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The need to make human spaceflight as safe as technically possible is a characteristic of this special branch of space missions and drives the cost and feasibility of human space exploration. Between the time prospective astronauts first apply for a chance to fly into space and the actual time when they climb into the spacecraft on top of a rocket for the first flight, risk awareness, mitigation, and assessment are present as a constant background reflection. What drives human explorers to accept the remaining non-mitigatable risks and when is the individual "go" decision made? In light of future long-term missions; leading humans again from LEO into deep space a sound understanding of this decision process may lead to an improved selection and composition of capable space expedition crews. • Astronauts launching on a rocket are visibly exposed to an assumingly life threatening risk. • Human rating for a spacecraft requires enhanced risk mitigation in form of highest technical reliability standards. • Tolerable remaining risks should be in balance with expected flight results (science, technology). • Training is a key factor to positively tip the balance towards performing a spaceflight despite the risk. [ABSTRACT FROM AUTHOR]

A long-duration microgravity environment has numerous detrimental effects on the human physiology. The most obvious solution for this problem related to long duration space exploration missions is to remedy the lack of gravity. This could be done using short arm human centrifuges but they do not seem to be sufficiently effective, perhaps because of the short duration exposure of this countermeasure and/or the huge body gravity gradient. New views have to be investigated, such as to see if a (very) long-arm rotating system generating a continuous 1 g or partial gravity field might resolve this issue. Besides the expected benefits regarding astronauts' microgravity pathologies, additionally the spacecraft itself, its on-board (sub-)systems and procedures might benefit from a rotating configuration. In this paper we address very briefly the medical issues, but the work is mainly focused on the advantages regarding engineering, operations, life support, safety and budget of having a constantly rotating spacecraft first in Low Earth Orbit and later for long duration missions to Mars. A large rotating spacecraft is feasible and affordable to build, operate and maintain. It has advantages for governmental and commercial use but also in light of the expected increase in space tourism. It will also save crew time and billions of dollars now being spent to counteract the effects of microgravity. A continuous rotating spacecraft providing Artificial Gravity will: • Improve crew health and wellbeing. • Improve mission safety and success. • Reduce costs significantly. • Simplify numerous operations in flight. • Provides the use of 1 g verified systems. [ABSTRACT FROM AUTHOR]