10 results on '"Martynowicz, Helena"'
Search Results
2. Sleep Bruxism and Sleep Structure in Comorbid Insomnia and Obstructive Sleep Apnea (COMISA) Syndrome: A Polysomnographic Study.
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Blaszczyk, Bartlomiej, Meira e Cruz, Miguel, Waliszewska-Prosol, Marta, Wieckiewicz, Mieszko, Nowacki, Dorian, Kanclerska, Justyna, Lachowicz, Gabriella, Wojakowska, Anna, Michalek-Zrabkowska, Monika, Przegralek, Jakub, Smardz, Joanna, Antosz, Katarzyna, Mazur, Grzegorz, and Martynowicz, Helena
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SLEEP apnea syndromes ,SLEEP bruxism ,BRUXISM ,INSOMNIA ,SLEEP disorders ,COMORBIDITY - Abstract
Introduction: Comorbid insomnia and obstructive sleep apnea (COMISA) is not a well-identified sleep disorder, despite having a significant impact on health. This study investigates the relationship between sleep bruxism (SB) and sleep architecture in patients with COMISA, obstructive sleep apnea (OSA), and in those without any sleep disorders. Methods: 119 patients were included in the study and divided into three groups: OSA, COMISA, and a control group. Polysomnographic (PSG) examination provided parameters related to sleep architecture, OSA, and characteristics of SB. Results: The bruxism episode index (BEI) and other SB parameters were not found to be statistically different between the three groups (p > 0.05). There was no statistical difference in measured sleep architecture between the COMISA and OSA groups (p > 0.05). In comparison to the control group, participants in the COMISA group were found to have an increased apnea–hypopnea index (AHI), oxygen desaturation index (ODI), respiratory disturbance index (RDI), all arousals (AA), and respiratory arousals (RA) (p < 0.05). Among COMISA patients, AA and RA were shown to have a positive linear correlation with the number of bradycardia events per hour (r = 0.49, r = 0.48, p < 0.05). Conclusions: SB does not occur in patients with COMISA more frequently than in patients with OSA or those without any sleep disorders. PSG parameters are not specific for COMISA; therefore, in order to differentiate this disorder from OSA alone, a comprehensive patient assessment has to be performed. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Fabry disease and sleep disorders: a systematic review.
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Blaszczyk, Bartlomiej, Wieckiewicz, Mieszko, Kusztal, Mariusz, Michalek-Zrabkowska, Monika, Lachowicz, Gabriella, Mazur, Grzegorz, and Martynowicz, Helena
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ANGIOKERATOMA corporis diffusum ,SLEEP disorders ,SLEEP apnea syndromes ,SLEEP interruptions ,ENZYME replacement therapy - Abstract
Background: Fabry disease (FD) is an X-chromosome-linked disorder characterized by a reduced or complete absence of the enzyme a-galactosidase, resulting in the accumulation of lysosomal globotriaosylceramide. Despite the presence of these deposits in multiple organs, the problem of sleep disorders within this population has very rarely been documented. Objective: This study aimed to investigate the types and prevalence of sleep disorders among patients with FD. Methods: Screening of the following medical databases using key terms was performed on 10 February 2023: PubMed, Scopus, and Embase. A total of 136 records were identified. The quality assessment of the studies was conducted by using tools from the National Institutes of Health (NIH) and critical appraisal tools from the Joanna Briggs Institute (JBI). Results: The study included nine studies on sleep disorders in patients with FD. The overall quality of the majority of these studies was assessed as either poor or fair. Among 330 patients, there was a slightly higher representation of female patients (56%). Sleep problems manifested 4-5 years after the onset of FD and sometimes even after 10-11 years. Genotypes of disease associated with sleep problems were rarely described. Within the FD population, the most commonly reported conditions were excessive daytime sleepiness (EDS) as well as obstructive and central sleep apnea (OSA, CSA). However, EDS occurred more frequently in FD patients, while the prevalence of OSA and CSA was within the ranges observed in the general population. The studies included indicated a lack of association between organ impairment by primary disease and EDS and OSA. The effectiveness of enzyme replacement therapy (ERT) in treating sleep disorders was not demonstrated. Conclusion: The findings of this report revealed the presence of many sleep-related disorders within the FD population. However, very few studies on this subject are available, and their limited results make it difficult to truly assess the real extent of the prevalence of sleep disturbances among these individuals. There is a need to conduct further studies on this topic, involving a larger group of patients. It is important to note that there are no guidelines available for the treatment of sleep disorders in patients with FD. [ABSTRACT FROM AUTHOR]
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- 2023
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4. An exploratory study on the association between serotonin and sleep breathing disorders.
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Wieckiewicz, Mieszko, Martynowicz, Helena, Lavigne, Gilles, Lobbezoo, Frank, Kato, Takafumi, Winocur, Efraim, Wezgowiec, Joanna, Danel, Dariusz, Wojakowska, Anna, Mazur, Grzegorz, and Smardz, Joanna
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SEROTONIN , *SLEEP disorders , *TRYPTOPHAN hydroxylase , *SLEEP apnea syndromes , *BLOOD sampling , *RESPIRATION - Abstract
This exploratory observational study aimed to evaluate whether the blood levels of serotonin and enzymes involved in serotonin synthesis are associated with sleep breathing parameters. A total of 105 patients were included in this study, who were subjected to single-night polysomnography with simultaneous audio–video recordings. Peripheral blood samples were collected to estimate the serum levels of serotonin, tryptophan hydroxylase 1 (TPH1), and aromatic l-amino acid decarboxylase (AADC). Results showed a negative correlation between blood serotonin levels, and oxygen desaturation index (ODI) (p = 0.027), central apnea (p = 0.044) and obstructive apnea (OA) (p = 0.032) scores. Blood TPH1 levels were negatively correlated with average (p = 0.003) and minimal saturation (p = 0.035) and positively correlated with apnea–hypopnea index (p = 0.010), OA (p = 0.049), and hypopnea index (p = 0.007) scores. A tendency to sleep-disordered breathing seemed to co-occur with lower blood serotonin and higher TPH1 levels. Clinical Trial Registration :www.ClinicalTrials.gov, identifier NCT04214561 [ABSTRACT FROM AUTHOR]
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- 2023
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5. The Modulation of Adipokines, Adipomyokines, and Sleep Disorders on Carcinogenesis.
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Brzecka, Anna, Martynowicz, Helena, Daroszewski, Cyryl, Majchrzak, Maciej, Ejma, Maria, Misiuk-Hojło, Marta, Somasundaram, Siva G., Kirkland, Cecil E., and Kosacka, Monika
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SLEEP disorders , *ADIPOKINES , *SLEEP duration , *SLEEP interruptions , *SLEEP quality - Abstract
Obesity and sarcopenia, i.e., decreased skeletal muscle mass and function, are global health challenges. Moreover, people with obesity and sedentary lifestyles often have sleep disorders. Despite the potential associations, metabolic disturbances linking obesity, sarcopenia, and sleep disorders with cancer are neither well-defined nor understood fully. Abnormal levels of adipokines and adipomyokines originating from both adipose tissue and skeletal muscles are observed in some patients with obesity, sarcopenia and sleep disorders, as well as in cancer patients. This warrants investigation with respect to carcinogenesis. Adipokines and adipomyokines may exert either pro-carcinogenic or anti-carcinogenic effects. These factors, acting independently or together, may significantly modulate the incidence and progression of cancer. This review indicates that one of the possible pathways influencing the development of cancer may be the mutual relationship between obesity and/or sarcopenia, sleep quantity and quality, and adipokines/adipomyokines excretion. Taking into account the high proportion of persons with obesity and sedentary lifestyles, as well as the associations of these conditions with sleep disturbances, more attention should be paid to the individual and combined effects on cancer pathophysiology. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Polysomnographic Evaluation of Sleep Bruxism Intensity and Sleep Architecture in Nonapneic Hypertensives: A Prospective, Observational Study.
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Kanclerska, Justyna, Wieckiewicz, Mieszko, Poreba, Rafal, Szymanska-Chabowska, Anna, Gac, Pawel, Wojakowska, Anna, Frosztega, Weronika, Michalek-Zrabkowska, Monika, Mazur, Grzegorz, and Martynowicz, Helena
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SLEEP bruxism ,BRUXISM ,SLEEP apnea syndromes ,TEMPOROMANDIBULAR disorders ,OXYGEN saturation ,SCIENTIFIC observation ,SLEEP disorders - Abstract
Sleep bruxism (SB) is a repetitive jaw muscle activity characterized by clenching or grinding of the teeth, which is classified under sleep-related movement disorders in the International Classification of Sleep Disorders—Third Edition. Because the potential common pathomechanism of SB and arterial hypertension is the activation of the sympathetic system as well as an increase in inflammatory factors, we aimed to examine the intensity of SB and the sleep architecture among patients with arterial hypertension. The study included a total of 91 Caucasian adult patients, among whom 31 had arterial hypertension diagnosed according to the current European Society of Cardiology/European Society of Hypertension (ESC/EHS) hypertension guidelines. The control group consisted of 61 normotensive patients. Patients with obstructive sleep apnea were excluded. A single full-night polysomnographic examination was conducted in the Sleep Laboratory, and then the results were analyzed based on the guidelines of the American Academy of Sleep Medicine. Bruxism episode index (BEI) was higher in the hypertensive group compared to normotensives. The groups also showed statistically significant differences in polysomnographic sleep indexes. Similar to BEI, arousal index, apnea–hypopnea index, and snoring were higher in hypertensives compared to normotensives. On the other hand, the mean and minimal oxygen saturation were lower in hypertensives compared to normotensives. A statistically significant positive correlation was observed between oxygen desaturation index and BEI in the hypertensive group, whereas this correlation was not statistically significant in the case of normotensives. In summary, nonapneic hypertensives had higher SB intensity, altered sleep architecture, decreased mean oxygen saturation, and increased snoring compared to normotensives. The results suggest that dental screening is necessary for patients with arterial hypertension, especially those presenting with the symptoms of SB. [ABSTRACT FROM AUTHOR]
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- 2022
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7. A polysomnographic study on the relationship between sleep bruxism intensity and sleep quality.
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Smardz, Joanna, Martynowicz, Helena, Wojakowska, Anna, Winocur-Arias, Orit, Michalek-Zrabkowska, Monika, Mazur, Grzegorz, and Wieckiewicz, Mieszko
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SLEEP quality ,SLEEP bruxism ,SLEEP disorders ,BRUXISM ,MASTICATORY muscles - Abstract
Objective: To evaluate the correlation between the Bruxism Episodes Index (BEI) that determines the number of bruxism episodes per hour of sleep and sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI).Methods: Seventy-seven participants (56 women and 21 men) in which probable sleep bruxism was diagnosed using guidelines of the American Academy of Sleep Medicine underwent video-polysomnography. Sleep quality was measured using PSQI.Results: The analysis showed the lack of a statistically significant correlation between the BEI and PSQI scores (p = 0.55). Analysis also showed that the study group (bruxers) and control group (non-bruxers) did not differ significantly in terms of PSQI scores (p = 0.88).Conclusion: The intensity of bruxism seems not to affect the quality of sleep. However, the topic of the relationship between sleep quality and the occurrence of sleep bruxism requires further research, taking into account co-occurring sleep disorders and sleep architecture. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Obstructive Sleep Apnea and Sleep Structure Assessed in Polysomnography and Right Ventricular Strain Parameters.
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Macek, Piotr, Poręba, Małgorzata, Stachurska, Aneta, Martynowicz, Helena, Mazur, Grzegorz, Gać, Paweł, and Poręba, Rafał
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SLEEP apnea syndromes ,POLYSOMNOGRAPHY ,SLEEP disorders - Abstract
Our study aimed to assess functional, structural changes of the right ventricular using strain parameters and sleep structure using polysomnography in patients with obstructive sleep apnea (OSA). Our study group consisted of 43 patients, 29 men, 14 women. The mean age was 56.36 ± 14.77. All patients underwent full night polysomnography and transthoracic echocardiography. The right ventricular global longitudinal strain was measured by 2D speckle-tracking echocardiography. The prevalence of OSA (AHI ≥ 5) was 76.7% in the studied group. We observed a significant positive correlation between OAH and average free wall strain (r = 0.37), snore and mid-free wall strain (r = 0.34), average HR, and basal free wall strain (r = 0.34). Moreover, CSB was positively correlated with basal septal strain and mid septal strain (r = 0.36 and 0.42). In summary, among patients with sleep disorders, functional disorders of the right ventricle, assessed using the strain method, are partly observed. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Parasomnias and obstructive sleep apnea syndrome: in search for a parasomnia evaluating tool appropriate for OSAS screening.
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WIECZOREK, TOMASZ, LORENC, MACIEJ, MARTYNOWICZ, HELENA, PIOTROWSKI, PATRYK, MAZUR, GRZEGORZ, and RYMASZEWSKA, JOANNA
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PARASOMNIAS ,SLEEP disorder diagnosis ,REACTIVE oxygen species ,HOSPITAL care ,OXYGEN in the body ,SLEEP apnea syndromes ,PREDICTIVE tests ,SLEEP disorders ,SEVERITY of illness index ,DISEASE complications ,DIAGNOSIS ,DISEASE risk factors - Abstract
Background. Obstructive sleep apnea syndrome (OSAS) is the most common form of sleep-disordered breathing. It is also a known major risk factor of parasomnias. Objectives. To verify if an additional diagnostic tool for parasomnia assessment might be useful in OSAS screening. Additionally, to investigate the possible relations of parameters measured during polygraphy evaluation and the severity/frequency of parasomnia episodes in order to find the pathophysiological background of increased frequency of parasomnias in OSAS cases. Material and methods. Parasomnia evaluation with the Paris Arousal Disorder Severity Scale (PADSS) and OSAS evaluation with polygraphy in a group of 105 adult patients hospitalized for assessment of possible OSAS. Results. According to the polygraphic evaluation, patients were divided into: non-OSAS (n = 19, 18.1%), mild OSAS (n = 31, 29.52%), moderate OSAS (n = 21, 20%) and severe OSAS (n = 34, 32.38%). Based on the recommended cut-off score of 13 points in PADSS, two groups of patients emerged after the parasomnia evaluation: with positive (n = 10) and negative (n = 95) results. PADSS achieved sensitivity of 10.9% and 92% specificity when used for moderate and severe OSAS screening. The positive predictive value (PPV) reached 60%, negative predictive value (NPV) - 48.4%. A statistically significant elongation of the percentage of estimated sleep time below 80% blood oxygen saturation emerged in patients with positive PADSS scores (p = 0,006). Focusing on the parasomnia frequency criterion did not significantly affect the results. Conclusions. Due to low sensitivity, PPV and NPV PADSS cannot be used as a screening tool in possible OSAS assessment. Another tool with higher sensitivity should be developed, also including assessment of other parasomnias and sleep-related movement disorders. Cyclic intermittent hypoxia might be the cause of the higher frequency of arousal disorders in OSAS patients. [ABSTRACT FROM AUTHOR]
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- 2018
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10. The Co-Occurrence of Sexsomnia, Sleep Bruxism and Other Sleep Disorders.
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Martynowicz, Helena, Smardz, Joanna, Wieczorek, Tomasz, Mazur, Grzegorz, Poreba, Rafal, Skomro, Robert, Zietek, Marek, Wojakowska, Anna, Michalek, Monika, and Wieckiewicz, Mieszko
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SLEEP disorders , *NON-REM sleep , *COMORBIDITY , *SLEEPTALKING , *PATIENTS , *SLEEP bruxism - Abstract
Background: Sleep sex also known as sexsomnia or somnambulistic sexual behavior is proposed to be classified as NREM (non-rapid eye movement) parasomnia (as a clinical subtype of disorders of arousal from NREM sleep—primarily confusional arousals or less commonly sleepwalking), but it has also been described in relation to REM (rapid eye movement) parasomnias. Methods: The authors searched the PubMed database to identify relevant publications and present the co-occurrence of sexsomnia and other sleep disorders as a non-systematic review with case series. Results: In the available literature the comorbidity of sexsomnia and other sleep disorders were reported mainly in case reports and less in case series. Sexsomnia was reported both with one and with multiple sleep-related disorders, with NREM parasomnias and obstructive sleep apnea (OSA) being the most commonly reported. Furthermore, the authors enrich the article with new findings concerning two novel cases of sleep bruxism triggering recurrent sexsomnia episodes. Conclusions: Sexsomnia has still not been reported in the literature as often as other parasomnias. The coexistence of sexsomnia and other sleep-related disorders should be more thoroughly examined. This could help both in sexsomnia as well as other sleep-related disorders management. [ABSTRACT FROM AUTHOR]
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- 2018
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