56 results on '"Acrospiroma pathology"'
Search Results
2. Apocrine Papillary Hidrocystoma With Mucinous Metaplasia (Goblet Cell Type): A Case Report and Review of the Literature.
- Author
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Epperson J and Bergfeld W
- Subjects
- Male, Humans, Aged, Goblet Cells metabolism, Goblet Cells pathology, Metaplasia pathology, Apocrine Glands pathology, Hidrocystoma pathology, Sweat Gland Neoplasms pathology, Adenoma, Sweat Gland pathology, Skin Neoplasms pathology, Acrospiroma pathology
- Abstract
Abstract: Mucinous metaplasia (goblet cell type) is exceptionally rare in the skin. This is the second case of apocrine papillary hidrocystoma with mucinous metaplasia (goblet cell type) and a review of the literature exploring the significance and frequency of mucinous metaplasia with goblet cells in nongenital skin. The patient is an elderly man who presented with a blue-pigmented nodule on the scalp that was clinically suggestive of an atypical nevus. Histologically, the lesion was composed of a simple cyst of cuboidal cells with decapitation secretion and mucinous metaplasia with goblet cells. Papillary formation was identified in the cysts. Most cases of cutaneous mucinous metaplasia have been reported on genital skin, usually after chronic inflammation of the area. This type of mucinous metaplasia is categorized as benign mucinous metaplasia of the genitalia (BMM) and is believed to be unrelated to apocrine glands owing to the different histologic features and absence of apocrine differentiation by immunohistochemistry. Mucinous metaplasia (goblet cell type) has been previously reported in benign adnexal tumors (eccrine acrospiroma/hidroadenoma, mixed tumor, and syringocystadenoma papilliferum) and in malignant tumors (apocrine hidradenocarcinoma and squamous cell carcinoma). To date, mucinous metaplasia has not been identified in the histologically normal apocrine glands., Competing Interests: This manuscript has not been published previously and is not currently under review for publication elsewhere. There are no conflicts of interest to disclose at the time of writing. Please contact us with any questions or concerns, and thank you for your consideration., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
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3. Incidence, survival, and prognostic factors associated with malignant nodular hidradenoma in the United States.
- Author
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Ugwu N, Cheraghlou S, Ko CJ, and Cohen JM
- Subjects
- Humans, United States epidemiology, Incidence, Prognosis, Acrospiroma epidemiology, Acrospiroma complications, Acrospiroma pathology, Sweat Gland Neoplasms epidemiology, Sweat Gland Neoplasms pathology, Carcinoma, Skin Appendage, Skin Neoplasms epidemiology, Skin Neoplasms complications, Adenoma, Sweat Gland complications, Adenoma, Sweat Gland pathology
- Abstract
Competing Interests: Conflicts of interest None disclosed.
- Published
- 2023
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4. Cutaneous ultrasound: key diagnostic tool for the relapse of a single eccrine spiradenoma.
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Gracia-Darder I, Arean Cuns C, and García-Martínez FJ
- Subjects
- Humans, Male, Middle Aged, Recurrence, Ultrasonography, Acrospiroma diagnostic imaging, Acrospiroma pathology, Skin Neoplasms diagnostic imaging, Skin Neoplasms pathology, Sweat Gland Neoplasms diagnostic imaging, Sweat Gland Neoplasms pathology
- Abstract
Eccrine spiradenoma is a rare, benign, adnexal skin tumor of the sweat gland. It is frequently solitary and presents as a small lesion in the dermal or the subcutaneous fat layer. Eccrine spiradenomas rarely progress to malignant transformation but they can relapse. Due to its rarity, there have been few reports about the sonographic appearances of eccrine spiradenoma. Sonographic findings were reported in a relapsing case of an eccrine spiradenoma, located in the deep dermal layers and hypodermis of the preauricular region in a middle-aged man. Ultrasound was very useful to suspect the relapse. Histology was correlated with the sonography and discussed the previously reported imaging findings of eccrine spiradenoma and other sweat gland tumors., (© 2021. Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB).)
- Published
- 2022
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5. Glioma-Associated Oncogene-1 Expression in Basal Cell Carcinoma and Its Histologic Mimics.
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Gradecki SE, Eid MV, Pramoonjago P, and Wick MR
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- Acrospiroma metabolism, Acrospiroma pathology, Carcinoma, Adenoid Cystic metabolism, Carcinoma, Adenoid Cystic pathology, Carcinoma, Basal Cell pathology, Carcinoma, Merkel Cell pathology, Carcinoma, Squamous Cell pathology, Humans, Immunohistochemistry, Sebaceous Gland Neoplasms metabolism, Sebaceous Gland Neoplasms pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms metabolism, Sweat Gland Neoplasms pathology, Carcinoma, Basal Cell metabolism, Carcinoma, Merkel Cell metabolism, Carcinoma, Squamous Cell metabolism, Skin Neoplasms metabolism, Zinc Finger Protein GLI1 metabolism
- Abstract
Abstract: Basal cell carcinoma (BCC) is the most common skin cancer, and it has numerous histologic mimics with variable prognoses and treatments. Although some immunohistochemical stains can be used for the differential diagnosis of BCC, variability and overlap in results can complicate their interpretation. Immunohistochemical staining for glioma-associated oncogene-1 (Gli-1) was performed on 26 nodular BCCs, 22 infiltrative BCCs, 9 basaloid squamous cell carcinomas, 12 desmoplastic trichoepitheliomas, 19 Merkel cell carcinomas, 11 sebaceous carcinomas, 10 cylindromas, 14 spiradenomas, 12 adenoid cystic carcinomas (AdCC), and 1 solitary trichoepithelioma. Strength of staining was scored as 0, 1+, 2+, or 3+, and distribution of staining was categorized as diffuse, multifocal, or focal. Strong, diffuse Gli-1 expression was seen in all tumors with basal epidermal-type differentiation, including BCC, trichoepithelioma, and basaloid squamous cell carcinoma. All examples of Merkel cell carcinoma were negative for cytoplasmic expression. Seven out of 11 sebaceous carcinomas were negative for Gli-1, and the remaining 4 showed 1+ expression. Cylindroma, spiradenoma, and AdCC, each an adnexal skin tumor, showed the most variable staining, but with cylindroma and spiradenoma demonstrating comparable labeling patterns. Overall, although Gli-1 may not distinguish between basal epidermal-type tumors, it may have a role in separating that group from lesions with adnexal differentiation, particularly sebaceous carcinoma, but also cylindroma, spiradenoma, and AdCC. Any cytoplasmic staining seems to exclude the diagnosis of Merkel cell carcinoma., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
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6. Metaplastic spiradenocarcinoma: Report of two cases with sarcomatous differentiation.
- Author
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Held L, Ruetten A, Saggini A, Kempter W, Tiedke C, Weber-Kuhn S, De Saint Aubain N, and Mentzel T
- Subjects
- Acrospiroma complications, Acrospiroma pathology, Adenocarcinoma pathology, Adenocarcinoma surgery, Adult, Aged, Carcinoma, Adenoid Cystic complications, Carcinoma, Adenoid Cystic pathology, Cell Differentiation, Diagnosis, Differential, Female, Humans, Immunohistochemistry methods, Lost to Follow-Up, Margins of Excision, Sarcoma diagnosis, Skin Neoplasms surgery, Staining and Labeling methods, Sweat Gland Neoplasms surgery, Adenocarcinoma diagnosis, Metaplasia pathology, Sarcoma pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Abstract
Spiradenocarcinoma (SC) is a very rare malignant skin adnexal tumor with sweat gland differentiation that develops from a pre-existing spiradenoma, cylindroma, or hybrid tumor called spiradenocylindroma, or arises de novo. We present two exceptionally rare SC cases showing sarcomatous differentiation; we also discuss the clinicopathologic features of SC, as well as its differential diagnoses and available therapeutic modalities. Given the aggressive behavior of SC, rapid diagnosis and complete removal of the tumor with tumor-free margins is mandatory. Owing to the marked morphological heterogeneity of individual SC cases, dermatopathologists must be familiar with the different possible histopathologic manifestations of this neoplasm., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2021
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7. Unusual skin tumour with a large cystic component.
- Author
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Ishikawa A, Kuraoka K, Zaitsu J, Saito A, Fujimoto S, Uemura T, and Taniyama K
- Subjects
- Acrospiroma pathology, Acrospiroma surgery, Adenocarcinoma pathology, Adenocarcinoma surgery, Aged, 80 and over, Dermatologic Surgical Procedures, Female, Humans, Leg pathology, Leg surgery, Skin pathology, Skin Neoplasms pathology, Skin Neoplasms surgery, Acrospiroma diagnosis, Adenocarcinoma diagnosis, Skin Neoplasms diagnosis
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2021
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8. Clinicopathologic Characterization of Hidradenoma on Acral Sites: A Diagnostic Pitfall With Digital Papillary Adenocarcinoma.
- Author
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Wiedemeyer K, Gill P, Schneider M, Kind P, and Brenn T
- Subjects
- Acrospiroma chemistry, Acrospiroma surgery, Adenocarcinoma, Papillary chemistry, Adenocarcinoma, Papillary surgery, Adult, Aged, Aged, 80 and over, Alberta, Biomarkers, Tumor analysis, Biopsy, Diagnosis, Differential, Female, Fingers, Humans, Immunohistochemistry, Male, Middle Aged, Predictive Value of Tests, Scotland, Skin Neoplasms chemistry, Skin Neoplasms surgery, Sweat Gland Neoplasms chemistry, Sweat Gland Neoplasms surgery, Thumb, Toes, Treatment Outcome, Young Adult, Acrospiroma pathology, Adenocarcinoma, Papillary pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Abstract
Hidradenomas are benign sweat gland tumors that typically present as small nodules in adulthood. Their anatomic distribution is wide and rarely includes acral sites. In this setting, reliable separation from digital papillary adenocarcinoma is important, but notoriously difficult. Hematoxylin and eosin-stained sections of 25 hidradenomas on acral skin were retrieved. The clinical presenting features and morphologic findings were recorded, and follow-up was obtained. Immunohistochemistry was performed for AE1/3, CK5/6, EMA, CEA, SMA, S100, p40, and p63. The tumors presented as solitary nodules on the hands (n=17) and feet (n=8) of adults (age range: 20 to 81 y; median: 50 y), with an equal sex distribution. Histologically, the well-circumscribed tumors were lobular, with a solid and cystic growth within dermis. Duct and squamous differentiation and vascularized hyaline stroma were frequent. The majority (n=18) were poroid hidradenomas. Scattered cytologic atypia and mitotic activity (median: 2/10 HPF) were common, and a pseudoinfiltrative growth of strands in a hyaline to sclerotic matrix was noted in 5 tumors. No papillary structures, atypical mitoses, or tumor necrosis were present. Immunohistochemically, all tumors expressed AE1/3, CK5/6, p40, and p63 strongly and diffusely. Luminal differentiation was highlighted by epithelial membrane antigen and carcinoembryonic antigen staining. S100 and SMA staining was absent. Follow-up (1 to 288 mo; median: 61 mo), available for 20 patients, showed no local recurrences and no disease-related mortality. Acral hidradenomas and digital papillary adenocarcinomas share a well-circumscribed dermal growth pattern containing solid, cystic, and tubular areas with mitotic activity and at least focal cytologic atypia. Lack of papillary structures and the diffuse positivity for p40 and p63 in the absence of S100 and SMA expression are helpful features in favor of acral hidradenoma.
- Published
- 2020
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9. PIK3CA and AKT1 mutations in hidradenoma papilliferum.
- Author
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Goto K, Maeda D, Kudo-Asabe Y, Hibiya T, Hayashi A, Fukayama M, Ohashi K, and Goto A
- Subjects
- Acrospiroma diagnosis, Acrospiroma pathology, Adult, Biomarkers, Tumor metabolism, Cell Transformation, Neoplastic, Class I Phosphatidylinositol 3-Kinases, Female, Genotype, Humans, Immunohistochemistry, Middle Aged, Mutation, Phenotype, Phosphatidylinositol 3-Kinases metabolism, Proto-Oncogene Proteins c-akt metabolism, Sequence Analysis, DNA, Skin Neoplasms diagnosis, Skin Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms pathology, Vulvar Neoplasms diagnosis, Vulvar Neoplasms pathology, Acrospiroma genetics, Biomarkers, Tumor genetics, Phosphatidylinositol 3-Kinases genetics, Proto-Oncogene Proteins c-akt genetics, Skin Neoplasms genetics, Sweat Gland Neoplasms genetics, Vulvar Neoplasms genetics
- Abstract
Aims: Hidradenoma papilliferum (HP) is a benign vulvar neoplasm that arises from anogenital mammary-like glands, and its morphology is similar to mammary intraductal papilloma. The aim of this study was to investigate oncogenic mutations involved in the tumourigenesis of HP. We focused specifically on PIK3CA and AKT1 mutations, which are both reported to be detected in 33% of mammary intraductal papillomas., Methods: In total, seven HP cases were analysed. Clinicopathological analyses and immunohistochemistry for oestrogen receptor, p63, smooth muscle actin (SMA), p53 and β-catenin were performed. Furthermore, PIK3CA , AKT1, BRAF and KRAS hot spot mutations were examined by Sanger sequencing., Results: Morphologically, all HPs had a papillary and tubular architecture with a biphasic pattern of epithelial and myoepithelial cells. Immunohistochemistry revealed that oestrogen receptor expression was restricted to epithelial cells, whereas p63 and SMA were exclusively expressed in myoepithelial cells. The patterns of p53 and β-catenin immunostaining suggested wild-type genotypes. Direct sequencing revealed the presence of somatic PIK3CA mutations (Ex9. c.1633G>A, p.E545K and Ex20. c.3140A>G, p.H1047R) in two of the HPs and an AKT1 (c.49G>A, p.E17K) mutation in one. BRAF and KRAS mutations were not found in any of the HP cases., Conclusions: PIK3CA and AKT1 are frequently mutated in HP tumours (29% and 14%, respectively). PIK3CA/AKT1 pathway alterations in HP further support the hypothesis that HP is the vulvar (anogenital mammary-like gland) analogue of breast intraductal papilloma., Competing Interests: Competing interestsNone declared., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)
- Published
- 2017
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10. Case for diagnosis. A bluish nodule on the scalp.
- Author
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Martinez-Cabriales SA, Miranda-Maldonado I, and Ocampo-Candiani J
- Subjects
- Adult, Dermoscopy, Humans, Male, Acrospiroma pathology, Head and Neck Neoplasms pathology, Scalp pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Abstract
Acrospiroma, also known as hidradenoma, is a rare cutaneous tumor that has several histological characteristics. As a consequence, a high index of suspicion is necessary for its diagnosis. Here we report a case that illustrates the importance of a good clinical-pathologic correlation in order to recognize this disease.
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- 2017
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11. Case of basal cell carcinoma with myoepithelial differentiation: Its characteristic clinical and histopathological features.
- Author
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Namiki T, Miura K, Ueno M, Tanaka K, and Yokozeki H
- Subjects
- Acrospiroma pathology, Aged, Biomarkers, Tumor metabolism, Carcinoma, Basal Cell diagnosis, Carcinoma, Basal Cell metabolism, Carcinoma, Basal Cell surgery, Cell Differentiation, Dermoscopy, Face, Humans, Immunohistochemistry, Male, Myoepithelioma diagnosis, Myoepithelioma metabolism, Myoepithelioma surgery, Plastic Surgery Procedures, Skin Neoplasms diagnosis, Skin Neoplasms metabolism, Skin Neoplasms surgery, Skin Transplantation, Acrospiroma diagnosis, Carcinoma, Basal Cell pathology, Myoepithelioma pathology, Skin Neoplasms pathology
- Published
- 2016
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12. Dermoscopy of Skin Adnexal Neoplasms:A Continuous Challenge.
- Author
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di Meo N, Stinco G, Gatti A, Fadel M, Vichi S, and Trevisan G
- Subjects
- Acrospiroma pathology, Aged, Female, Humans, Skin Neoplasms pathology, Acrospiroma diagnostic imaging, Dermoscopy, Skin Neoplasms diagnostic imaging
- Abstract
Dear Editor, Apocrine hidradenoma is a rare benign adnexal tumor related to the more common poroma, as they both originate from sweat glands. Hidradenoma usually has an eccrine differentiation, but an apocrine differentiation is possible. Due to its rarity and non-specific clinical appearance it is difficult to differentiate it from other malignant cutaneous lesions. In this challenging task, dermatoscopy could be particularly helpful to better describe, recognize, and differentiate these lesions. Unfortunately, the literature offers only few dermatoscopic descriptions of this rare cutaneous neoplasm. A 70-year-old woman in fair general condition was referred to our Department for an asymptomatic 10×8 mm single nodule on her left scapula. This nodule was red, dome shaped, well circumscribed, firm, and mildly tender (Figure 1). The patient reported that it had been present since approximately 7 months. The lesion was neither painful nor itchy and there was no bleeding. A skin examination did not show any other lesions with the same features or other suspicious lesions. Dermatoscopy revealed milky-pinkish areas with dotted vessels, linear-irregular vessels, and hairpin vessels: some of these aspects can also be found in amelanotic melanoma (1). There were also homogeneous blue areas similar to lacunae, characteristic but not exclusive to vascular or sarcomatous neoplasms and basal cell carcinoma (1,2). Furthermore, small ulcerations covered by an amber crust were identified, which can usually be found in basal cell carcinoma. Regarding the background of the lesion, we noticed peculiar, translucent, pinkish, soft, large lobular areas (Figure 2). On the basis of this analysis, we suspected an atypical presentation of a basal cell carcinoma, an amelanotic melanoma, or a sarcomatous skin neoplasm. A metastasis of an unknown solid tumor was also taken into consideration. The histological examination revealed an adnexal neoplasm and specifically an apocrine hidradenoma. The neoplasm had variably sized nests and nodules of neoplastic epithelial cells, with a small ductular lumens confined within the upper dermis. The lesion was composed mainly of two cell types: polygonal and smaller, elongated, and darker cells. The cuboidal/polygonal cells were seen lining the duct-like spaces and slots and resembled those of poroma (Figure 3). The adnexal skin tumors group includes a complex variety of uncommon tumors that can be distinguished only histologically, and most of them are benign (3). Searching the literature for "hidradenoma dermoscopy" and "adnexal dermoscopy" yields multiple descriptions of poromas but few dermatoscopic descriptions of hidradenoma (4). There was only one report of the presence of "arborizing vessels"(5), and another described "reddish purple areas and some linear or hairpin-like vessels on the surface of the tumor" (6). In another paper we found: "irregular scar like whitish areas and a polymorphous vascular pattern including irregular reddish-purple areas mimicking lacunar appearance of hemangiomas with thick hairpin vessels at the periphery" (7). It is very difficult make use of such scant data especially in order to detect a leading pattern for a specific diagnosis. Moreover, the described structures lack in specificity, being also present in many other lesions. Analyzing our dermatoscopic image and comparing it to the other ones available in the literature, we identified a peculiar background. It consisted in the presence of multilobular translucent and pinkish soft areas, which fit the previously described dermatoscopic criteria. We hypothesize there is a correlation between this feature and the histopathological presentation with variably sized nests and nodules. Of course, further case reports of hidradenoma are needed to identify the soft lobular background as a distinctive dermatoscopic feature. Due to the lack of specific features both clinically than dermatoscopically, histopathological analysis remains the only gold standard for diagnosis of these benign mimicking lesions.
- Published
- 2016
13. Zosteriform configuration of multiple eccrine spiradenomas of the scalp.
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Sorin T, Vignaud JM, Colson T, Gauchotte G, De Runz A, Brix M, Cuny JF, and Simon E
- Subjects
- Acrospiroma pathology, Aged, Biopsy, Cell Transformation, Neoplastic pathology, Diagnosis, Differential, Humans, Male, Neoplasms, Multiple Primary pathology, Scalp pathology, Skin Neoplasms pathology, Skin Transplantation, Tomography, X-Ray Computed, Acrospiroma diagnosis, Acrospiroma surgery, Neoplasms, Multiple Primary diagnosis, Neoplasms, Multiple Primary surgery, Scalp surgery, Skin Neoplasms diagnosis, Skin Neoplasms surgery
- Abstract
Background: Eccrine spiradenoma (ES) is a benign adnexal tumor predominantly located in the head and neck regions. Multiple neoplasms located on the scalp have been reported but never with a zosteriform configuration on the first trigeminal area., Case Report: We describe an original case report of a 75-year-old Caucasian man presenting multiple subcutaneous blue and purple nodules disseminated on the first left trigeminal dermatome. All the nodules appeared gradually on a one-year period. Biopsy revealed a nodular adnexal tumor in the dermis without malignant eccrine spiradenoma (MES) transformation. The surgical procedure was performed in a manner to protect the galea aponeurotica in the upper half on the first left trigeminal area. The frontalis muscle was raised with the surgical specimen in the lower half of the first trigeminal area. A split-thickness skin graft was applied on the surgical defect. Histological examination revealed multilobular well-defined tumors located in the dermis., Conclusion: The presence of multiple subcutaneous nodules in a trigeminal pattern should suggest a multiple localized zosteriform ES. The diagnosis is focused on clinical findings and the treatment is based on a large surgical excision. The histological examination is essential for not to fail a MES transformation., (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)
- Published
- 2016
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14. [Thumb Reconstruction after Oncological Resection of a Rare Aggressive Digital Papillary Adenocarcinoma: A Case Report].
- Author
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Brodbeck R, Schmitz M, and Horch RE
- Subjects
- Adenocarcinoma, Papillary pathology, Adult, Amputation, Surgical methods, Arthrodesis methods, Diagnosis, Differential, Female, Humans, Magnetic Resonance Imaging, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Reoperation, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology, Thumb pathology, Acrospiroma pathology, Acrospiroma surgery, Adenocarcinoma, Papillary surgery, Neoplasm Recurrence, Local surgery, Plastic Surgery Procedures, Skin Neoplasms surgery, Surgical Flaps surgery, Sweat Gland Neoplasms surgery, Thumb surgery
- Abstract
We present the case of a 44-year-old female with an aggressive digital papillary adenocarcinoma of the right thumb. Aggressive digital papillary adenocarcinomas are rare tumours originating from sweat glands of the skin on the hand or foot. The tumour was located at the extensor side and had been excised in 2 operations after diagnosis as an eccine hidradenoma, which is exceptional in this case. The tumour was radically excised and the defect was reconstructed using arthrodesis, and a retrogradely perfused pedicle radialis fascial flap with skin graft, due to which amputation was avoided., (© Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2015
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15. Lightning strikes thrice.
- Author
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McCalmont TH
- Subjects
- Biopsy, Diagnosis, Differential, Female, Humans, Acrospiroma pathology, Eccrine Porocarcinoma pathology, Skin Neoplasms pathology
- Published
- 2014
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16. Complex adnexal tumours of the skin: a report of three cases and review of literature.
- Author
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London V, Saadat P, and Vadmal MS
- Subjects
- Acrospiroma pathology, Cystadenoma pathology, Female, Humans, Male, Middle Aged, Neoplasms, Adnexal and Skin Appendage surgery, Neoplasms, Complex and Mixed surgery, Skin Neoplasms surgery, Sweat Gland Neoplasms pathology, Syringoma pathology, Neoplasms, Adnexal and Skin Appendage pathology, Neoplasms, Complex and Mixed pathology, Skin Neoplasms pathology
- Abstract
Aims: Complex or composite adnexal tumours of the skin (CATS) are unusual neoplasms composed of two or more histopathologically distinct subtypes of appendageal neoplasms coexisting in a single cutaneous lesion. The authors report three examples of CATS, review literature and discuss their probable histogenesis., Methods and Results: Of the three tumours described, one tumour showed a mixture of a proliferating pilar tumour and syringocystadenoma papilliferum, the second lesion was composed of a proliferating pilar tumour and tubulopapillary hidradenoma and the third tumour exhibited a syringocystadenoma papilliferum and tubulopapillary hidradenoma in combination., Conclusions: CATS are rare tumours. The authors reported three unique cases in addition to the 10 other reported cases. These three cases further strengthen the hypothesis of a 'folliculosebaceous apocrine' unit as the most likely point of origin of CATS.
- Published
- 2012
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17. Cutaneous myoepithelioma arising within hidradenoma of the scalp.
- Author
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Jakate K, Wong K, Sirbovan J, and Hanna W
- Subjects
- Cell Proliferation, Dermis metabolism, Dermis pathology, Humans, Immunohistochemistry, Male, Middle Aged, Neoplasm Proteins metabolism, Acrospiroma metabolism, Acrospiroma pathology, Head and Neck Neoplasms, Myoepithelioma metabolism, Myoepithelioma pathology, Neoplasms, Second Primary metabolism, Neoplasms, Second Primary pathology, Scalp metabolism, Scalp pathology, Skin Neoplasms, Sweat Gland Neoplasms metabolism, Sweat Gland Neoplasms pathology
- Abstract
A 62-year-old man presented with a 2-year history of a 2-cm cystic mass involving his occiput. There had been recent enlargement, and the clinical impression was that of a pilar cyst. Histopathological sections showed a partially dermal solid and cystic proliferation. The tumor contained areas of glandular differentiation with cuboidal to columnar cells lining luminal and cystic spaces. A concurrent spindle cell proliferation was seen interspersed between glands and also formed broad, cellular sheets of cells. The stroma was sclerotic and without chondroid or myxoid elements. Immunohistochemistry showed that the spindled cells expressed S100 protein, cytokeratin and smooth muscle myosin. The immunohistochemical profile and the relationship with ductal elements supported myoepithelial differentiation. The proliferation warranted the diagnosis of myoepithelioma arising from a hidradenoma, which to our knowledge has not been previously described. In addition to discussing this case, we provide a brief review of epithelial-myoepithelial neoplasms encountered in the skin., (Copyright © 2011 John Wiley & Sons A/S.)
- Published
- 2012
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18. Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma.
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Gatti A, di Meo N, and Trevisan G
- Subjects
- Acrospiroma diagnosis, Aged, Diagnosis, Differential, Humans, Male, Melanoma diagnosis, Skin Neoplasms diagnosis, Sweat Gland Neoplasms diagnosis, Acrospiroma pathology, Dermoscopy, Melanoma pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Abstract
Eccrine acrospiroma, better known as eccrine poroma, is a benign adnexal neoplasm of the skin. Its clinical aspect can masquerade as some other nodular and cystic lesions. The current dermoscopy literature offers very few case studies. Moreover, these very few examples present a totally different appearance pattern compared to the one we examined. Its homogeneous blue pattern suggested the better-known nodular malignant melanoma; in fact, this dermoscopic appearance was due to the Tyndall effect.
- Published
- 2010
19. A skin tumor in a young girl. Diagnosis: Clear cell hidradenoma.
- Author
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Gonul M, Cakmak SK, Gul U, Han O, and Karagece U
- Subjects
- Child, Diagnosis, Differential, Female, Humans, Acrospiroma pathology, Skin pathology, Skin Neoplasms pathology
- Published
- 2010
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20. Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma.
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Battistella M, Mateus C, Lassau N, Chami L, Boukoucha M, Duvillard P, Cribier B, and Robert C
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- Acrospiroma pathology, Adenocarcinoma pathology, Adult, Female, Humans, Male, Middle Aged, Skin Neoplasms pathology, Sunitinib, Treatment Outcome, Acrospiroma drug therapy, Adenocarcinoma drug therapy, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Indoles therapeutic use, Neoplasm Metastasis, Pyrroles therapeutic use, Skin Neoplasms drug therapy
- Abstract
Background: Adnexal carcinomas are rare and diverse cutaneous tumours. They are locally aggressive and have the potential for distant metastasis. Metastatic adnexal carcinomas are very resistant to conventional chemotherapies. Sunitinib, an oral tyrosine kinase inhibitor, is reportedly effective for the treatment of various solid cancers. Its use in adnexal carcinomas has never been reported., Observations: The first patient had metastatic clear cell hidradenocarcinoma and was stabilized over 8 months with sunitinib, before she relapsed. The second patient had a metastatic malignant hair follicle tumour (trichoblastic carcinoma) and achieved a partial remission with sunitinib, and disease stabilized after 10 months. Dynamic contrast-enhanced ultrasound (DCE-US) performed to evaluate tumour vascularization during treatment depicted a dramatic and early decrease in the tumour blood volume., Conclusions: Sunitinib was effective in controlling the disease in our two patients. DCE-US using linear raw data may have an early predictive value for tumour response to sunitinib. Further studies involving larger cohorts of patients are warranted in order to confirm the efficacy of sunitinib in these rare tumours.
- Published
- 2010
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21. Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases.
- Author
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Tanese K, Sato T, and Ishiko A
- Subjects
- Aged, 80 and over, Humans, Japan, Male, Treatment Outcome, Acrospiroma pathology, Hand, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Abstract
Malignant eccrine spiradenoma (MES) is an extremely rare cutaneous malignant tumour. An 86-year-old man presented at our hospital with an enlarging tumour on the dorsum of the left hand. An excisional biopsy was taken and histological examination showed a solid island of cells of two distinct types: cells with abundant cytoplasm and oval vesicular nuclei, and small round cells with less cytoplasm and hyperchromatic nuclei with a high frequency of mitosis. We diagnosed this tumour as MES. Although we did not perform further treatment because of the patient's age, there was no sign of recurrence or metastasis in the 2 years of follow-up after excisional biopsy. We reviewed cases of malignant eccrine spiradenoma in the English and Japanese literature and found that 'sarcomatous' or 'squamous' change in histopathology was significantly correlated with a poorer prognosis. It is therefore important for treatment planning to evaluate the entire specimen histologically.
- Published
- 2010
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22. Fine-needle aspiration cytology of metastatic eccrine porocarcinoma.
- Author
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Yu L, Olsen S, Lowe L, Michael C, and Jing X
- Subjects
- Aged, 80 and over, Biopsy, Fine-Needle, Bowen's Disease pathology, Humans, Immunohistochemistry, Male, Neoplasms, Multiple Primary metabolism, Neoplasms, Multiple Primary pathology, Penile Neoplasms pathology, Acrospiroma pathology, Lymphatic Metastasis pathology, Skin Neoplasms pathology
- Abstract
Eccrine porocarcinoma (EP), although rare, is widely recognized as the most common malignant sweat gland tumor. EP typically grows slowly and usually is cured by surgical excision with clear margins. An elevated mortality rate, however, is observed when regional lymph nodes are involved. We herein describe cytohistologic findings in a case of metastatic EP. An 86-year-old man with a history of EP of the left lateral ankle and squamous cell carcinoma in situ (Bowen's disease) of the penis presented with enlarged left inguinal lymph nodes. A superficial fine-needle aspiration (FNA) was performed and demonstrated a hypercellular sample with discohesive clusters and/or individual tumor cells. The tumor cells were round or oval with most of the cells showing dense, refractile cytoplasm. Intracytoplasmic vacuoles were readily appreciated in some of the cells. Nuclear enlargement, high N/C ratio, nuclear hyperchromasia, bi- and multinucleation, and prominent nucleoli were seen. A diagnosis of metastatic eccrine porocarcinoma was rendered. Enlarged retroperitoneal lymph nodes were detected and CT-guided left retroperitoneal core biopsy was performed 1 week later. The biopsy revealed features consistent with metastatic eccrine porocarcinoma., ((c) 2009 Wiley-Liss, Inc.)
- Published
- 2009
- Full Text
- View/download PDF
23. A malignant eccrine poroma in a pregnant woman: case report and review of the literature.
- Author
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Kairi-Vassilatou E, Grapsa D, Dafnios N, Smyrniotis V, Hasiakos D, and Kondi-Pafiti A
- Subjects
- Acrospiroma metabolism, Adult, Female, Humans, Pregnancy, Acrospiroma pathology, Carcinoma, Skin Appendage pathology, Pregnancy Complications, Neoplastic, Skin Neoplasms pathology
- Abstract
Malignant eccrine poroma is a rare cutaneous neoplasm that originates from the intraepidermal portion of the eccrine gland. It affects mainly elderly people while its occurrence in younger adults is extremely rare. We present the first reported case of a malignant eccrine poroma in a pregnant woman, with emphasis on its pathologic and immunohistochemical features. Early diagnosis and treatment of eccrine neoplasms are of crucial importance when pregnancy coexists, because of their tendency to aggravate under the influence of gestation-related changes.
- Published
- 2007
24. Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells.
- Author
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Kamiya H, Kitajima Y, and Ban M
- Subjects
- Acrospiroma pathology, Aged, Aged, 80 and over, Female, Humans, Neoplasm Invasiveness, Neoplasms, Basal Cell pathology, Bowen's Disease pathology, Carcinoma, Skin Appendage pathology, Cell Transformation, Neoplastic pathology, Skin Neoplasms pathology
- Abstract
Bowen's disease rarely exhibits multiple combinations of premalignant and/or malignant skin lesions. Bowen's disease with invasive adnexal carcinoma was originally described by Kao, but is not well recognized by clinicians due to its rarity and lack of specific clinical features of this condition. Herein, we describe three unusual cases of Bowen's disease with invasive adnexal carcinoma. The two distinct neoplastic areas exhibited continuity both clinically and histologically. The plaque lesions possessed clinical features typical of Bowen's disease. In cases 1 and 3, we confirmed the adnexal tumor within tumors of Bowen's disease, the diagnosis of which is eccrine porocarcinoma. The tumor in case 2 was characteristic to trichilemmal carcinoma. Immunohistochemically, the tumor cells of Bowen's disease and the adnexal carcinoma differed in antigenicities. The present cases support a notion that Bowen's disease maintains a pluripotential nature.
- Published
- 2006
- Full Text
- View/download PDF
25. Eccrine porocarcinoma arising from preexisting eccrine poroma of the scalp after radiotherapy for cervical cancer.
- Author
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Kose R, Coban YK, and Ciralik H
- Subjects
- Acrospiroma diagnosis, Acrospiroma pathology, Disease Progression, Female, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms pathology, Humans, Middle Aged, Neoplasms, Radiation-Induced diagnosis, Neoplasms, Radiation-Induced pathology, Neoplasms, Second Primary diagnosis, Neoplasms, Second Primary pathology, Skin Neoplasms diagnosis, Skin Neoplasms pathology, Sweat Gland Neoplasms diagnosis, Sweat Gland Neoplasms pathology, Uterine Cervical Neoplasms radiotherapy, Acrospiroma etiology, Head and Neck Neoplasms etiology, Neoplasms, Radiation-Induced etiology, Neoplasms, Second Primary etiology, Radiotherapy adverse effects, Scalp pathology, Skin Neoplasms etiology, Sweat Gland Neoplasms etiology
- Abstract
Eccrine porocarcinoma may arise from eccrine poroma or it may occur de novo. We present a rapidly growing occipital malignant eccrine poroma on the scalp following to a radiotherapy for cervical carcinoma. A wide excision with skin grafting resulted no recurrence during a 1-year followup. Although malignant transformation is well known for other skin cancers this was not reported for eccrine poroma.
- Published
- 2006
26. Pigmented eccrine poroma occurring on the scalp: Derivation of melanocytes in the tumor.
- Author
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Ohata U, Hara H, and Suzuki H
- Subjects
- Aged, Carcinoembryonic Antigen analysis, Cell Nucleus ultrastructure, Cytoplasmic Granules ultrastructure, Diagnosis, Differential, Humans, Intercellular Junctions ultrastructure, Male, Melanins analysis, Nevus, Pigmented diagnosis, Acrospiroma pathology, Head and Neck Neoplasms pathology, Melanocytes pathology, Scalp pathology, Skin Neoplasms pathology
- Abstract
We describe a man with a pigmented poroma on the scalp mimicking a pigmented melanocytic nevus. Histopathological examination showed that melanocytes were mostly distributed at the periphery of the tumor masses. It is suggested that melanocytes in the tumor masses may have migrated from the adjacent epidermis.
- Published
- 2006
- Full Text
- View/download PDF
27. Malignant eccrine poroma.
- Author
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Ansari NA
- Subjects
- Acrospiroma surgery, Biopsy, Needle, Diagnosis, Differential, Humans, Immunohistochemistry, Risk Assessment, Skin Neoplasms surgery, Sweat Gland Neoplasms surgery, Acrospiroma pathology, Cell Transformation, Neoplastic pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Published
- 2005
28. Eccrine poroma in an unusual site: a clinical and dermoscopic simulator of amelanotic melanoma.
- Author
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Altamura D, Piccolo D, Lozzi GP, and Peris K
- Subjects
- Acrospiroma pathology, Aged, Humans, Male, Sweat Gland Neoplasms pathology, Acrospiroma diagnosis, Dermoscopy, Melanoma, Amelanotic diagnosis, Skin Neoplasms diagnosis, Sweat Gland Neoplasms diagnosis
- Published
- 2005
- Full Text
- View/download PDF
29. Hidroacanthoma simplex: a case report and analysis of 70 Japanese cases.
- Author
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Anzai S, Arakawa S, Fujiwara S, and Yokoyama S
- Subjects
- Acrospiroma surgery, Aged, Biopsy, Needle, Female, Follow-Up Studies, Humans, Immunohistochemistry, Japan, Skin Neoplasms surgery, Sweat Gland Neoplasms surgery, Treatment Refusal, Acrospiroma pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Published
- 2005
- Full Text
- View/download PDF
30. Expression of CD10 in basal cell carcinoma.
- Author
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Yada K, Kashima K, Daa T, Kitano S, Fujiwara S, and Yokoyama S
- Subjects
- Acrospiroma metabolism, Acrospiroma pathology, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor analysis, Carcinoma, Basal Cell pathology, Carcinoma, Squamous Cell pathology, Female, Hair Diseases metabolism, Hair Diseases pathology, Humans, Immunohistochemistry, Male, Middle Aged, Pilomatrixoma metabolism, Pilomatrixoma pathology, Skin Neoplasms pathology, Syringoma metabolism, Syringoma pathology, Carcinoma, Basal Cell metabolism, Carcinoma, Squamous Cell metabolism, Neprilysin biosynthesis, Sebaceous Gland Neoplasms metabolism, Skin Neoplasms metabolism
- Abstract
We investigated the expression of CD10 by an immunohistochemical method in 51 basal cell carcinomas (BCCs), eight pilomatricomas, five trichoblastomas, two trichofolliculomas, three sebaceomas, five sebaceous carcinomas, ten syringomas, two spiradenomas, ten poromas, four porocarcinomas, one eccrine duct carcinoma (not otherwise specified, NOS), six mixed tumors of apocrine origin, and nine squamous cell carcinomas (SCCs). We detected strong expression of CD10 in tumor cells of BCC (86%), and found that the smaller the number of positive tumor cells, the larger the number of positive stromal cells, in particular in sclerosing BCCs. Spearman's rank correlation test revealed a significant negative correlation in BCCs between the expression of CD10 in tumor cells and that in stromal cells (P = 0.001). In all pilomatricomas (100%) and in four trichoblastomas (80%), strong expression was also detected in tumor cells. There was no detectable expression in trichofolliculomas. One sebaceoma (33%) and two sebaceous carcinomas (40%) expressed CD10 in a similar fashion to BCCs. All tumors of eccrine gland origin, including syringoma, spiradenoma, poroma, porocarcinoma, and eccrine duct carcinoma (NOS), did not express CD10. Five mixed tumors (83%) were immunopositive. In SCC, CD10 was overexpressed only in the stromal cells. These findings support the hypothesis that BCC is derived from the folliculo-sebaceous apocrine unit, especially having the same origin as trichoblastoma and pilomatricoma. CD10 might be an indicator of tumor invasiveness if it is expressed in stromal cells, while it might be a marker of follicular differentiation if it is expressed in the actual tumor cells of cutaneous epithelial neoplasms.
- Published
- 2004
- Full Text
- View/download PDF
31. [Pigmented eccrine poroma].
- Author
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Elloumi-Jellouli A, Marrak H, Ben Ammar S, Ben Ayed M, and Mokhtar I
- Subjects
- Adult, Female, Humans, Skin Pigmentation, Acrospiroma pathology, Skin Neoplasms pathology
- Published
- 2004
- Full Text
- View/download PDF
32. Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature.
- Author
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Ohta M, Hiramoto M, Fujii M, and Togo T
- Subjects
- Acrospiroma surgery, Adult, Female, Head and Neck Neoplasms surgery, Humans, Skin Neoplasms surgery, Sweat Gland Neoplasms surgery, Acrospiroma pathology, Head and Neck Neoplasms pathology, Scalp, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Abstract
Background: Nodular hidradenocarcinoma was first reported as clear-cell eccrine carcinoma by Keasby and Hadley in 1954 (Cancer 1954;7:934-52) and rare malignant tumor. Several synonyms and related terms for nodular hidradenocarcinoma have appeared in the literature., Objective: They have potential for uncontrollable local recurrence, tend to metastasize, and often cause death. Most cases have been reported in the pathology literature with limited clinical information., Methods: We report a 27-year-old woman with nodular hidradenocarcinoma on the scalp., Result: The management of rare cases is not well defined. In our case, she was only treated with a wide local excision, and no recurrence was observed 2 years after excision., Conclusion: Most authors have concluded that early wide surgical excision of the tumor is the treatment of choice. The efficiency of adjuvant therapy generally has not established.
- Published
- 2004
- Full Text
- View/download PDF
33. Clear cell eccrine porocarcinoma with extensive cutaneous metastasis and peripheral lymphocyte dysfunction.
- Author
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Lan CC, Yu HS, Liao WT, Hsu RC, Chung JC, Tsai KB, and Chen GS
- Subjects
- Acrospiroma immunology, Aged, Aged, 80 and over, Female, Humans, Lymphocytes immunology, Receptors, Interleukin-2 blood, Skin Neoplasms immunology, Skin Neoplasms pathology, Sweat Gland Neoplasms immunology, Acrospiroma pathology, Skin Neoplasms secondary, Sweat Gland Neoplasms pathology
- Abstract
An 81-year-old woman came to our clinic (Department of Dermatology, Kaohsiung Medical University, Kaohsiung, Taiwan) with multiple erythematous, indurated papules over the left side of her face. Two years earlier, the patient had a skin biopsy done at a similar anatomical area with the histopathological diagnosis of Bowen's disease. After reviewing surgical specimens and confirming no systemic involvement, clear cell eccrine porocarcinoma with extensive cutaneous metastasis has been diagnosed. In addition, the peripheral blood lymphocyte function of the patient was evaluated. The expression of interleukin-2 receptors on lymphocytes after stimulation is abnormal compared with the age-matched normal control and a patient with cutaneous squamous cell carcinoma. This clinical manifestation of eccrine porocarcinoma is exceptional, and lymphocyte dysfunction in this patient has probably contributed to extensive cutaneous metastasis.
- Published
- 2003
- Full Text
- View/download PDF
34. Unusual metastatic spread of a malignant eccrine poroma.
- Author
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Erel E, Tarr G, Butterworth MS, and Butler PE
- Subjects
- Aged, Aged, 80 and over, Humans, Lymphatic Metastasis, Male, Acrospiroma pathology, Skin Neoplasms secondary, Sweat Gland Neoplasms pathology
- Abstract
Malignant eccrine poroma is a rare skin tumor which commonly presents as verrucous plaques or polypoid growths. We report an 83 year old male who presented with an ulcerating eccrine poroma on the left arm. Though the tumor was excised with wide margins, axillary lymphadenopathy due to regional metastasis developed four months later, followed by lymphangitic cutaneous spread at six months. Though the prognosis for this tumor is better than previously thought, it still must certainly be considered potentially fatal.
- Published
- 2002
35. Eccrine porocarcinoma in a child that evolved rapidly from an eccrine poroma.
- Author
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Valverde K, Senger C, Ngan BY, and Chan HS
- Subjects
- Acrospiroma surgery, Biopsy, Needle, Child, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Immunohistochemistry, Skin Neoplasms surgery, Sweat Gland Neoplasms surgery, Treatment Outcome, Acrospiroma pathology, Cell Transformation, Neoplastic pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Published
- 2001
- Full Text
- View/download PDF
36. Syringoid eccrine carcinoma.
- Author
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Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, and Kruslin B
- Subjects
- Acrospiroma surgery, Biopsy, Needle, Diagnosis, Differential, Follow-Up Studies, Humans, Male, Middle Aged, Skin Neoplasms surgery, Sweat Gland Neoplasms surgery, Syringoma surgery, Acrospiroma pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology, Syringoma pathology
- Abstract
A rare case of a syringoid eccrine carcinoma in a 52-year-old male patient is described. During the first hospitalization, syringoma was diagnosed, both clinically and histologically, keeping in mind the possibility of its malignant alteration. Difficulties in making a diagnosis with histological and immunohistochemical examinations are reported. The possibility of differential diagnosis of primary breast carcinoma and methods of its exclusion are also described. Treatment of the patient was surgical with good results.
- Published
- 2001
- Full Text
- View/download PDF
37. Tender blue mass in an 8 year old.
- Author
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Yashar SS, Newbury RO, and Cunningham BB
- Subjects
- Child, Humans, Male, Acrospiroma pathology, Skin Neoplasms pathology
- Published
- 2000
- Full Text
- View/download PDF
38. [Lung neoplasms revealing a rare cutaneous tumor: eccrine porocarcinoma].
- Author
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Permal S, Chemal N, Dhote R, Palangie A, and Christoforov B
- Subjects
- Aged, Diagnosis, Differential, Female, Humans, Prognosis, Acrospiroma pathology, Carcinoma, Squamous Cell secondary, Eccrine Glands pathology, Lung Neoplasms secondary, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Abstract
Introduction: Eccrine sweat gland carcinoma, which belongs to the eccrine sweat gland carcinoma family, is a rare malignancy of the skin with a potential aggressive growth and metastatic spread., Exegesis: We report here a case of malignant eccrine poroma arising on the upper leg, with widespread pulmonary metastases., Conclusion: A brief synopsis of the pathological and clinical aspects of eccrine sweat gland carcinoma is presented with the currently available therapies.
- Published
- 2000
- Full Text
- View/download PDF
39. Eccrine porocarcinoma, tricholemmal carcinoma and multiple squamous cell carcinomas in a single patient.
- Author
-
Cribier B, Lipsker D, and Grosshans E
- Subjects
- Acrospiroma diagnosis, Acrospiroma therapy, Aged, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell therapy, Female, Follow-Up Studies, Humans, Neoplasms, Basal Cell diagnosis, Neoplasms, Basal Cell therapy, Neoplasms, Multiple Primary diagnosis, Neoplasms, Multiple Primary therapy, Skin Neoplasms diagnosis, Skin Neoplasms therapy, Acrospiroma pathology, Carcinoma, Squamous Cell pathology, Neoplasms, Basal Cell pathology, Neoplasms, Multiple Primary pathology, Skin Neoplasms pathology
- Abstract
A 75-year old woman without remarkable medical history presented with a large eccrine porocarcinoma of the trabelucar type located on her leg. This tumor was associated with two invasive squamous cell carcinomas of the legs, two Bowen's diseases of her thigh and arm and multiple actinic keratoses of the face. Despite major surgery, local recurrence of the porocarcinoma was observed 6 months later. During the 3-year follow-up after a second surgical intervention, this lesion did not reccur, but the patient developed a rapidly enlarging ulcerated tumor of the forehead which proved to be tricholemmal carcinoma. Although no carcinogenetic factor or familial history of multiple neoplasms could be evidenced, the occurrence of multiple tumors of various histogenesis over a 1 year period of time is unlikely to be fortuitous. Such an association of rare adnexal neoplasms has not yet been described.
- Published
- 1999
40. Poral neoplasm with combined sebaceous and apocrine differentiation.
- Author
-
Gianotti R, Coggi A, and Alessi E
- Subjects
- Aged, Cell Differentiation, Humans, Male, Acrospiroma pathology, Apocrine Glands pathology, Sebaceous Glands pathology, Skin Neoplasms pathology
- Published
- 1998
- Full Text
- View/download PDF
41. [Non-melanomatous malignant skin tumors of the hand].
- Author
-
Glicenstein J
- Subjects
- Acrospiroma pathology, Acrospiroma surgery, Carcinoma, Basal Cell pathology, Carcinoma, Basal Cell surgery, Carcinoma, Merkel Cell pathology, Carcinoma, Merkel Cell surgery, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell surgery, Diagnosis, Differential, Fingers, Hand Dermatoses diagnosis, Hand Dermatoses pathology, Histiocytoma, Benign Fibrous pathology, Histiocytoma, Benign Fibrous surgery, Humans, Precancerous Conditions diagnosis, Precancerous Conditions pathology, Sarcoma, Kaposi pathology, Sarcoma, Kaposi surgery, Skin pathology, Skin Neoplasms diagnosis, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms surgery, Hand, Precancerous Conditions surgery, Skin Neoplasms surgery
- Abstract
Non-melanomatous malignant skin tumors of the hand are the same as those observed on other parts of the body, but with specific characteristics of frequency, aetiology, site and sometimes misleading clinical features. The author analyses these characteristics in relation to precancerous tumors: solar keratoses, arsenical keratoses, radiation dermatitis, kerato-acanthomas, Bowen's disease and malignant tumors: basal cell, squamous cell and other rarer carcinomas. He then outlines the principles of surgical treatment with reference to anaesthesia, usually local or regional, and resection, whose extent and depth depend on the nature and site of the lesion.
- Published
- 1998
42. Eccrine poroma associated with Bowen's disease.
- Author
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Watanabe T, Murakami T, Okochi H, Kikuchi K, and Furue M
- Subjects
- Acrospiroma pathology, Aged, Aged, 80 and over, Bowen's Disease pathology, Diagnosis, Differential, Female, Humans, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology, Acrospiroma etiology, Bowen's Disease complications, Skin Neoplasms complications, Sweat Gland Neoplasms etiology
- Published
- 1998
- Full Text
- View/download PDF
43. Clear-cell porocarcinoma: another cutaneous marker of diabetes mellitus.
- Author
-
Requena L, Sarasa JL, Piqué E, Fariña MC, Olivares M, and Martín L
- Subjects
- Aged, Biomarkers, Tumor analysis, Cell Differentiation, Cell Nucleus ultrastructure, Cytoplasm ultrastructure, Cytoplasmic Granules ultrastructure, Diabetes Mellitus, Type 2 enzymology, Eccrine Glands pathology, Glycogen analysis, Humans, Immunohistochemistry, Male, Microvilli ultrastructure, Mucin-1 analysis, Phosphorylases analysis, Phosphorylases deficiency, Acrospiroma pathology, Diabetes Mellitus, Type 2 pathology, Skin Neoplasms pathology
- Abstract
The relationship between clear-cell syringoma and diabetes mellitus is well established. We present a case of clear-cell porocarcinoma in a diabetic patient. The lesion consisted of a 5-cm nodule on the lateral aspect of the left leg. Histopathologically, the neoplasm was composed of irregular aggregations of neoplastic cells with striking clear-cell appearance, showing features of ductal differentiation. The clear-cell appearance of neoplastic cells was due to glycogen accumulation within their cytoplasm. Immunohistochemistry and ultrastructural studies also supported the diagnosis of a neoplasm with sweat ductal differentiation. Enzyme histochemical reactions for phosphorylase immunoreactivity on fresh, unfixed sections of the neoplasm demonstrated that this immunoreactivity was remarkably decreased. Some adnexal neoplasms of the skin mostly composed of clear cells may be cutaneous markers of diabetes mellitus. Phosphorylase activity deficiency in diabetic patients may be responsible for glycogen accumulation in neoplastic cells resulting in clear-cell appearance of these neoplasms.
- Published
- 1997
- Full Text
- View/download PDF
44. Primary metaplastic carcinoma (carcinosarcoma) of the skin. A clinicopathologic study of four cases and review of the literature.
- Author
-
Patel NK, McKee PH, Smith NP, and Fletcher CD
- Subjects
- Acrospiroma pathology, Aged, Aged, 80 and over, Carcinoma, Squamous Cell pathology, Carcinosarcoma secondary, Cell Nucleolus ultrastructure, Cell Nucleus ultrastructure, Chondrosarcoma pathology, Cytoplasm ultrastructure, Diagnosis, Differential, Epithelium pathology, Facial Neoplasms pathology, Follow-Up Studies, Humans, Leiomyosarcoma pathology, Male, Mesoderm pathology, Metaplasia, Neoplasm Recurrence, Local, Neoplasms, Multiple Primary pathology, Osteosarcoma pathology, Rhabdomyosarcoma pathology, Scalp pathology, Survival Rate, Sweat Gland Neoplasms pathology, Carcinosarcoma pathology, Skin Neoplasms pathology
- Abstract
Metaplastic carcinoma (carcinosarcoma, sarcomatoid carcinoma, malignant mixed tumor) is a biphasic tumor comprising malignant epithelial and heterologous mesenchymal elements. Primary cutaneous cases are rare, with only seven cases documented in the English literature to date. We present four further cases, including three that developed in association with squamous cell carcinoma and one in an eccrine porocarcinoma. Heterologous malignant mesenchymal elements included malignant osteosarcoma, chondrosarcoma, leiomyosarcoma, and rhabdomyosarcomas. In contrast to metaplastic carcinomas arising in visceral sites, those primarily arising in the skin do not appear to behave in a very aggressive manner (Recurrence rate 22%, metastasis rate 22%, overall mortality 11%). However, the numbers involved are small and the follow-up period is short. In view of recent developments and progress in our understanding of the possible histogenesis of such tumors, we suggest that metaplastic carcinoma rather than carcinosarcoma is the most appropriate term with which to describe these very rare cutaneous neoplasms.
- Published
- 1997
- Full Text
- View/download PDF
45. Histogenesis of clear cell hidradenoma: immunohistochemical study of keratin expression.
- Author
-
Ohnishi T and Watanabe S
- Subjects
- Acrospiroma metabolism, Humans, Immunohistochemistry, Keratins chemistry, Retrospective Studies, Skin Neoplasms metabolism, Acrospiroma pathology, Keratins biosynthesis, Skin Neoplasms pathology
- Abstract
The expression of cytokeratins in 10 cases of clear cell hidradenoma, including 3 cases of solid cystic hidradenoma, were examined using 21 kinds of monoclonal antibodies. We divided them into three histologic patterns: massive nests with a few lumina (M nests), nests with some tubular lumina (L nests), and nests in solid cystic hidradenomas (S nests). All hidradenomas showed similar immunoreactivities to those in the lower dermal ducts or secretory cells of normal eccrine glands. With antibodies against simple epithelial cytokeratins (CKs 7, 8, 18, and 19), however, different immunostaining was noted among the three histologic patterns. Namely, the M nests failed to react to them, although some luminal cells in the L nests revealed a positive staining. Furthermore, a majority of luminal cells in the S nests revealed a positive staining with them. Therefore, we think that the luminal cells in solid cystic hidradenoma mainly differentiate toward the secretory cells, and that the M nests mainly differentiate toward the dermal duct. Those in the L nests are thought to differentiate toward the dermal duct and the secretory cells. The proportion of the differentiation toward luminal cells of dermal ducts to the differentiation toward secretory cells was the main difference among the three nests. In addition, there was no difference in immunophenotypes between clear cells and epidermoid cells in the two kinds of hidradenomas.
- Published
- 1997
- Full Text
- View/download PDF
46. Pigmented sweat gland tumor mimicking melanoma.
- Author
-
Roaf V, Chin N, and Lynfield Y
- Subjects
- Diagnosis, Differential, Humans, Male, Middle Aged, Acrospiroma pathology, Melanoma pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Abstract
Eccrine poroma, a common adnexal neoplasm, usually presents as a solitary, smooth, flesh-colored nodule on the foot or hand. Eccrine porocarcinoma is extremely rare and much more variable in its morphology and location. Both tumors can contain melanocytes and melanin. We describe a patient with an enlarging, eroded brownish black nodule on his shoulder. Examination of a biopsy specimen showed it to be derived from acrosyringium and to contain abundant melanin and scattered dendritic melanocytes. Eccrine poroma and porocarcinoma should be considered in the clinical differential diagnosis of pigmented tumors.
- Published
- 1997
47. Porocarcinoma of the heel. A case report with unusual histologic features.
- Author
-
D'Amato MS, Patterson RH, Guccion JG, White JC, and Krasnow SH
- Subjects
- Acrospiroma surgery, Biopsy, Carcinoma, Squamous Cell surgery, Cell Division physiology, Heel surgery, Humans, Male, Middle Aged, Skin Neoplasms surgery, Sweat Gland Neoplasms surgery, Acrospiroma pathology, Carcinoma, Squamous Cell pathology, Heel pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Abstract
Background: Eccrine porocarcinoma is an uncommon neoplasm of the intraepidermal sweat gland duct., Methods: A case of porocarcinoma of the right heel in a male age 51 years is described with a review of pertinent literature. The surgically excised neoplasm was evaluated by routine histology and transmission electron microscopy., Results: The porocarcinoma showed extensive nuclear pleomorphisms with frequent, multinucleated tumor giant cells, focal epidermotrophic spread within the epidermis, a peripheral, eccrine syringofibroadenoma-like growth pattern, and an origin in a contiguous eccrine poroma. Ultrastructurally, the squamous tumor cells contained rare intracytoplasmic lumens., Conclusions: The extensive nuclear pleomorphism with frequent tumor giant cells was an unusual feature of the porocarcinoma. Its epidermotrophic spread within the epidermis and its origin in a contiguous eccrine poroma supported the diagnosis of porocarcinoma. The eccrine syringofibroadenoma-like growth pattern in the periphery of the tumor was a unique and previously undescribed feature of the porocarcinoma. The presence of intracytoplasmic lumens in squamous tumor cells mimicked embryonic development of the intraepidermal sweat gland duct.
- Published
- 1996
- Full Text
- View/download PDF
48. Multiple malignant eccrine poroma and a linear epidermal nevus.
- Author
-
Hamanaka S and Otsuka F
- Subjects
- Aged, Arm, Female, Humans, Acrospiroma pathology, Neoplasms, Multiple Primary pathology, Nevus pathology, Skin Neoplasms pathology, Sweat Gland Neoplasms pathology
- Abstract
A 68-year-old woman developed three reddish nodules on a linear epidermal nevus on the right arm. The nodules and linear lesion were resected. The histology revealed the two larger nodules to be eccrine porocarcinoma and the other to be eccrine poroepithelioma. The linear lesion was actually epidermal nevus. To our knowledge, this is the first description of adnexal tumors developing on epidermal nevus.
- Published
- 1996
- Full Text
- View/download PDF
49. Eccrine or apocrine poroma? Six poromas with divergent adnexal differentiation.
- Author
-
Harvell JD, Kerschmann RL, and LeBoit PE
- Subjects
- Adult, Aged, Cell Differentiation, Female, Humans, Male, Middle Aged, Acrospiroma pathology, Sebaceous Glands pathology, Skin Neoplasms pathology, Sweat Glands pathology
- Abstract
We describe six cases of benign eccrine poroma-like neoplasms with divergent adnexal differentiation. Four cases exhibited sebaceous differentiation in the form of individual or clustered sebocytes with or without sebaceous ducts. One case showed both sebaceous and hair follicle differentiation, and one case showed sebaceous and possible apocrine secretory differentiation. Clinically, most were skin-colored, red, or purple papules or nodules. One patient had a preoperative diagnosis of Bowen's disease, with an erythematous plaque. None recurred following biopsy. Previous reports of similar lesions have suggested a possible role for human papilloma virus (HPV) in their pathogenesis; however, immunohistochemical staining for HPV structural antigens was negative in all six of these cases. Similarities to previously reported cases of eccrine poroma-like neoplasms with sebaceous differentiation are discussed. Given the evidence of sebaceous and follicular differentiation seen in this study and the common embryologic origin of follicular, sebaceous, and apocrine structures, it follows that at least some benign neoplastic proliferations with histopathologic features of "eccrine" poroma could be of apocrine origin.
- Published
- 1996
- Full Text
- View/download PDF
50. Pigmented eccrine poroma: a simulant of nodular melanoma.
- Author
-
Mousawi A and Kibbi AG
- Subjects
- Acrospiroma pathology, Aged, Diagnosis, Differential, Hand, Humans, Male, Sweat Gland Neoplasms pathology, Acrospiroma diagnosis, Melanoma diagnosis, Skin Neoplasms diagnosis, Sweat Gland Neoplasms diagnosis
- Published
- 1995
- Full Text
- View/download PDF
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