1. Clinical relevance of peroxisome proliferator-activated receptor-gamma expression in myxoid liposarcoma.
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Akihiko Takeuchi, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Shinji Miwa, Seiichi Munesue, Yasuhiko Yamamoto, Hiroyuki Tsuchiya, Takeuchi, Akihiko, Yamamoto, Norio, Shirai, Toshiharu, Hayashi, Katsuhiro, Miwa, Shinji, Munesue, Seiichi, Yamamoto, Yasuhiko, and Tsuchiya, Hiroyuki
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LIPOSARCOMA ,PGC-1 protein ,TRANSCRIPTION factors ,NUCLEAR receptors (Biochemistry) ,IMMUNOHISTOCHEMISTRY ,POLYMERASE chain reaction ,MULTIVARIATE analysis ,PATIENTS ,PROTEIN metabolism ,RNA metabolism ,CANCER relapse ,LONGITUDINAL method ,SOFT tissue tumors ,SURVIVAL ,RETROSPECTIVE studies ,REVERSE transcriptase polymerase chain reaction - Abstract
Background: Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor that belongs to the nuclear hormone receptor superfamily. PPARγ is essential in adipocyte differentiation from precursor cells. Its antitumorigenic effects are reported in certain malignancies; however, its effects in liposarcoma are unclear.Methods: We analyzed PPARγ expression using immunohistochemistry (IHC) in 46 patients with myxoid liposarcoma [MLS; median age, 47 years (range, 14-90 years) and mean follow-up period, 91 months (range, 13-358 months)]. PPARγ mRNA expression levels were measured by quantitative reverse transcription polymerase chain reaction. Further, we evaluated the correlation of PPARγ expression with clinical outcomes.Results: We found that the metastasis-free survival rate was significantly higher in lower PPARγ expressers [34 patients with labeling index (LI) <50 %] than in higher expressers (12 patients with LI ≥50 %; p = 0.01). Cox multivariate analysis revealed that a higher PPARγ level was an independent predictor of metastasis (relative risk = 6.945, p = 0.026). Furthermore, using 28 fresh MLS specimens, we confirmed an increased PPARγ mRNA expression level in the higher LI group (p = 0.001).Conclusions: In this study, higher PPARγ expression in MLS was a risk factor associated with distant metastasis; therefore, it would be a novel prognostic marker for MLS. Further analyses will help to understand the correlation between PPARγ expression and tumor malignancy in liposarcoma. [ABSTRACT FROM AUTHOR]- Published
- 2016
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