1. Definitive weekly hypofractionated radiotherapy in cutaneous squamous cell carcinoma: response rates and outcomes in elderly patients unfit for surgery.
- Author
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De Felice F, Musio D, De Falco D, Grapulin L, Magnante AL, Caiazzo R, Bulzonetti N, and Tombolini V
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Male, Pain, Radiation Dose Hypofractionation, Treatment Outcome, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell radiotherapy, Head and Neck Neoplasms radiotherapy, Skin Neoplasms radiotherapy, Skin Neoplasms surgery
- Abstract
Introduction: The optimal definitive radiotherapy (RT) scheme in cutaneous squamous cell carcinoma (cSCC) remains controversial, especially in elderly patients., Methods: Data of elderly patients with cSCC lesion(s) treated with weekly hypofractionated RT (8 Gy per week per 7-8 weeks) were analyzed., Results: Eighteen patients (median age 89 years) with 23 cSCC lesions have been identified including nine males (50%) and nine females (50%). The most common tumor localization was the head and neck region (n = 21; 91.3%), and the majority of lesions (n = 15; 65.2%) was stage ≥ III. At diagnosis, pain and bleeding were ascribed in 13 (56.5%) and eight (34.8%) cSCC, respectively. Compliance with weekly hypofractionated RT was excellent. The overall response rate at 12 weeks after treatment was 95.7%. Bleeding and pain relief were achieved in all cases. Severe toxicity was not recorded. The 1-year overall survival was 66.0%. The 1-year progression-free survival was 58.7%., Conclusions: Weekly hypofractionated RT provides a safe, efficient, and cost-effective treatment in elderly cSCC patients with minimal side effects., (© 2021 The Authors. International Journal of Dermatology published by Wiley Periodicals LLC on behalf of the International Society of Dermatology.)
- Published
- 2022
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