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Matrix solid phase dispersion (MSPD) is a rapid and flexible sample pretreatment method that accomplishes sample disruption, extraction, filtering and purification in one step and is especially suitable for solid, semisolid and viscous samples. More than 30 years have elapsed since it was first proposed, and there are many published reviews. However, there is no review on the use of MSPD to extract active compounds from natural products. In this review, the latest developments from 2015–2021 in MSPD microextraction techniques, including sorbents, elution solvents and assisted MSPD extraction, along with their applications in natural products, are systematically discussed and classified according to the structure of the active constituents, which mainly refer to phenolic acids, flavonoids, alkaloids, anthraquinones and terpenes. [ABSTRACT FROM AUTHOR]

[Display omitted] • A carbon black-assisted miniaturized solid phase extraction method was established. • Carbamate residues were determined by SFC-IM-Q-TOF/MS. • The CCS values of carbamate pesticides were accurately measured for identification. • This method was highly efficient, highly sensitive and environmentally friendly. In this study, the qualitative and quantitative analysis of carbamate pesticide residues was achieved by a miniaturized solid phase extraction (SPE) method and supercritical fluid chromatography (SFC) combined with ion mobility quadrupole time-of-flight mass spectrometry (IM-Q-TOF/MS). The target compounds in real samples were enriched using the miniaturized SPE method, and the parameters affecting enrichment efficiency were evaluated with the optimal enrichment conditions as follows: carbon black (20 mg) and methanol used as the elution solvent with a volume of 200 µL. Meanwhile, the back temperature, back pressure and make-up solvent in SFC were investigated, and the corresponding optimal conditions were 60 °C, 140 bar and methanol with 0.1% formic acid, respectively. Subsequently, accurate mass values of nine carbamate pesticides were identified by IM-Q-TOF/MS. Through method validation and sample analysis, the results indicated that satisfactory validation parameters, such as linearity (R2 > 0.99), limit of detection (<7.01 ng/mL), limit of quantitation (<23.36 ng/mL), precision (0.21–3.91%) and reproducibility (0.08–4.76%), were obtained. Finally, this method was successfully applied to the enrichment and detection of carbamate residues in real samples of ginger. [ABSTRACT FROM AUTHOR]

A rapid, efficient, and environmentally friendly matrix solid‐phase dispersion microextraction was established to determine and quantify terpenoids in Radix Curcumae using ultra‐high‐performance liquid chromatography with a diode array detector. Various parameters affecting the extraction were investigated in detail, such as the grinding time, amount of adsorbent, type and concentration of elution solvent, and pH. The optimization of single‐factor and response surface methodology was performed to confirm the best conditions in this procedure. The final optimized conditions were obtained by applying 70 mg of cucurbituril as adsorbent, 149 s as the optimum grinding time, and 228 mM of 3‐(N,N‐dimethylpalmitylammonio)propanesulfonate aqueous solution (pH 6.5) as the optimal elution solvent. The validated method showed a satisfactory linear range of 0.10–10 µg/mL for curdione and furanodiene, 0.01–10 µg/mL for isocurcumenol and germacrone, and 0.05–10 µg/mL for furanodienone, while the correlation coefficients ranged from 0.9945 to 0.9970. The recoveries of the investigated analytes at two spiked concentration levels (0.1 and 1.0 µg/mL) ranged from 96.53 to 104.60%. In addition, this method displayed acceptable reproducibility (relative standard deviation ≤ 3.66%). The results showed that the newly proposed matrix solid‐phase dispersion microextraction method was successfully applied to analyze curdione, isocurcumenol, furanodienone, germacrone and furanodiene in Radix Curcumae samples. [ABSTRACT FROM AUTHOR]

[Display omitted] • A plant sorbent assisted mini-SPE method is proposed. • Novel microwave-induced activated carbons was utilized as the plant sorbent in this work. • Activated carbon was prepared by microwave chemical reaction from hawthorn leaves. • The approach was successfully applied in the extraction of multiple pesticide residues in Dendrobium officinale. A simple and green plant sorbent-based miniaturized solid phase extraction (mini-SPE) method was presented for the detection of multi-pesticide residues in Dendrobium officinale by ultra-high performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry. Activated carbons prepared from hawthorn leaves were used as a green sorbent in microwave (MW) assisted mini-SPE process. Various parameters such as the type and concentration of extraction solvent, MW time and MW temperature, were investigated in detail to obtain the optimum conditions in this procedure. Under the final optimized conditions, this method displayed a satisfactory linearity, with its correlation coefficients ranged from 0.9927 to 0.9991. The limits of detection ranged between 0.08 and 1.35 ng/mL for the seven pesticides. And the recoveries of the pesticides in Dendrobium officinale ranged from 81.17 to 106.12% at two spiked levels (0.05 and 5 ug/mL), indicating the accuracy of the proposed mini-SPE method was acceptable. Besides, the reproducibility of the method was satisfactory, with the RSDs lower than 0.37% for retention time, 3.72% for peak area, respectively. The proposed mini-SPE method was efficiently applied for the determination and extraction of the pesticides in Dendrobium officinale, thus demonstrating that this method was reliable. [ABSTRACT FROM AUTHOR]