12 results on '"Knutson, Kristen L."'
Search Results
2. Associations between sleep disturbances, diabetes and mortality in the UK Biobank cohort: A prospective population‐based study.
- Author
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von Schantz, Malcolm, Ong, Jason C., and Knutson, Kristen L.
- Subjects
DIABETES ,LIFE expectancy ,MORTALITY ,SLEEP ,PHYSICIANS ,LONGITUDINAL method - Abstract
Non‐communicable diseases, including diabetes, are partly responsible for the deceleration of improvements of life expectancy in many countries. Diabetes is also associated with sleep disturbances. Our aim was to determine whether sleep disturbances, particularly in people with diabetes, were associated with increased mortality risk. Data from the UK Biobank were analysed (n = 487,728, mean follow‐up time = 8.9 years). The primary exposure was sleep disturbances, assessed through the question: Do you have trouble falling asleep at night or do you wake up in the middle of the night? The primary outcome was mortality. We also dichotomized sleep disturbances into "never/sometimes" versus "usually" (frequently), and combined with the presence/absence of diabetes: 24.2% of participants reported "never/rarely" experiencing sleep disturbances, 47.8% "sometimes" and 28.0% "usually". In age‐ and sex‐adjusted models, frequent sleep disturbances were associated with an increased risk of all‐cause mortality (hazard ratio [HR], 1.31; 95% confidence interval [CI], 1.26–1.37), which remained significant in the fully adjusted model (HR 1.13, 95% CI 1.09–1.18). The presence of both diabetes and frequent sleep disturbances was associated with greater risk of all‐cause mortality than either condition alone. In the fully adjusted model, the hazard ratio for all‐cause mortality was 1.11 (95% CI, 1.07–1.15) for frequent sleep disturbances alone, 1.67 (95% CI, 1.57–1.76) for diabetes alone and 1.87 for both (95% CI, 1.75–2.01). Frequent sleep disturbances (experienced by more than one quarter of the sample) were associated with increased risk of all‐cause mortality. Mortality risk was highest in those with both diabetes and frequent sleep disturbances. Complaints of difficulty falling or staying asleep merit attention by physicians. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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3. Associations between Diet and Sleep Duration in Different Menopausal Stages.
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Zhu, Bingqian, Grandner, Michael A., Jackson, Nicholas J., Pien, Grace W., Srimoragot, Manassawee, Knutson, Kristen L., and Izci-Balserak, Bilgay
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SALT-free diet ,PHOSPHORUS ,SODIUM ,DIET ,CARBOHYDRATE content of food ,POTASSIUM ,SLEEP disorders ,CHOLINE ,DIETARY sucrose ,DESCRIPTIVE statistics ,MENOPAUSE ,VITAMIN B1 ,FOLIC acid ,WOMEN'S health ,DIETARY proteins ,SELENIUM ,DISEASE risk factors - Abstract
This study aimed to determine which dietary factors were associated with habitual sleep duration in pre/peri- and post-menopausal women. Data from the 2007–2008 National Health and Nutrition Examination Survey were used (N = 1,783). Habitual sleep duration was categorized as very short (<5 h), short (5–6 h), normal (7–8 h), and long (≥9 h). Diet assessment was performed following validated procedures. In pre/peri-menopausal women (n = 1,116), controlling for the confounders, fewer number of foods, less intake of protein, carbohydrates, thiamin (B1), food folate, total choline, phosphorus, sodium, potassium, and selenium were significantly associated with a higher risk for very short sleep. Being on a low-salt diet was related to a lower risk for long sleep. In comparison, in post-menopausal women (n = 667), controlling for the confounders, more sugar intake, less intake of phosphorus and zinc were related to a higher risk for short sleep. There were novel associations between diet and sleep duration, particularly among pre/peri-menopausal women. Future research is needed to confirm those causal relationships. [ABSTRACT FROM AUTHOR]
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- 2021
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4. Association Between Inpatient Sleep Loss and Hyperglycemia of Hospitalization.
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DePietro, Regina H., Knutson, Kristen L., Spampinato, Lisa, Anderson, Samantha L., Meltzer, David O., Van Cauter, Eve, and Arora, Vineet M.
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HYPERGLYCEMIA , *HOSPITAL care , *BLOOD sugar , *SLEEP disorders , *COHORT analysis , *ACTIGRAPHY , *INSOMNIA , *LONGITUDINAL method , *PREDIABETIC state , *RESEARCH funding , *LOGISTIC regression analysis , *RETROSPECTIVE studies , *DISEASE complications - Abstract
Objective: To determine whether inpatient sleep duration and efficiency are associated with a greater risk of hyperglycemia in hospitalized patients with and without diabetes.Research Design and Methods: In this retrospective analysis of a prospective cohort study, medical inpatients ≥50 years of age were interviewed, and their charts were reviewed to obtain demographic data and diagnosis. Using World Health Organization criteria, patients were categorized as having normal blood glucose, impaired fasting blood glucose, or hyperglycemia based on morning glucose from the electronic health record. Wrist actigraphy measured sleep. Multivariable ordinal logistic regression models, controlling for subject random effects, tested the association between inpatient sleep duration and proportional odds of hyperglycemia versus impaired fasting blood glucose or impaired fasting blood glucose versus normal blood glucose in hospitalized adults.Results: A total of 212 patients (60% female and 74% African American) were enrolled. Roughly one-third (73, 34%) had diabetes. Objective inpatient sleep measures did not differ between patients with or without diabetes. In ordinal logistic regression models, each additional hour of in-hospital sleep was associated with an 11% (odds ratio 0.89 [95% CI 0.80, 0.99]; P = 0.043) lower proportional odds of a higher glucose category the next morning (hyperglycemia vs. elevated and elevated vs. normal). Every 10% increase in sleep efficiency was associated with an 18% lower proportional odds of a higher glucose category (odds ratio 0.82 [95% CI 0.74, 0.89]; P < 0.001).Conclusions: Among medical inpatients, both shorter sleep duration and worse sleep efficiency were independently associated with greater proportional odds of hyperglycemia and impaired fasting glucose. [ABSTRACT FROM AUTHOR]- Published
- 2017
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5. Chronotype Is Independently Associated With Glycemic Control in Type 2 Diabetes.
- Author
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REUTRAKUL, SIRIMON, HOOD, MEGAN M., CROWLEY, STEPHANIE J., MORGAN, MARY K., TEODORI, MARSHA, KNUTSON, KRISTEN L., and VAN CAUTER, EVE
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TYPE 2 diabetes treatment ,SLEEP disorders ,CALORIE ,MULTIPLE regression analysis ,CIRCADIAN rhythms ,METABOLIC regulation - Abstract
OBJECTIVE--To examine whether chronotype and daily caloric distribution are associated with glycemic control in patients with type 2 diabetes independently of sleep disturbances. RESEARCH DESIGN AND METHODS--Patients with type 2 diabetes had a structured interview and completed questionnaires to collect information on diabetes history and habitual sleep duration, quality, and timing. Shift workers were excluded. A recently validated construct derived from mid-sleep time on weekends was used as an indicator of chronotype. One-day food recall was used to compute the temporal distribution of caloric intake. Hierarchical linear regression analyses controlling for demographic and sleep variables were computed to determine whether chronotype was associated with HbA
1c values and whether this association was mediated by a higher proportion of caloric intake at dinner. RESULTS--We analyzed 194 completed questionnaires. Multiple regression analyses adjusting for age, sex, race, BMI, insulin use, depressed mood, diabetes complications, and perceived sleep debt found that chronotype was significantly associated with glycemic control (P = 0.001). This association was partially mediated by a greater percentage of total daily calories consumed at dinner. CONCLUSIONS--Later chronotype and larger dinner were associated with poorer glycemic control in patients with type 2 diabetes independently of sleep disturbances. These results suggest that chronotype may be predictive of disease outcomes and lend further support to the role of the circadian system in metabolic regulation. [ABSTRACT FROM AUTHOR]- Published
- 2013
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6. Sociodemographic and cultural determinants of sleep deficiency: Implications for cardiometabolic disease risk
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Knutson, Kristen L.
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AGE distribution , *CARDIOVASCULAR diseases risk factors , *CULTURE , *RACE , *SEX distribution , *SLEEP disorders , *CULTURAL values , *SOCIOECONOMIC factors , *DISEASE complications - Abstract
Abstract: Sleep is a biological imperative associated with cardiometabolic disease risk. As such, a thorough discussion of the sociocultural and demographic determinants of sleep is warranted, if not overdue. This paper begins with a brief review of the laboratory and epidemiologic evidence linking sleep deficiency, which includes insufficient sleep and poor sleep quality, with increased risk of chronic cardiometabolic diseases such as obesity, diabetes and hypertension. Identification of the determinants of sleep deficiency is the critical next step to understanding the role sleep plays in human variation in health and disease. Therefore, the majority of this paper describes the different biopsychosocial determinants of sleep, including age, gender, psychosocial factors (depression, stress and loneliness), socioeconomic position and race/ethnicity. In addition, because sleep duration is partly determined by behavior, it will be shaped by cultural values, beliefs and practices. Therefore, possible cultural differences that may impact sleep are discussed. If certain cultural, ethnic or social groups are more likely to experience sleep deficiency, then these differences in sleep could increase their risk of cardiometabolic diseases. Furthermore, if the mechanisms underlying the increased risk of sleep deficiency in certain populations can be identified, interventions could be developed to target these mechanisms, reduce sleep differences and potentially reduce cardiometabolic disease risk. [Copyright &y& Elsevier]
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- 2013
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7. The Impact of Sleep Consultation Prior to a Diagnostic Polysomnogram on Continuous Positive Airway Pressure Adherence.
- Author
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Pamidi, Sushmita, Knutson, Kristen L., Ghods, Farbod, and Mokhlesi, Babak
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CONTINUOUS positive airway pressure , *SLEEP apnea syndromes , *SLEEP disorders , *PRESSURE breathing , *AFRICAN Americans - Abstract
The article discusses a study which examined the impact of having a sleep specialist consultation prior to the diagnostic polysomnograms (PSG) on initial adherence to continuous positive airway pressure (CPAP) therapy. Several variables for predicting CPAP adherence include severity of sleep apnea based on the apnea-hypopnea index (AHI) and the Epworth Sleepiness Scale (ESS). Worse adherence to CPAP therapy was observed from African Americans.
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- 2012
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8. The metabolic consequences of sleep deprivation.
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Knutson, Kristen L., Spiegel, Karine, Penev, Plamen, and Van Cauter, Eve
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OBESITY ,METABOLIC disorders ,BIOCHEMISTRY ,SLEEP disorders ,DIABETES - Abstract
Summary: The prevalence of diabetes and obesity is increasing at an alarming rate worldwide, and the causes of this pandemic are not fully understood. Chronic sleep curtailment is a behavior that has developed over the past 2–3 decades. Laboratory and epidemiological studies suggest that sleep loss may play a role in the increased prevalence of diabetes and/or obesity. Current data suggest the relationship between sleep restriction, weight gain and diabetes risk may involve at least three pathways: (1) alterations in glucose metabolism; (2) upregulation of appetite; and (3) decreased energy expenditure. The present article reviews the current evidence in support of these three mechanisms that might link short sleep and increased obesity and diabetes risk. [Copyright &y& Elsevier]
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- 2007
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9. Objectively Measured Sleep Characteristics among Early-Middle-Aged Adults.
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Lauderdale, Diane S., Knutson, Kristen L., Yan, Lijing L., Rathouz, Paul J., Hulley, Stephen B., Sidney, Steve, and Kiang Liu
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SLEEP disorders ,DISEASE risk factors ,SLEEP ,SEX differences (Biology) ,LIFESTYLES ,APNEA ,INCOME - Abstract
Despite mounting evidence that sleep duration is a risk factor across diverse health and functional domains, little is known about the distribution and determinants of sleep. In 2003–2004, the authors used wrist activity monitoring and sleep logs to measure time in bed, sleep latency (time required to fall asleep), sleep duration, and sleep efficiency (percentage of time in bed spent sleeping) over 3 days for 669 participants at one of the four sites of the Coronary Artery Risk Development in Young Adults (CARDIA) study (Chicago, Illinois). Participants were aged 38–50 years, 58% were women, and 44% were Black. For the entire sample, mean time in bed was 7.5 (standard deviation (SD), 1.2) hours, mean sleep latency was 21.9 (SD, 29.0) minutes, mean sleep duration was 6.1 (SD, 1.2) hours, and mean sleep efficiency was 80.9 (SD, 11.3)%. All four parameters varied by race-sex group. Average sleep duration was 6.7 hours for White women, 6.1 hours for White men, 5.9 hours for Black women, and 5.1 hours for Black men. Race-sex differences (p < 0.001) remained after adjustment for socioeconomic, employment, household, and lifestyle factors and for apnea risk. Income was independently associated with sleep latency and efficiency. Sleep duration and quality, which have consequences for health, are strongly associated with race, sex, and socioeconomic status. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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10. Objective sleep, a novel risk factor for alterations in kidney function: the CARDIA study.
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Petrov, Megan E., Kim, Yongin, Lauderdale, Diane S., Lewis, Cora E., Reis, Jared P., Carnethon, Mercedes R., Knutson, Kristen L., and Glasser, Stephen P.
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SLEEP disorders , *KIDNEY physiology , *GLOMERULAR filtration rate , *CORONARY heart disease risk factors , *CARDIOVASCULAR diseases , *MEDICAL screening - Abstract
Objective To determine the association between objectively measured sleep and 10-year changes in estimated glomerular filtration rate (eGFR). Methods From 2003 to 2005, an ancillary sleep study was conducted at the Chicago site of the Coronary Artery Risk Development in Young Adults (CARDIA) study. Community-based black and white adults (aged 32–51 years) wore a wrist actigraph for up to six nights to record sleep duration and fragmentation. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI). Participants without history of cardiovascular or chronic kidney diseases, proteinuria, or hypertension at the 2000–2001 CARDIA examination were followed over 10 years ( n = 463). eGFR was estimated from serum creatinine (eGFR Cr ) at the 2000–2001, 2005–2006, and 2010–2011 CARDIA examinations, whereas cystatin-C-estimated eGFR (eGFR Cys ) was measured at the 2000–2001 and 2005–2006 examinations. Generalized estimating equation regression and linear models estimated the associations of each sleep parameter with changes in eGFR Cr and eGFR Cys , controlling for cardiovascular and renal risk. Results Sleep parameters were not related to 5-year change in eGFR Cys . However, each 1 h decrease in sleep duration was significantly associated with a 1.5 mL/min/1.73 m 2 higher eGFR Cr [95% confidence interval (CI), 0.2–2.7], and each one-point increase in PSQI was significantly associated with a 0.5 mL/min/1.73 m 2 higher eGFR Cr (95% CI, 0.04–0.9) over 10 years. Conclusion In this community-based sample, shorter sleep and poorer sleep quality were related to higher kidney filtration rates over 10 years. [ABSTRACT FROM AUTHOR]
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- 2014
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11. The association between sleep characteristics and prothrombotic markers in a population-based sample: Chicago Area Sleep Study.
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Tosur, Zehra, Green, David, De Chavez, Peter John, Knutson, Kristen L., Goldberger, Jeffrey J., Zee, Phyllis, Liu, Kiang, Kim, Kwang-Youn, and Carnethon, Mercedes R.
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SLEEP disorders , *THROMBOSIS , *BIOMARKERS , *CORONARY disease , *MORTALITY , *PATHOLOGICAL physiology , *SLEEP apnea syndromes , *MEDICAL screening - Abstract
Background and aim Short sleep duration and poor quality sleep are associated with coronary heart disease (CHD) mortality; however, the underlying pathophysiologic process remains unclear. Sleep apnea may confound the association because of its relationship with formation of thrombi, the vascular occlusive process in CHD. We tested whether sleep duration and quality were associated with prothrombotic biomarkers in adults with a low probability of apnea. Methods We included adults aged 35-64years recruited from the community and who had an apnea hypopnea index <15 after one night of screening (n=506). Sleep duration and maintenance were determined from 7days of wrist actigraphy; daytime sleepiness was estimated using the Epworth Sleepiness Scale. Factor VIII (FVIII), von Willebrand factor (vWF), thrombin antithrombin (TAT) complexes, and plasminogen activator inhibitor-1 (PAI-1) were measured in fasting blood. Results Sleep duration, maintenance, and daytime sleepiness were not associated with FVIII, vWf, or TAT. Sleep maintenance was modestly inversely associated with higher levels of log-transformed PAI-1 (β=-0.07, standard error (SE)=0.03 per 4.8%, p=0.04) following adjustment for demographic characteristics, cardiovascular risk factors, and body mass index (BMI). Conclusions Mild impairment in sleep was modestly associated with activation of coagulation; further study is needed to evaluate the role of fibrinolytic factors in sleep-mediated coronary thrombosis. [ABSTRACT FROM AUTHOR]
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- 2014
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12. Dietary nutrients associated with short and long sleep duration. Data from a nationally representative sample
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Grandner, Michael A., Jackson, Nicholas, Gerstner, Jason R., and Knutson, Kristen L.
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SLEEP disorders , *SLEEP-wake cycle , *NUTRITION , *HEALTH risk assessment , *WEIGHT gain , *OBESITY - Abstract
Abstract: Short sleep duration is associated with weight gain and obesity, diabetes, cardiovascular disease, psychiatric illness, and performance deficits. Likewise, long sleep duration is also associated with poor physical and mental health. The role of a healthy diet in habitual sleep duration represents a largely unexplored pathway linking sleep and health. This study evaluated associations between habitual sleep parameters and dietary/nutritional variables obtained via the National Health and Nutrition Examination Survey (NHANES), 2007–2008. We hypothesized that habitual very short (<5h) short (5–6h) and long (9+h) sleep durations are associated with intake of a number of dietary nutrient variables. Overall, energy intake varied across very short (2036kcal), short (2201kcal), and long (1926kcal) sleep duration, relative to normal (2151kcal) sleep duration (p =0.001). Normal sleep duration was associated with the greatest food variety (17.8), compared to very short (14.0), short (16.5) and long (16.3) sleep duration (p <0.001). Associations between sleep duration were found across nutrient categories, with significant associations between habitual sleep duration and proteins, carbohydrates, vitamins and minerals. In stepwise analyses, significant contributors of unique variance included theobromine (long sleep RR=0.910, p <0.05), vitamin C (short sleep RR=0.890, p <0.05), tap water (short sleep RR=0.952, p <0.001; very short (<5h) sleep RR=0.941, p <0.05), lutein+zeaxanthin (short sleep RR=1.123, p <0.05), dodecanoic acid (long sleep RR=0.812, p <0.05), choline (long sleep RR=0.450, p =0.001), lycopene (very short (<5h) sleep RR=0.950, p <0.05), total carbohydrate (very short (<5h) sleep RR=0.494, p <0.05; long sleep RR=0.509, p <0.05), selenium (short sleep RR=0.670, p <0.01) and alcohol (long sleep RR=1.172, p <0.01). Overall, many nutrient variables were associated with short and/or long sleep duration, which may be explained by differences in food variety. Future studies should assess whether these associations are due to appetite dysregulation, due to short/long sleep and/or whether these nutrients have physiologic effects on sleep regulation. In addition, these data may help us better understand the complex relationship between diet and sleep and the potential role of diet in the relationship between sleep and obesity and other cardiometabolic risks. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
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