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A field experiment was conducted at the Rajasthan College of Agriculture, Maharana Pratap University of Agriculture and Technology -Udaipur during Kharif season 2015 and 2016 to test the efficacy of different herbicide and herbicide mixtures against weeds in soybean. Monocot weeds were predominant (57.68 %) in the experimental field compared to Broad leaved weeds (42.31 %). However, Echinochloa colona (40.55 %) and Corchorus olitorius (23.68%) were dominant in soybean at 30 DAS. Among different weed control treatments, post-emergence and tank mix combination of propaquizafop + imazethapyr (75+75 g ha-1) and imazethapyr + quizalofop-ethyl (75+60 g ha-1) at 21 DAS were most effective in respect of reducing weed density, weed biomass, nutrient removal by weed and improving yield attributes, yield and quality of soybean compared to other treatments. Highest seed yield (2271 kg ha-1), Haulm yield (3127 kg ha-1) of soybean and maximum net return (... 51550/ha) were also recorded with propaquizafop 75 g ha-1 + imazethapyr 75 g ha-1 followed by imazethapyr + quizalofop-ethyl (75+60 g ha-1). Further, they were also found responsible for highest uptake of N, P and K in soybean and lowest uptake of these plant nutrients by weeds. [ABSTRACT FROM AUTHOR]