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The purpose of the work – the analysis of specialized scientific literature for the study and generalization of data on modern views on the treatment of generalized periodontitis in persons with severe general somatic diseases. Dystrophic-inflammatory diseases of the periodontal tissues are polyethiological, pathogenesis of which is closely associated with pathological processes caused by the most important systems of the body malfunction. An integrated treatment approach to periodontal diseases, which in addition to local therapy involves the detection and timelyttreatment of somatic pathology, is an important condition for achieving positive results. The article presents modern scientific researches of common pathogenetically significant changes in generalized periodontitis and somatic diseases (cardiovascular, respiratory, endocrine, nervous system, gastrointestinal tract diseases), which allow a clearer understanding of the periodontal diseases genesis nature and effective therapeutic and prophylactic measures development. Conclusions. The duration of general-somatic disease increases the incidence and prevalence of generalized periodontitis in people of all ages, complicates the course with a tendency to progression. This fact requires a special approach to the treatment of generalized periodontitis in patients taking into account the pathogenesis, features of the course and treatment of an underlying disease.