10 results on '"Machet MC"'
Search Results
2. [Dual localisation of ischaemic fasciitis with local relapse at one site].
- Author
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Kervarrec T, Lagier L, Machet MC, and Machet L
- Subjects
- Back, Biopsy, Capillaries, Fasciitis diagnostic imaging, Fasciitis pathology, Fibroblasts pathology, Fibroma pathology, Fibroma surgery, Humans, Ischemia pathology, Magnetic Resonance Imaging, Middle Aged, Recurrence, Scapula, Skin Diseases diagnostic imaging, Skin Diseases pathology, Fasciitis surgery, Skin Diseases surgery
- Abstract
Introduction: Ischaemic fasciitis (IF) is a rare pseudosarcomatous proliferation initially described on the pressure points of long-term bedridden patients. Healing is the rule after surgical excision. No multifocal localisations have been reported to date. Herein, we describe the case of a patient with FI affecting two sites and having recurred at one of them., Observation: A 50-year-old woman with scoliosis and mental retardation consulted for a hard skin lesion next to her right scapula. Elastofibroma was diagnosed on the basis of a surgical biopsy sample. Early local recurrence led to a second resection four months later. Histologically, central fibrinoid necrosis was observed, surrounded by collagenous tissue containing occasionally atypical fibroblasts and numerous capillaries. The diagnosis of ischaemic fasciitis was made by a national expert. Six months later, we observed a 13-cm purplish erythematous infiltrated mass with a 6-cm ulceration at the surgical site. A second 6-cm non-ulcerated indurated purplish lesion was visible next to the right greater trochanter. The scan showed deep soft-tissue infiltration with subfascial extension and contact with the greater trochanter. Superficial biopsies of both lesions showed only an appearance of granulation tissue. MRI performed after five months showed an extension of lesions at the two sites with an appearance evocative of ischaemic fasciitis. Surgical excision was refused by the patient and her family., Discussion: We report a rare case of ischaemic fasciitis at two separate sites with local relapse after surgical excision., (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
3. Cutaneous Rosai-Dorfman Disease Located on the Breast: Rapid Effectiveness of Methotrexate After Failure of Topical Corticosteroids, Acitretin and Thalidomide.
- Author
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Nadal M, Kervarrec T, Machet MC, Petrella T, and Machet L
- Subjects
- Acitretin therapeutic use, Administration, Cutaneous, Aged, Anti-Inflammatory Agents administration & dosage, Clobetasol administration & dosage, Female, Humans, Immunosuppressive Agents therapeutic use, Keratolytic Agents therapeutic use, Retreatment, Thalidomide therapeutic use, Treatment Failure, Breast Diseases drug therapy, Dermatologic Agents therapeutic use, Histiocytosis, Sinus drug therapy, Methotrexate therapeutic use, Skin Diseases drug therapy
- Published
- 2015
- Full Text
- View/download PDF
4. Reversal of multifocal cutaneous lymphoproliferative disease associated with Epstein-Barr virus after withdrawal of methotrexate therapy for rheumatoid arthritis.
- Author
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Maruani A, Wierzbicka E, Machet MC, Abdallah-Lotf M, de Muret A, and Machet L
- Subjects
- Aged, Antirheumatic Agents therapeutic use, Epstein-Barr Virus Infections complications, Female, Humans, Immunosuppressive Agents therapeutic use, Lymphoproliferative Disorders pathology, Methotrexate therapeutic use, Remission Induction, Skin Diseases pathology, Antirheumatic Agents adverse effects, Arthritis, Rheumatoid drug therapy, Epstein-Barr Virus Infections chemically induced, Immunosuppressive Agents adverse effects, Lymphoproliferative Disorders virology, Methotrexate adverse effects, Skin Diseases virology
- Abstract
Patients treated with immunosuppressive agents are prone to developing lymphoproliferative disorders, in particular Epstein-Barr virus-associated lymphoproliferative disease. This complication was reported first in post-transplanted patients treated with cyclosporine, and, more recently, in patients receiving long-term methotrexate therapy for inflammatory disease. We describe the case of a 70-year-old female patient with multifocal cutaneous lymphoproliferative disease occurring in the course of long-term, weekly methotrexate therapy for rheumatoid arthritis. Immunohistochemical study revealed the presence of latent membrane protein within neoplastic cells. Cutaneous lesions initially continued to increase in number and size in the first 2 months and finally disappeared completely within 5 months after discontinuation of methotrexate. The patient is now in complete remission with 12-months' follow-up. Despite initial progression after cessation of immunosuppressive therapy, Epstein-Barr virus-induced lymphoproliferative disease may disappear completely within months, thus avoiding pointless chemotherapy.
- Published
- 2007
- Full Text
- View/download PDF
5. [High-resolution ultrasonography: utility in diagnosis, treatment, and monitoring dermatologic diseases].
- Author
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Machet L, Ossant F, Bleuzen A, Grégoire JM, Machet MC, and Vaillant L
- Subjects
- Adolescent, Adult, Aged, Carcinoma, Basal Cell diagnostic imaging, Carcinoma, Basal Cell pathology, Carcinoma, Squamous Cell diagnostic imaging, Carcinoma, Squamous Cell pathology, Ehlers-Danlos Syndrome diagnostic imaging, Ehlers-Danlos Syndrome pathology, Female, Follow-Up Studies, Hemangioma diagnostic imaging, Humans, Keratosis diagnostic imaging, Keratosis pathology, Lip Neoplasms diagnostic imaging, Lip Neoplasms pathology, Male, Melanoma diagnostic imaging, Melanoma pathology, Middle Aged, Monitoring, Physiologic, Neoplasm Recurrence, Local diagnostic imaging, Neoplasm Recurrence, Local pathology, Pregnancy, Pregnancy Complications, Neoplastic diagnostic imaging, Pregnancy Complications, Neoplastic pathology, Psoriasis diagnostic imaging, Psoriasis pathology, Scleroderma, Localized diagnostic imaging, Scleroderma, Localized pathology, Scleroderma, Systemic diagnostic imaging, Scleroderma, Systemic pathology, Skin pathology, Skin Aging, Skin Diseases pathology, Skin Diseases therapy, Skin Neoplasms diagnostic imaging, Skin Neoplasms pathology, Time Factors, Ultrasonography, Skin diagnostic imaging, Skin Diseases diagnostic imaging
- Abstract
Although less precise than histological examination, high-resolution skin imaging is a noninvasive technique that provides complementary information to the clinical examination: the lesion's US structure as well as its lateral and depth extension. Ultrasonography helps in diagnosis and initial management by measuring melanoma thickness (so as to remove this lesion with safety margins) before destructive treatment (cryosurgery or radiotherapy), by showing tumor limits, or by detecting subclinical recurrence during the follow-up. In this paper, ultrasound images will be correlated with clinical and histological data in various clinical situations such as tumors, edema, cutaneous infiltration, sclerous tissues, hyperlaxity, and cutaneous aging.
- Published
- 2006
- Full Text
- View/download PDF
6. Bullous hemorrhagic dermatosis occurring at sites distant from subcutaneous injections of heparin: three cases.
- Author
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Perrinaud A, Jacobi D, Machet MC, Grodet C, Gruel Y, and Machet L
- Subjects
- Aged, Aged, 80 and over, Female, Hemorrhage chemically induced, Humans, Injections, Subcutaneous, Male, Middle Aged, Skin Diseases pathology, Skin Diseases, Vesiculobullous pathology, Anticoagulants adverse effects, Heparin adverse effects, Skin Diseases chemically induced, Skin Diseases, Vesiculobullous chemically induced
- Abstract
Cutaneous side effects from heparin administration are rare and usually located at injection sites. We report 3 cases of intraepidermal hemorrhagic blisters occurring distant from sites of subcutaneous injections of heparin. A causative link is suggested by a temporal relationship between heparin introduction and onset of disease as well as exclusion of other causes, but the mechanism remains unknown.
- Published
- 2006
- Full Text
- View/download PDF
7. [Genital papules revealing a Churg-Strauss syndrome].
- Author
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Rivollier C, Martin L, Machet L, Machet MC, and Lorette G
- Subjects
- Administration, Oral, Anti-Inflammatory Agents administration & dosage, Anti-Inflammatory Agents therapeutic use, Biopsy, Churg-Strauss Syndrome drug therapy, Churg-Strauss Syndrome pathology, Cyclophosphamide administration & dosage, Cyclophosphamide therapeutic use, Follow-Up Studies, Humans, Immunosuppressive Agents administration & dosage, Immunosuppressive Agents therapeutic use, Male, Middle Aged, Penile Diseases drug therapy, Penile Diseases pathology, Prednisone administration & dosage, Prednisone therapeutic use, Recurrence, Skin pathology, Skin Diseases drug therapy, Skin Diseases pathology, Time Factors, Churg-Strauss Syndrome diagnosis, Penile Diseases diagnosis, Skin Diseases diagnosis
- Abstract
Introduction: Cutaneous lesions are rarely inaugural in Churg and Strauss syndrome. We report the case of a patient in whom recurrent papular lesions of the penis revealed a Churg-Strauss granulomatous angeitis., Observation: A 54 year-old man consulted for recurrent non-infiltrated and painless erythematous papules of the penis over the past 4 years. His past history revealed severe asthma, which had appeared at the same time, nasal polyposis and chronic sinusitis. Other than the genital organs, the clinical examination was normal. Histological exploration of a cutaneous biopsy of the penis showed a necrotic granulomatous vasculitis. The usual biological examinations were normal. Research for proteinuria, hematuria and measurement of polynuclear anticytoplasm antibodies were negative. Pulmonary X-ray revealed a bilateral interstitial syndrome with micronodules. The broncho-alveolar wash revealed moderate granulocyte alveolitis with numerous eosinophilic polynuclears. The electromyogram showed a reduction in the sensitive potential of the nerves explored in the 4 limbs. Churg-Strauss granulomatous angeitis was diagnosed. Treatment with 0.8 mg/kg/day of prednisone was initiated. The cutaneous lesions disappeared rapidly. Since three months later there had been no relapse, corticosteroid therapy was slowly and progressively reduced. Nine months later, the patient exhibited new papular lesions of the glans penis and progressive relapse of asthma. Treatment with cyclophosphamide (Endoxan(R)) combined with systemic corticosteroids was initiated., Discussion: In view of the concomitance of necrotic granulomatous vasculitis in the cutaneous biopsies, severe, recent corticosteroid-dependent asthma, eosinophil-rich pulmonary infiltrate, allergic rhinitis, chronic sinusitis and the onset of a neuropathy, the diagnosis of Churg-Strauss syndrome was retained. The absence of hypereosinophilia in the blood during diagnosis can be explained by the oral corticosteroid therapy at low doses because of the asthma and sinusitis. However, hypereosinophil blood levels had been reported in several prior hemograms. Damage to the genital organ is exceptional during Churg-Strauss syndrome and is usually of granulomatous prostatitis form. Only one other case has been reported. Our observation is original in that it was isolated to the genital skin, which led to the diagnosis of Churg and Strauss granulomatous angeitis with systemic involvement.
- Published
- 2002
8. [Cutaneous periarteritis nodosa: diagnostic and therapeutic aspects of 9 cases].
- Author
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Maillard H, Szczesniak S, Martin L, Garot D, Machet MC, Machet L, Lorette G, and Vaillant L
- Subjects
- Adrenal Cortex Hormones therapeutic use, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Diagnosis, Differential, Humans, Immunosuppressive Agents therapeutic use, Leg Ulcer diagnosis, Leg Ulcer pathology, Prognosis, Retrospective Studies, Skin pathology, Polyarteritis Nodosa diagnosis, Polyarteritis Nodosa drug therapy, Polyarteritis Nodosa pathology, Skin Diseases diagnosis, Skin Diseases drug therapy, Skin Diseases pathology
- Abstract
Background: Cutaneous periarteritis nodosa (PAN) is distinguished from systemic PAN by the lack of visceral involvement. The aim of this study was to describe the clinical presentation, laboratory findings, clinical course, and treatment in cutaneous PAN., Patients and Methods: We retrospectively reviewed the files of patients hospitalized for vasculitis in our Dermatology unit where approximately 20 cases of vasculitis are seen each year. Inclusion criteria were skin signs suggestive of PAN and a histological image of leukocytoclastic vasculitis of an arteriole., Results: Nine cases of cutaneous PAN were treated in our unit between 1976 and 1997. Follow-up ranged from 32 months to 22 years. No cases of systemic PAN had been diagnosed during this period. These 9 cases of cutaneous PAN all had the same clinical presentation: nodules on the lower limbs in all cases associated with nodules on the upper limbs in half of the cases. Neuropathy was found in 3 of the 9 cases. No systemic involvement was observed. The most frequently used treatment protocol was general corticosteroid therapy (0.5 mg/kg/d prednisone or prednisolone). Immunosuppressive drugs, colchicine, dapsone, non-steroidal anti-inflammatory drugs and intravenous immunoglobulins were also used with efficacy., Discussion: Cutaneous PAN is a particular form of vasculitis associating skin signs with locoregional neuromuscular involvement. The differential diagnosis with other types of vasculitis is sometimes a difficult task. The clinical course is the fundamental diagnostic clue in cutaneous PAN. A benign course and the absence of visceral involvement allow initiating a symptomatic treatment such as colchicine. The development of neuromuscular signs may warrant the use of general corticosteroid therapy.
- Published
- 1999
9. [Disseminated xanthosiderohistiocytosis with cardiac involvement and monoclonal gammapathy].
- Author
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Lazrak K, Machet MC, Forest JL, Machet L, Lorette G, and Pasquiou C
- Subjects
- Female, Histiocytes pathology, Histiocytosis, Non-Langerhans-Cell pathology, Humans, Immunoglobulin G, Immunoglobulin kappa-Chains, Middle Aged, Pericardium pathology, Skin Diseases pathology, Xanthomatosis pathology, Aortic Valve Stenosis etiology, Hemosiderosis complications, Histiocytosis, Non-Langerhans-Cell complications, Hypergammaglobulinemia complications, Skin Diseases etiology, Xanthomatosis complications
- Abstract
Xanthosiderohistiocytosis is a rare non-Langerhans histiocytosis (4 reported cases). The clinical characteristics include diffuse, sometimes deep, dark-brown infiltrations of the skin. Histological examination reveals abundant deposits of haemosiderin within the histiocyte proliferation. This entity is a clinical form of Montgomery's disease (xanthoma disseminatum) which has been reported in over 100 cases. Our case of disseminated xanthosiderohistiocytosis was particular because it involved the heart and was associated with a monoclonal gammapathy. Five cases have been reported associating xanthoma disseminatum and monoclonal gammapathy, including one case of xanthosiderohistiocytosis. In our case, rapidly increasing levels of monoclonal immunoglobulin suggested an evolution towards a myeloma. A monoclonal gammapathy should be looked for and monitored in cases of xanthosiderohistiocytosis, and more generally xanthoma disseminatum because of the risk of developing lymphoma or myeloma.
- Published
- 1993
10. [Langerhans-cell histiocytosis in the adult: regressive parotid involvement following thalidomide therapy].
- Author
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Bensaid P, Machet L, Vaillant L, Machet MC, Scotto B, and Lorette G
- Subjects
- Adult, Female, Humans, Intertrigo etiology, Parotid Diseases drug therapy, Parotid Diseases pathology, Pregnancy, Pregnancy Complications, Hematologic, Histiocytosis, Langerhans-Cell complications, Parotid Diseases etiology, Skin Diseases etiology, Thalidomide therapeutic use
- Published
- 1992
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