginsenoside Rg1 on lymphatic transport of silica was actively correlated with its pro-lymphangiogenic identity. And VEGFR-3 inhibitor SAR131675 blocked these above effects of ginsenoside Rg1. These findings suggest that ginsenoside Rg1 exhibits good protective effect against lung burden of silica during experimental silicosis through improving lymphatic transport of intrapulmonary silica, which is potentially associated with the activation of VEGF-C/VEGFR-3 signaling pathway., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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