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• Sonochemical synthesis of Tungsten Trioxide nanoballs (WO 3 NBs) decorated on multi-layered graphene sheets. • The WO 3 NBs/GR nanocomposite was applied to the electrochemical sensor towards Progesterone. • The nanocomposite exhibits very low detection limit (4.28 nM). • The nanocomposite is successfully applied for real sample analysis in human blood serum samples. Herein, we have reported a simple sonochemical synthesis of multi-layer graphene covered tungsten trioxide nanoballs (WO 3 NBs) and the nanocomposite was characterized by FESEM, HRTEM, XRD, XPS, CV and EIS. Furthermore, progesterone (PGT) is a preferred marker for various biological problems like pregnancy problem, mood swings, anxiety, depression, nervousness and body pain. Therefore, its selective and sensitive determination in various biological fluids is beneficial for the evaluation of malformation problems. We describe the fabrication of an amperometric and non-enzymatic biosensor based on WO 3 NBs@GR nanocomposite modified electrode for nanomolar detection of PGT. The results showed that the nanocomposite modified electrode exhibit well-defined electro-oxidation peak compared to bare and control electrodes, demonstrating the superior electrocatalytic ability and performances. The fabricated modified sensor was facilitates the analysis of PGT in the concentration ranges of 0.025–1792.5 µM with a low detection limit of 4.28 nM. Further, the as-prepared WO 3 NBs@GR electrode has been applied to determination of PGT in human blood samples with outstanding recovery results and more importantly, the facile and environment-friendly sonochemical construction strategy extended here, may be open a cost-effective way for setting up the nanocomposites based (bio) sensing platform. [ABSTRACT FROM AUTHOR]

Abstract Herein, we developed a silver nanoparticles decorated iron pyrite flowers (FeS 2 @Ag NL) based nanocomposite was prepared by a sonochemical method. The formation of FeS 2 @Ag NL nanocomposite was confirmed by XRD, XPS, HR-TEM and analytical techniques. The FeS 2 @Ag NL/SPCE was potentially applied towards electrochemical detection of toxic herbicide (acifluorfen-AFF). This provided an efficient sensor platform anchoring FeS 2 @Ag NL on its surface. Under optimized conditions of differential pulse voltammetric transduction, a linear relationship between the current and the concentration was obtained in the range of 0.05–1126.45 µM for Acifluorfen. The detection limit was observed to be 0.0025 µM. the modified sensor exhibits excellent electrochemical performance, including good linear range, nanomolar detection limit, high sensitivity, and desirable stability. Particularly, the practical applicability was revealed by quantifying the AFF concentration in biological samples. [ABSTRACT FROM AUTHOR]

Abstract In this paper, mesoporous tungsten sulfide electrocatalyst (MP-WS 2) were developed through a facile sonochemical technique (SC) and utilized as an electrocatalyst for the sensitive electrochemical detection of Psychoactive drug. The as-prepared SC-MP-WS 2 NRs and HT-WS 2 NPs (hydrothermally synthesized) were characterized using XRD, Raman, XPS, FESEM, HRTEM, BET, EDX, and electrochemical analysis, which exposed the formation of WS 2 in the form of mesoporous nanorods in shape. Further, the use of the as-developed SC-MP-WS 2 NRs and HT-WS 2 NPs as an electrocatalyst for the detection of clonazepam (CNP). Interestingly, the SC-MP-WS 2 NRs modified screen-printed carbon electrode (SC-MP-WS 2 NRs/SPCE) exhibited an excellent electrocatalytic performance, and enhanced reduction peak current when compared to HT-WS 2 NPs with unmodified electrode. Moreover, as-prepared SC-MP-WS 2 NRs/SPCE displayed wide linear response range (10–551 µM), lower detection limit (2.37 nM) and high sensitivity (24.32 µAµM–1cm−2). Furthermore, SC-MP-WS 2 NRs/SPCE showed an excellent selectivity even in the existence of potentially co-interfering compounds. The proposed sensor was successfully applied for the determination of CNP in biological and drug samples with acceptable recovery. [ABSTRACT FROM AUTHOR]

• Magnetic properties based Fe 3 O 4 NPs@rGOS nanocomposite have been. • The Fe 3 O 4 NPs@rGOS nanocomposite has used for electrochemical sensor application. • The Fe 3 O 4 NPs@rGOS nanocomposite has been developed pico-molar LOD. • Such a unique nanocomposite was successfully applied to the real sample analysis. In this study, a super-active Iron (II, III) oxide nanospheres (Fe 3 O 4 NPs) decorated reduced graphene oxide (rGOS) nanocomposite was developed. Fe 3 O 4 NPs were stabilized on rGOS through electrostatic interactions in the aqueous medium. This process involves an ultrasound assisted reduction reaction of the GOS. The as-synthesized Fe 3 O 4 NPs@rGOS was characterized through the HRTEM, SEM, XRD, Raman, elemental mapping and EDX analysis. The Fe 3 O 4 NPs@rGOS modified GCE was developed for the determination of biomarker. Uric acid is important biomarker based on gout and kidney stone with high adverse effect in human body. The results obtained showed that the modified electrode Fe 3 O 4 NPs@rGOS shows good electrochemical reduction peak compared to bare electrode and control electrodes. The Fe 3 O 4 NPs@rGOS modified sensor linear range 0.02–783.6 µM was observed with nanomolar LOD 0.12 nM. In addition, the modified Fe 3 O 4 NPs@rGOS/GCE sensor has been applied to determination of uric acid concentration in urine and blood serum samples. Furthermore, advantages of the modified sensor are high stability, repeatability and reproducibility. [ABSTRACT FROM AUTHOR]