1. Orally Administered Polysaccharide Derived from Blackcurrants (Ribes nigrum L.) Improves Skin Hydration in Ultraviolet-Irradiated Hairless Mice.
- Author
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Ashigai H, Komano Y, Wang G, Kawachi Y, Sunaga K, Yamamoto R, Takata R, and Yanai T
- Subjects
- Animals, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal chemistry, Anti-Inflammatory Agents, Non-Steroidal isolation & purification, Dermatitis, Atopic etiology, Dermatitis, Atopic immunology, Dermatitis, Atopic metabolism, Dietary Carbohydrates administration & dosage, Dietary Carbohydrates analysis, Dietary Carbohydrates isolation & purification, Dietary Fiber administration & dosage, Dietary Fiber analysis, Dietary Fiber therapeutic use, Dietary Supplements analysis, Female, Gene Expression Regulation radiation effects, Interleukin-6 antagonists & inhibitors, Interleukin-6 genetics, Interleukin-6 metabolism, Matrix Metalloproteinase 13 chemistry, Matrix Metalloproteinase 13 genetics, Matrix Metalloproteinase 13 metabolism, Mice, Hairless, Plant Extracts administration & dosage, Plant Extracts chemistry, Plant Extracts isolation & purification, Prebiotics administration & dosage, Prebiotics analysis, Radiation Injuries, Experimental immunology, Radiation Injuries, Experimental metabolism, Radiation Injuries, Experimental therapy, Skin immunology, Skin radiation effects, Specific Pathogen-Free Organisms, Ultraviolet Rays adverse effects, Water metabolism, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Dermatitis, Atopic therapy, Dietary Carbohydrates therapeutic use, Fruit chemistry, Plant Extracts therapeutic use, Ribes chemistry, Skin metabolism
- Abstract
Blackcurrants (Ribes nigrum L.) have various benefits for human health. In particular, a polysaccharide derived from blackcurrant was found to be an immunostimulating food ingredient in a mouse model. We named a polysaccharide derived from blackcurrant cassis polysaccharide (CAPS). In a previous clinical study, we reported that CAPS affects skin dehydration, demonstrating its effectiveness against skin inflammation was related to atopic dermatitis; skin inflammation caused skin dehydration. However, there are no studies regarding CAPS effectiveness against skin dehydration. The current study aimed to investigate CAPS effectiveness against skin dehydration. We further demonstrate the effect of oral administration of CAPS on skin dehydration caused by ultraviolet (UV) irradiation-induced inflammation in mice. We found that CAPS administration suppresses skin dehydration caused by UV irradiation. We also found that CAPS decreases interleukin-6 and matrix metalloproteinase transcription levels in the mouse skin. These results show that CAPS improves skin hydration in UV-irradiated mice.
- Published
- 2018
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