1. A study on the in vitro percutaneous absorption of silver nanoparticles in combination with aluminum chloride, methyl paraben or di-n-butyl phthalate.
- Author
-
Domeradzka-Gajda K, Nocuń M, Roszak J, Janasik B, Quarles CD Jr, Wąsowicz W, Grobelny J, Tomaszewska E, Celichowski G, Ranoszek-Soliwoda K, Cieślak M, Puchowicz D, Gonzalez JJ, Russo RE, and Stępnik M
- Subjects
- Aluminum Chloride, Aluminum Compounds administration & dosage, Aluminum Compounds chemistry, Aluminum Compounds pharmacology, Animals, Chlorides administration & dosage, Chlorides chemistry, Chlorides pharmacology, Cosmetics administration & dosage, Cosmetics chemistry, Dibutyl Phthalate administration & dosage, Dibutyl Phthalate chemistry, Dibutyl Phthalate pharmacology, In Vitro Techniques, Mass Spectrometry, Metal Nanoparticles administration & dosage, Parabens administration & dosage, Parabens chemistry, Parabens pharmacology, Particle Size, Silver administration & dosage, Silver chemistry, Skin metabolism, Surface Properties, Swine, Cosmetics pharmacology, Metal Nanoparticles chemistry, Silver pharmacokinetics, Skin drug effects, Skin Absorption drug effects
- Abstract
Some reports indicate that the silver released from dermally applied products containing silver nanoparticles (AgNP) (e.g. wound dressings or cosmetics) can penetrate the skin, particularly if damaged. AgNP were also shown to have cytotoxic and genotoxic activity. In the present study percutaneous absorption of AgNP of two different nominal sizes (Ag15nm or Ag45nm by STEM) and surface modification, i.e. citrate or PEG stabilized nanoparticles, in combination with cosmetic ingredients, i.e. aluminum chloride (AlCl
3 ), methyl paraben (MPB), or di-n-butyl phthalate (DBPH) was assessed using in vitro model based on dermatomed pig skin. The inductively coupled plasma mass spectrometry (ICP-MS) measurements after 24h in receptor fluid indicated low, but detectable silver absorption and no statistically significant differences in the penetration between the 4 types of AgNP studied at 47, 470 or 750μg/ml. Similarly, no significant differences were observed for silver penetration when the AgNP were used in combinations with AlCl3 (500μM), MPB (1250μM) or DBPH (35μM). The measured highest amount of Ag that penetrated was 0.45ng/cm2 (0.365-0.974ng/cm2 ) for PEG stabilized Ag15nm+MPB., (Copyright © 2017 Elsevier B.V. All rights reserved.)- Published
- 2017
- Full Text
- View/download PDF