1. Surfactant protein D is a candidate biomarker for subclinical tobacco smoke-induced lung damage.
- Author
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Johansson SL, Tan Q, Holst R, Christiansen L, Hansen NC, Hojland AT, Wulf-Johansson H, Schlosser A, Titlestad IL, Vestbo J, Holmskov U, Kyvik KO, and Sorensen GL
- Subjects
- Adolescent, Adult, Aged, Cross-Sectional Studies, Denmark, Female, Forced Expiratory Volume, Genetic Association Studies, Humans, Lung Diseases chemically induced, Lung Diseases genetics, Male, Middle Aged, Prognosis, Pulmonary Surfactants metabolism, Vital Capacity, Young Adult, Biomarkers analysis, Haplotypes genetics, Lung Diseases diagnosis, Polymorphism, Single Nucleotide genetics, Pulmonary Surfactant-Associated Protein D genetics, Smoking adverse effects
- Abstract
Variation in surfactant protein D (SP-D) is associated with lung function in tobacco smoke-induced chronic respiratory disease. We hypothesized that the same association exists in the general population and could be used to identify individuals sensitive to smoke-induced lung damage. The association between serum SP-D (sSP-D) and expiratory lung function was assessed in a cross-sectional design in a Danish twin population (n = 1,512, 18-72 yr old). The adjusted heritability estimates for expiratory lung function, associations between SP-D gene (SFTPD) single-nucleotide polymorphisms or haplotypes, and expiratory lung function were assessed using twin study methodology and mixed-effects models. Significant inverse associations were evident between sSP-D and the forced expiratory volume in 1 s and forced vital capacity in the presence of current tobacco smoking but not in nonsmokers. The two SFTPD single-nucleotide polymorphisms, rs1923536 and rs721917, and haplotypes, including these single-nucleotide polymorphisms or rs2243539, were inversely associated with expiratory lung function in interaction with smoking. In conclusion, SP-D is phenotypically and genetically associated with lung function measures in interaction with tobacco smoking. The obtained data suggest sSP-D as a candidate biomarker in risk assessments for subclinical tobacco smoke-induced lung damage. The data and derived conclusion warrant confirmation in a longitudinal population following chronic obstructive pulmonary disease initiation and development.
- Published
- 2014
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