1. Successful Treatment of Macroglossia Due to Lymphatic Malformation With Sirolimus.
- Author
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Yesil S, Bozkurt C, Tanyildiz HG, Tekgunduz SA, Candir MO, Toprak S, and Sahin G
- Subjects
- Administration, Oral, Antibiotics, Antineoplastic administration & dosage, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Monitoring, Female, Humans, Infant, Treatment Outcome, Lymphatic Abnormalities complications, Lymphatic Abnormalities diagnosis, Lymphatic Abnormalities physiopathology, Lymphatic Abnormalities therapy, Macroglossia etiology, Macroglossia physiopathology, Macroglossia therapy, Sirolimus administration & dosage
- Abstract
Objective: To evaluate the effectiveness and safety of sirolimus therapy in a child with macroglossia due to lymphatic malformation., Methods: Sirolimus treatment was applied to the patient with an initial dosing of 0.8 mg/m2 per dose, administered orally, twice daily at approximately 12-hour intervals., Results: After 9 months of sirolimus therapy, there was a nearly complete resolution of lymphatic malformation. The last evaluation was performed 6 months after withdrawal of treatment, and the lesion had almost completely resolved., Conclusion: This article presents a novel approach to the treatment of lymphatic malformation of the tongue using sirolimus, which appears to be safe and effective for the management of complex cases., (© The Author(s) 2015.)
- Published
- 2015
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