Descriptor: "Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]" / Topic: spain - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]"' showing total 114 results

Start Over Descriptor "Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]" Topic spain

114 results on '"Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]"'

1. Modelos predictivos de la epidemia de COVID-19 en España con curvas de Gompertz

Author: Pablo Sánchez-Villegas, Antonio Daponte Codina, [Sánchez-Villegas,P, Daponte Codina,A] Escuela Andaluza de Salud Pública, Granada, España. [Sánchez-Villegas,P, Daponte Codina,A] Observatorio de Salud y Medio Ambiente de Andalucía (OSMAN), Granada, España. [Sánchez-Villegas,P, and Daponte Codina,A] CIBER de Epidemiología y Salud Pública (CIBERESP), España.
Subjects: Coronavirus disease 2019 (COVID-19), Gompertz function, Contagios, Health Care::Population Characteristics [Medical Subject Headings], Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Forecasting [Medical Subject Headings], Article, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 03 medical and health sciences, 0302 clinical medicine, Pandemic, Humans, Predicción, National level, 030212 general & internal medicine, Mortality, Socioeconomics, Pandemics, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Vital Statistics::Mortality [Medical Subject Headings], SARS-CoV-2, business.industry, 030503 health policy & services, Health Care::Health Services Administration::Organization and Administration::Public Health Administration [Medical Subject Headings], Public Health, Environmental and Occupational Health, Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings], COVID-19, International health, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], Geography, Work (electrical), Spain, Mortalidad, Public aspects of medicine, RA1-1270, Infection, 0305 other medical science, business, Forecasting
Abstract: Resumen: Durante la crisis de salud internacional provocada por la pandemia de COVID-19, además de conocer los datos sobre contagios, muertes y ocupación de camas hospitalarias también es necesario hacer predicciones que ayuden a la gestión de la crisis por parte de las autoridades sanitarias. El presente trabajo tiene como objetivo describir la metodología utilizada para la elaboración de modelos predictivos de contagios y defunciones para la epidemia de COVID-19 en España basados en curvas de Gompertz. La metodología se aplica al total del país y a cada una de sus comunidades autónomas. De acuerdo con los datos oficiales publicados a la fecha de realización de este trabajo, y a través de los modelos descritos, estimamos un total de alrededor de 240.000 contagiados y 25.000 fallecidos al final de la epidemia. Pronosticamos el final de la epidemia entre los meses de junio y julio de 2020. Abstract: During the international health crisis caused by the COVID-19 pandemic, it is necessary not only to know the data on infections, deaths and the occupation of hospital beds, but also to make predictions that help health authorities in the management of the crisis. The present work aims to describe the methodology used to develop predictive models of infections and deaths for the COVID-19 epidemic in Spain, based on Gompertz curves. The methodology is applied to the country as a whole and to each of its Autonomous Communities. Based on the official data available on the date of this work, and through the models described, we estimate a total of around 240.000 infected and 25.000 deaths at the end of the epidemic. At a national level, we forecast the end of the epidemic between June and July 2020.
Published: 2021
Full Text: View/download PDF

2. ¿Cuántas víctimas colaterales se asocian con los usuarios de la carretera responsables de los accidentes de tráfico?

Author: Eladio Jiménez-Mejías, Daniel Molina-Soberanes, Elena Moreno-Roldán, Pablo Lardelli-Claret, Virginia Martínez-Ruiz, Luis Miguel Martín-de los Reyes, [Martínez-Ruiza,V, Lardelli-Clareta,P, Molina-Soberanesa,D, Martín-de los Reyesa,LM, Moreno-Roldána,E, Jiménez-Mejías,E] Department of Preventive Medicine and Public Health, School of Medicine, University of Granada, Granada, Spain. [Martínez-Ruiza,V, Jiménez-Mejías,E] CIBER de Epidemiología y Salud Pública (CIBERESP), Spain. [Martínez-Ruiza,V, Jiménez-Mejías,E] Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain. [Molina-Soberanesa,D, and Martín-de los Reyesa,LM] Doctorate Program in Clinical Medicine and Public Health, University of Granada, Granada, Spain.
Subjects: Adult, Male, Automobile Driving, Injury control, Epidemiology, Accident prevention, Poison control, Injury, Health outcomes, Víctimas colaterales, Car drivers, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 03 medical and health sciences, 0302 clinical medicine, Road crash, Accidente de tráfico, Persons::Persons::Men::Nurses, Male [Medical Subject Headings], Humans, Epidemiología, Registries, 030212 general & internal medicine, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Lesión, Road user, Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Registries [Medical Subject Headings], Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], 030503 health policy & services, Accidents, Traffic, Public Health, Environmental and Occupational Health, Persons::Persons::Occupational Groups::Police [Medical Subject Headings], Police, Collateral casualties, Death, Health Care::Environment and Public Health::Public Health::Accidents::Accidents, Traffic [Medical Subject Headings], Geography, Muerte, Spain, Female, Anthropology, Education, Sociology and Social Phenomena::Human Activities::Automobile Driving [Medical Subject Headings], 0305 other medical science, human activities, Humanities
Abstract: We wish to thank the Spanish Directorate General of Traffic forallowing access to their database of traffic accidents with victims,and K. Shashok for improving the use of English in the manuscript., Objective: To estimate the number of collateral casualties associated with road users considered responsible for a road crash. Method: We analyzed the case series comprising all 790,435 road users involved in road crashes with victims in Spain from 2009 to 2013, recorded in a nationwide police-based registry. For each road user assumed to be responsible for a crash, we collected information relative to health outcomes in other people involved in it, and obtained the total number of collateral casualties per 100 road users considered responsible for the crash. We then estimated the strength of associations between sex, age and the number of collateral casualties generated by car drivers considered responsible for the crash, and calculated rate ratios and corresponding 95% confidence intervals. Results: Pedestrians responsible for crashes were associated with the lowest number of collateral casualties (13.1/100), whereas the highest number (153/100) was observed for bus drivers responsible for crashes. Car drivers were associated with 104.4/100 collateral casualties. The youngest and the oldest car drivers responsible for crashes were associated with 33% and 41% more deaths, respectively, than the 25-4 year old group. Male drivers were associated with 22% more collateral casualties than female drivers. Conclusions: Regardless of the type of road user who was responsible for a road crash, their active contribution to the crash led to an additional number of collateral casualties in other, non-responsible users. The number and severity of collateral casualties were related to the type of vehicle and the number of people involved. These results are potentially useful to support the need to promote safer driver practices among subgroups of high-risk drivers., Objetivo: Estimar el número de víctimas colaterales asociadas a los usuarios de las vías de tráfico respon-sables de una colisión. Método: Se estudió la serie de casos formada por los 790.435 usuarios de la vía implicados en accidentes de tráfico con víctimas en España, entre 2009 y 2013, recogidos en el Registro de Accidentes de Tráfico con Víctimas de la Dirección General de Tráfico. Para cada uno de los usuarios considerado responsable se recogió información sobre las consecuencias sanitarias para las otras personas implicadas en el mismo accidente, y se calculó el número total de víctimas colaterales por cada 100 usuarios responsables. A continuación se estimó la fuerza de asociación de la edad y el sexo de los conductores de turismo con el número de víctimas colaterales generadas por ellos, y se obtuvieron las correspondientes razones detasas y sus intervalos de confianza del 95%.Resultados: Los peatones responsables de atropellos se asociaron al menor número de víctimas colaterales (13,1/100), mientras que la cifra más alta de estas (153/100) se asoció a los conductores de autobús responsables del accidente. Los de turismo implicaron a 104,4/100. Los conductores de turismo más jóvenes (64 años) implicaron respectivamente un 33% y un41% más de víctimas colaterales que el grupo de 25-34 años. Los varones se asociaron a un 22% más de víctimas colaterales que las mujeres. Conclusiones: Independientemente del tipo de usuario responsable del accidente, su contribución activase asoció a un número adicional de víctimas colaterales, cuyas magnitud y gravedad dependieron sobre todo del tipo de vehículo conducido. Este trabajo puede ser útil para reforzar las actuaciones destinadas a prevenir la accidentalidad en los usuarios de alto riesgo.
Published: 2021
Full Text: View/download PDF

3. Validation of living with chronic illness scale in a type 2 diabetes mellitus population

Author: Leire Ambrosio, Silvia Corchon, Jorge Caro-Bautista, Eva Timonet-Andreu, David Pérez-Manchón, Gloria Carvajal-Carrascal, Carmen Rodriguez-Blazquez, Alejandra Fuentes-Ramírez, Marta Aranda-Gallardo, Ministerio de Ciencia, Innovación y Universidades (España), European Regional Development Fund, [Caro-Bautista,J] Andalusian Public Health System, District of Primary Health Care of Málaga-Valle del Guadalhorce and Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain. [Rodríguez-Blázquez,C] National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain. [Perez-Manchon,D] Faculty of Health, Camilo José Cela University, Madrid, Spain. [Timonet-Andreu,E] Department of Cardiology, Costa del Sol Hospital and Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain. [Carvajal-Carrascal,G, Fuentes-Ramírez,A] Facultad de Enfermería y Rehabilitación, Universidad de La Sabana, Chía, Colombia. [Corchon,S] Faculty of Nursing and Chiropody, University of Valencia, Valencia, Spain. [Aranda-Gallardo,M] Department of Internal Medicine, Costa del Sol Hospital, Marbella, Málaga, Spain. [Ambrosio,L] School of Health Sciences, NIHR ARC Wessex, University of Southampton, Southampton, United Kingdom, and This study has been funded by the Ministry of Science, Innovation and University of the Spanish Government (FEDER/Ministerio de Ciencia, Innovación y Universidades—Agencia Estatal de Investigación/ Proyecto (CSO2017-82691-R)).
Subjects: Male, Intraclass correlation, España, Chronic illness, Geographical Locations::Geographic Locations::Americas::South America::Colombia [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Surveys and Questionnaires, Medicine, Persons::Persons::Patients::Outpatients [Medical Subject Headings], education.field_of_study, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings], General Medicine, Middle Aged, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Personal Satisfaction [Medical Subject Headings], Confirmatory factor analysis, Checklist, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of Results [Medical Subject Headings], Diabetes mellitus tipo 2, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Feasibility Studies [Medical Subject Headings], Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Quality of Life [Medical Subject Headings], Long-term condition, Psicometría, lcsh:R858-859.7, Female, Psychometric, Clinical psychology, Adult, Population, Check Tags::Male [Medical Subject Headings], Health Care::Health Services Administration::Organization and Administration::Professional Practice::Referral and Consultation [Medical Subject Headings], Colombia, lcsh:Computer applications to medicine. Medical informatics, Estudio de validación, Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Psychometrics [Medical Subject Headings], Social support, Quality of life (healthcare), Cronbach's alpha, Study validation, Type 2 diabetes mellitus, Humans, COSMIN, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Data Collection::Checklist [Medical Subject Headings], Persons::Persons::Age Groups::Adult [Medical Subject Headings], education, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, Research, Enfermedad crónica, Public Health, Environmental and Occupational Health, Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 [Medical Subject Headings], Reproducibility of Results, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Cross-Sectional Studies, Check Tags::Female [Medical Subject Headings], Diabetes Mellitus, Type 2, Spain, Quality of Life, Observational study, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Factor Analysis, Statistical [Medical Subject Headings], business
Abstract: Background Worldwide, type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic diseases and one of those producing greatest impact on patients’ day-to-day quality of life. Our study aim is to validate the “Living with Chronic Illness Scale” for a Spanish-speaking T2DM population. Methods In this observational, international, cross-sectional study, 582 persons with T2DM were recruited in primary care and outpatient hospital consultations, in Spain and Colombia, during the period from May 2018 to June 2019. The properties analysed were feasibility/acceptability, internal consistency, reliability, precision and (structural) content-construct validity including confirmatory factor analysis. The COSMIN checklist was used to assess the methodological/psychometric quality of the instrument. Results The scale had an adequate internal consistency and test retest reliability (Cronbach’s alpha = 0.90; intraclass correlation coefficient = 0.96, respectively). In addition, the instrument is precise (standard error of measurement = 3.34, with values s = 0.56), quality of life (WHOQOL-BREF) (rs = 0.51–0.30) and ssatisfaction with life (SLS-6) (rs = 0.50–0.38). The original 26-items version of the scale did not support totally the confirmatory factor analysis. The COSMIN checklist is favourable for all the properties analysed, although weaknesses are detected for structural validity. Conclusions The LW-CI-T2DM is a valid, reliable and accurate instrument for use in clinical practice to determine how a person’s life is affected by the presence of diabetes. This instrument correlates well with the associated constructs of social support, quality of life and satisfaction. Additional research is needed to determine how well the questionnaire structure performs when robust factor analysis methods are applied.
Published: 2021

4. Role of patients associations in connective tissue calcifiying diseases: a position statement from EuroSoftCalc.Net group

Author: Valdivielso, Pedro, Jacinto, Marta, Devernois, Guillemette, Laplana, Jorge, García-Fernández, Maria, Martin, Ludovic, [Valdivielso,P, García-Fernández,M] Departamento de Medicina y Dermatología, School of Medicine, Spain and Instituto de Investigación Biomédica de Málaga (IBIMA), Facultad de Medicina, University of Málaga, Boulevard Luis Pasteur, Málaga, Spain. [Jacinto,M] Associação Pseudoxantoma Elástico Portugal, Lisbon, Portugal [Devernois,G] Association, Jouars‑Pontchartrain, France. [Laplana,J] Asociación Española de Afectados Por Pseudoxantoma Elástico, Malaga, Spain. [Martin,L] PXE Consultation Center, MAGEC Nord Reference Center for Rare Skin Diseases, Angers University Hospital, Angers, France., and This article is based upon work from COST Action 16115 EuroSoftCalcNet, supported by COST (European Cooperation in Science and Technology)
Subjects: Geographical Locations::Geographic Locations::Europe::France [Medical Subject Headings], España, lcsh:Medicine, Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Thinking::Decision Making [Medical Subject Headings], Associations, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Rare Diseases [Medical Subject Headings], Calcification, Tejido conectivo, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Calcificación fisiológica, Humans, European Union, Geographical Locations::Geographic Locations::Historical Geographic Locations::European Union [Medical Subject Headings], Position Statement, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Portugal, Enfermedades raras, lcsh:R, Geographical Locations::Geographic Locations::Europe::Portugal [Medical Subject Headings], Connective Tissue, Spain, Asociación, France, Anatomy::Tissues::Connective Tissue [Medical Subject Headings], Connective tissue, Rare disease
Abstract: Patients have been showing a growing interest in taking active participation in decision making, and having the opportunity to drive clinical investigation. This is more common for patients who have a rare disease than for those with more prevalent diseases. The EuroSoftCalc.Net COST Action, a group of clinicians and researchers involved in the dystrophic calcification process held a meeting in which three representatives of patients’ associations, coming from Portugal, France and Spain, discussed the role of patients and their associations, namely in the Action, and also the main concerns in their countries. The disparities in health care between European Union countries with regard to connective tissue calcifying diseases, and the existing conflicts of interest, were a matter of debate during the meeting. As a consequence of the presentations and the debate that followed, it became clear that, despite their countries, the main concerns of the patients are identical, namely a lack of specific therapy and follow-up clinical guidelines, delays in the diagnosis, difficulties in getting members to enrol to associations, and/or difficulties with doctors’ explanations for the diseases. The attendees also agreed that EuroSoftCalc.Net group should help to set up new associations where no Patient Associations presently exist, and, furthermore, should release diagnosis and follow-up guidelines, especially helpful in countries, and/or for diseases, where no multidisciplinary consultations are available.
Published: 2021

5. Validation of a modified version of the Spanish Geriatric Oral Health Assessment Index (GOHAI-SP) for adults and elder people

Author: Francisco Javier Barón-López, Napoleón Pérez-Farinós, Francisco Jesús Carmona-González, Julia Wärnberg, Javiera Aguirre-Bustamante, [Aguirre-Bustamante,J] Facultad de Odontología, Universidad San Sebastián,Concepción, Chile. [Aguirre-Bustamante,J, Wärnberg,J] Department of Nursing, School of Health Sciences, University of Málaga - Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Barón-López,FJ, Pérez-Farinós,N] Department of Public Health, School of Medicine, University of Málaga - Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Carmona-González,FJ] Unidad de Gestión Clínica Torrequebrada, Distrito de Atención Primaria Costa del Sol. Servicio Andaluz de Salud, Benalmádena, Málaga, Spain. [Pérez-Farinós,N, Wärnberg,J] Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain., and The PREDIMED-Plus trial at the University of Málaga is funded by the Spanish Ministry of Health (Carlos III Health Institute) through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (grant references PI13/00492, PI16–00662 and PI19–00386) and the Consejería de Salud de la Junta de Andalucía (grant references PI0458/2013, PS0358/2016 and PI0137/2018). None of the funding sources took part in the design, collection, analysis or interpretation of the data or in the decision to submit the manuscript for publication.
Subjects: Gerontology, Male, Calidad de vida, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Data Collection::Health Surveys::Dental Health Surveys [Medical Subject Headings], Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Communication::Language [Medical Subject Headings], Gerodontology, Oral Health, Assessment index, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Demography::Health Status::Geriatric Assessment [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Quality of life, Surveys and Questionnaires, Medicine, Dental Care, Dental Health Surveys, Diseases::Stomatognathic Diseases::Tooth Diseases::Tooth Loss [Medical Subject Headings], Reliability (statistics), Language, Primary health care, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Aged, 80 and over, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings], Middle Aged, Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of Results [Medical Subject Headings], Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Quality of Life [Medical Subject Headings], Oral and maxillofacial surgery, Female, 0305 other medical science, Attitude to Health, Research Article, Toothbrushing, Oral health-related quality of life, Salud bucal, Oral health, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Attitude::Attitude to Health [Medical Subject Headings], Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance::Metabolic Syndrome X [Medical Subject Headings], Anciano, Check Tags::Male [Medical Subject Headings], Dental Caries, Health Care::Health Care Facilities, Manpower, and Services::Health Services::Dental Health Services::Dental Care [Medical Subject Headings], Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Psychometrics [Medical Subject Headings], 03 medical and health sciences, Tooth Loss, 030502 gerontology, Atención primaria de salud, Humans, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Socioeconomic Factors [Medical Subject Headings], General Dentistry, Geriatric Assessment, Aged, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, GOHAI, Discriminant validity, Reproducibility of Results, Andalucía, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], 030206 dentistry, Focus group, Comprehension, lcsh:RK1-715, Socioeconomic Factors, Check Tags::Female [Medical Subject Headings], Spain, Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over [Medical Subject Headings], Diseases::Stomatognathic Diseases::Tooth Diseases::Tooth Demineralization::Dental Caries [Medical Subject Headings], lcsh:Dentistry, Quality of Life, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Dentistry::Preventive Dentistry::Oral Hygiene::Toothbrushing [Medical Subject Headings], Health Care::Population Characteristics::Health::Oral Health [Medical Subject Headings], business
Abstract: Background The Geriatric Oral Health Assessment Index (GOHAI) was developed and validated in 1990 and translated into Spanish in 1999. Since then, the original version has been used in numerous studies, but it has not been re-evaluated in terms of language in the new generations of older adults. The purpose of this study is to confirm the validity of the Spanish version of the Geriatric Oral Health Assessment Index (GOHAI-SP) after three decades to be used as part of an ongoing field trial. Methods The GOHAI-SP was pilot tested in a focus group to confirm linguistic comprehension. A version with minor language changes was administered to individuals with metabolic syndrome aged 55–75 years from one health care district in southern Spain as part of an ongoing field trial (PREDIMED-Plus). Clinical evaluation included assessment of dental and periodontal status. The psychometric properties of the GOHAI-SP were evaluated through stability and internal consistency measures, and concurrent and discriminant validity were assessed. Results The new version of the GOHAI-SP was administered to 100 individuals. The application time was reduced by 7 min. The alpha value for reliability was 0.87. The item-scale correlation coefficients ranged from 0.54 to 0.75, and the test–re-test correlation for the total score was 0.75. There were inverse correlations between GOHAI-SP scores and the number of lost teeth and the decayed-missing-filled teeth index (p Conclusions The GOHAI-SP questionnaire remains a valid and useful tool to assess oral health-related quality of life in primary health care settings. A linguistic update of the questionnaire brought improvements to the instrument application. Trial registration The PREDIMED-Plus trial is registered in the ISRCTN registry with reference number ISRCTN89898870. Registration date: 4th July 2014.
Published: 2020
Full Text: View/download PDF

6. Genomic surveillance of enterovirus associated with aseptic meningitis cases in southern Spain, 2015-2018

Author: Luis Martínez-Martínez, Matthieu Prot, María Cabrerizo, Ana Belén Pérez, Eduardo Agüera, Fabiana Gámbaro, Etienne Simon-Loriere, Maria Dolores Fernandez-Garcia, Regional Government of Andalusia (España), Instituto de Salud Carlos III, Nvidia Corporation, Institut Pasteur [Paris] (IP), Hospital Universitario Reina Sofia [Cordoue, Espagne], Instituto Maimonides de Investigación Biomédica de Cordoba (IMIBIC), Universidad de Córdoba = University of Córdoba [Córdoba]-Hospital Universitario Reina Sofía, Universidad de Córdoba = University of Córdoba [Córdoba], Instituto de Salud Carlos III [Madrid] (ISC), CIBER de Epidemiología y Salud Pública (CIBERESP), IdiPAZ - Instituto de Investigación La Paz [Madrid, Spain], This work was funded by the Junta de Andalucía, Consejería de Salud y Familias (Project number PI-0216-2019) and by the Acción Estratégica en Salud Intramural (Project number PI20CIII/00005). MD Fernandez-Garcia received a Miguel Servet Research Contract (CP18/00067) from the Strategic Action in Health 2018 and funded by National Institute of Health Carlos III (ISCIII). ESL acknowledges funding from the INCEPTION programme (Investissements d’Avenir grant ANR-16-CONV-0005)., ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), [Gámbaro,F, Prot,M, Simon-Loriere,E] Institut Pasteur, Paris, France. [Pérez,AB, Agüera,E, Martínez-Martínez,L] Hospital Universitario Reina Sofía, Córdoba, Spain. [Pérez,AB, Martínez-Martínez,L, and Fernandez-Garcia,MD] Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. [Martínez-Martínez,L] Universidad de Córdoba, Córdoba, Spain. [Cabrerizo,M] National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain. [Cabrerizo,M] CIBER de epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Cabrerizo,M] Red de Investigación Translacional en Infectología Pediátrica (RITIP), IdiPaz, Madrid, Spain.
Subjects: Male, Echovirus, España, medicine.disease_cause, Genome, law.invention, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Human disease, law, Meningitis, Aseptic, Phylogeny, Enterovirus, Multidisciplinary, Aseptic meningitis, Genomics, Enterovirus B, Human, ARN, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Recombinant DNA, Medicine, RNA, Viral, Female, Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome, Microbial::Genome, Viral [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, DNA [Medical Subject Headings], Adult, Adolescent, Genotype, Genómica, Science, Check Tags::Male [Medical Subject Headings], Genome, Viral, Biology, Microbiology, Article, Persons::Persons::Age Groups::Adolescent [Medical Subject Headings], Young Adult, Virology, medicine, Enterovirus Infections, Humans, Meningitis, Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Viral [Medical Subject Headings], Persons::Persons::Age Groups::Adult [Medical Subject Headings], Author Correction, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Outbreak, Sequence Analysis, DNA, medicine.disease, Diseases::Virus Diseases::RNA Virus Infections::Picornaviridae Infections::Enterovirus Infections [Medical Subject Headings], Check Tags::Female [Medical Subject Headings], Metagenomics, Spain, Diseases::Nervous System Diseases::Central Nervous System Diseases::Central Nervous System Infections::Meningitis::Meningitis, Aseptic [Medical Subject Headings], RNA, Organisms::Viruses::RNA Viruses::Picornaviridae::Enterovirus::Enterovirus B, Human [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Phylogeny [Medical Subject Headings], [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract: Author Correction: Genomic surveillance of enterovirus associated with aseptic meningitis cases in southern Spain, 2015-2018. Sci Rep. 2021 Nov 18;11(1):22899. doi: 10.1038/s41598-021-02194-2. New circulating Enterovirus (EV) strains often emerge through recombination. Upsurges of recombinant non-polio enteroviruses (NPEVs) associated with neurologic manifestations such as EVA71 or Echovirus 30 (E30) are a growing public health concern in Europe. Only a few complete genomes of EVs circulating in Spain are available in public databases, making it difficult to address the emergence of recombinant EVs, understand their evolutionary relatedness and the possible implication in human disease. We have used metagenomic (untargeted) NGS to generate full-length EV genomes from CSF samples of EV-positive aseptic meningitis cases in Southern Spain between 2015 and 2018. Our analyses reveal the co-circulation of multiple Enterovirus B (EV-B) types (E6, E11, E13 and E30), including a novel E13 recombinant form. We observed a genetic turnover where emergent lineages (C1 for E6 and I [tentatively proposed in this study] for E30) replaced previous lineages circulating in Spain, some concomitant with outbreaks in other parts of Europe. Metagenomic sequencing provides an effective approach for the analysis of EV genomes directly from PCR-positive CSF samples. The detection of a novel, disease-associated, recombinant form emphasizes the importance of genomic surveillance to monitor spread and evolution of EVs. This work was funded by the Junta de Andalucía, Consejería de Salud y Familias (Project number PI-0216-2019) and by the Acción Estratégica en Salud Intramural (Project number PI20CIII/00005). MD Fernandez-Garcia received a Miguel Servet Research Contract (CP18/00067) from the Strategic Action in Health 2018 and funded by National Institute of Health Carlos III (ISCIII). ESL acknowledges funding from the INCEPTION programme (Investissements d’Avenir grant ANR-16-CONV-0005). Sí
Published: 2021
Full Text: View/download PDF

7. Impact of the COVID-19 Pandemic on Palliative Care in Cancer Patients in Spain

Author: Cristina M. Beltran-Aroca, Eloy Girela-López, Antonio Llergo-Muñoz, Rafael Ruiz-Montero, Leticia Rubio, [Beltran-Aroca,CM, and Girela-López,E] Section of Legal and Forensic Medicine, Facultad de Medicina y Enfermería, Universidad de Córdoba, Córdoba, Spain. [Ruiz-Montero,R] Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía, Universidad de Córdoba, Avenida Menéndez Pidal s/n, Córdoba, Spain. [Llergo-Muñoz,A] UGC Cuidados Paliativos, Hospital Universitario Reina Sofía, Avenida Menéndez Pidal s/n, Córdoba, Spain. [Rubio,L] Department of Human Anatomy and Legal Medicine, Instituto de Investigación Biomédica de Málaga (IBIMA), Facultad de Medicina, Universidad de Málaga, Málaga, Spain.
Subjects: medicine.medical_specialty, Palliative care, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings], Health, Toxicology and Mutagenesis, legal medicine, Ética, ECOG Performance Status, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Palliative Care [Medical Subject Headings], Article, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Neoplasms, Pandemic, Health care, Medicine, cancer, Humans, Risk factor, Pandemics, Cancer, Pandemias, Retrospective Studies, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], palliative care, business.industry, SARS-CoV-2, Medicina legal, pandemic, Medical jurisprudence, Ethical issues, Public Health, Environmental and Occupational Health, Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings], COVID-19, Retrospective cohort study, Diseases::Neoplasms [Medical Subject Headings], medicine.disease, Neoplasias, Cuidados paliativos, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], Spain, Emergency medicine, ethical issues, Female, business, Legal medicine
Abstract: Background: The COVID-19 pandemic outbreak has severely affected healthcare organizations worldwide, and the provision of palliative care (PC) to cancer patients has been no exception. The aim of this paper was to analyse the levels of health care provided by the Clinical Management Unit for PC in Córdoba (Spain) for cancer patients. Method: a retrospective cohort study was conducted. It analyzed the PC internal management database including all cancer patients treated in the period of 2018–2021. Results: 1967 cases were studied. There was a drop in cancer cases (p = 0.008), deaths at the PC hospital (p &lt, 0.001), and referrals from primary care (p &lt, 0.001). However, there was a rise in highly complex clinical situations (p = 0.020) and in ECOG performance status scores of 3–4 (p &lt, 0.001). The pandemic was not shown to be a risk factor for survival in the PC program (0.99 [0.82–1.20], p = 0.931). However, being female (p = 0.005), being older and having a high Karnofsky Performance Status (KPS) score (p &lt, 0.001) could be indicators of a longer stay. Conclusion: The COVID-19 pandemic has presented a challenge in the management of patients requiring PC and has highlighted the urgent needs of the healthcare system if it is to continue providing a level of care which meets the needs of patients and their families.
Published: 2021

8. Influence of gender and education on cocaine users in an outpatient cohort in Spain

Author: Antonia Serrano, Fernando Rodríguez de Fonseca, María Flores-López, Juan Jesús Ruiz, Nerea Requena-Ocaña, Francisco Javier Pavón, Nuria García-Marchena, Alicia Martín, Juan Suárez, Pedro Araos, María Pedraz, [Requena-Ocaña,N, Flores-Lopez,M, García-Marchena.N, Pedraz,M, Serrano,A, Suarez,J, Pavón,FJ, Rodríguez de Fonseca,F, Araos,P] Laboratorio de Medicina Regenerativa (LMR), Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain. [Requena-Ocaña,N, San Martín,A] Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Campus de Somosaguas, Pozuelo de Alarcón, Madrid, Spain. [García-Marchena,N] Institut D, Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Unidad de Adicciones-Servicio de Medicina Interna, Campus Can Ruti, Carrer del Canyet s/n, 08916 Badalona, Spain. [Ruiz,JJ] Centro Provincial de Drogodependencias (CPD) de Málaga, Diputación de Málaga, C/Ana Solo de Zaldívar, Málaga, Spain. [Suarez,J] Department of Anatomy, Legal Medicine and History of Science, School of Medicine, University of Malaga, Boulevard Louis Pasteur, Málaga, Spain. [Pavón,FJ] Instituto de Investigación Biomédica de Málaga (IBIMA), Unidad de Gestión Clínica del Corazón, Hospital Universitario Virgen de la Victoria de Málaga, Malaga, Spain. [Pavón,FJ] Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Calle de Melchor Fernández Almagro, Madrid, Spain. [Araos,P] Departamento de Psicobiología y Metdología de las CC del Comportamiento, Facultad de Psicología, Universidad de Málaga, Málaga, Spain., The authors stated that they had received the following financial support for the research, authorship, and/or publication of this article: The present study has been supported by the following research programmes and projects: RETICS Thematic Networks Sub-programme (Addiction Disorders Network, RD16/0017/0001 and RD16/0017/0021), financed by Carlos III Health Institute (ISCIII), Ministry of Economy and Competitiveness (MINECO) and the European Regional Development Fund/European Social Fund (ERDF/ESF), Health Research Projects (PI16/01953, PI16/01689, PI17/02026, and PI19/00886) financed by ISCIII and ERDF/ESF, Research Projects on drug addiction (PND2017/043, PND2018/033, PND2018/044, and PND2019/040) financed by the Government Delegation for the National Plan on Drugs, Ministry of Health, Social and Equality Services, and ERDF/ESF, and Health Research Project (PI-0140-2018) financed by Health and Social Welfare Department, Government of Andalusia, and ERDF/ESF. MFL has a pre-doctoral research contract (PFIS [F18/00249]) financed by the ISCIII. NGM has a ‘Sara Borrell’ Research Contract (CD19/00019) financed by ISCIII and ERDF-EU. AS, JS and FJP have a ‘Miguel Servet’ Research Contract (CPII19/00031, CPII17/00024, and CPII19/00022, respectively) financed by by ISCIII and ERDF-EU. PA has a Research Contract (UMA18-FEDERJA-059) financed by the Department of Economy and Knowledge-Government of Andalusia and ERDF-EU.
Subjects: Male, Educación, España, Trastornos relacionados con cocaína, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Principal Component Analysis [Medical Subject Headings], Psychiatry and Psychology::Mental Disorders::Anxiety Disorders [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Psychiatry and Psychology::Mental Disorders::Mental Disorders Diagnosed in Childhood::Feeding and Eating Disorders of Childhood [Medical Subject Headings], Cohort Studies, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Cocaine, Psychiatry and Psychology::Mental Disorders::Mood Disorders::Depressive Disorder::Depressive Disorder, Major [Medical Subject Headings], Outpatients, Prevalence, Psychology, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings], Diseases::Chemically-Induced Disorders::Substance-Related Disorders::Cocaine-Related Disorders [Medical Subject Headings], media_common, Persons::Persons::Patients::Outpatients [Medical Subject Headings], Multidisciplinary, Alcoholismo, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Sex Factors [Medical Subject Headings], Pacientes ambulatorios, Chemicals and Drugs::Polycyclic Compounds::Bridged Compounds::Bicyclo Compounds::Bicyclo Compounds, Heterocyclic::Azabicyclo Compounds::Tropanes::Cocaine [Medical Subject Headings], Diagnostic and Statistical Manual of Mental Disorders, Eating disorders, Alcoholism, Cohort, Educational Status, Medicine, Female, Diseases::Chemically-Induced Disorders::Substance-Related Disorders::Marijuana Abuse [Medical Subject Headings], Chemicals and Drugs::Organic Chemicals::Aza Compounds::Azabicyclo Compounds::Tropanes::Cocaine [Medical Subject Headings], Adult, medicine.medical_specialty, media_common.quotation_subject, Science, Cocaine-related disorders, Estudios de género, Protective factor, Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders::Alcohol-Related Disorders::Alcoholism [Medical Subject Headings], Clase social, Check Tags::Male [Medical Subject Headings], Major depressive disorder, Article, Education, Information Science::Information Science::Information Services::Documentation::Vocabulary, Controlled::Diagnostic and Statistical Manual of Mental Disorders [Medical Subject Headings], Cocaine-Related Disorders, Prevalence of mental disorders, Sex Factors, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Central Nervous System Depressants::Tranquilizing Agents::Anti-Anxiety Agents [Medical Subject Headings], Trastorno depresivo mayor, Human behaviour, medicine, Humans, Psychiatry and Psychology::Mental Disorders::Schizophrenia and Disorders with Psychotic Features::Psychotic Disorders [Medical Subject Headings], Effects of sleep deprivation on cognitive performance, Risk factor, Psychiatry, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Depressive Disorder, Major, Trastornos de ansiedad, Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition [Medical Subject Headings], business.industry, Addiction, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Policy [Medical Subject Headings], Abstinence, medicine.disease, Health Care::Population Characteristics::Socioeconomic Factors::Educational Status [Medical Subject Headings], Social class, Psychotic Disorders, Check Tags::Female [Medical Subject Headings], Spain, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings], Gender studies, business, Prevalencia, Anxiety disorders
Abstract: Gender significantly influences sociodemographic, medical, psychiatric and addiction variables in cocaine outpatients. Educational level may be a protective factor showing less severe addictive disorders, longer abstinence periods, and better cognitive performance. The aim was to estimate gender-based differences and the influence of educational level on the clinical variables associated with cocaine use disorder (CUD). A total of 300 cocaine-consuming patients undergoing treatments were recruited and assessed using the Psychiatric Research Interview for Substance and Mental Diseases according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Women developed CUD later but exhibited more consumption of anxiolytics, prevalence of anxiety disorders, eating disorders, and major depressive disorders. Alcohol and cannabis use disorders were more frequent in men. A predictive model was created and identified three psychiatric variables with good prognosis for distinguishing between women and men. Principal component analysis helped to describe the different profile types of men and women who had sought treatment. Low educational levels seemed to be a risk factor for the onset, development, and duration of CUD in both genders. Women and men exhibited different clinical characteristics that should be taken into account when designing therapeutic policies. The educational level plays a protective/risk role in the onset, development and progression of CUD, thus prolonging the years of compulsory education and implementing cognitive rehabilitation programmes could be useful.
Published: 2021

9. Metalloproteinases 1 and 3 as Potential Biomarkers in Breast Cancer Development

Author: Amanda Rocío González Ramírez, Sandra Ríos Arrabal, Pablo Torne Poyatos, Alejandro Alonso, Angela Ximena Argote Camacho, María Auxiliadora Olivares Urbano, Juan David Rejón García, María Isabel Núñez, [Argote Camacho,AX] Department of Surgery, Clínico San Cecilio University Hospital, Granada, Spain. [González Ramírez,AR] Bio-Health Research Foundation of Eastern Andalusia—Alejandro Otero (FIBAO), Granada, Spain. [Pérez Alonso,AJ] Department of Surgery, Virgen de las Nieves University Hospital, Granada, Spain. [Rejón García,JD] Andalusian Tumour Bank Network, Granada, Spain. [Olivares Urbano,MA, Ríos Arrabal,S, Nuñez,MI] Department of Radiology and Physical Medicine, University of Granada, Granada, Spain. [Torné Poyatos,P] Department of Surgery and Its Specialties, University of Granada, Granada, Spain. [Nuñez,MI] Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada, Granada, Spain. [Nuñez,MI] Biosanitary Research Institute, ibs.Granada, Granada, Spain., and This research was funded by Fundación Progreso Salud, grant number PI-0730-2013, and by ISCIII, grant number PIE16/00045.
Subjects: Oncology, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Endopeptidases::Metalloendopeptidases::Collagenases::Matrix Metalloproteinase 2 [Medical Subject Headings], Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Metalloproteases [Medical Subject Headings], Metaloproteinasas de la matriz, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings], Disease, Matrix metalloproteinase, medicine.disease_cause, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Endopeptidases::Metalloendopeptidases::Collagenases::Matrix Metalloproteinase 1 [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Cohort Studies, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Endopeptidases::Metalloendopeptidases::Matrix Metalloproteinases::Matrix Metalloproteinases, Secreted::Matrix Metalloproteinase 3 [Medical Subject Headings], MMP inhibitors, Medicine, Breast, Biology (General), Spectroscopy, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Aged, 80 and over, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Metalloproteases::Metalloendopeptidases::Collagenases::Matrix Metalloproteinase 9 [Medical Subject Headings], Mortality rate, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Proteinase Inhibitory Proteins, Secretory::Tissue Inhibitor of Metalloproteinases [Medical Subject Headings], Proteolytic enzymes, Tissue Inhibitor of Metalloproteinases, General Medicine, Diseases::Neoplasms::Neoplastic Processes::Carcinogenesis::Cocarcinogenesis [Medical Subject Headings], Middle Aged, Immunohistochemistry, Computer Science Applications, Chemistry, Matrix Metalloproteinase 9, Disease Progression, Matrix Metalloproteinase 2, Female, Matrix Metalloproteinase 3, Matriz extracelular, MMPs, Matrix Metalloproteinase 1, Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, Pharmacological [Medical Subject Headings], medicine.medical_specialty, QH301-705.5, extracellular matrix, Breast Neoplasms, Catalysis, Article, metalloproteinases, Inorganic Chemistry, Breast cancer, breast cancer, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence [Medical Subject Headings], Internal medicine, Biomarkers, Tumor, Humans, Metaloproteasas, immunohistochemical expression, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, Linfedema del cáncer de mama, Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings], Aged, Retrospective Studies, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression [Medical Subject Headings], business.industry, Organic Chemistry, Inhibidores de la metaloproteinasa de la matriz, biomarkers, Retrospective cohort study, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], medicine.disease, Biomarcadores, Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over [Medical Subject Headings], Spain, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], diagnostic factors, Case-Control Studies, Metalloproteases, business, Carcinogenesis, epithelial-to-mesenchymal transition (EMT)
Abstract: Breast cancer continues to be one of the main causes of morbidity and mortality globally and was the leading cause of cancer death in women in Spain in 2020. Early diagnosis is one of the most effective methods to lower the incidence and mortality rates of breast cancer. The human metalloproteinases (MMP) mainly function as proteolytic enzymes degrading the extracellular matrix and plays important roles in most steps of breast tumorigenesis. This retrospective cohort study shows the immunohistochemical expression levels of MMP-1, MMP-2, MMP-3, and MMP-9 in 154 women with breast cancer and 42 women without tumor disease. The samples of breast tissue are assessed using several tissue matrices (TMA). The percentages of staining (≤50%–&gt, 50%) and intensity levels of staining (weak, moderate, or intense) are considered. The immunohistochemical expression of the MMP-1-intensity (p = 0.043) and MMP-3 percentage (p = 0.018) and intensity, (p = 0.025) present statistically significant associations with the variable group (control–case), therefore, expression in the tumor tissue samples of these MMPs may be related to the development of breast cancer. The relationships between these MMPs and some clinicopathological factors in breast cancer are also evaluated but no correlation is found. These results suggest the use of MMP-1 and MMP-3 as potential biomarkers of breast cancer diagnosis.
Published: 2021

10. Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study

Author: Sandra Colorado, María José Sánchez, Ana Jimenez, Antonio Agudo, Pilar Amiano, Elena Salamanca-Fernández, Marcela Guevara, Nicolás Olea, Fernando Vela, Josu Delfrade, Juan P. Arrebola, Miguel Rodríguez-Barranco, Maria Dolores Chirlaque, [Salamanca-Fernández,E, Rodríguez-Barranco,M, Sánchez,MJ] Andalusian School of Public Health (EASP), Campus Universitario de Cartuja, Granada, Spain. [Salamanca-Fernández,E, Arrebola,JP, Vela,F, Olea,N, Sánchez,MJ] Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain. [Rodríguez-Barranco,M, Amiano,P, Delfrade,J, Chirlaque,MD, Colorado,S, Guevara,M, Sánchez,MJ] CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Amiano,P, Jimenez,A] Public Health Division of Gipuzkoa, BioDonostia Research Institute, Donostia-San Sebastian, Spain. [Delfrade,J, Guevara,M] Navarra Public Health Institute, Pamplona, Spain. [Delfrade,J, Guevara,M] Navarra Institute for Health Research (IdiSNA), Pamplona, Spain. [Chirlaque,MD, Colorado,S] Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. [Chirlaque,MD] Department of Health and Sciences, University of Murcia, Murcia, Spain. [Colorado,S] Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia. [Arrebola,JP, Sánchez,MJ] Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain. [Olea,N] Department of Radiology, University of Granada, Granada, Spain. [Agudo,A] Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute - IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain., and This work was supported by the Ministry of economy and competitiveness and the National Institute of Health: Instituto de Salud Carlos III (ISCIII). Exps: PI14/00067, PI14/01716, PI14/01880, PI14/00556. BA15/00093. FFIS-CC 2016–06 AECC 'Junta provincial de Murcia'. FEDER and AECC 2015. Dr. J.P. Arrebola is under contract within Ramon y Cajal program (RYC-2016-20155, Ministerio de Economía, Industria y Competitividad, Spain). The EPIC-Spain cohort was supported by the Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), the Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain).
Subjects: Oncology, Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants [Medical Subject Headings], Male, Neoplasias de la próstata, Health, Toxicology and Mutagenesis, Endocrine Disruptors, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Cohort Studies, Prostate cancer, Breast cancer, Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Acyclic::Acrylates::Methacrylates::Bisphenol A-Glycidyl Methacrylate [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], education.field_of_study, Factors de risc en les malalties, Hazard ratio, Middle Aged, European Prospective Investigation into Cancer and Nutrition, Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure [Medical Subject Headings], Environmental pollutants, Diseases::Male Urogenital Diseases::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms [Medical Subject Headings], Bisphenol a, Endocrine disruptor, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk [Medical Subject Headings], Neoplasias de la mama, Population study, Female, Public aspects of medicine, RA1-1270, Disruptores endocrinos, Adult, Risk, medicine.medical_specialty, endocrine system, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], Risk factors in diseases, Population, Estudios de cohortes, Case-cohort, Check Tags::Male [Medical Subject Headings], Breast Neoplasms, Càncer de mama, Phenols, Bisfenol A glicidil metacrilato, Internal medicine, Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings], medicine, Humans, Benzhydryl Compounds, education, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings], Aged, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Càncer de pròstata, Proportional hazards model, business.industry, urogenital system, Research, Public Health, Environmental and Occupational Health, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Endocrine Disruptors [Medical Subject Headings], Prostatic Neoplasms, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Benzhydryl Compounds [Medical Subject Headings], Environmental Exposure, medicine.disease, Industrial medicine. Industrial hygiene, RC963-969, Check Tags::Female [Medical Subject Headings], Spain, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Sensitivity and Specificity::Limit of Detection [Medical Subject Headings], business, Contaminantes ambientales
Abstract: This work was supported by the Ministry of economy and competitiveness and the National Institute of Health: Instituto de Salud Carlos III (ISCIII). Exps: PI14/00067, PI14/01716, PI14/01880, PI14/00556. BA15/00093. FFIS-CC 2016-06 AECC "Junta provincial de Murcia". FEDER and AECC 2015. Dr. J.P. Arrebola is under contract within Ramon y Cajal program (RYC-2016-20155, Ministerio de Economia, Industria y Competitividad, Spain). The EPIC-Spain cohort was supported by the Health Research Fund (FIS) -Instituto de Salud Carlos III (ISCIII), the Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology -ICO (Spain)., Background Bisphenol A (BPA) is an endocrine disruptor that it is present in numerous products of daily use. The aim of this study was to assess the potential association of serum BPA concentrations and the risk of incident breast and prostate cancer in a sub-cohort of the Spanish European Prospective Investigation into Cancer and Nutrition (EPIC). Methods We designed a case-cohort study within the EPIC-Spain cohort. Study population consisted on 4812 participants from 4 EPIC-Spain centers (547 breast cancer cases, 575 prostate cancer cases and 3690 sub-cohort participants). BPA exposure was assessed by means of chemical analyses of serum samples collected at recruitment. Borgan II weighted Cox regression was used to estimate hazard ratios. Results Median follow-up time in our study was 16.9 years. BPA geometric mean serum values of cases and sub-cohort were 1.12 ng/ml vs 1.10 ng/ml respectively for breast cancer and 1.33 ng/ml vs 1.29 ng/ml respectively for prostate cancer. When categorizing BPA into tertiles, a 40% increase in risk of prostate cancer for tertile 1 (p = 0.022), 37% increase for tertile 2 (p = 0.034) and 31% increase for tertile 3 (p = 0.072) was observed with respect to values bellow the limit of detection. No significant association was observed between BPA levels and breast cancer risk. Conclusions We found a similar percentage of detection of BPA among cases and sub-cohort from our population, and no association with breast cancer risk was observed. However, we found a higher risk of prostate cancer for the increase in serum BPA levels. Further investigation is needed to understand the influence of BPA in prostate cancer risk., Ministry of economy and competitiveness, National Institute of Health: Instituto de Salud Carlos III (ISCIII), AECC "Junta provincial de Murcia" PI14/00067- PI14/01716- PI14/01880- PI14/00556- BA15/00093- FFIS-CC 2016-06, Spanish Government RYC-2016-20155, Health Research Fund (FIS) -Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, Catalan Institute of Oncology -ICO (Spain)
Published: 2021

11. In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain

Author: Suárez-García, Inés, Perales-Fraile, Isabel, González-García, Andrés, Muñoz-Blanco, Arturo, Manzano, Luis, Fabregate, Martín, Díez-Manglano, Jesús, Aizpuru, Eva Fonseca, Fernández, Francisco Arnalich, García, Alejandra García, Gómez-Huelgas, Ricardo, Ramos-Rincón, José-Manuel, SEMI-COVID-19 Network, SEMI-COVID-19 Network, [Suárez-García,I] Infectious Diseases Group, Department of Internal Medicine, Hospital Universitario Infanta Sofía, FIIB HUIS HHEN, Madrid, Spain. [Suárez-García,I, Perales-Fraile,I] Facultad de Ciencias Biomédicas y de la Salud, Universidad Europea, Madrid, Spain. [Perales-Fraile,I] Department of Internal Medicine, Hospital Universitario Infanta Sofía, FIIB HUIS HHEN, Madrid, Spain. [González-García,A] Unidad de Enfermedades Sistémicas Autoinmunes y Minoritarias, Servicio de Medicina Interna, IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Muñoz-Blanco,A] Department of Internal Medicine, Hospital Universitario Infanta Sofía, Madrid, Spain. [Manzano,L, and Fabregate,M] Servicio de Medicina Interna, IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Díez-Manglano,J] Servicio de Medicina Interna, Hospital Royo Vilanova, Zaragoza, Spain. [Fonseca Aizpuru,E] Servicio de Medicina Interna, Hospital de Cabueñes, Gijón, Asturias, Spain. [Arnalich Fernández,F] Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid, Spain. [García García,A] Servicio de Medicina Interna, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Gómez-Huelgas,R] Internal Medicine Department, Regional University Hospital of Málaga, Biomedical Research Institute of Málaga (IBIMA), University of Málaga (UMA), Málaga, Spain. [Ramos-Rincón,JM] Department of Clinical Medicine, Miguel Hernandez University of Elche, Alicante, Spain.
Subjects: Male, Phenomena and Processes::Immune System Phenomena::Immunocompromised Host [Medical Subject Headings], Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Shock::Multiple Organ Failure [Medical Subject Headings], España, Logistic regression, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Hematologic Cancers and Related Disorders, 0302 clinical medicine, Medical Conditions, Odds Ratio, Hospital Mortality, Aged, 80 and over, Hematology, Organic Compounds, Prognosis, Virus, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Models [Medical Subject Headings], Oncology, Nephrology, Hematologic Neoplasms, Physical Sciences, Medicine, Cohort study, medicine.medical_specialty, Myocarditis, Science, Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Hematologic Neoplasms [Medical Subject Headings], Multiple Organ Failure, Immunology, Check Tags::Male [Medical Subject Headings], Heart failure, Oportunidad relativa, 03 medical and health sciences, Signs and Symptoms, Humans, Aged, Retrospective Studies, Chemicals and Drugs::Polycyclic Compounds::Steroids [Medical Subject Headings], Chemical Compounds, Biology and Life Sciences, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Covid 19, Odds ratio, medicine.disease, Logistic Models, Check Tags::Female [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Registries [Medical Subject Headings], Clinical Medicine, Neoplasias hematológicas, Viral Diseases, Diseases::Cardiovascular Diseases::Heart Diseases::Cardiomyopathies::Myocarditis [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings], Cancer Treatment, 030204 cardiovascular system & hematology, Lung and Intrathoracic Tumors, Mortalidad hospitalaria, Cohort Studies, Medicine and Health Sciences, 030212 general & internal medicine, Registries, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Odds Ratio [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Diseases::Respiratory Tract Diseases::Lung Diseases::Respiratory Distress Syndrome, Adult [Medical Subject Headings], Multidisciplinary, Diagnóstico, Insuficiencia cardíaca, Middle Aged, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunosuppression [Medical Subject Headings], Insuficiencia multiorgánica, Hospitalization, Chemistry, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization [Medical Subject Headings], Infectious Diseases, Renal Cancer, Miocarditis, Steroids, Female, Research Article, Immune Suppression, Inmunosupresión, Immunocompromised Host, Internal medicine, medicine, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, SARS-CoV-2, Organic Chemistry, Cancer, Diseases::Cardiovascular Diseases::Heart Diseases::Heart Failure [Medical Subject Headings], Cancers and Neoplasms, COVID-19, Retrospective cohort study, Huésped Inmunocomprometido, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], Spain, Mortalidad, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Hospital Mortality [Medical Subject Headings], business, Immunosuppression
Abstract: BackgroundWhether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of this study was to evaluate the clinical characteristics and outcome of IS patients hospitalized with COVID-19 compared to non-IS patients.MethodsWe designed a retrospective cohort study. We included all patients hospitalized with laboratory-confirmed COVID-19 from the SEMI-COVID-19 Registry, a large multicentre national cohort in Spain, from March 27thuntil June 19th, 2020. We used multivariable logistic regression to assess the adjusted odds ratios (aOR) of in-hospital death among IS compared to non-IS patients.ResultsAmong 13 206 included patients, 2 111 (16.0%) were IS. A total of 166 (1.3%) patients had solid organ (SO) transplant, 1081 (8.2%) had SO neoplasia, 332 (2.5%) had hematologic neoplasia, and 570 (4.3%), 183 (1.4%) and 394 (3.0%) were receiving systemic steroids, biological treatments, and immunosuppressors, respectively. Compared to non-IS patients, the aOR (95% CI) for in-hospital death was 1.60 (1.43–1.79) for all IS patients, 1.39 (1.18–1.63) for patients with SO cancer, 2.31 (1.76–3.03) for patients with haematological cancer and 3.12 (2.23–4.36) for patients with SO transplant. The aOR (95% CI) for death for patients who were receiving systemic steroids, biological treatments and immunosuppressors compared to non-IS patients were 2.16 (1.80–2.61), 1.97 (1.33–2.91) and 2.06 (1.64–2.60), respectively. IS patients had a higher odds than non-IS patients of in-hospital acute respiratory distress syndrome, heart failure, myocarditis, thromboembolic disease and multiorgan failure.ConclusionsIS patients hospitalized with COVID-19 have a higher odds of in-hospital complications and death compared to non-IS patients.
Published: 2021
Full Text: View/download PDF

12. Use of Different Food Classification Systems to Assess the Association between Ultra-Processed Food Consumption and Cardiometabolic Health in an Elderly Population with Metabolic Syndrome (PREDIMED-Plus Cohort)

Author: Josep Vidal, Jose M. Ordovas, José Alfredo Martínez, Ángel M. Alonso-Gómez, Estefanía Toledo, Nerea Becerra-Tomás, Dolores Corella, Aurora Bueno-Cavanillas, Jessica Vaquero-Luna, María Concepción Barceló-Iglesias, Beatriz Pérez-Sanz, Antonio García Ríos, María Julia Ajejas Bazán, Ramon Estruch, Vicente Martín Sánchez, Rodrigo San-Cristobal, Miguel Ángel Martínez-González, Xavier Pintó, Dora Romaguera, Jesús Vioque, José J. Gaforio, Pilar Matía-Martín, Lluis Serra-Majem, Itziar Abete, Camille Lassale, Júlia Muñoz-Martínez, Jose Lopez-Miranda, Stephanie K. Nishi, José Lapetra, Lidia Daimiel, Anai Moreno-Rodriguez, Clotilde Vázquez, José V. Sorlí, Celia Martinez-Perez, José Manuel Santos-Lozano, Maira Bes-Rastrollo, Julia Wärnberg, Emilio Ros, María Rosa Bernal-López, Pilar Guallar-Castillón, Nancy Babio, Oscar Lecea-Juarez, María Dolores Zomeño, Olga Castañer, Josep A. Tur, Jordi Salas-Salvadó, Francisco J. Tinahones, Olga Portolés, Jadwiga Konieczna, [Martinez-Perez,C, Ordovás,JM, Daimiel,L] Nutritional Genomics and Epigenomics Group, Precision Nutrition and Obesity Program, IMDEA Food, CEI UAM + CSIC, Madrid, Spain. [San-Cristobal,R, Martinez, JA] Cardiometabolic Nutrition Group, Precision Nutrition and Cardiometabolic Health Program, IMDEA Food, CEI UAM + CSIC, Madrid, Spain. [Guallar-Castillon,P] Cardiovascular and Nutritional Epidemiology Group, IMDEA Food, CEI UAM + CSIC, Madrid, Spain. [Guallar-Castillon,P] Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid—IdiPaz Hospital, Madrid, Spain. [Guallar-Castillon,P, Vioque,J, Bueno-Cavanillas,A, Martín Sánchez,V, Gaforio,JJ] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. [Guallar-Castillon,P] Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, USA. [Martínez-González,MA, Salas-Salvadó,J, Corella,D, Castañer,O, Martinez,JA, Alonso-Gómez,AM, Wärnberg,J, Romaguera,D, López-Miranda,J, Estruch,R, Tinahones,FJ, Lapetra,J, Serra-Majem,L, Tur,JA, Pintó,X, Vázquez,C, Ros,E, Bes-Rastrollo,M, Babio,N, Sorlí,JV, Lassale,C, Vaquero-Luna,J, Konieczna,J, García Ríos,A, Santos-Lozano,JM, Toledo,E, Becerra-Tomás,N, Portoles,O, Abete,I, Moreno-Rodriguez,A] Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Martínez-González,MA, Toledo,E] Department of Preventive Medicine and Public Health, University of Navarra, IdiSNA, Pamplona, Spain. [Martínez-González,MA] Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA. [Salas-Salvadó,J, Becerra-Tomás,T, Nishi,SK] Unitat de Nutrició Humana, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Reus, Spain. [Salas-Salvadó,J, Becerra-Tomás,N] Human Nutrition Unit, Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain. [Corella,D, Portoles,O] Department of Preventive Medicine, University of Valencia, Valencia, Spain. [Castañer,O, Zomeño,MD, Muñoz-Martínez,J] Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. [Martinez,JA, Pérez-Sanz,B, Abete,I] Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain. [Alonso-Gómez,AM, Moreno-Rodriguez,A] Bioaraba Health Research Institute, Osakidetza Basque Health Service, Araba University Hospital, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain. [Wärnberg, Ajejas Bazán,MJ] Department of Nursing, School of Health Sciences, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, Málaga. [Vioque,J] Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-UMH), Alicante, Spain. [Romaguera,D, Konieczna,J] Research Group on Nutritional Epidemiology & Cardiovascular Physiopathology (NUTRECOR), Health Research Institute of the Balearic Islands (IdISBa), University Hospital Son Espases (HUSE), Palma de Mallorca, Spain. [López-Miranda,J, García Ríos,A] Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Córdoba, Spain. [Estruch,R] Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain. [Tinahones,FJ] Department of Endocrinology, Instituto de Investigación Biomédica de Málaga (IBIMA), Virgen de la Victoria Hospital, University of Málaga, Málaga, Spain. [Lapetra,J, Santos-Lozano,JM] Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, Sevilla, Spain. [Serra-Majem,L] Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria and Service of Preventive Medicine, Complejo Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canary Health Service, Las Palmas de Gran Canaria, Spain. [Bueno-Cavanillas,A] Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain. [Tur,JA] Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands-IUNICS & IDISBA, Palma de Mallorca, Spain. [Martín Sánchez,V] Institute of Biomedicine (IBIOMED), University of León, León, Spain. [Pintó,X] Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain. [Gaforio,JJ] Departamento de Ciencias de la Salud, Centro de Estudios Avanzados en Olivar y Aceites de Oliva, Universidad de Jaén, Jaén, Spain. [Matía-Martín,P] Department of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Vidal,J] Biomedical Research Centre for Diabetes and Metabolic Diseases Network (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Vidal,J, Ros,E] Endocrinology and Nutrition Service, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain. [Vázquez,C] Department of Endocrinology and Nutrition, Hospital Fundación Jiménez Díaz, Instituto de Investigaciones Biomédicas IISFJD, University Autónoma, Madrid, Spain. [Ajejas Bazán,MJ] Department of Nursing, Faculty of Nursing, Physiotherapy and Podiatry, Universidad Complutense de Madrid, Madrid, Spain. [Barceló-Iglesias,MC] Centro Salud Cabo Huertas, Alicante, Spain. [Bernal-López,MR] Internal Medicine Department, Instituto de Investigación Biomédica de Málaga (IBIMA), Regional University Hospital of Malaga, Malaga, Spain. [Zomeño,MD] School of Health Sciences, Blanquerna-Ramon Llull University, Barcelona, Spain. [Lecea-Juarez,O] Atención Primaria, Osasunbidea, Servicio Navarro de Salud, Pamplona, Spain. [Ordovás,JM] Nutrition and Genomics Laboratory, JM_USDA Human Nutrition Research Center on Aging, Tufts University, Boston, USA., The PREDIMED-Plus trial was supported by the European Research Council (Advanced Research grant 2014–2019, agreement #340918, granted to M.Á.M.-G.), the official Spanish institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigación para la Salud (FIS) which is co-funded by the European Regional Development Fund (coordinated FIS projects led by J.S-S. and J.V., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332), and the Especial Action Project 'Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus' (J.S.-S.), the Recercaixa (grant number 2013ACUP00194) (J.S.-S.). Moreover, J.S-S. gratefully acknowledges the financial support by ICREA under the ICREA Academia program, the SEMERGEN grant, Department of Health of the Government of Navarra (61/2015), the Fundació La Marató de TV (Ref. 201630.10), the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 (D.R.), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant, grant of support to research groups 35/2011 (Balearic Islands Government, and FEDER funds) (J.A.T.). R.S.-C. acknowledges financial support from the Juan de la Cierva Program Training Grants of the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades (FJC2018-038168- I). N.B.-T. acknowledges financial support from the Juan de la Cierva Formación Program Training Grants of the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades (FJC2018-036016-I). M.R.B.-L. was supported by 'Miguel Servet Type I' program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER. S.K.N. acknowledges financial support from the Canadian Institute for Health Research, CIHR Fellowship. J.K. was supported by the ‘FOLIUM’ programme within the FUTURMed project from the Fundación Instituto de Investigación Sanitaria Illes Balears (financed by 2017 annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Program 2014–2020 of the Balearic Islands. C.M.-P. was financially supported by a joint grant from the Community of Madrid and the European Social Fund (grant PEJD-2019-POST/SAL-15892). The METHYL-UP project was supported by the Spanish Ministry of Science and Innovation (RTI2018-095569-B-I00, Programa de Proyectos Orientados a los Retos de la Sociedad 'Projects Toward Society Challenges Program').
Subjects: Síndrome metabólico, Male, Food processing, Mediterranean diet, NOVA, Obesidad, Índice de masa corporal, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, ultra-processed food, Medicine, TX341-641, Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight [Medical Subject Headings], Body mass index, classification systems, Incidence, IARC, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings], Metabolic syndrome, 3. Good health, Nutrición, Cohort, Manipulación de alimentos, Dieta, Factores de riesgo cardiometabólico, Concordance, UNC, Check Tags::Male [Medical Subject Headings], Clasificación, Classification systems, Diet Surveys, Article, 03 medical and health sciences, food processing, Humans, Diseases::Cardiovascular Diseases [Medical Subject Headings], Aged, 030109 nutrition & dietetics, Health Care::Health Care Economics and Organizations::Organizations::International Agencies [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], PREDIMED-Plus, medicine.disease, Obesity, Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [Medical Subject Headings], Blood pressure, Check Tags::Female [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], Linear Models, Fast Foods, Older people, 0301 basic medicine, Síndrome metabòlica, Food Handling, Overweight, Diet, Mediterranean, Persones grans, Cohort Studies, cardiometabolic risk, Endocrinología, 030212 general & internal medicine, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], 2. Zero hunger, Metabolic Syndrome, Nutrition and Dietetics, Technology and Food and Beverages::Technology, Industry, and Agriculture::Industry::Food Industry::Food Handling [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Diet Therapy::Diet, Mediterranean [Medical Subject Headings], Middle Aged, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Nutrition Surveys::Diet Surveys [Medical Subject Headings], Female, Technology and Food and Beverages::Food and Beverages::Food::Fast Foods [Medical Subject Headings], medicine.symptom, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance::Metabolic Syndrome X [Medical Subject Headings], Dietética y nutrición, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings], Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence [Medical Subject Headings], Environmental health, Alimentos ultraprocesados, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Linear Models [Medical Subject Headings], Nutrició, Nutrition, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, Nutrition. Foods and food supply, Cardiometabolic Risk Factors, Dieta mediterránea, Cardiometabolic risk, Ultra-processed food, Diet, Spain, IFIC, Sobrepeso, business, diet, Food Science
Abstract: The PREDIMED-Plus trial was supported by the European Research Council (Advanced Research grant 2014–2019; agreement #340918; granted to M.Á.M.-G.); the official Spanish institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigación para la Salud (FIS) which is co-funded by the European Regional Development Fund (coordinated FIS projects led by J.S-S. and J.V., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332), and the Especial Action Project “Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus” (J.S.-S.); the Recercaixa (grant number 2013ACUP00194) (J.S.-S.). Moreover, J.S-S. gratefully acknowledges the financial support by ICREA under the ICREA Academia program; the SEMERGEN grant; Department of Health of the Government of Navarra (61/2015), the Fundació La Marató de TV (Ref. 201630.10); the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 (D.R.); grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant; grant of support to research groups 35/2011 (Balearic Islands Government; FEDER funds) (J.A.T.). R.S.-C. acknowledges financial support from the Juan de la Cierva Program Training Grants of the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades (FJC2018-038168- I). N.B.-T. acknowledges financial support from the Juan de la Cierva Formación Program Training Grants of the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades (FJC2018-036016-I). M.R.B.-L. was supported by “Miguel Servet Type I” program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER. S.K.N. acknowledges financial support from the Canadian Institute for Health Research, CIHR Fellowship. J.K. was supported by the ‘FOLIUM’ programme within the FUTURMed project from the Fundación Instituto de Investigación Sanitaria Illes Balears (financed by 2017 annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Program 2014–2020 of the Balearic Islands. C.M.-P. was financially supported by a joint grant from the Community of Madrid and the European Social Fund (grant PEJD-2019- POST/SAL-15892). The METHYL-UP project was supported by the Spanish Ministry of Science and Innovation (RTI2018-095569-B-I00, Programa de Proyectos Orientados a los Retos de la Sociedad “Projects Toward Society Challenges Program”)., The association between ultra-processed food (UPF) and risk of cardiometabolic disorders is an ongoing concern. Different food processing-based classification systems have originated discrepancies in the conclusions among studies. To test whether the association between UPF consumption and cardiometabolic markers changes with the classification system, we used baseline data from 5636 participants (48.5% female and 51.5% male, mean age 65.1 4.9) of the PREDIMEDPlus (“PREvention with MEDiterranean DIet”) trial. Subjects presented with overweight or obesity and met at least three metabolic syndrome (MetS) criteria. Food consumption was classified using a 143-item food frequency questionnaire according to four food processing-based classifications: NOVA, International Agency for Research on Cancer (IARC), International Food Information Council (IFIC) and University of North Carolina (UNC). Mean changes in nutritional and cardiometabolic markers were assessed according to quintiles of UPF consumption for each system. The association between UPF consumption and cardiometabolic markers was assessed using linear regression analysis. The concordance of the different classifications was assessed with intra-class correlation coefficients (ICC3, overall = 0.51). The highest UPF consumption was obtained with the IARC classification (45.9%) and the lowest with NOVA (7.9%). Subjects with high UPF consumption showed a poor dietary profile. We detected a direct association between UPF consumption and BMI (p = 0.001) when using the NOVA system, and with systolic (p = 0.018) and diastolic (p = 0.042) blood pressure when using the UNC system. Food classification methodologies markedly influenced the association between UPF consumption and cardiometabolic risk markers., European Research Council (ERC) European Commission #340918, Centro de Investigacion Biomedica en Red-Fisiopatologia de la Obesidad y Nutricion PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441 PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471 PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332
Published: 2021
Full Text: View/download PDF

13. Health, Work, and Social Problems in Spanish Informal Caregivers: Does Gender Matter? (The CUIDAR-SE Study)

Author: Juan Oliva-Moreno, Luz María Peña-Longobardo, Isabel Larrañaga-Padilla, María del Mar García-Calvente, María del Río-Lozano, [Peña-Longobardo,LM, Oliva-Moreno,J] Departamento de Análisis Económico y Seminario de Investigación en Economía y Salud (SIES), Universidad de Castilla-La Mancha, Toledo, Spain. [Río-Lozano,MD, García-Calvente,MDM] Escuela Andaluza de Salud Pública (EASP), Granada, Spain. [Río-Lozano,MD, García-Calvente,MDM] Instituto de Investigación Biosanitaria de Granada ibs. Granada, Granada, Spain. [Larrañaga-Padilla,I] Departamento de Salud del Gobierno Vasco, Delegación de Salud de Gipuzkoa, San Sebastián, Spain., and This project has received funding from Instituto de Salud Carlos III and the European Regional Development Fund (PI12/00498 and PI16/00207) and from Ministry of Economy (ECO2017-83771-C3-1-R). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Subjects: Male, Gerontology, Health, Toxicology and Mutagenesis, Psychological intervention, Primary health care, Logistic regression, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Características sexuales, Atención al paciente, Gender differences, 030212 general & internal medicine, Problemas sociales, caregiver, Health work, Salud global, 030503 health policy & services, Gender Identity, Cuidadores, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Social Environment::Social Support [Medical Subject Headings], Informal care, social problems, informal care, Caregivers, gender differences, Social relationship, Medicine, Female, 0305 other medical science, Psychology, Social problems, Adult, Family home, Adolescent, Check Tags::Male [Medical Subject Headings], Social issues, Article, Persons::Persons::Age Groups::Adolescent [Medical Subject Headings], Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Social Problems [Medical Subject Headings], 03 medical and health sciences, Social support, Persons::Persons::Caregivers [Medical Subject Headings], Humans, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Health problems, Public Health, Environmental and Occupational Health, Social Support, work problems, Caregiver, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Personality::Personality Development::Psychosexual Development::Gender Identity [Medical Subject Headings], Check Tags::Female [Medical Subject Headings], Spain, health problems, Work problems
Abstract: (1) Background: The aim of this study was (i) to analyze problems faced by informal caregivers in three areas of their life: health, work and finances, and family and social relationships, (ii) to investigate the main determinants of these problems, and (iii) to explore differences between men and women. (2) Methods: The study population consisted of people aged ≥18 years living in a family home who were providing unpaid care to a dependent person in the same or another home and who were registered as caregivers with the Primary Health Care District of Granada or the Provincial Council of Gipuzkoa. Several logistic regression models were built to analyze the likelihood of caregivers experiencing health, work-related, or social problems as a result of their caregiving responsibilities. (3) Results: Informal female caregivers were more likely to experience problems attributed to caregiving than their male counterparts, particularly in the areas of health and work. Additional factors associated with an increased likelihood of problems were low perceived social support, performance of ungratifying tasks, and fewer years as a caregiver. (4) Conclusions: Informal caregivers in Spain face significant problems as a result of their caregiving duties, and the impact on men and women is different. Policies and interventions to mitigate the negative effects of unpaid caregiving should incorporate differential strategies to meet the specific needs of male and female caregivers in different caregiving contexts.
Published: 2021

14. Medidas de contención de la violencia de género durante la pandemia de COVID-19

Author: Isabel Ruiz-Pérez, Guadalupe Pastor-Moreno, [Ruiz-Pérez,I, Pastor-Moreno,G] Escuela Andaluza de Salud Pública, Granada, España. [Ruiz-Pérez,I] CIBER de Epidemiología y Salud Pública (CIBERESP), España., and Este trabajo ha sido financiado por el CIBER de Epidemiología y Salud Pública (CIBERESP).
Subjects: Counseling, Domestic Violence, Health Care::Environment and Public Health::Public Health::Public Health Practice::Communicable Disease Control::Infection Control::Quarantine [Medical Subject Headings], Declaration, Gender-Based Violence, Pandemia de COVID-19, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Social Problems::Violence::Domestic Violence [Medical Subject Headings], 030212 general & internal medicine, media_common, Economic uncertainty, 030503 health policy & services, Welfare economics, Cuarentena, Mobile Applications, Police, Europe, Women's Health Services, Quarantine, Health Resources, Female, Public aspects of medicine, RA1-1270, 0305 other medical science, Adult, media_common.quotation_subject, COVID-19 pandemic, Health Care::Health Services Administration::Organization and Administration::Security Measures [Medical Subject Headings], 03 medical and health sciences, Emergency Shelter, Hotlines, Political science, Humans, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Socioeconomic Factors [Medical Subject Headings], Pandemics, Royal decree, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Violencia de compañero íntimo, Contingency plan, Government, Information Dissemination, SARS-CoV-2, Emergency Medical Service Communication Systems, Public Health, Environmental and Occupational Health, COVID-19, Social Support, Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings], Unrest, United States, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], Intimate partner violence, Interpersonal violence, Crisis Intervention, Latin America, Spain, Communicable Disease Control, Unemployment, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Criminology::Crime::Violence::Domestic Violence [Medical Subject Headings]
Abstract: Resumen: Las crisis, las emergencias y las épocas de disturbios se han relacionado con un aumento de la violencia interpersonal, incluida la violencia hacia las mujeres. A raíz de la declaración de estado de alarma y confinamiento se han puesto en marcha nuevas medidas encaminadas a paliar el posible impacto de la violencia de género (Plan de Contingencia contra la violencia de género ante la crisis del coronavirus o Real Decreto-Ley de medidas urgentes). Se revisan en este documento las medidas de contención adoptadas hasta el momento por el gobierno de España y las comunidades autónomas, y las iniciativas formuladas en diferentes países. Ante la ausencia de medidas económicas concretas planteadas hasta la fecha y el escenario de incertidumbre económica concluimos que no es posible prevenir la violencia de género de manera integral sin considerar el aumento del desempleo, la temporalidad y la inestabilidad laboral, la dependencia económica o la sobrecarga de tareas reproductivas, entre otros elementos que la facilitan. Abstract: Crises, emergencies and times of unrest have been linked to increased interpersonal violence, including violence against women. Following the declaration of alarm status and quarantine, different measures have been implemented to mitigate the possible effect of gender violence (Contingency Plan against Gender-Based Violence in Coronavirus Crisis or Royal Decree Law on Emergency Measures). This document reviews the measures adopted so far by the government of Spain, the autonomous governments and the initiatives formulated in different countries. In the absence of concrete economic measures to date, and the scenario of economic uncertainty, we conclude that it is not possible to prevent gender-based violence in a comprehensive way, without considering the increase in unemployment, temporary and instability employment, economic dependency or the overload of household chores and reproductive tasks, among other elements that facilitate it.
Published: 2021
Full Text: View/download PDF

15. Anxiety and fear related to coronavirus disease 2019 assessment in the Spanish population: A cross-sectional study

Author: Regina Allande-Cussó, Juan Jesús García-Iglesias, Juan Gómez-Salgado, Adolfo Romero Ruiz, Marta Linares Manrique, Carlos Ruiz-Frutos, Macarena Romero-Martín, [Allande-Cussó,R] Nursing Department, Faculty of Nursing, Podiatry and Physiotherapy, University of Seville, Seville, Spain. [Linares Manrique,M] Nursing Department, Faculty of Health Sciences of Melilla, University of Granada, Spain. [Gómez-Salgado,J, García-Iglesias,JJ, Ruiz-Frutos,C] Department of Sociology, Social Work and Public Health, Faculty of Labour Sciences, University of Huelva, Spain. [Gómez-Salgado,J, Ruiz-Frutos,C] Safety and Health Postgraduate Programme, Universidad de Especialidades Espíritu Santo, Ecuador. [Romero Ruiz,A] Nursing and Podiatry Department, Faculty of Health Sciences, University of Málaga, Spain, Malaga, Spain. [Romero Ruiz,A] Instituto de Investigación Biomédica de Málaga (IBIMA), Malaga, Spain. [Romero-Martín,M] Department of Nursing, Faculty of Nursing, University of Huelva, Spain., and Universidad de Sevilla. Departamento de Enfermería
Subjects: Male, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Cross-sectional study, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Check Tags::Male [Medical Subject Headings], Surveys, Anxiety, Stress, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Ansiedad, Salud pública, Environmental health, Pandemic, Miedo, Humans, Medicine, Survey, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Anxiety [Medical Subject Headings], Aged, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Public health, Multidisciplinary, Coronavirus disease 2019, SARS-CoV-2, business.industry, Questionnaire, COVID-19, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Fear, Middle Aged, 3212 Salud Publica, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], Spanish population, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Cross-Sectional Studies, Encuestas y cuestionarios, Check Tags::Female [Medical Subject Headings], Spain, Estrés fisiológico, Female, medicine.symptom, business, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Fear [Medical Subject Headings]
Abstract: Background:The coronavirus disease 2019 pandemic has affected millions of people worldwide, compromising the responsiveness of governments and states and thus generating anxiety and fear at the population level.Objective:To assess the level of anxiety and fear of coronavirus disease 2019 in a Spanish adult population group.Methods:A descriptive cross-sectional study, using the anxiety and fear of COVID-19 assessment scale (AMICO, for its acronym in Spanish). The sample was composed of 1038 subjects. Univariate and bivariate statistical analyses were performed, after analysis of normality in the data distribution. Categorical regression analyses were also executed.Findings:The total sample size was 1036 subjects, 56.3% was made up of females, with a mean age of 48.11 years (SD = 15.13). The mean score obtained on the AMICO scale was 5.54 points (SD = 1.83), with a score range between 1.22 and 10. Bivariate analysis only demonstrated statistically significant differences in the mean score of the scale and the variables: sex, marital status, work area and academic level. The executed categorical regression analysis revealed an R2value of 0.75 and a significance of p = 0.00.Conclusions:The results obtained show that the Spanish population presents moderate anxiety levels to coronavirus disease 2019. Women, married, with primary and/or secondary education level, and working in the public transport, services and/or hospitality sectors are more likely to have high levels of fear and anxiety.Application to Practice:These results could be used for therapeutic and preventive psychological interventions, and also to plan new research under sex perspective and observing the socio-economic environment.
Published: 2021

16. Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis

Author: Immaculada Grau, Cristina Garcia-de-la-Maria, José Antonio Lepe Jiménez, Lara García-Álvarez, Mercedes Marín, Carmen Ardanuy, José M. Miró, Patricia Muñoz, José María Marimón, Arístides de Alarcón, Manuel Almela, Miguel Ángel Goenaga, Beatriz Orden, Javier de la Torre, Enrique Navas, F. Fernandez, María Ercibengoa, Carlos Ruiz de Alegría, María Carmen Fariñas, José A. Oteo, Universidad de Cantabria, Institut d'Investigacions Biomèdiques August Pi i Sunyer, [Ercibengoa,M, Ardanuy,C, Grau,I, Marín,M, Muñoz,P, Marimón,JM] CIBER Enfermedades Respiratorias-CIBERES, Madrid, Spain. [Goenaga,MA] Servicio de Enfermedades Infecciosas, Hospital Universitario, Donostia, Spain. [Ardanuy,C] Servicio de Microbiologia, Hospital Universitari de Bellvitge. Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), University of Barcelona, Barcelona, Spain. [Grau,I] Servicio de Enfermedades Infecciosas, Hospital Universitari de Bellvitge. Institut d’ Investigació Biomèdica de Bellvitge (IDIBELL), University of Barcelona, Barcelona, Spain. [García-de-la-Maria,C, Miro,JM] Servicio de Enfermedades Infecciosas, Hospital Clínic de Barcelona, Institut d’ Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. [Almela,M] Servicio de Microbiología, Hospital Clínic de Barcelona, Institut d’ Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [Navas,E] Servicio de Enfermedades Infecciosas, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Fariñas,MC] Servicio de Enfermedades Infecciosas, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain. [Ruiz de Alegría,C] Servicio de Microbiología, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain. [de la Torre,J] Grupo de Enfermedades Infecciosas de la Unidad de Medicina Interna, Hospital Costa del Sol, Marbella, Málaga, Spain. [Fernández,F] Servicio de Microbiología, Hospital Costa del Sol, Marbella, Málaga, Spain. [Marín,M, Muñoz,P] Departamento de Medicina, Servicio de Microbiología y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio, Marañón, Madrid, Spain. [Orden,B] Departamento de Microbiología, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain. [Oteo,JA, García-Álvarez,L] Departamento de Enfermedades Infecciosas, Hospital Universitario San Pedro, Logroño, La Rioja, Spain. [de Alarcón,A, and Lepe Jiménez,JA] Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine. Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBIS), University of Seville/CSIC/University Virgen del Rocío and Virgen Macarena, Sevilla, Spain. [Marimón,JM] Servicio de Microbiología, Hospital Universitario Donostia-IIS Biodonostia, San Sebastián, Spain.
Subjects: 0301 basic medicine, Male, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings], Epidemiology, Antibiotic resistance, Antibiotics, Bacteremia, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Estreptococos viridans, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Medical microbiology, Diagnòstic, Risk Factors, Monitoreo epidemiológico, Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Streptococcal Infections [Medical Subject Headings], Diagnosis, 030212 general & internal medicine, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Aged, 80 and over, Endocarditis, Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Bacteremia [Medical Subject Headings], Streptococcus Viridans, Middle Aged, Prognosis, Viridans Streptococci, Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Endocarditis, Bacterial [Medical Subject Headings], Multicenter study, Infeccions, Infectious Diseases, Epidemiologic surveillance, Infective endocarditis, Epidemiological Monitoring, Female, Persons::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings], Research Article, Adult, medicine.medical_specialty, Multicentre studies, medicine.drug_class, 030106 microbiology, Check Tags::Male [Medical Subject Headings], Infections, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Young Adult, Internal medicine, Streptococcal Infections, Streptococcus tigurinus, medicine, Humans, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiological Monitoring [Medical Subject Headings], lcsh:RC109-216, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Epidemiologia, Aged, Retrospective Studies, Estudio multicéntrico, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Organisms::Bacteria::Gram-Positive Bacteria::Gram-Positive Cocci::Streptococcaceae::Streptococcus::Viridans Streptococci [Medical Subject Headings], business.industry, Antibiotic, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Endocarditis, Bacterial, medicine.disease, Parasitology, Check Tags::Female [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over [Medical Subject Headings], Spain, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings], business
Abstract: [Background] Streptococcus tigurinus was recently described as a new streptococcal species within the viridans group streptococci (VGS). The objectives of the present work were to analyse the clinical and microbiological characteristics of S. tigurinus isolated from patients with bacteraemias, to determine the prevalence of S. tigurinus among VGS endocarditis in Spain, and to compare the clinical characteristics and outcomes of endocarditis caused by S. tigurinus and other VGS., [Methods] Retrospective nationwide study, performed between 2008 and 2016 in 9 Spanish hospitals from 7 different provinces comprising 237 cases of infective endocarditis. Streptococcal isolates were identified by sequencing fragments of their 16S rRNA, sodA and groEL genes. Clinical data of patients with streptococcal endocarditis were prospectively collected according to a pre-established protocol., [Results] Patients with endocarditis represented 7/9 (77.8%) and 26/86 (30.2%) of the bacteraemias caused by S. tigurinus and other VGS, respectively (p, [Conclusions] In this multicenter study performed in Spain, S. tigurinus showed a higher predilection for the endocardial endothelium as compared to other VGS. However, clinical characteristics and outcomes of endocarditis caused by S. tigurinus did not significantly differ from endocarditis caused by other oral streptococci., JMM received a personal 80:20 research grant from the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain during 2017–19.
Published: 2019
Full Text: View/download PDF

17. Impact of Covid-19 containment on community pharmaceutical spending in Andalusia - Spain

Author: Antonio J. García Ruiz, Francisco Florido Alba, Nuria García-Agua, Antonio Clavero Barranquero, Ángel Martín Reyes, [Florido Alba,F] Malaga Pharmacists Association. Malaga, Spain. [García-Agua,N, Martín Reyes,Á, and García Ruiz,AJ] Health Economics and Rational Use of Medicines. Department of Pharmacology and Clinical Therapeutics. Biomedical Research Institute of Malaga (IBIMA). University of Malaga. Malaga, Spain. [Clavero Barranquero,A] Department of Statistics and Econometrics. University of Málaga. Malaga, Spain.
Subjects: Programas gubernamentales, Phenomena and Processes::Physical Phenomena::Time::Time Factors [Medical Subject Headings], mesh:National Health Programs, España, Models, econometric, Pharmaceutical Science, Pharmacy, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Statistical::Models, Economic [Medical Subject Headings], Gastos en salud, Modelos econométricos, Chemicals and Drugs::Pharmaceutical Preparations::Prescription Drugs [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Pandemic, Programas nacionales de salud, interrupted time series analysis, Original Research, Pandemias, education.field_of_study, mesh:COVID-19, mesh:Financial Management, Farmacia, National health programs, Health Care::Health Care Economics and Organizations::Health Planning::National Health Programs [Medical Subject Headings], mesh:Interrupted Time Series Analysis, Gestión financiera, covid-19, national health programs, Information Science::Information Science::Communications Media::Telecommunications::Telephone [Medical Subject Headings], Government programs, mesh:Prescription Drugs, mesh:Health Expenditures, models econometric, government programs, Análisis de series de tiempo interrumpido, Interrupted time series analysis, prescription drugs, Population, Health expenditures, Sample (statistics), RM1-950, mesh:Spain, pandemics, Medicamentos bajo prescripción, Health Care::Health Services Administration::Organization and Administration::Professional Practice::Referral and Consultation [Medical Subject Headings], Financial management, pharmacies, Pharmacy and materia medica, mesh:Pandemics, Health Care::Health Care Economics and Organizations::Economics::Costs and Cost Analysis::Health Expenditures [Medical Subject Headings], Environmental health, Health Care::Health Care Economics and Organizations::Economics::Financial Management [Medical Subject Headings], spain, Medical prescription, education, mesh:Government Programs, Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Pharmacies [Medical Subject Headings], Pandemics, Consumption (economics), Pharmacies, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Prescription drugs, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Government Programs [Medical Subject Headings], business.industry, mesh:Pharmacies, mesh:Models, Econometric, COVID-19, Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings], financial management, RS1-441, Econometric model, Spain, health expenditures, Therapeutics. Pharmacology, business
Abstract: Background: In the field of health, the year 2020 will be remembered for testing (stressing) all health institutions and their forms of management (centralised and decentralised). The everyday activity of primary and hospital care was significantly altered by the introduction of telephone consultations, which reduce the number of visits to health centres or hospitals and are still relevant today in the face of successive waves of the pandemic. Objective: To analyse whether population confinement due to the COVID-19 pandemic had an impact on the dispensing of medications in community pharmacies and the associated spending during the period March-July 2020 in Andalusia (Spain). Methods: A time series analysis applying econometric model analysis techniques to confirm or rule out whether the lockdown caused by the COVID-19 pandemic had an impact on the dispensing of medications by community pharmacies and the associated expenditures. The variables used were the number of medication containers dispensed by community pharmacies (charged to the public funds of the Spanish National Health System) and the expenditure on prescription drugs, both in relation to the population. The analysis was performed within the region of Andalusia, which has 8,464,441 inhabitants. Results: The data obtained from the time series confirmed that there were no significant differences during the studied period between the number of medication containers actually dispensed and the number that would have been expected to be dispensed according to the trend in this variable for the sample period. The expenditure results followed the same pattern. Conclusions: The health crisis produced by the COVID-19 lockdown had no impact on medication consumption in Andalusia.
Published: 2021

18. New models for donor-recipient matching in lung transplantations

Author: Pedro Antonio Gutiérrez, S. Cárcel, C. J. C. Robles-Arista, A. Salvatierra-Velázquez, J. M. Dueñas-Jurado, A. Casado-Adam, F. Santos-Luna, César Hervás-Martínez, [Dueñas-Jurado,JM, Cárcel,S, Robles-Arista,CJC] Intensive Care Unit, Reina Sofia University Hospital, Cordoba, Spain. [Gutiérrez,PA, Hervás-Martínez,C] Department of Computer Science and Numerical Analysis, Universidad de Córdoba, Córdoba, Spain. [Casado-Adam,A] General and Digestive Surgery Unit, Reina Sofia University Hospital, Cordoba, Spain. [Santos-Luna,F] Pneumology and Lung Transplant Service, Reina Sofia University Hospital, Cordoba, Spain. [Salvatierra-Velázquez,A] Thoracic Surgery and Lung Transplantation Service, Reina Sofia University Hospital, Cordoba, Spain. [Cárcel,S] Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), Cordoba, Spain., and This study was funded by the Spanish Ministry of Economy and Competitiveness (MINECO), and FEDER funds (EU) to PAG and CHM (TIN2017-85887-C2-1-P and TIN2017- 90567-REDT).
Subjects: Male, Vital capacity, Critical Care and Emergency Medicine, Traumatic Brain Injury, medicine.medical_treatment, Respiratory System, 030204 cardiovascular system & hematology, Concepción de donantes, Vascular Medicine, law.invention, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, law, Persons::Persons::Tissue Donors [Medical Subject Headings], Ischemia, Fraction of inspired oxygen, Medicine and Health Sciences, Respiratory System Procedures, Trauma Medicine, Multidisciplinary, Graft Survival, Tissue Donors, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Organ Transplantation::Lung Transplantation [Medical Subject Headings], Survival Rate, Chemistry, Obtención de tejidos y órganos, Donation, Physical Sciences, Lung transplantations, Medicine, Female, Anatomy, Donor, Traumatic Injury, Phenomena and Processes::Immune System Phenomena::Immune System Processes::Transplantation Immunology::Host vs Graft Reaction::Graft Survival [Medical Subject Headings], Research Article, Lung Transplantation, Chemical Elements, medicine.medical_specialty, Tissue and Organ Procurement, Science, Check Tags::Male [Medical Subject Headings], Surgical and Invasive Medical Procedures, Health Care::Health Care Facilities, Manpower, and Services::Health Services::Tissue and Organ Procurement [Medical Subject Headings], 03 medical and health sciences, FEV1/FVC ratio, Trasplante de pulmón, medicine, Cardiopulmonary bypass, Lung transplantation, Humans, Intensive care medicine, Mechanical ventilation, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Transplantation, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Survival Rate [Medical Subject Headings], business.industry, Biology and Life Sciences, Organ Transplantation, Receptores de trasplantes, Transplant Recipients, Oxygen, 030228 respiratory system, Check Tags::Female [Medical Subject Headings], Spain, Trasplante, Lungs, business, Neurotrauma
Abstract: ObjectiveOne of the main problems of lung transplantation is the shortage of organs as well as reduced survival rates. In the absence of an international standardized model for lung donor-recipient allocation, we set out to develop such a model based on the characteristics of past experiences with lung donors and recipients with the aim of improving the outcomes of the entire transplantation process.MethodsThis was a retrospective analysis of 404 lung transplants carried out at the Reina Sofía University Hospital (Córdoba, Spain) over 23 years. We analyzed various clinical variables obtained via our experience of clinical practice in the donation and transplantation process. These were used to create various classification models, including classical statistical methods and also incorporating newer machine-learning approaches.ResultsThe proposed model represents a powerful tool for donor-recipient matching, which in this current work, exceeded the capacity of classical statistical methods. The variables that predicted an increase in the probability of survival were: higher pre-transplant and post-transplant functional vital capacity (FVC), lower pre-transplant carbon dioxide (PCO2) pressure, lower donor mechanical ventilation, and shorter ischemia time. The variables that negatively influenced transplant survival were low forced expiratory volume in the first second (FEV1) pre-transplant, lower arterial oxygen pressure (PaO2)/fraction of inspired oxygen (FiO2) ratio, bilobar transplant, elderly recipient and donor, donor-recipient graft disproportion requiring a surgical reduction (Tailor), type of combined transplant, need for cardiopulmonary bypass during the surgery, death of the donor due to head trauma, hospitalization status before surgery, and female and male recipient donor sex.ConclusionsThese results show the difficulty of the problem which required the introduction of other variables into the analysis. The combination of classical statistical methods and machine learning can support decision-making about the compatibility between donors and recipients. This helps to facilitate reliable prediction and to optimize the grafts for transplantation, thereby improving the transplanted patient survival rate.
Published: 2021

19. Factors Related to Gender Violence and Sex Education in Adolescents: A Cross-Sectional Study

Author: Marina García-Gámez, Francisco Javier del Río, María González-Cano-Caballero, Cristina Guerra-Marmolejo, Eloisa Fernandez-Ordoñez, Eloísa Fernández-Fernández, Psicología, [Guerra-Marmolejo,C, García-Gámez,M, Fernández-Ordóñez,E] Department of Nursing, Faculty of Health Sciences, University of Málaga, Málaga, Spain. [Fernández-Fernández,E] Agencia Sanitaria Costa del Sol, Costa del Sol Hospital, Marbella, Spain. [González-Cano-Caballero,M] Department of Nursing, School of Nursing, Physiotherapy and Podiatry, University of Seville, Seville, Spain. [del Río,FJ] Department of Psychology, Institute of Biomedical Research and Innovation of Cádiz (INIBICA), University of Cádiz, Puerto Real, Cádiz, Spain., and Universidad de Sevilla. Departamento de Enfermería
Subjects: Male, Cross-sectional study, Health, Toxicology and Mutagenesis, Intimate Partner Violence, 050109 social psychology, Amor, romantic love myths, Sex Education, Gender-Based Violence, Ambivalence, Psychiatry and Psychology::Behavioral Disciplines and Activities::Behavioral Sciences::Sexology::Sex Education [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], sexual double standards, 0302 clinical medicine, nursing, risk factors, school medical service, 030212 general & internal medicine, gender violence, Adolescente, Reproductive health, Gender violence, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Sex Factors [Medical Subject Headings], 05 social sciences, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Social Behavior::Social Discrimination::Sexism [Medical Subject Headings], Romance, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Sexismo, Medicine, Enfermería, Psychology, Clinical psychology, Factores de riesgo, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Attitude [Medical Subject Headings], Educación sexual, sexual health, Check Tags::Male [Medical Subject Headings], Nursing, Violence, Sex education, Violencia de género, Article, Servicios de salud escolar, Persons::Persons::Age Groups::Adolescent [Medical Subject Headings], 03 medical and health sciences, Sex Factors, ambivalent sexism, Humans, 0501 psychology and cognitive sciences, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Social Problems::Violence [Medical Subject Headings], Sexual double standard, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Love [Medical Subject Headings], Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Salud sexual, business.industry, Public Health, Environmental and Occupational Health, Intimate partner violence, Anthropology, Education, Sociology and Social Phenomena::Education::Schools [Medical Subject Headings], Cross-Sectional Studies, Ambivalent sexism, Spain, Double standard, adolescent, business
Abstract: Background: For school medical services and the staff responsible for sex education for adolescents, it is important to understand the factors that may influence gender violence. The aim of this study is to determine whether the presence of sexist attitudes, double standards and/or romantic myths contributes to the risk of gender violence. Methods: This cross-sectional study was carried out at five secondary schools in the province of Malaga (Spain). In total, 879 adolescents aged 12–18 years were included, studying years 1–4 of compulsory secondary education. Their attitudes were measured on the following scales: Ambivalent Sexism Inventory (ASI), Double Standard Scale (DSS) and Romantic Love Myths Scale (EMA). Results: Significant differences were observed among the age/year groups for the mean scores obtained on each of the above scales (DSS, p &lt, 0.01, EMA, p &lt, ASI, p &lt, 0.01). By gender, the boys recorded higher scores for ASI and lower ones for DSS (p &lt, 0.01). The Spearman’s rho value revealed significant relationships between the presence of sexual double standards and that of romantic myths and ambivalent attitudes (p &lt, 0.01). Conclusions: Adolescents commonly express romantic love myths, sexist attitudes and sexual double standards. These three factors, which are significantly correlated, influence the presence of violence in dating relationships.
Published: 2021

20. Association between Crystalline Silica Dust Exposure and Silicosis Development in Artificial Stone Workers

Author: Jose Joaquín Martínez-López, David Lozano-Paniagua, Tesifón Parrón-Carreño, Raquel Alarcón-Rodríguez, Antonio F. Hernández, Mar Requena-Mullor, [Requena-Mullor,M, Alarcón-Rodríguez,R, Parrón-Carreño,T, and Lozano-Paniagua,D] Department of Nursing, Physiotherapy and Medicine, University of Almería, Almería, Spain. [Martínez-López,JJ] Andalusian Council of Health and Families at Almería Province, Almería, Spain. [Hernández,AF] Department of Legal Medicine and Toxicology, University of Granada School of Medicine, Granada, Spain. [Hernández,AF] Instituto de Investigación Biosanitaria, Granada (ibs.GRANADA), Madrid, Spain. [Hernández,AF] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Subjects: Health, Toxicology and Mutagenesis, Respirable Crystalline Silica, Exposición profesional, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Enfermedades pulmonares, 030212 general & internal medicine, Exposición por inhalación, pulmonary disease, Dust, Occupational exposure, Silicon Dioxide, Material particulado, occupational epidemiology, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Inhalation Exposure [Medical Subject Headings], respirable crystalline silica, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Equipment and Supplies, Hospital::Surgical Attire::Masks [Medical Subject Headings], Medicine, Occupational risk, Silicosis, Chemicals and Drugs::Inorganic Chemicals::Silicon Compounds::Silicon Dioxide [Medical Subject Headings], Article, Artificial stone, 03 medical and health sciences, silicosis, Environmental health, Respirable crystalline silica, medicine, Humans, Personal protective equipment, Chemicals and Drugs::Complex Mixtures::Particulate Matter [Medical Subject Headings], Riesgos laborales, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, Public Health, Environmental and Occupational Health, occupational exposure, Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Occupational Exposure [Medical Subject Headings], medicine.disease, Diseases::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial::Pneumoconiosis::Silicosis [Medical Subject Headings], Silica dust, Occupational epidemiology, Cross-Sectional Studies, 030228 respiratory system, Lung disease, Spain, Pulmonary disease, business, artificial stone
Abstract: Occupational exposure to respirable crystalline silica (SiO2 ) is one of the most common and serious risks because of the health consequences for the workers involved. Silicosis is a progressive, irreversible, and incurable fibrotic lung disease caused by the inhalation of respirable crystalline silica dust. A cross-sectional epidemiological study was carried out to assess the occupational risk factors that may contribute to the onset of silicosis in workers carrying out work activities with the inhalation of silica compact dust. The study population consisted of 311 artificial stone workers from the province of Almeria (southeast of Spain). Among them, 64 were previously diagnosed with silicosis and the rest of the participants (n = 247 workers) were not diagnosed with such a disease. The workers showing a greater risk of developing silicosis were those who installed kitchen worktops at consumers’ homes, as they did not use face-masks or were not provided with personal protective equipment (PPE) by their business. The results of this study provide support for the evidence indicating that silicosis is a major emerging health concern for workers in the artificial stone sector. Exposure to crystalline silica dust thus can influence the development of silicosis in those cases where individual and collective protection measures are not used or adequately applied.
Published: 2021

21. Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study

Author: Inmaculada Salcedo-Leal, Nicolás Francisco Fernández-Martínez, Antonio Cárdenas-Cruz, Rocío Ortiz González-Serna, Álvaro Serrano-Ortiz, Eladio Jiménez-Mejías, Mario Rivera-Izquierdo, Álvaro Romero-Duarte, Rafael Ruiz-Montero, Marina Pérez-Contreras, Inmaculada Guerrero-Fernández de Alba, [Romero-Duarte,A, Cárdenas-Cruz,A] School of Medicine, University of Granada, Granada, Spain. [Rivera-Izquierdo,M, Guerrero-Fernández de Alba,I] Service of Preventive Medicine and Public Health, Hospital Universitario Clínico San Cecilio, Granada, Spain. [Rivera-Izquierdo,M, Jiménez-Mejías,E] Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain. [[Rivera-Izquierdo,M] Instituto de Investigación Biosanitaria, ibs.GRANADA, Granada, Spain. [Guerrero-Fernández de Alba,I] Service of Preventive Medicine and Public Health, Complejo Hospitalario de Jaén, Jaén, Spain. [Pérez-Contreras,M] Service of Preventive Medicine and Public Health, Hospital Universitario de Puerto Real, Puerto Real, Cádiz, Spain. [Fernández-Martínez,F, Ruiz-Montero,R, Serrano-Ortiz,A, Ortiz González-Serna,R, Salcedo-Leal,I] Unidad de Gestión Clínica Interniveles de Prevención, Promoción y Vigilancia de la Salud, Hospital Universitario Reina Sofía, Córdoba, Spain. [Fernández-Martínez,NF, Salcedo-Leal,I] Instituto Maimónides de Investigación Biomédica de Córdoba (Imibic), Córdoba, Spain. [Jiménez-Mejías,E] Chair of Teaching and Research in Family Medicine, SEMERGEN-UGR, University of Granada, Granada, Spain. [Cárdenas-Cruz,A] Intensive Care Unit, Hospital de Poniente, El Ejido, Almería, Spain., and This study was supported by the Chair of Teaching and Research in Family Medicine SEMERGEN-UGR, University of Granada
Subjects: Male, Pediatrics, Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Pain::Headache [Medical Subject Headings], Estadísticas de secuelas y discapacidad, Hospitalización, Aftercare, Logistic regression, Cohort Studies, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Sequelae, 0302 clinical medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Retrospective Studies [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Statistical::Logistic Models [Medical Subject Headings], Palpitations, Longitudinal Studies, 030212 general & internal medicine, Young adult, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Aged, 80 and over, Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospitals [Medical Subject Headings], Follow-up, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Aftercare [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization::Patient Readmission [Medical Subject Headings], General Medicine, Middle Aged, Hospital readmission, Persistent symptoms, Primary care, Patient Discharge, Hospitalization, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization [Medical Subject Headings], Diseases::Cardiovascular Diseases::Heart Diseases::Arrhythmias, Cardiac [Medical Subject Headings], Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Health [Medical Subject Headings], Cohort, Disease Progression, Signos y síntomas, Medicine, Female, Mental health, Health Care::Health Services Administration::Quality of Health Care::Outcome and Process Assessment (Health Care)::Outcome Assessment (Health Care) [Medical Subject Headings], medicine.symptom, Persons::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings], Research Article, Cohort study, Adult, medicine.medical_specialty, Long COVID, Readmisión del paciente, education, Check Tags::Male [Medical Subject Headings], Disease cluster, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Cluster Analysis [Medical Subject Headings], Patient Readmission, Salud mental, Young Adult, 03 medical and health sciences, Atención primaria de salud, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings], medicine, Humans, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Post-discharge, Pandemics, Aged, Retrospective Studies, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression [Medical Subject Headings], SARS-CoV-2, business.industry, Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction [Medical Subject Headings], COVID-19, Retrospective cohort study, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Pain [Medical Subject Headings], Complicaciones, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], Check Tags::Female [Medical Subject Headings], Spain, Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization::Patient Discharge [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], Observational study, business, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract: This study was supported by the Chair of Teaching and Research in Family Medicine SEMERGEN-UGR, University of Granada., We thank the Chair of Teaching and Research in Family Medicine SEMERG EN-UGR for supporting this work. We also thank all the healthcare professionals of the Preventive Medicine and Public Health services of the Hospital San Cecilio, Reina Sofía, Jaén and Puerto Real for their ideas and support, and Ángela Rivera-Izquierdo for improving the use of English in the manuscript., Background Long-term effects of COVID-19, also called Long COVID, affect more than 10% of patients. The most severe cases (i.e. those requiring hospitalization) present a higher frequency of sequelae, but detailed information on these effects is still lacking. The objective of this study is to identify and quantify the frequency and outcomes associated with the presence of sequelae or persistent symptomatology (SPS) during the 6 months after discharge for COVID-19.MethodsRetrospective observational 6-month follow-up study conducted in four hospitals of Spain. A cohort of all 969 patients who were hospitalized with PCR-confirmed SARS-CoV-2 from March 1 to April 15, 2020, was included. We collected all the SPS during the 6 months after discharge reported by patients during follow-up from primary care records. Cluster analyses were performed to validate the measures. The main outcome measures were return to the Emergency Services, hospital readmission and post-discharge death. Surviving patients' outcomes were collected through clinical histories and primary care reports. Multiple logistic regression models were applied.ResultsThe 797 (82.2%) patients who survived constituted the sample followed, while the rest died from COVID-19. The mean age was 63.0 years, 53.7% of them were men and 509 (63.9%) reported some sequelae during the first 6 months after discharge. These sequelae were very diverse, but the most frequent were respiratory (42.0%), systemic (36.1%), neurological (20.8%), mental health (12.2%) and infectious (7.9%) SPS, with some differences by sex. Women presented higher frequencies of headache and mental health SPS, among others. A total of 160 (20.1%) patients returned to the Emergency Services, 35 (4.4%) required hospital readmission and 8 (1.0%) died during follow-up. The main factors independently associated with the return to Emergency Services were persistent fever, dermatological SPS, arrythmia or palpitations, thoracic pain and pneumonia.ConclusionsCOVID-19 cases requiring hospitalization during the first wave of the pandemic developed a significant range of mid- to long-term SPS. A detailed list of symptoms and outcomes is provided in this multicentre study. Identification of possible factors associated with these SPS could be useful to optimize preventive follow-up strategies in primary care for the coming months of the pandemic., Chair of Teaching and Research in Family Medicine SEMERGEN-UGR, University of Granada
Published: 2021

22. Effects of Whole-Grain and Sugar Content in Infant Cereals on Gut Microbiota at Weaning: A Randomized Trial

Author: Salvador Genovés, Julio Plaza-Díaz, Sophie Schutte, Luis Manuel Sanchez-Siles, Maria Jose Bernal, Francisco M. Codoñer, Empar Chenoll, Angel Gil, [Plaza-Diaz,J, Gil,A] Department of Biochemistry & Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain. [Plaza-Diaz,J, Gil,A] Instituto de Investigación Biosanitaria IBS. GRANADA, Complejo Hospitalario Universitario de Granada, Granada, Spain. [Plaza-Diaz,J] Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada. [Bernal,MJ, Schutte,S, Sanchez-Siles,LM] Research and Nutrition Department, Hero Group, Alcantarilla, Murcia, Spain. [Bernal,MJ, Sanchez-Siles,LM] Institute for Research and Nutrition, Hero Group, Lenzburg, Switzerland. [Chenoll,E, Genovés,S, Codoñer,FM] Biopolis-ADM, Paterna, Spain. [Gil,A] Institute of Nutrition & Food Technology 'José Mataix', Biomedical Research Center, University of Granada, Granada, Spain. [Gil,A] CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain., and This research was partially funded by European funding from ICEX and FEDER—Program R + D Invest 539 in Spain 2015. European Regional Development Fund: 201503473.
Subjects: 0301 basic medicine, Male, intestinal microbiota, Intestinal microbiota, Dietary Sugars, Grano comestible, Ensayo clínico controlado aleatorio, Gut flora, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], TX341-641, Food science, Persons::Persons::Age Groups::Infant [Medical Subject Headings], Nutrition and Dietetics, biology, Microbiota, food and beverages, Infant food, Whole grains, whole grains, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Child Nutritional Physiological Phenomena::Infant Nutritional Physiological Phenomena::Weaning [Medical Subject Headings], Phenomena and Processes::Microbiological Phenomena::Microbiota [Medical Subject Headings], Chemicals and Drugs::Carbohydrates::Sugar Phosphates [Medical Subject Headings], Female, Proteobacteria, Fenómenos fisiológicos nutricionales del lactante, Microbioma gastrointestinal, Publication Type::Study Characteristics::Clinical Trial::Randomized Controlled Trial [Medical Subject Headings], Check Tags::Male [Medical Subject Headings], Complementary feeding, Weaning, Article, complementary feeding, 03 medical and health sciences, Technology and Food and Beverages::Food and Beverages::Food::Foods, Specialized::Infant Food [Medical Subject Headings], infant food, Escherichia, infant cereals, Humans, Sugar, Feces, Cereales integrales, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], 030109 nutrition & dietetics, Nutrition. Foods and food supply, Infant, biology.organism_classification, Gastrointestinal Microbiome, 030104 developmental biology, Enterococcus, Alimentos para lactantes, Check Tags::Female [Medical Subject Headings], Spain, Destete, Infant cereals, Bacteroides, Food Science
Abstract: The introduction of complementary foods during infancy marks an important step in the development of the infant gut microbiome. Infant cereals are popular weaning foods but consistent evidence on their effect on the intestinal microbiota, especially when differing in nutritional quality, is lacking. Fecal samples from 4–7-month-old Spanish infants who consumed infant cereals differing in whole grain and sugar content as first weaning foods were analyzed on changes in microbial composition by massively parallel sequencing of the 16S ribosomal RNA gene at baseline and after 7 weeks of intervention. Samples were obtained from a previous trial conducted in Spain demonstrating whole-grain cereal acceptability. In total, samples of 18 infants consuming 0% whole grain cereals with 24 g sugar (0-WG) and 25 infants consuming 50% whole grain cereals with 12 g sugar (50-WG) were analyzed. Microbial composition changed significantly over time (p = 0.001), per intervention group (p = 0.029) and per infant (p = 0.001). Abundance of genus Veillonella increased in both groups while Enterococcus decreased. Within the 0-WG group, phylum Actinobacteria decreased along with genus Bifidobacterium. In the 50-WG, we observed an increase in Lachnoclostridium and Bacteroides. In addition, 50-WG decreased Proteobacteria and Escherichia to levels lower than 0-WG. Although weaning itself appeared to be responsible for most changes, the increased presence of anaerobic fermenters together with inhibition of pathogenic Escherichia may indicate a supporting effect of infant cereals with 50% whole grains and a reduced sugar content over infant cereals manufactured with refined hydrolyzed flours on the infant microbiota. In fact, using a novel methodology for the identification of microbial signatures, we found two groups of microbial taxa predictive of infants consuming enriched whole-grain infant cereals with a high predictive value of about 93%.
Published: 2021
Full Text: View/download PDF

23. A multi-stakeholder multicriteria decision analysis for the reimbursement of orphan drugs (FinMHU-MCDA study)

Author: de Andrés-Nogales F., Cruz E., Calleja M.Á., Delgado O., Gorgas M.Q., Espín J., Mestre-Ferrándiz J., Palau F., Ancochea A., Arce R., Domínguez-Hernández R., Casado M.Á., Gómez Pajuelo P., Gorgas Torner M.Q., López Andrés A., López Rodríguez M., Marín Ballvé A., Martín Herranz M.I., Morell Baladrón A., Sánchez Martínez F.I., Antoñanzas F., Bonanad S., Caballero T., Cabasés J.M., Cruz J., García-Goñi M., Gil R., Pajuelo P.G., Torner M.Q.G., Andrés A.L., Rodríguez M.L., Ballvé A.M., Herranz M.I.M., Baladrón A.M., Mur C., Machado M.P., Martínez F.I.S., Santos A.R., Suárez M., Trillo J.L., the FinMHU-MCDA Group, Institut Català de la Salut, [de Andrés-Nogales F] Pharmacoeconomics & Outcomes Research Iberia (PORIB), 28224 Pozuelo de Alarcón, Spain. [Cruz E] Asociación Española de Medicamentos Biosimilares, Madrid, Spain. [Calleja MA] Servicio de Farmacia, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Delgado O] Servicio de Farmacia, Hospital Universitario Son Espases, Palma de Mallorca, Spain. [Gorgas MQ] Servei de Farmàcia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Espín J] Escuela Andaluza de Salud Pública, Granada, Spain. Instituto de Investigación Biosanitaria (IBS), Granada, Spain. CIBER de Epidemiología Y Salud Pública (CIBERESP), Madrid, Spain, Vall d'Hebron Barcelona Hospital Campus, [de Andrés-Nogales,F, Domínguez-Hernández,R, Casado,MÁ] Pharmacoeconomics & Outcomes Research Iberia (PORIB), Pozuelo de Alarcón, Madrid, Spain. [Cruz,E] Asociación Española de Medicamentos Biosimilares, Madrid, Spain. [Calleja,MÁ] Servicio de Farmacia, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Delgado,O] Servicio de Farmacia, Hospital Universitario Son Espases, Palma de Mallorca, Spain. Servicio de Farmacia, Hospital Universitari Vall D’Hebron, Barcelona, Spain. [Espín,J] Escuela Andaluza de Salud Pública, Granada, Spain. [Espín,J] Instituto de Investigación Biosanitaria (IBS), Granada, Spain. [Espín,J] CIBER de Epidemiología Y Salud Pública (CIBERESP), Madrid, Spain. [Mestre-Ferrándiz,J] Consultor Económico Independiente, Madrid, Spain. [Mestre-Ferrándiz,J] Madrid, Spain. [Palau,F] Servicio de Medicina Genética y CIBERER, Hospital Universitari Sant Joan de Déu, Hospital Clínic y Universitat de Barcelona, Barcelona, Spain. [Ancochea,A] Federación Española de Enfermedades Raras (FEDER), Madrid, Spain. [Arce,R] Asociación Española de Laboratorios de Medicamentos Huérfanos y Ultrahuérfanos (AELMHU), Barcelona, Spain., and This project was carried out with an unrestricted grant from AELMHU (Aso‑ciación Española de Laboratorios de Medicamentos Huérfanos y Ultrahuér‑fanos). AELMHU was not involved in the design of the study and collection, analysis, and interpretation of data and writing the manuscript
Subjects: Orphan Drug Production, Cost-Benefit Analysis, España, Disease, Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Thinking::Decision Making [Medical Subject Headings], Other subheadings::Other subheadings::/drug therapy [Other subheadings], fenómenos psicológicos::procesos mentales::pensamiento::toma de decisión [PSIQUIATRÍA Y PSICOLOGÍA], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::enfermedades raras [ENFERMEDADES], Medicine, Pharmacology (medical), 030212 general & internal medicine, Malalties rares - Tractament, Genetics (clinical), Reimbursement, Multinomial logistic regression, Técnicas de apoyo en la toma de decisiones, 030503 health policy & services, General Medicine, Multiple-criteria decision analysis, Rare diseases, tecnología, industria y agricultura::industria::industria fabril::industria farmacéutica::producción de medicamentos huérfanos [TECNOLOGÍA, INDUSTRIA Y AGRICULTURA], 0305 other medical science, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Decision Support Techniques [Medical Subject Headings], medicine.medical_specialty, Decision Making, Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Psychological Phenomena::Mental Processes::Thinking::Decision Making [PSYCHIATRY AND PSYCHOLOGY], Medicaments orfes - Cost-eficàcia, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Rare Diseases [Medical Subject Headings], Decision Support Techniques, Orphan drug, 03 medical and health sciences, Technology and Food and Beverages::Technology, Industry, and Agriculture::Industry::Drug Industry::Orphan Drug Production [Medical Subject Headings], Quality of life (healthcare), Health Care::Health Care Economics and Organizations::Economics::Costs and Cost Analysis::Cost-Benefit Analysis [Medical Subject Headings], Rare Diseases, Orphan drugs, Humans, Humanities::Humanities::Philosophy::Life::Quality of Life [Medical Subject Headings], Technology, Industry, and Agriculture::Industry::Manufacturing Industry::Drug Industry::Orphan Drug Production [TECHNOLOGY, INDUSTRY, AND AGRICULTURE], Adverse effect, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, Enfermedades raras, Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Rare Diseases [DISEASES], Research, Multicriteria decision analysis, Medicamento huérfano, Mecanismo de reembolso, Spain, Family medicine, Economic evaluation, Quality of Life, business
Abstract: Background Patient access to orphan medicinal products (OMPs) is limited and varies between countries, reimbursement decisions on OMPs are complex, and there is a need for more transparent processes to know which criteria should be considered to inform these decisions. This study aimed to determine the most relevant criteria for the reimbursement of OMPs in Spain, from a multi-stakeholder perspective, and using multicriteria decision analysis (MCDA). Methods An MCDA was developed in 3 phases and included 28 stakeholders closely related to the field of rare diseases (6 physicians, 5 hospital pharmacists, 7 health economists, 4 patient representatives and 6 members from national and regional health authorities). Initially [phase A], a bibliographic review was conducted to identify the potential reimbursement criteria. Then, a reduced advisory board (8 members) proposed, selected, and defined the final list of criteria that could be relevant for reimbursement. A discrete choice experiment (DCE) [phase B] was developed to determine the relevance and relative importance weight of such criteria according to the stakeholders’ preferences by choosing between pairs of hypothetical financing scenarios. A multinomial logit model was fitted to analyze the DCE responses. Finally [phase C], the advisory board review the results using a deliberative process. Results Thirteen criteria were selected, related to 4 dimensions: patient population, disease, treatment, and economic evaluation. Nine criteria were deemed relevant for decision-making and associated with a higher relative importance: Health-related quality of life (HRQL) (23.53%), treatment efficacy (14.64%), availability of treatment alternatives (13.51%), disease severity (12.62%), avoided costs (11.21%), age of target population (7.75%), safety (seriousness of adverse events) (4.72%), quality of evidence (3.82%) and size of target population (3.12%). The remaining criteria had a Conclusion The reimbursement of OMPs in Spain should be determined by its effect on patient’s HRQL, the extent of its therapeutic benefit from efficacy and the availability of other therapeutic options. Furthermore, the severity of the rare disease should also influence the decision along with the potential of the treatment to avoid associated costs.
Published: 2021

24. Protocol for a randomized pilot study (FIRST STEPS): implementation of the Incredible Years-ASLD® program in Spanish children with autism and preterm children with communication and/or socialization difficulties

Author: Fátima Valencia, Inmaculada Navas, Maria Elias, Laia Villalta, Marina Romero-González, Almudena Ramírez, Alexandra Garriz, Elena Urbiola, [Valencia,F, Urbiola,E, Garriz,A] Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Romero-González,M, Navas,I, Ramírez,A] Maternity Hospital, Hospital Regional Universitario de Málaga, Málaga, Spain. [Romero-González,M, Ramírez,A] Department of Brain Health, CIMES, Faculty of Medicine-IBIMA, UMA, Málaga, Spain. [Elías,M, Villalta,L] Department of Psychiatry and Psychology, Hospital Sant Joan de Déu de Barcelona, L’Hospitalet de Llobregat, Spain. [Villalta,L] Children and Adolescent Mental Health Research Group, Research Institute Sant Joan de Déu, Esplugues de Llobregat, Spain., and This paper reports on independent research financially supported by the Alicia Koplowitz Foundation.
Subjects: Parents, Medicine (General), Information Science::Information Science::Communication [Medical Subject Headings], Autism Spectrum Disorder, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology, Social::Family::Family Relations::Parenting [Medical Subject Headings], Psychological intervention, Medicine (miscellaneous), Pilot Projects, law.invention, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Study Protocol, 0302 clinical medicine, Randomized controlled trial, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Multicenter Studies as Topic [Medical Subject Headings], law, Autistic children, Medicine, Multicenter Studies as Topic, Pharmacology (medical), Child, Child development, Randomized Controlled Trials as Topic, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings], Parenting, Communication, 05 social sciences, Pilot, Autism spectrum disorder, Child, Preschool, Premature Birth, 050104 developmental & child psychology, Clinical psychology, medicine.medical_specialty, Parenting intervention, Pilotos, Psychiatry and Psychology::Mental Disorders::Mental Disorders Diagnosed in Childhood::Child Development Disorders, Pervasive::Autistic Disorder [Medical Subject Headings], ASD, Desarrollo infantil, 03 medical and health sciences, R5-920, Complex intervention, Intervention (counseling), Humans, 0501 psychology and cognitive sciences, Persons::Persons::Age Groups::Child [Medical Subject Headings], Autistic Disorder, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Pilot Projects [Medical Subject Headings], Infants autistes, business.industry, Public health, Trastorno del espectro del autismo, Socialization, medicine.disease, Mental health, Responsabilidad parental, Desenvolupament infantil, Preterm children, Spain, randomized controlled trial, Autism, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Socialization [Medical Subject Headings], Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Obstetric Labor Complications::Obstetric Labor, Premature::Premature Birth [Medical Subject Headings], business, Persons::Persons::Parents [Medical Subject Headings], Persons::Persons::Age Groups::Child::Child, Preschool [Medical Subject Headings], 030217 neurology & neurosurgery, Nacimiento prematuro
Abstract: Abstract Having access to parenting interventions in the early years is key to improve the developmental outcomes of children with neurodevelopmental problems. The Incredible Years® (IY) Parent Program is a group intervention that has demonstrated efficacy in terms of reducing stress in parents, as well as improving behavioral, emotional, and social outcomes in children. The program has been recently adapted for families of children with autism or language delays (IY-ASLD®). This intervention has not yet been implemented in the Spanish Public Health System, where there is a scarcity of evidence-based interventions being offered to families with young children presenting neurodevelopmental problems. The main aims of this study are to determine the feasibility of implementing the IY-ASLD® program within Spanish Child Mental Health Services and to examine parents’ acceptability and satisfaction with the intervention. As a secondary objective, we aim to evaluate its preliminary effectiveness in terms of reducing parental stress and behavioral difficulties in their children. The FIRST STEPS study is a multicenter, pilot randomized controlled trial comparing the IY-ASLD® program with a treatment-as-usual (TAU) condition. Approximately 70 families of children with autism spectrum disorder (ASD) and preterm children with communication and/or socialization difficulties (aged 2–5 years) will be recruited. Families will be assessed prior to randomization and after the intervention. Due to the COVID-19 pandemic, the intervention will consist of 22 weekly online sessions (approximately 6 months). The FIRST STEPS pilot trial will demonstrate the feasibility and acceptability of reliably implementing the IY-ASLD® program within the Spanish Public Health System. The results of this study could represent the first step to inform policymakers in Spain when designing evidence-based healthcare pathways for families of children presenting ASD symptoms or neurodevelopmental difficulties at early stages. Trial registration ClinicalTrials.gov NCT04358484. Registered on 04 April 2020
Published: 2021

25. Impacto de la formación en entrevista motivacional para médicos: diseño y evaluación de un Programa Formativo (MOTIVA)

Author: Julia Bóveda-Fontan, Remedios Martín-Álvarez, Luis Ángel Pérula-de-Torres, Josep M. Bosch-Fontcuberta, Manuel Campiñez-Navarro, Nieves Barragán-Brun, [Barragán-Brun,N, Martín-Álvarez,R, Campíñez-Navarro,M] EAP Vallcarca, EBA Vallcarca, Barcelona, España. [Bosch-Fontcuberta,JM] EAP Encants, Institut Català de la Salut, Barcelona, España. [Bóveda-Fontan,J] CS Colmeiro, SERGAS, Vigo, Pontevedra, España. [Pérula-de-Torres,LA] Instituto Maimónides de Investigación Biomédica-IMIBIC, Hospital Reina Sofía, Córdoba, España. [Barragán-Brun,N, Bosch-Fontcuberta,JM, Campíñez-Navarro,M, Bóveda-Fontan,J, Pérula-de-Torres,LA] Miembro del Grupo Programa Comunicación y Salud de semFYC, and Este trabajo recibió una Beca Isabel Fernández 2012 de la semFYC.
Subjects: Médicos de familia, Family physicians, España, The motivational interview, Entrevista motivacional, Information Science::Information Science::Communication::Cybernetics::Feedback [Medical Subject Headings], Continuing medical education, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 03 medical and health sciences, 0302 clinical medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings], 030212 general & internal medicine, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], lcsh:R5-920, Evaluación, 030503 health policy & services, Competence professional, Competencia profesional, General Medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Double-Blind Method [Medical Subject Headings], Assessment training, Health Care::Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [Medical Subject Headings], Psychiatry and Psychology::Psychological Phenomena and Processes::Psychology, Applied::Counseling::Directive Counseling::Motivational Interviewing [Medical Subject Headings], Spain, Health Care::Health Services Administration::Quality of Health Care::Clinical Competence [Medical Subject Headings], Formación médica continuada, Persons::Persons::Occupational Groups::Health Personnel::Physicians::Physicians, Family [Medical Subject Headings], 0305 other medical science, Family Practice, lcsh:Medicine (General)
Abstract: Resumen: Objetivo: Desarrollar un programa de formación en Entrevista Motivacional (EM) para Médicos de Familia y evaluar el impacto. Diseño: Ensayo clínico multicéntrico a doble ciego y aleatorizado, con 2 ramas (experimental (GE) y control (GC)) de Médicos de Familia, con un seguimiento de 12 meses. Emplazamiento: 32 Centros de Atención Primaria. Descripción de la muestra: 54 médicos (GC = 28, GE = 26). Intervenciones: Programa de formación MOTIVA en EM con un curso presencial inicial (16 h), seguido de actividades en línea durante 12 meses y reuniones presenciales (entrevistas basadas en problemas con feedback de expertos). Medidas principales: las habilidades comunicativas en EM se evaluaron en base a videograbaciones (VG) con la escala EVEM 2.0, por parejas de revisores. Se analizaron 236 VG con pacientes estandarizados y 96 VG con pacientes reales. Resultados: Los resultados promedio en la escala EVEM (hasta 56 puntos) al inicio del estudio fueron GE = 21,27 (IC 95% 15,8-26,7) y GC = 20,23 (IC95% 16,4-23,9) sin diferencias entre ambos grupos (p = 0,79). Después del curso, la puntuación GE aumentó en 13,89 puntos (P
Published: 2021

26. A Growth Modulation Index-Based GEISTRA Score as a New Prognostic Tool for Trabectedin Efficacy in Patients with Advanced Soft Tissue Sarcomas: A Spanish Group for Sarcoma Research (GEIS) Retrospective Study

Author: Roberto Diaz-Beveridge, Luis Miguel De Sande-González, Antonio López Pousa, Jordi Rubió-Casadevall, Javier Martin-Broto, Pablo Luna, Juan Antonio Carrasco, Claudia M Valverde-Morales, Andres Poveda, Gloria Marquina, María Ángeles Vaz Salgado, Javier Martinez-Trufero, Antonio Gutierrez, Ana De Juan, Juana María Cano, Ibon Gurruchaga-Sotes, Isabel Sevilla, Josefina Cruz-Jurado, Jerónimo Martínez-García, Rosa Alvarez, David S. Moura, Institut Català de la Salut, [Martínez-Trufero J] Javier Martinez-Trufero, Medical Oncology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain. [De Sande-González LM] Medical Oncology Department, Complejo Asistencial Universitario de Leon, Leon, Spain. [Luna P] Medical Oncology Department, Hospital Universitario Son Espases, Palma de Mallorca, Spain. [Martin-Broto J] Medical Oncology Department, Hospital Universitario Virgen del Rocio, Instituto de Biomedicina de Sevilla (IBiS, CSIC, US, HUVR), Sevilla, Spain. [Álvarez R] Medical Oncology Department, Hospital Universitario Gregorio Marañon, Madrid, Spain. [Marquina G] Medical Oncology Department, Hospital Universitario Clinico San Carlos, Madrid, Spain. [Valverde-Morales CM] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, [Martínez-Trufero,J, Gurruchaga-Sotes,I] Javier Martinez-Trufero, Medical Oncology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain. [De Sande-González,LM] Medical Oncology Department, Complejo Asistencial Universitario de Leon, Leon, Spain. [Luna,P] Medical Oncology Department, Hospital Universitario Son Espases, Palma de Mallorca, Spain. [Martin-Broto,J] Medical Oncology Department, Hospital Universitario Virgen del Rocio, Instituto de Biomedicina de Sevilla (IBiS, CSIC, US, HUVR), Sevilla, Spain. [Álvarez,R] Medical Oncology Department, Hospital Universitario Gregorio Marañon, Madrid, Spain. [Marquina,G] Medical Oncology Department, Hospital Universitario Clinico San Carlos, Madrid, Spain. [Diaz-Beveridge,R] Medical Oncology Department, Hospital Politécnico La Fe, Valencia, Spain. [Poveda,A] Medical Oncology Department, Instituto Valenciano de Oncologia, Valencia, Spain. [Cano,JM] Medical Oncology Department, Hospital General de Ciudad Real, Ciudad Real, Spain. [Cruz-Jurado,J] Medical Oncology Department, Hospital Universitario Canarias, Santa Cruz de Tenerife, Spain. [López Pousa,A] Medical Oncology Department, Hospital Universitario Santa Creu i Sant Pau, Barcelona, Spain. [Vaz Salgado,MA] Medical Oncology Department, Hospital Universitario Ramon y Cajal, RYCIS, CIBERONC, Madrid, Spain. [Valverde-Morales,C] Medical Oncology Department, Hospital Universitario Vall D’Hebron, Barcelona, Spain. [Sevilla,I] Investigación Clínica y Traslacional en Cáncer, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Medical Oncology Department, Hospitales Universitarios Regional y Virgen de la Victoria de Málaga, Malaga, Spain. [Martínez-García,J] Medical Oncology Department, Hospital Virgen de la Arrixaca, Murcia, Spain. [Rubio-Casadevall,J] Medical Oncology Department, Instituto Catalan Oncologia, Girona, Spain. [De Juan,A] Medical Oncology Department, Hospital Marqués de Valdecilla, Santander, Spain. [Carrasco,JA] Medical Oncology Department, Hospital Alvaro Cunqueiro, Vigo, Spain. [Moura,DS] Instituto de Biomedicina de Sevilla (IBiS, CSIC, US, HUVR), Sevilla, Spain. [Gutiérrez,A] Hematology Department, Hospital Universitario Son Espases, 07010 Palma de Mallorca, Spain., and This research was funded by the Spanish Group for Research on Sarcoma (grant number: NA) and partially by PharmaMar. PharmaMar S.A. did not have any role in study design, or in collection, analysis and interpretation of data.
Subjects: 0301 basic medicine, Oncology, Advanced soft tissue sarcomas, Cancer Research, Multivariate analysis, sarcoma, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings], Trabectedina, España, Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Sarcoma [Medical Subject Headings], Other subheadings::Other subheadings::/drug therapy [Other subheadings], Metastasis, Prognostic score, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Trabectedin, Tumors de parts toves, Soft tissue sarcoma, Pronóstico, Soft tissue, Liposarcoma, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, prognostic score, GEISTRA, L-sarcoma, growth modulation index, prognostic score, sarcoma, trabectedin, 030220 oncology & carcinogenesis, trabectedin, Sarcoma, L-sarcoma, medicine.drug, medicine.medical_specialty, Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiazoles::Thiamine::Thiamine Triphosphate [Medical Subject Headings], GEISTRA, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance::Multivariate Analysis [Medical Subject Headings], Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Neoplasms::Neoplasms by Site::Soft Tissue Neoplasms [DISEASES], epidemiología y bioestadística::epidemiología::usos de la epidemiología::efectividad [SALUD PÚBLICA], lcsh:RC254-282, Article, Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Sarcoma::Leiomyosarcoma [Medical Subject Headings], 03 medical and health sciences, Internal medicine, medicine, Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Sarcoma::Liposarcoma [Medical Subject Headings], neoplasias::neoplasias por localización::neoplasias de los tejidos blandos [ENFERMEDADES], Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, Retrospective cohort study, medicine.disease, 030104 developmental biology, Spain, Medicaments - Eficàcia, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings], Epidemiology and Biostatistics::Epidemiology::Uses of Epidemiology::Effectiveness [PUBLIC HEALTH], Leiomiosarcoma, business, growth modulation index
Abstract: The aim of this study was to identify an easily reliable prognostic score that selects the subset of advanced soft tissue sarcoma (ASTS) patients with a higher benefit with trabectedin in terms of time to progression and overall survival. A retrospective series of 357 patients with ASTS treated with trabectedin as second- or further-line in 19 centers across Spain was analyzed. First, it was confirmed that patients with high growth modulation index (GMI &gt, 1.33) were associated with the better clinical outcome. Univariate and multivariate analyses were performed to identify factors associated with a GMI &gt, 1.33. Thus, GEISTRA score was based on metastasis free-interval (MFI ≤ 9.7 months), Karnofsky &lt, 80%, Non L-sarcomas and better response in the previous systemic line. The median GMI was 0.82 (0–69), with 198 patients (55%) with a GMI &lt, 1, 41 (11.5%) with a GMI 1–1.33 and 118 (33.1%) with a GMI &gt, 1.33. The lowest GEISTRA score showed a median of time-to-progression (TTP) and overall survival (OS) of 5.7 and 19.5 months, respectively, whereas it was 1.8 and 3.1 months for TTP and OS, respectively, for the GEISTRA 4 score. This prognostic tool can contribute to better selecting candidates for trabectedin treatment in ASTS.
Published: 2021

27. Excess mortality in patients with schizophrenia spectrum disorders in Malaga (Spain): A cohort study

Author: Yolanda Pardo, Sebastián Díaz-Ruiz, Berta Moreno-Küstner, Fermin Mayoral-Cleries, Yolanda Sanchidrián, Jose Guzman-Parra, [Moreno-Küstner,B, Sanchidrián,Y] Departamento de Personalidad, Evaluación y Tratamiento Psicológico, Grupo GAP, Facultad de Psicología, Universidad de Málaga, Spain. [Guzman-Parra,J, Pardo,Y, Mayoral-Cleries,F] Department of Mental Health, University General Hospital of Malaga. Biomedical Research Institute of Malaga (IBIMA), Spain. [Díaz-Ruiz,S] Instituto de Medicina Legal de Málaga, Spain., and Fermin Mayoral Cleries and Jose Guzman-Parra have received funding from the Andalusia Government in the grants for human resources reinforcement in the research activity (Acción A de intesificación 2017 and Acción B de refuerzos de larga duración 2014). Berta Moreno Küstner has received funding from the Andalusian Government (P10-CTS-5862), and from the Ministry of Health (Ministry of Health, Social Services and Equality, Spain (Grant: PI16/00647) and co-founded by European Regional Development Fund (FEDER)
Subjects: Male, Epidemiology, Poison control, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis [Medical Subject Headings], Esquizofrenia, Comorbidity, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Cohort Studies, Risk Factors, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Comorbidity [Medical Subject Headings], Cause of Death, Neoplasms, Risk of mortality, Medicine, psychosis, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Cause of Death [Medical Subject Headings], Psychiatry and Psychology::Behavioral Disciplines and Activities::Schizophrenic Psychology [Medical Subject Headings], education.field_of_study, Hazard ratio, Diseases::Neoplasms [Medical Subject Headings], Middle Aged, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Self-Injurious Behavior::Suicide [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Actuarial Analysis::Life Tables::Quality-Adjusted Life Years [Medical Subject Headings], Psychiatry and Mental health, Suicide, Cardiovascular Diseases, Cohort, Female, Schizophrenic Psychology, Original Article, Quality-Adjusted Life Years, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Social Conditions [Medical Subject Headings], Cohort study, Factores de riesgo, Adult, Trastornos psicóticos, Population, Check Tags::Male [Medical Subject Headings], Life Expectancy, Psychiatry and Psychology::Mental Disorders::Schizophrenia and Disorders with Psychotic Features::Schizophrenia [Medical Subject Headings], Humans, Suicidio, education, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Diseases::Cardiovascular Diseases [Medical Subject Headings], Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Evaluación de resultado en la atención de salud, business.industry, Public Health, Environmental and Occupational Health, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Life Expectancy [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Health outcomes, Psychosis, Persons::Persons::Age Groups::Infant::Infant, Newborn [Medical Subject Headings], schizophrenia, Years of potential life lost, Risk factors, Check Tags::Female [Medical Subject Headings], Spain, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], Life expectancy, Schizophrenia, business, Demography
Abstract: Aims There is evidence that patients with schizophrenia spectrum disorders present higher mortality in comparison with the general population. The aim of this study was to analyse the causes of mortality and sociodemographic factors associated with mortality, standardised mortality ratios (SMRs), life expectancy and potential years of life lost (YLL) in patients with schizophrenia spectrum disorders in Spain. Methods The study included a cohort of patients from the Malaga Schizophrenia Case Register (1418 patients; 907 males; average age 42.31 years) who were followed up for a minimum of 10 years (median = 13.43). The factors associated with mortality were analysed with a survival analysis using Cox's proportional hazards regression model. Results The main causes of mortality in the cohort were circulatory disease (21.45%), cancer (17.09%) and suicide (13.09%). The SMR of the cohort was more than threefold that of the population of Malaga (3.19). The life expectancy at birth was 67.11 years old, which is more than 13 years shorter than that of the population of Malaga. The YLL was 20.74. The variables associated with a higher risk of mortality were age [adjusted hazard ratio (AHR) = 1.069, p < 0.001], male gender (AHR = 1.751, p < 0.001) and type of area of residence (p = 0.028; deprived urban zone v. non-deprived urban area, AHR = 1.460, p = 0.028). In addition, receiving welfare benefit status in comparison with employed status (AHR = 1.940, p = 0.008) was associated with increased mortality. Conclusions There is excess mortality in patients with schizophrenia spectrum disorders and also an association with age, gender, socioeconomic inequalities and receiving welfare benefits. Efforts directed towards improved living conditions could have a positive effect on reducing mortality.
Published: 2021

28. Physician-perceived utility of the EORTC QLQ-GINET21 questionnaire in the treatment of patients with gastrointestinal neuroendocrine tumours: a multicentre, cross-sectional survey (QUALINETS)

Author: Teresa Alonso, Guillermo de la Cruz, Neus Canal, Lourdes García, Alberto Carmona, Javier Sastre, Javier Gallego, Isabel Sevilla, Guillermo Crespo, Jaume Capdevila, Ángel Segura, Marta Benavent, Ignacio García Escobar, Ipsen, [Benavent,M] Virgen Del Rocío University Hospital, Biomedicine Institut Biomedicina of Sevilla (IBIS), Sevilla, Spain. [Sastre,J] San Carlos Clinic Hospital, San Carlos Hospital Research Institute (IdISSC), Madrid, Spain. [García Escobar,I] San Pedro De Alcántara Hospital, Cáceres, Spain. [Segura,A] Politécnico La Fe University Hospital, Valencia, Spain. [Capdevila,J] Teknon Oncologic Institut (IOT), Teknon Medical Center, Vall Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Carmona,A] Morales Meseguer General University Hospital, Murcia, Spain. [Sevilla,I] Clinical and Translational Research in Cancer, Biomedical Research Institut of Malaga (IBIMA), Regional University Hospital and Virgen de la Victoria University Hospital of Málaga, Málaga, Spain. [Alonso,T] Ramón y Cajal Hospital, Madrid, Spain. [Crespo,G] Burgos University Hospital, Burgos, Spain. [García,L] Segovia General Hospital, Segovia, Spain. [Canal,N] IQVIA Information S.A., Barcelona, Spain. [de la Cruz,G] Ipsen Pharma S.A., Barcelona, Spain. [Gallego,J] Hospital General Universitario de Elche, Elche, Alicante, Spain., This study was sponsored by Ipsen, Institut Català de la Salut, [Benavent M] Virgen Del Rocío University Hospital, Biomedicine Institut Biomedicina of Sevilla (IBIS), Sevilla, Spain. [Sastre J] San Carlos Clinic Hospital, San Carlos Hospital Research Institute (IdISSC), Madrid, Spain. [Escobar IG] San Pedro De Alcántara Hospital, Cáceres, Spain. [Segura A] Politécnico La Fe University Hospital, Valencia, Spain. [Capdevila J] Teknon Oncologic Institut (IOT), Teknon Medical Center. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Carmona A] Morales Meseguer General University Hospital, Murcia, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: Male, Information Science::Information Science::Communication [Medical Subject Headings], Cross-sectional study, Health-related quality of life, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Neuroendocrine tumours, Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms [DISEASES], Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires::Health Care Surveys::Patient Reported Outcome Measures [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Routine clinical practice, 030212 general & internal medicine, ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida [ATENCIÓN DE SALUD], Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Gastrointestinal Neoplasms, Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospitals [Medical Subject Headings], Communication, Outcome measures, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings], General Medicine, Health Care::Health Care Facilities, Manpower, and Services::Health Personnel::Physicians [Medical Subject Headings], Middle Aged, humanities, Tumors neuroendocrins, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Neuroendocrine Tumors, 030220 oncology & carcinogenesis, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Quality of Life [Medical Subject Headings], lcsh:R858-859.7, Female, Persons::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings], Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors [Medical Subject Headings], Adult, medicine.medical_specialty, Attitude of Health Personnel, Pacients - Satisfacció, Check Tags::Male [Medical Subject Headings], lcsh:Computer applications to medicine. Medical informatics, 03 medical and health sciences, Young Adult, Quality of life (healthcare), neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales [ENFERMEDADES], Physicians, medicine, Humans, In patient, Patient Reported Outcome Measures, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Diseases::Digestive System Diseases::Digestive System Neoplasms::Gastrointestinal Neoplasms [Medical Subject Headings], Quality of Life Research, Aged, Health related quality of life, Médicos, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Portugal, técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios::encuestas sobre atención a la salud::medidas de resultados percibidos por los pacientes [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], business.industry, Research, Public Health, Environmental and Occupational Health, QLQ-GINET21 questionnaire, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Tumores neuroendocrinos, Clinical utility, Geographical Locations::Geographic Locations::Europe::Portugal [Medical Subject Headings], Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life [HEALTH CARE], Cross-Sectional Studies, Check Tags::Female [Medical Subject Headings], Spain, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Attitude::Attitude of Health Personnel [Medical Subject Headings], Avaluació de resultats (Assistència sanitària), Physical therapy, Quality of Life, EORTC QLQ-GINET21, Calidad de Vida, business, Comunicación
Abstract: [Background and objective] Patient-reported outcome measures can provide clinicians with valuable information to improve doctor-patient communication and inform clinical decision-making. The aim of this study was to evaluate the physician-perceived utility of the QLQ-GINET21 in routine clinical practice in patients with gastrointestinal neuroendocrine tumours (GI-NETs). Secondary aims were to explore the patient, clinician, and/or centre-related variables potentially associated with perceived clinical utility., [Methods] Non-interventional, cross-sectional, multicentre study conducted at 34 hospitals in Spain and Portugal (NCT02853422). Patients diagnosed with GI-NETs completed two health-related quality of life (HRQoL) questionnaires (QLQ-C30, QLQ-GINET21) during a single routine visit. Physicians completed a 14-item ad hoc survey to rate the clinical utility of QLQ-GINET21 on three dimensions: 1)therapeutic and clinical decision-making, 2)doctor-patient communication, 3)questionnaire characteristics., [Results] A total of 199 patients at 34 centres were enrolled by 36 participating clinicians. The highest rated dimension on the QLQ-GINET21 was questionnaire characteristics (86.9% of responses indicating “high utility”), followed by doctor-patient communication (74.4%), and therapeutic and clinical decision-making (65.8%). One physician-related variable (GI-NET patient volume > 30 patients/year) was associated with high clinical utility and two variables (older age/less experience treating GI-NETs) with low clinical utility., [Conclusions] Clinician-perceived clinical utility of QLQ-GINET21 is high. Clinicians valued the instruments’ capacity to provide a better understanding of patient perspectives and to identify the factors that had the largest influence on patient HRQoL., This study was sponsored by Ipsen.
Published: 2021

29. Presence of Parabens and Bisphenols in Food Commonly Consumed in Spain

Author: Lourdes Rodrigo, Margarita Aguilera, Ana Rivas, Yolanda Gálvez-Ontiveros, Inmaculada Moscoso-Ruiz, Alberto Zafra-Gómez, [Gálvez-Ontiveros,Y, Rivas,A] Department of Nutrition and Food Science, University of Granada, Campus of Cartuja, Granada, Spain. [Moscoso-Ruiz,I, Zafra-Gómez,A] Department of Analytical Chemistry, University of Granada, Campus of Fuentenueva, Granada, Spain. [Rodrigo,L] Department of Legal Medicine and Toxicology, University of Granada, Granada, Spain. [Aguilera,M] Department of Microbiology, Faculty of Pharmacy, University of Granada, Campus of Cartuja, Granada, Spain. [Gálvez-Ontiveros,Y, Aguilera,M, Rivas,A, Zafra-Gómez,A] Instituto de Investigación Biosanitaria, Ibs-Granada, Granada, Spain., and This work was carried out within the frame of GP/EFSA/ENCO/380 2018/03/G04: OBEMIRISK: Knowledge platform for assessing the risk of Bisphenols on gut microbiota and its role in obesogenic phenotype: looking for biomarkers. This research was also funded by Plan Estatal de I + D + I 2013-2016, Proyecto cofinanciado FEDER-ISCIII PI17/01758, Proyecto cofinanciado FEDER-Consejería de Salud y Familias, Junta de Andalucía PE-0250-2019, Proyecto cofinaciado FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/ Proyecto (P18-RT-4247) and by Fundación Mapfre MAPFRE2018.
Subjects: Bisphenol B, Bisphenol A, Health (social science), Bisphenol, España, Parabens, Plant Science, Bisphenols, 010501 environmental sciences, lcsh:Chemical technology, 01 natural sciences, Health Professions (miscellaneous), Microbiology, Bisphenol AF, Article, parabens, Parabenos, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], chemistry.chemical_compound, Human health, Alimentos, Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols [Medical Subject Headings], lcsh:TP1-1185, Food science, 0105 earth and related environmental sciences, Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Sulfones [Medical Subject Headings], Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Chemistry, food, 010401 analytical chemistry, Mean value, Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Benzhydryl Compounds [Medical Subject Headings], 0104 chemical sciences, Spanish population, Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Carbocyclic::Benzoates::Hydroxybenzoates::Parabens [Medical Subject Headings], Bisphenol S, bisphenols, Food, Spain, Food Science
Abstract: Given the widespread use of bisphenols and parabens in consumer products, the assessment of their intake is crucial and represents the first step towards the assessment of the potential risks that these compounds may pose to human health. In the present study, a total of 98 samples of food items commonly consumed by the Spanish population were collected from different national supermarkets and grocery stores for the determination of parabens and bisphenols. Our analysis demonstrated that 56 of the 98 food samples contained detectable levels of parabens with limits of quantification (LOQ) between 0.4 and 0.9 ng g&minus, 1. The total concentration of parabens (sum of four parabens: &sum, parabens) ranged from below the LOQ to 281.7 ng g&minus, 1, with a mean value of 73.86 ng g⁻1. A total of 52% of the samples showed detectable concentrations of bisphenols. Bisphenol A (BPA) was the most frequently detected bisphenol in the food samples analysed, followed by bisphenol S (BPS) and bisphenol E (BPE). Bisphenol AF (BPAF), bisphenol B (BPB) and bisphenol P (BPP) were not found in any of the analysed samples. LOQ for these bisphenols were between 0.4 and 4.0 ng g&minus, 1.
Published: 2021

30. Frailty, Complexity, and Priorities in the Use of Advanced Palliative Care Resources in Nursing Homes

Author: María P. García-Ruiz, Emilio Mota-Romero, María Paz García-Caro, Daniel Puente-Fernández, Rafael Montoya-Juárez, Beatriz Tallón-Martín, [Mota-Romero,E] Primary Care Center Dr. Salvador Caballero García Andalusian, Health Service, Government of Andalusia. Granada, Andalusia, Spain. [Tallón-Martín,B] Geroinnova Nursing-Home, Fuente Vaqueros, Granada, Andalusia, Spain. [García-Ruiz,MP] Caridad y Consolación Nursing-Home, Jaén, Andalusia, Spain. [Puente-Fernandez,D] Doctoral Program in Clinical Medicine and Public Health, University of Granada, Granada, Andalusia, Spain. [García-Caro,MP, Montoya-Juarez,R] Department of Nursing, Mind, Brain and Behaviour Research Institute, University of Granada, Granada, Andalusia, Spain., and This study has been fully funded by Consejería de Salud, Junta de Andalucía (Fundación Pública Andaluza Progreso y Salud, Proyecto AP-0105-2016)
Subjects: Palliative care, Persons::Persons::Age Groups::Adult::Aged::Frail Elderly [Medical Subject Headings], nursing homes, Complexity index, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, 030212 general & internal medicine, Patient transfer, Cognitive impairment, Casas de salud, lcsh:R5-920, palliative care, Frailty, Atención dirigida al paciente, Pronóstico, frailty, complexity, prognosis, palliative care complexity, patient transfer, General Medicine, Prognosis, Cuidados paliativos, Fragilidad, medicine.symptom, 0305 other medical science, lcsh:Medicine (General), Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Asthenia [Medical Subject Headings], Poor prognosis, medicine.medical_specialty, Barthel index, Nursing homes, Article, 03 medical and health sciences, 030502 gerontology, medicine, Humans, Palliative care complexity, Estudio multicéntrico, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, Diagnostic instrument, Disciplines and Occupations::Health Occupations::Nursing::Specialties, Nursing::Hospice and Palliative Care Nursing [Medical Subject Headings], Andalucía, Complexity, Health Care::Health Care Facilities, Manpower, and Services::Health Services::Patient Care::Palliative Care [Medical Subject Headings], Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Residential Facilities::Nursing Homes [Medical Subject Headings], Cross-Sectional Studies, Spain, Family medicine, Immunology, Delirium, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings], business
Abstract: Background and objectives: This study aimed to determine the frailty, prognosis, complexity, and palliative care complexity of nursing home residents with palliative care needs and define the characteristics of the cases eligible for receiving advanced palliative care according to the resources available at each nursing home. Materials and Methods: In this multi-centre, descriptive, and cross-sectional study, trained nurses from eight nursing homes in southern Spain selected 149 residents with palliative care needs. The following instruments were used: the Frail-VIG index, the case complexity index (CCI), the Diagnostic Instrument of Complexity in Palliative Care (IDC-Pal), the palliative prognosis index, the Barthel index (dependency), Pfeiffer&rsquo, s test (cognitive impairment), and the Charlson comorbidity index. A consensus was reached on the complexity criteria of the Diagnostic Instrument of Complexity in Palliative Care that could be addressed in the nursing home (no priority) and those that required a one-off (priority 2) or full (priority 1) intervention of advanced palliative care resources. Non-parametric tests were used to compare non-priority patients and patients with some kind of priority. Results: A high percentage of residents presented frailty (80.6%), clinical complexity (80.5%), and palliative care complexity (65.8%). A lower percentage of residents had a poor prognosis (10.1%) and an extremely poor prognosis (2%). Twelve priority 1 and 14 priority 2 elements were identified as not matching the palliative care complexity elements that had been previously identified. Of the studied cases, 20.1% had priority 1 status and 38.3% had priority 2 status. Residents with some kind of priority had greater levels of dependency (p &lt, 0.001), cognitive impairment (p &lt, 0.001), and poorer prognoses (p &lt, 0.001). Priority 1 patients exhibited higher rates of refractory delirium (p = 0.003), skin ulcers (p = 0.041), and dyspnoea (p = 0.020). Conclusions: The results indicate that there are high levels of frailty, clinical complexity, and palliative care complexity in nursing homes. The resources available at each nursing home must be considered to determine when advanced palliative care resources are required.
Published: 2021

31. Molecular characterization of multidrug resistant Enterobacterales strains isolated from liver and kidney transplant recipients in Spain

Author: Fernandez-Martinez, Marta, Gonzalez-Rico, Claudia, Gozalo-Marguello, Monica, Marco, Francesc, Gracia-Ahufinger, Irene, Aranzamendi, Maitane, Sanchez-Diaz, Ana M., Vicente-Rangel, Teresa, Chaves, Fernando, Calvo Montes, Jorge, Martinez-Martinez, Luis, Carmen Farinas, Maria, ENTHERE Study Grp, Spanish Soc Infect Dis Clinical Mi, Spanish Network Res Infect Dis REI, Universidad de Cantabria, [Fernandez-Martinez, Marta] Hosp Univ Marques de Valdecilla, Serv Microbiol, Santander, Spain, [Gozalo-Marguello, Monica] Hosp Univ Marques de Valdecilla, Serv Microbiol, Santander, Spain, [Calvo Montes, Jorge] Hosp Univ Marques de Valdecilla, Serv Microbiol, Santander, Spain, [Fernandez-Martinez, Marta] Inst Invest Valdecilla IDIVAL, Santander, Spain, [Gonzalez-Rico, Claudia] Inst Invest Valdecilla IDIVAL, Santander, Spain, [Gozalo-Marguello, Monica] Inst Invest Valdecilla IDIVAL, Santander, Spain, [Calvo Montes, Jorge] Inst Invest Valdecilla IDIVAL, Santander, Spain, [Carmen Farinas, Maria] Inst Invest Valdecilla IDIVAL, Santander, Spain, [Gonzalez-Rico, Claudia] Hosp Univ Marques Valdecilla, Serv Enfermedades Infecciosas, Santander, Spain, [Carmen Farinas, Maria] Hosp Univ Marques Valdecilla, Serv Enfermedades Infecciosas, Santander, Spain, [Marco, Francesc] Univ Barcelona, Hosp Clin ISGlobal, Ctr Diagnost Biomed, Serv Microbiol, Barcelona, Spain, [Gracia-Ahufinger, Irene] Hosp Univ Reina Sofia, Unidad Microbiol, Cordoba, Spain, [Martinez-Martinez, Luis] Hosp Univ Reina Sofia, Unidad Microbiol, Cordoba, Spain, [Gracia-Ahufinger, Irene] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain, [Martinez-Martinez, Luis] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain, [Aranzamendi, Maitane] Hosp Univ Cruces, Serv Microbiol, Baracaldo, Vizcaya, Spain, [Aranzamendi, Maitane] Inst Invest Sanitaria Biocruces, Vizcaya, Spain, [Sanchez-Diaz, Ana M.] Hosp Univ Ramon y Cajal, Serv Microbiol, Madrid, Spain, [Vicente-Rangel, Teresa] Hosp Gen Univ Gregorio Maranon, Serv Microbiol Clin & Enfermedades Infecciosas, Madrid, Spain, [Chaves, Fernando] Hosp Univ 12 Octubre, Serv Microbiol, Madrid, Spain, [Martinez-Martinez, Luis] Univ Cordoba, Hosp Univ Reina Sofia, IMIBIC, Dept Microbiol,Unidad Microbiol, Cordoba, Spain, Plan Nacional de I+D+i and Instituto de Salud Carlos III, Spanish Network for Research in Infectious Diseases, European Development Regional Fund 'A way to achieve Europe', Operative Program Intelligent Growth, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Ciencia, Innovacion y Universidades, ENTHERE Study Group, the Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbiology (GESITRA-SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI), [Fernández-Martínez,M, Gozalo-Margüello,M, Calvo Montes,J] Servicio de Microbiología, Hospital Universitario Marqués de Valdecilla, Santander, Spain. [Fernández-Martínez,M, González-Rico,C, Calvo Montes,J, Fariñas,MC] Instituto de Investigación Valdecilla-IDIVAL, Santander, Spain. [González-Rico,C, Fariñas,MC] Servicio de Enfermedades Infecciosas, Hospital Universitario Marqués de Valdecilla, Santander, Spain. [Marco,F] Servicio de Microbiología, Centro Diagnóstico Biomédico, Hospital Clínic. ISGlobal, Universidad de Barcelona, Barcelona, Spain. [Gracia-Ahufinger,I, Martínez-Martínez,L] Unidad de Microbiología, Hospital Universitario Reina Sofía, Córdoba, Spain. [Gracia-Ahufinger,I, Martínez-Martínez,L] Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. [Aranzamendi,M] Servicio de Microbiología, Hospital Universitario de Cruces, Baracaldo, Vizcaya, Spain. [Aranzamendi,M] Instituto de Investigación Sanitaria Biocruces, Vizcaya, Spain. [Sánchez-Díaz,AM] Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Vicente-Rangel,T] Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Chaves,F] Servicio de Microbiología, Hospital Universitario 12 de Octubre, Madrid, Spain. [Martínez-Martínez,L] Departamento of Microbiología, Unidad de Microbiología, Hospital Universitario Reina Sofía, IMIBIC, Universidad de Córdoba, Córdoba, Spain., and Te study was co-fnanced by the Euro pean Development Regional Fund 'A way to achieve Europe' and the Operative Program Intelligent Growth 2014‐2020.
Subjects: 0301 basic medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Organ Transplantation::Pancreas Transplantation [Medical Subject Headings], Klebsiella pneumoniae, Epidemiology, España, Riñón, medicine.disease_cause, Kidney, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Lactamase-producing enterobacteriaceae, Resistencia a múltiples medicamentos, Phenomena and Processes::Microbiological Phenomena::Drug Resistance, Microbial::Drug Resistance, Bacterial::Drug Resistance, Multiple, Bacterial [Medical Subject Headings], 0302 clinical medicine, Enterobacterales, Drug Resistance, Multiple, Bacterial, Prevalence, Colonization, Multidrug-resistant, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings], Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae [Medical Subject Headings], High-risk clones, Multidisciplinary, Surveillance, biology, Antimicrobials, Bacterial Infections, Hospitals, Citrobacter freundii, Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Escherichia::Escherichia coli [Medical Subject Headings], Anti-Bacterial Agents, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Microbiological Techniques::Microbial Sensitivity Tests [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Organ Transplantation::Kidney Transplantation [Medical Subject Headings], Medicine, Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Klebsiella::Klebsiella pneumoniae [Medical Subject Headings], Pancreas Transplantation, Infection, Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Carbapenems [Medical Subject Headings], Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Organ Transplantation::Liver Transplantation [Medical Subject Headings], Science, 030106 microbiology, Microbial Sensitivity Tests, Infections, Microbiology, Article, Diseases::Bacterial Infections and Mycoses::Bacterial Infections [Medical Subject Headings], 03 medical and health sciences, Enterobacteriaceae, Enterobacter cloacae, medicine, Escherichia coli, Infección, Humans, Clinical microbiology, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Transplantation, business.industry, biology.organism_classification, Kidney Transplantation, Transplant Recipients, Liver Transplantation, Multiple drug resistance, Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Citrobacter::Citrobacter freundii [Medical Subject Headings], Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Enterobacter::Enterobacter cloacae [Medical Subject Headings], Carbapenems, Spain, Trasplante, business
Abstract: The objective of this study was to analyse the mechanisms of resistance to carbapenems and other extended-spectrum-?-lactams and to determine the genetic relatedness of multidrug-resistant Enterobacterales (MDR-E) causing colonization or infection in solid-organ transplantation (SOT) recipients. Prospective cohort study in kidney (n= 142), liver (n= 98) or kidney/pancreas (n= 7) transplant recipients between 2014 and 2018 in seven Spanish hospitals. We included 531 MDR-E isolates from rectal swabs obtained before transplantation and weekly for 4?6 weeks after the procedure and 10 MDR-E from clinical samples related to an infection. Overall, 46.2% Escherichia coli, 35.3% Klebsiella pneumoniae, 6.5% Enterobacter cloacae, 6.3% Citrobacter freundii and 5.7% other species were isolated. The number of patients with MDR-E colonization post-transplantation (176; 71.3%) was 2.5-fold the number of patients colonized pre-transplantation (71; 28.7%). Extended spectrum ?-lactamases (ESBLs) and carbapenemases were detected in 78.0% and 21.1% of MDR-E isolates respectively. In nine of the 247 (3.6%) transplant patients, the microorganism causing an infection was the same strain previously cultured from surveillance rectal swabs. In our study we have observed a low rate of MDR-E infection in colonized patients 4?6 weeks post-transplantation. E. coli producing blaCTX-M-G1 and K. pneumoniae harbouring blaOXA-48 alone or with blaCTX-M-G1 were the most prevalent MDR-E colonization strains in SOT recipients. Acknowledgements The authors thank Mª Jesús Lecea and Laura Álvarez for technical assistance. Tis research was supported by ‘Plan Nacional de I+D+i and Instituto de Salud Carlos III (Fondo de Investigaciones Sanitarias 13/01191), Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, and the Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0007, RD16/0016/0010, RD16/0016/0012, RD16/0016/0011, RD16/0016/0008, RD16/0016/0002). Te study was co-fnanced by the European Development Regional Fund “A way to achieve Europe” and the Operative Program Intelligent Growth 2014‐2020.
Published: 2021

32. Epidemiology, treatment, and survival in small cell lung cancer in Spain: Data from the Thoracic Tumor Registry

Author: Bartomeu Massuti, Paola García Coves, M. Guirado, Julia Calzas, Ana Ortega, R. López-Castro, Edel del Barco, Oscar Juan, Delvys Rodriguez-Abreu, Rosario García-Campelo, Jose Manuel Trigo, Francisco Aparisi, Enric Carcereny, Joaquim Bosch-Barrera, Mariano Provencio, Manuel Cobo, Fernando Faria Franco, José Luis González-Larriba, Manuel Domine, S. Cerezo, Marta Domenech, [Franco,F, Provencio,M] Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain. [Carcereny,E, Domènech,M] Catalan Institute of Oncology, Hospital Universitari Germans Trias i Pujol, B-ARGO, IGTP, Badalona, Spain. [Guirado,M, García Coves,P] Hospital General Universitario de Elche, Elche, Spain. [Ortega,AL] Hospital Universitario de Jaén, Jaén, Spain. [López-Castro,R] Hospital Clínico Universitario de Valladolid, Valladolid, Spain. [Rodríguez-Abreu,D] Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain. [García-Campelo,R] Complejo Hospitalario Universitario A Coruña, A Coruña, Spain. [Del Barco,E] Hospital Universitario de Salamanca, Salamanca, Spain. [Juan,O] Hospital Universitario y Politécnico La Fe, Valencia, Spain. [Aparisi,F] Hospital General de Valencia, Valencia, Spain. [González-Larriba,JL] Hospital Universitario Clínico San Carlos, Madrid, Spain. [Domine,M] Hospital Universitario Fundación Jiménez Díaz, IIS-FJD, Madrid, Spain. [Trigo,JM, Cobo,M] Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria, IBIMA, Málaga, Spain. [Cerezo,S] Hospital General La Mancha Centro, Alcázar de San Juan, Spain. [Calzas,J] Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain. [Massutí,B] Hospital General Universitario de Alicante, Alicante, Spain. [Bosch-Barrera,J] Catalan Institute of Oncology, Girona, Spain., The TTR registry was supported by Fundación GECP, AstraZeneca, Novartis, Roche, the European Union’s Horizon 2020 research and innovation program (CLARIFY 875160)., and Servicio de Oncología. Hospital Universitario de Fuenlabrada
Subjects: Central Nervous System, Male, Lung Neoplasms, Survival, Epidemiology, medicine.medical_treatment, Terapéutica, España, Cancer Treatment, Carcinoma pulmonar de células pequeñas, Nervous System, Lung and Intrathoracic Tumors, Metastasis, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Small Cell Lung Cancer, chemistry.chemical_compound, STAGE, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Retrospective Studies [Medical Subject Headings], Basic Cancer Research, Medicine and Health Sciences, Registries, Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Follow-Up Studies [Medical Subject Headings], Neurological Tumors, Neoplasias torácicas, Etoposide, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Multidisciplinary, Supervivencia (salud pública), Middle Aged, respiratory system, Prognosis, Combined Modality Therapy, humanities, Survival Rate, PROPHYLACTIC CRANIAL IRRADIATION, Oncology, Neurology, CISPLATIN-BASED CHEMOTHERAPY, Medicine, Female, Anatomy, Health Care::Population Characteristics::Demography::Vital Statistics::Mortality::Survival Rate [Medical Subject Headings], RADIOTHERAPY, Research Article, medicine.drug, medicine.medical_specialty, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Combined Modality Therapy [Medical Subject Headings], Science, Check Tags::Male [Medical Subject Headings], Diseases::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms [Medical Subject Headings], Diagnostic Medicine, Internal medicine, Cancer Detection and Diagnosis, medicine, Humans, Epidemiología, Lung cancer, neoplasms, Aged, Retrospective Studies, Thoracic tumor, Cisplatin, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Chemotherapy, Diseases::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms::Bronchial Neoplasms::Carcinoma, Bronchogenic::Small Cell Lung Carcinoma [Medical Subject Headings], Small cell lung cancer, business.industry, Cancers and Neoplasms, Biology and Life Sciences, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], EFFICACY, medicine.disease, TRENDS, Small Cell Lung Carcinoma, Carboplatin, Non-Small Cell Lung Cancer, respiratory tract diseases, Treatment, chemistry, Check Tags::Female [Medical Subject Headings], Spain, Brain Metastasis, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings], Observational study, 1ST-LINE, business, Follow-Up Studies
Abstract: Background Small-cell lung cancer (SCLC) is an aggressive disease with high metastatic potential and poor prognosis. Due to its low prevalence, epidemiological and clinical information of SCLC patients retrieved from lung cancer registries is scarce. Patients and methods This was an observational multicenter study that enrolled patients with lung cancer and thoracic tumors, recruited from August 2016 to January 2020 at 50 Spanish hospitals. Demographic and clinical data, treatment patterns and survival of SCLC patients included in the Thoracic Tumor Registry (TTR) were analyzed. Results With a total of 956 cases, the age of 64.7 ± 9.1 years, 78.6% were men, 60.6% smokers, and ECOG PS 0, 1 or ≥ 2 in 23.1%, 53.0% and 23.8% of cases, respectively. Twenty percent of patients had brain metastases at the diagnosis. First-line chemotherapy (CT), mainly carboplatin or cisplatin plus etoposide was administered to >90% of patients. In total, 36.0% and 13.8% of patients received a second and third line of CT, respectively. Median overall survival was 9.5 months (95% CI 8.8–10.2 months), with an estimated rate of 70.3% (95% CI 67.2–73.4%), 38.9% (95% CI 35.4–42.4%), and 14.8% (95% CI 11.8–17.8%) at 6, 12 and 24 months respectively. Median progression-free survival was 6.3 months. Higher mortality and progression rates were significantly associated with male sex, older age, smoking habit, and ECOG PS 1–2. Long-term survival (> 2 years) was confirmed in 6.6% of patients, showing a positive correlation with better ECOG PS, poor smoking and absence of certain metastases at diagnosis. Conclusion This study provides an updated overview of the clinical situation and treatment landscape of ES-SCLC in Spain. Our results might assist oncologists to improve current clinical practice towards a better prognosis for these patients.
Published: 2021

33. Previous Usutu virus exposure partially protects magpies (Pica pica) against west Nile virus disease but does not prevent horizontal transmission

Author: María-Cruz Camacho, María Ángeles Risalde, Laura Muriel, Nereida Jiménez de Oya, Ana-Belén Blázquez, Miguel A. Martín-Acebes, Estela Escribano-Romero, Juan-Carlos Saiz, Ursula Höfle, CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), [Escribano-Romero,E, Jiménez de Oya,N, Blázquez,AB, Martín-Acebes,MA, Saiz,JC] Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain. [Camacho,MC, Höfle,U] Health and Biotechnology Research Group SaBio, National Institute for Game Rearch IREC (University of Castilla—La Mancha UCLM-National Research Council CSIC-Regional Government of Castilla—La Mancha JCCM), Ciudad Real, Spain. [Risalde,MA, Muriel,L] Departamento de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Córdoba (UCO), Córdoba, Spain. [Risalde,MA] Infectious Diseases Unit, Hospital Universitario Reina Sofía de Córdoba, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain., This work was supported by grants RTA2015-009 and E-RTA2017-003-C02 from Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (España), Escribano-Romero, E [0000-0002-5036-7607], de Oya, NJ [0000-0003-3129-813X], Blazquez, AB [0000-0002-0847-0977], Martín-Acebes, Miguel Ángel [0000-0001-6015-3613], Risalde, MA [0000-0001-6751-1305], Muriel, L [0000-0002-5513-0190], Saiz, JC [0000-0001-8269-5544], and Hofle, U [0000-0002-6868-079X]
Subjects: 0301 basic medicine, Diseases::Virus Diseases::RNA Virus Infections::Flaviviridae Infections::Flavivirus Infections [Medical Subject Headings], cross-protection, Cross Protection, viruses, Flaviviruses, Health Care::Environment and Public Health::Public Health::Disease Transmission, Infectious [Medical Subject Headings], Antibodies, Viral, Phenomena and Processes::Immune System Phenomena::Immunity::Cross Protection [Medical Subject Headings], Protección cruzada, Organisms::Eukaryota::Animals [Medical Subject Headings], Organisms::Viruses::RNA Viruses::Flaviviridae::Flavivirus [Medical Subject Headings], Passeriformes, Usutu virus, Neutralizing antibody, Diseases::Animal Diseases::Bird Diseases [Medical Subject Headings], Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Viral [Medical Subject Headings], biology, Transmission (medicine), virus diseases, avian host, QR1-502, Co-infection, Flavivirus, Titer, Infectious Diseases, Organisms::Viruses::RNA Viruses::Flaviviridae::Flavivirus::Encephalitis Viruses, Japanese::West Nile virus [Medical Subject Headings], Varroa destructor, Antibody, Avian host, West Nile virus, Cross-protection, Horizontal transmission, Magpie, 030106 microbiology, Viremia, Microbiology, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Birds::Passeriformes [Medical Subject Headings], Article, Flavivirus Infections, 03 medical and health sciences, co-infection, Virology, Diseases::Virus Diseases::Arbovirus Infections::Encephalitis, Arbovirus::West Nile Fever [Medical Subject Headings], medicine, Disease Transmission, Infectious, Animals, Adaptación al huésped, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Bird Diseases, biology.organism_classification, medicine.disease, 030104 developmental biology, Spain, biology.protein, Coinfección, magpie, West Nile Fever
Abstract: This article belongs to the Special Issue Viral Shedding and Transmission in Zoonotic Diseases., The mosquito-borne flaviviruses USUV and WNV are known to co-circulate in large parts of Europe. Both are a public health concern, and USUV has been the cause of epizootics in both wild and domestic birds, and neurological cases in humans in Europe. Here, we explore the susceptibility of magpies to experimental USUV infection, and how previous exposure to USUV would affect infection with WNV. None of the magpies exposed to USUV showed clinical signs, viremia, or detectable neutralizing antibodies. After challenge with a neurovirulent WNV strain, neither viremia, viral titer of WNV in vascular feathers, nor neutralizing antibody titers of previously USUV-exposed magpies differed significantly with respect to magpies that had not previously been exposed to USUV. However, 75% (6/8) of the USUV-exposed birds survived, while only 22.2% (2/9) of those not previously exposed to USUV survived. WNV antigen labeling by immunohistochemistry in tissues was less evident and more restricted in magpies exposed to USUV prior to challenge with WNV. Our data indicate that previous exposure to USUV partially protects magpies against a lethal challenge with WNV, while it does not prevent viremia and direct transmission, although the mechanism is unclear. These results are relevant for flavivirus ecology and contention., This work was supported by grants RTA2015-009 and E-RTA2017-003-C02 from Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA).
Published: 2021

34. Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Author: Jesús Rodríguez-Baño, Jerónimo Pachón, Jordi Carratalà, Pablo Ryan, Inmaculada Jarrín, María Yllescas, José Ramón Arribas, Juan Berenguer, Esther Aznar Muñoz, Pedro Gil Divasson, Patricia González Muñiz, Clara Muñoz Aguirre, Marta Díaz Menéndez, Fernando de la Calle Prieto, Marta Arsuaga Vicente, Elena Trigo Esteban, Ignacio Pérez Valero, Rosa de Miguel Buckley, Julen Cadiñaños Loidi, Beatriz Diaz Pollan, Luz Martín Carbonero, Juan Carlos Ramos Ramos, Belén Loeches Yagüe, Rocío Montejano Sánchez, Juan González García, Julio García Rodríguez, Margarita Ramírez, Isabel Gutiérrez, Francisco Tejerina, Teresa Aldámiz-Echevarría, Cristina Díez, Chiara Fanciulli, Leire Pérez-Latorre, Blanca Pinilla, Juan Carlos López, Ana Such Diaz, Elena Álvaro Alonso, Juan Torres Macho, Guillermo Cuevas Tascon, Eva Jiménez González de Buitrago, Fátima Brañas Baztán, Jorge Valencia de la Rosa, Mario Pérez Butragueño, Inés Fernández Jiménez, Gemma Muñiz Nicolás, Antonia Sepúlveda Berrocal, Alberto Gato Díez, María Pilar Toledano Sierra, María Paz García Butenegro, Ana Isabel Peláez Ballesta, Elena Morcillo Rodríguez, Isidoro Fernández Romero, Cristina Peláez Ballesta, María Isabel Guirado Torrecillas, Josune Goikoetxea Agirre, Elena Bereciartua Bastarrica, Laura Guio Carrión, Regino Rodríguez Álvarez, Marta Ibarrola Hierro, Isabel A. Pérez Hernández, Inés Pérez Zapata, Sergio Román Soto, Mohamed Kallouchi, Juan Ramón Domínguez Vicent, Rafae Silvariño Fernández, Jon Ugalde Espiñeira, Ainhoa Sanjuan López, Silvia García Martínez, Mikel Temprano Gogenola, Víctor Asensi, Silvia Suárez, Lucia Suárez, Carmen Yllera, María Rivas-Carmenado, Alberto Romero-Palacios, Jesús Ruiz Aragón, Patricia Jiménez Aguilar, Ma Luisa Fernández Ávila, Rosario Castilla Ortiz, Vanesa Alende Castro, Cristina Pérez García, Marta Fernández Morales, María Lorena María Valle Feijoo Begoña Rodríguez Ferreira, Joan Gómez-Junyent, Judit Villar-García, Inmaculada López-Montesinos, Itziar Arrieta-Aldea, Abora Rial-Villavecchia, Elisa García Vázquez, Aychel Elena Roura Piloto, Encarnación Moral Escudero, Alicia Hernández Torres, Helena Albendín Iglesias, David Vinuesa García, Clara Martínez Montes, Francisco Javier De la Hera Fernández, Francisco Anguita Santos, Andrés Ruiz Sancho, Vicens Díaz de Brito Fernández, Montserrat Sanmarti Vilamala, Sergio España Cueto, Daniel Molina Morant, Araceli González-Cuevas, Joel Elías Chara Cervantes, Guillem Policarpo Torres, Meritxell Ortega Montoliu, Mònica Angerri Nadal, Ariadna De Genover Gil, Eleni Patera, Rita Godoy Lorenzo, Evangelia Anna María Zioga, Virginia Isern Fernández, Carlos Enrique Sabbagh Fajardo, Ana Ferrer Ribera, Carlos Bea Serrano, Rosa Oltra Sempere, Sara Vela Bernal, Paloma Albiol Viñals, Miguel Pedromingo Kus, María Ángeles Garcinuño, Silvana Fiorante, Sergio Pérez Pinto, Alexandra de la Vega, María Carmen Fariñas Álvarez, Claudia González Rico, Francisco Arnaiz de las Revillas, Teresa Giménez, Jorge Calvo, Yolanda Meije Castillo, Alejandra Duarte Borges, Júlia Pareja Coca, Mercedes Clemente Presas, Xavier Sanz Salvador, Ma Teresa Pérez Rodríguez, Adrián Sousa, Alexandre Pérez González, Rebeca Longueira, Alejandro Araujo, Blanca Alonso Martínez, Laura García Escudero, Sara Lidia Kamel Rey, David Roa Alonso, Juan Pablo Avilés Parra, Iván Pelegrín Senent, Rosana Rouco Esteves Marques, Laia Raich Montiu, Jessica Souto Higueras, Manuel Alejandro Gálvez Bobadilla, Jorge Parra Ruiz, Violeta Ramos Sesma, Sara Velasco Fuentes, Laura García Pereña, Alfonso Lluna Carrascosa, Sergio Gilaberte Reyzábal, Mónica Liébana Gómez, Juan Salillas Hernando, Alberto Serrano Martínez, Miguel Torralba González de Suso, Patricia Martínez Martín, Isabel Rábago Lorite, Patricia González-Ruano Pérez, Beatriz Pérez-Monte Mínguez, Ángeles García Flores, Pere Comas Casanova, Andrea Martín Plata, Sergio Manuel Santana Báez, Oscar Sanz Peláez, Karim Mohamed Ramírez, José María Robaina Bordón, Helem Haydeé Vílchez Rueda, Melchor Riera Jaume, Gemma Mut Ramon, Meritxell Gavalda Manso, Lluis Planas Bibiloni, Laura Castelo Corral, Lucía Ramos Merino, Efrén Sánchez Vidal, María Rodríguez Mayo, Enrique Míguez Rey, José M. García de Lomas Guerrero, Javier De la Torre Lima, Ana Correa Ruiz, Fernando Fernández Sánchez, Nicolás Jiménez-García, José Luis Sierra-Monzón, Borja Gracia-Tello, María Hernández-Bonaga, Galadriel Pellejero, Marta Asín-Corrochano, Lucia Boix Palop, Esther Calbo, Cristina Badía, Beatriz Dietl, Gómez Lucía, Ángel Domínguez-Castellano, María José Ríos-Villegas, María D. del Toro, Zaira R. Palacios Baena, Elena Salamanca-Rivera, Elena Marín, Virginia Almadana, Salvador Pérez-Galera, Luisa González-Iglesias, Gabriela Abelenda-Alonso, Claudia Álvarez-Pouso, Francesc Escrihuela, Carlota Gudiol, Laia Lorenzo-Esteller, Jordi Niubó, Daniel Podzamczer, Miquel Pujol, Alexander Rombauts, Miguel Salvert Lletí, Ricardo Gil Sánchez, Marta Jiménez Escrig, Laura Parra Gómez, Mariona Tasias Pitarch, Marta Navarro Vilasaró, María Luisa Machado Sicilia, Aina Gomila Grange, Sonia Calzado Isbert, Nerea Carrasco Antón, Elizabet Petkova-Saiz, Alfonso Cabello Úbeda, Miguel Górgolas Hernández-Mora, Olga Sánchez-Pernaute, Carlos Dueñas Gutiérrez, Javier Martin Guerra, José Javier Castrodeza Sanz, Virginia Fernández Espinilla, Laura Rodríguez Fernández, Juan González-Moreno, Aroa Villoslada Gelabert, María Antonia Ribot Sanso, María Victoria Fernández-Baca, Almudena Hernández Milian, Miguel Ángel Morán Rodríguez, Zuriñe Ortiz de Zárate Ibarra, José Joaquin Portu Zapirain, Ester Saez de Adana Arroniz, Juan Carlos Gainzarain Arana, Olga Meca Birlanga, Ma Jesús del Amor Espín, Montserrat Viqueira González, Josefina García García, Onofre Martínez Madrid, Enrique Bernal Morell, Antonia Alcaraz, Ángeles Muñoz, Ignacio Pina, Vicente de la Rosa, Tamara Caínzos Romero, Sabela Sánchez Trigo, Ana Isabel Mariño Callejo, Hortensia Álvarez Díaz, Nieves Valcarce Pardeiro, Adriana Sánchez Serrano, Diana Piñar Cabezos, Eva Pilar García Villalba, Carmen Aguayo Jiménez, María Ruíz Campuzano, Virginia Naranjo Velasco, Marta Santos Peña, Juan Mora Delgado, Israel Sevilla Moreno, Cristina Lojo Cruz, Xabier Kortajarena Urkola, José Antonio Iribarren Loyarte, María Jesús Bustinduy Odriozola, Maialen Ibarguren Pinilla, Ignacio Álvarez Rodríguez, Francisco Javier Martínez Marcos, Francisco Javier Rodríguez Gómez, Isabel Asschert Agüero, Francisco Muñoz Beamud, Antonio José Ruiz Reina, Jara Llenas-García, Inmaculada González-Cuello, Elena Hellín-Valiente, Esther Martínez Birlanga, José Manuel Tafalla Torres, Jorge Calderón Parra, Gabriela Escudero López, Isabel Gutiérrez Martín, Ane Andrés Eisenhofer, Sonia García Prieto, Raquel Álvarez Franco, Daniel Roger Zapata, Blanca Martínez Cifre, Elena Aranda Rife, Irene Martín Rubio, André Barbosa Ventura, Javier Garrido, Concepción Gonzalo, Iván Piñero, Nieves de la Cruz Felipe, Eva Talavera García, Marta Lamata Subero, Paula Mendoza Roy, María Soledad García de Carlos, Justo Lajusticia Aisa, Lorea Arteche Eguizabal, Ainhoa Urrutia Losada, Saioa Domingo Echaburu, Pedro Ángel Cuadros Tito, Gurutz Orbe Narváez, Ma del Carmen Liébana Martos, Carolina Roldán Fontana, Carmen Herrero Rodríguez, Gaspar Duro Ruiz, Santiago Pérez Parra, Arantzazu Mera Fidalgo, Miquel Hortos Alsina, Ana Alberich Conesa, Lourdes Bladé Vidal, Nicolás Merchante Gutiérrez, Eva León Jiménez, Reinaldo Espíndola Gómez, María Erostarbe Gallardo, Pedro Martínez Pérez-Crespo, José Miguel Cisneros, Manuela Aguilar-Guisado, Teresa Aldabó, Claudio Bueno, Elisa Cordero-Matía, Ana Escoresca, Carmen Infante, Martín Guillermo, Sonsoles Salto, Francesca Gioia, Pilar Vizcarra, Jesús Fortún Abete, Pilar Martín Dávila, Santiago Moreno Guillén, José A. Oteo Revuelta, Concepción García-García, Paula Santibañez Sáenz, Cristina Cervera Acedo, José M. Azcona Gutiérrez, José María Reguera Iglesias, Antonio Plata Ciezar, Lucia Valiente de Santis, Beatriz Sobrino Diaz, Juan Diego Ruiz Mesa, Ministerio de Ciencia e Innovación, Fundación SEIMC/GeSIDA, Instituto de Salud Carlos III - ISCIII, European Regional Development Fund (ERDF/FEDER), Red Española de Investigación en SIDA, Red Española de Investigación en Patología Infecciosa, UAM. Departamento de Medicina, UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología, Universidad de Cantabria, SAM-COVID Study Group, [Rodríguez-Baño,J] Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Rodríguez-Baño,J, Pachón,J] Departamento de Medicina, Universidad de Sevilla, Spain. [Rodríguez-Baño,J, Pachón,J] Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain. [Pachón,J] Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen del Rocío, Sevilla, Spain. [Carratalà,J] Servei de Malalties Infeccioses, Hospital Universitari de Bellvitge, Barcelona, Spain. [Carratalà,J] Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona, Spain. [Carratalà,J] Universitat de Barcelona, Barcelona, Spain. [Ryan,P] Servicio de Medicina Interna, Hospital Universitario Infanta Leonor, Madrid, Spain. [Jarrín,I] Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, Spain. [Yllescas,M] Fundación SEIMC/GeSIDA, Madrid, Spain. [Arribas,JR] Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain. [Arribas,JR] Instituto de Investigación Hospital Universitario La Paz, Madrid, Spain. [Berenguer,J] Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Berenguer,J] Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Red de Investigación Cooperativa en Investigación en Sida (España), Red de Investigación Cooperativa en Investigación en Patología Infecciosa (España), Gilead Sciences, ViiV Healthcare, AbbVie Pharmaceuticals, Merck & Co, Janssen Biotech, Teva Pharmaceutical Industries, Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Universidad de Sevilla. Departamento de Medicina, Instituto Carlos III (España), and Unión Europea
Subjects: 0301 basic medicine, Male, law.invention, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], chemistry.chemical_compound, 0302 clinical medicine, Organisms::Viruses::RNA Viruses::Nidovirales::Coronaviridae [Medical Subject Headings], Randomized controlled trial, law, Adrenal Cortex Hormones, Clinical endpoint, Medicine, 030212 general & internal medicine, Hospital Mortality, Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Vital Statistics::Mortality [Medical Subject Headings], Adrenocortical hormones, Hazard ratio, General Medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Intubation::Intubation, Intratracheal [Medical Subject Headings], Middle Aged, Tocilizumab, Hospitalization, Infectious Diseases, Treatment Outcome, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections [Medical Subject Headings], Drug Therapy, Combination, Female, Cohort study, Microbiology (medical), medicine.medical_specialty, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections::Severe Acute Respiratory Syndrome [Medical Subject Headings], Combination therapy, Medicina, Hyperinflammatory state, 030106 microbiology, Estudios de cohortes, Antibodies, Monoclonal, Humanized, Article, 03 medical and health sciences, Internal medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings], Intubation, Intratracheal, Mortalitat, Humans, Corticosteroids, Mortality, Corticoesteroides, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings], Aged, Proportional Hazards Models, Retrospective Studies, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Inflammation, business.industry, SARS-CoV-2, COVID-19, Odds ratio, Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones [Medical Subject Headings], Corticosteroides, COVID-19 Drug Treatment, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Propensity Score [Medical Subject Headings], chemistry, Spain, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], Propensity score matching, Mortalidad, Monoclonal antibodies, business, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings], Anticossos monoclonals
Abstract: © 2020 The Author(s)., [Objectives]: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters., [Methods]: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs)., [Results]: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22–0.47; p < 0.001) for tocilizumab, 0.82 (0.71–1.30; p 0.82) for IHDC, 0.61 (0.43–0.86; p 0.006) for PDC, and 1.17 (0.86–1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02–0.17; p < 0.001)., [Conclusions]: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situation., IJ has received honoraria for participating in an advisory board from Gilead Sciences, and for educational activities from ViiV. JB has received research grants from AbbVie, Gilead Sciences, Merck, and ViiV, and honoraria for being a speaker or advisory board participation from AbbVie, Gilead Sciences, Janssen, Merck, and ViiV. JRA received fees for participating in an advisory board, being a speaker, and research grant support from Viiv, Janssen, Gilead, MSD, Teva, Alexa and Serono. PR is involved as speaker or advisory board participant for Gilead Sciences, AbbVie and ViiV. JR-B, JP, JC and MY have no conflicts of interest to declare. SAM-COVID was funded by Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (COV20/01031) co-funded by European Union (ERDF/ESF, “Investing in your future”) and Fundación SEIMC/GeSIDA. In addition, Juan Berenguer, Jesús Rodríguez-Baño, Inmaculada Jarrín, Jordi Carratalá, Jerónimo Pachón, and José R Arribas received funding for research from Plan Nacional de I+D+i 2013-2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades – co- financed by European Development Regional Fund “A way to achieve Europe”, Operative program Intelligent Growth 2014–2020 through the networks: Spanish AIDS Research Network (RIS) [RD16/0025/0017 (JB), RD16/0025/0018 (JRA), RD16/0025/00XX (IJ)] and Spanish Network for Research in Infectious Diseases (REIPI)[RD16/0016/0001 (JRB), RD16/0016/0005 (JC), and RD16/0016/0009 (JP).
Published: 2021

35. Spanish adaptation and validation of the Pain Assessment Scale in Advanced Dementia (PAINAD) in patients with dementia and impaired verbal communication: cross-sectional study

Author: María del Pilar Carrera-González, Manuel Rich-Ruiz, María Teresa Moreno-Casbas, Vanesa Cantón-Habas, Regional Government of Andalusia (España), Gobierno de Andalucía, [Cantón-Habas,V, Rich-Ruiz,M] Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Hospital Universitario Reina Sofía (HURS), Cordoba, Spain. [Carrera-González,MDP] Experimental and Clinical Physiopathology Research Group, Department of Health Sciences, University of Jaen Faculty of Experimental Sciences, Jaen, Spain. [Carrera-González,MDP] Ciber Fragility and Healthy Aging (CIBERFES), Madrid, Spain. [Moreno-Casbas,MT] Instituto de Salud Carlos III, Nursing and Healthcare Research Unit (Investén-isciii), Madrid, Spain., and This study was supported by Junta de Andalucía through a regional health research fund (Research code: PI-0357–2017).
Subjects: Information Science::Information Science::Communication [Medical Subject Headings], Intraclass correlation, España, Impaired verbal communication, Psychiatry and Psychology::Mental Disorders::Delirium, Dementia, Amnestic, Cognitive Disorders::Dementia [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Pain assessment, Surveys and Questionnaires, Pain assessment scale, Content validity, 030212 general & internal medicine, Dimensión del dolor, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Pain Measurement, Geriatrics, Communication, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings], General Medicine, Health Care::Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of Results [Medical Subject Headings], Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics [Medical Subject Headings], Scale (social sciences), Psicometría, Medicine, Psychometric, medicine.medical_specialty, Geriatric medicine, Psychometrics, Pain, Nursing, Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Psychometrics [Medical Subject Headings], 03 medical and health sciences, Atención primaria de salud, Demencia, medicine, Dementia, Humans, Aged, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, geriatric medicine, Construct validity, Reproducibility of Results, Health Care::Health Services Administration::Quality of Health Care::Outcome and Process Assessment (Health Care) [Medical Subject Headings], Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Pain [Medical Subject Headings], medicine.disease, Pain management, Cross-Sectional Studies, pain management, Spain, Physical therapy, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Neurologic Examination::Pain Measurement [Medical Subject Headings], Observational study, business, Primary healthcare, 030217 neurology & neurosurgery
Abstract: ObjectivesThe aim of this study was to adapt and validate the Pain Assessment in Advanced Dementia (PAINAD) scale in Spanish.DesignCross-sectional observational study.SettingTwo health districts of Andalusian provinces, located in the south of Spain, through the Andalusian network of Primary Healthcare centres and four institutions dedicated to the care of patients with dementia.ParticipantsA total of 100 older people, with a medical diagnosis of dementia and a score on the Global Deterioration Scale between 5 and 7 were assessed using the PAINAD scale.Primary and secondary outcome measuresPsychometric properties including content validity, construct validity and reliability of the scale have been tested.ResultsThe overall Item Content Validity Index was excellent (0.95). Regarding construct validity, it was confirmed that a lower use of analgesics implied a lower score on the PAINAD scale (pConclusionsThe Spanish version of the PAINAD scale is a valid tool to assess pain in patients with dementia and inability to communicate verbally.
Published: 2021

36. Factors Associated with Exposure to Dietary Bisphenols in Adolescents

Author: Celia Monteagudo, Alberto Zafra-Gómez, Ana Rivas, Inmaculada Salcedo-Bellido, Margarita Aguilera, Yolanda Gálvez-Ontiveros, Lourdes Rodrigo, Virginia Robles-Aguilera, [Robles-Aguilera, V, Gálvez-Ontiveros,Y, Monteagudo,C, Rivas,A] Department of Nutrition and Food Science, University of Granada, Cartuja Campus, Granada, Spain. [Gálvez-Ontiveros,Y, Salcedo-Bellido,I, Aguilera,M, Zafra-Gómez,A, Rivas,A] Instituto de Investigación Biosanitaria ibs-GRANADA, Granada, Spain. [Rodrigo,L] Department of Legal Medicine and Toxicology, University of Granada, Granada, Spain. [Salcedo-Bellido,I] Department of Preventive Medicine and Public Health, University of Granada, Cartuja Campus, Granada, Spain. [Salcedo-Bellido,I] Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública—CIBERESP), Monforte de Lemos 5, Madrid, Spain. [Aguilera,M] Department of Microbiology, Faculty of Pharmacy, University of Granada, Cartuja Campus, Granada, Spain. [Zafra-Gómez,A] Department of Analytical Chemistry, University of Granada, Fuentenueva Campus, Granada, Spain., and This research was carried out within the ‘GP/EFSA/ENCO/380 2018/03/G04: OBEMIRISK: Knowledge platform for assessing the risk of bisphenol on gut microbiota and its role in obesogenic phenotypes: looking for biomarkers’ framework. This research was also funded by Plan Estatal de I + D + I 2013–2016, with joint funding from FEDER-ISCIII PI17/01758, FEDER-Consejería de Salud y Familias, Junta de Andalucía PE-0250–2019, FEDER-Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/ Proyecto P18-RT-4247, and Fundación Mapfre MAPFRE2018.
Subjects: Male, Pediatric Obesity, Bisphenol, bisphenol A, Índice de masa corporal, 010501 environmental sciences, Overweight, Adolescents, 01 natural sciences, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Dietary Exposure, chemistry.chemical_compound, Eating, 0302 clinical medicine, Bisphenol A, bisphenol S, Persons::Persons::Men::Nurses, Male [Medical Subject Headings], Risk Factors, Odds Ratio, Medicine, TX341-641, adolescents, Sulfones, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Odds Ratio [Medical Subject Headings], Adolescente, Body mass index, Nutrition and Dietetics, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Sex Factors [Medical Subject Headings], Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Energy Intake [Medical Subject Headings], Bisphenol-S, Regression Analysis, Female, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, endocrine system, Adolescent, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings], 030209 endocrinology & metabolism, body mass index, Diet Surveys, Article, Dietary exposure, Exposición dietética, Persons::Persons::Age Groups::Adolescent [Medical Subject Headings], 03 medical and health sciences, Sex Factors, Phenols, Bisfenol A glicidil metacrilato, Environmental health, Humans, Benzhydryl Compounds, Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Sulfones [Medical Subject Headings], 0105 earth and related environmental sciences, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Nutrition. Foods and food supply, business.industry, urogenital system, Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Benzhydryl Compounds [Medical Subject Headings], Odds ratio, Stepwise regression, medicine.disease, Obesity, Confidence interval, Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity::Pediatric Obesity [Medical Subject Headings], Bisphenol S, chemistry, Spain, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Micronutrients [Medical Subject Headings], business, Food Science
Abstract: Obesogenic endocrine-disrupting chemicals, such as bisphenol A (BPA) and its analogue bisphenol S (BPS), seem to play an important role in the development of obesity, although contradictory results have been reported. The aim of the present study was to conduct a gender analysis of the factors associated with exposure to dietary bisphenols in 585 Spanish adolescents. Dietary BPA and BPS exposure was assessed using a food frequency questionnaire. Foods and macronutrients accounting for more than 95% of energy intake were selected for analysis. Stepwise regression was used to estimate the foods that most contributed to dietary bisphenol exposure in the sample. Gender-related factors associated with greater dietary bisphenol exposure were evaluated using multivariate logistic regression models. Canned tuna was the main dietary source of BPA and BPS in both adolescent boys and girls. Overweight/obese girls showed a higher risk of high dietary exposure to BPA (odds ratio (OR): 3.38, 95% confidence interval (CI): 1.25–9.07) and total bisphenols (OR: 2.81, 95% CI: 1.03–7.67) in comparison with girls with a BMI lower than 25 kg/m2 . Present results indicate a positive association of dietary exposure to both total bisphenols and BPA with being overweight/obese in adolescent girls., GP/EFSA/ENCO/380 2018/03/G04: OBEMIRISK: Knowledge platform for assessing the risk of bisphenol on gut microbiota and its role in obesogenic phenotypes: looking for biomarkers’ framework, Plan Estatal de I + D + I 2013–2016, FEDER-ISCIII PI17/01758, FEDER-Consejería de Salud y Familias, Junta de Andalucía PE-0250–2019, FEDER-Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/ Proyecto P18-RT-4247, Fundación Mapfre MAPFRE2018
Published: 2021

37. Long-term determinants of the seroprevalence of the Hepatitis E virus in wild boar (Sus scrofa)

Author: Ignacio García-Bocanegra, Maria A. Risalde, José A. Barasona, Saúl Jiménez-Ruiz, Patricia Barroso, Antonio Rivero-Juárez, Vidal Montoro, Pelayo Acevedo, Joaquín Vicente, Javier Caballero-Gómez, Ministerio de Economía y Competitividad (España), European Commission, Universidad de Castilla La Mancha, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), [Barroso,P, Acevedo,P, Jiménez-Ruiz,S, Montoro,V, Vicente,J] Instituto de Investigación en Recursos Cinegéticos (IREC) CSIC-UCLM-JCCM, Ciudad Real, Spain. [Risalde,MA] Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), Departamento de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Córdoba, Córdoba, Spain. [Risalde,MA, Caballero-Gómez,J, Rivero-Juárez,A] Unidad de Enfermedades Infecciosas, Grupo de Virología Clínica y Zoonosis, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía, Córdoba, Spain. [García-Bocanegra,I, Jiménez-Ruiz,S] Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), Departamento de Sanidad Animal, Universidad de Córdoba, Córdoba, Spain. [Barasona,JA] VISAVET, Animal Health Department, Veterinary School, Complutense University of Madrid, Madrid, Spain. [Montoro,V, Vicente,J] Escuela Técnica Superior de Ingenieros Agrónomos, Ciudad Real, Spain., This research was funded by the Ministerio de Economía y Competitividad (MINECO, AEI/FEDER, UE, and AGL2016-76358-R). S.J. is co-supported by the UCLM and the European Social Fund (2018/12504). J.C. received support from the Ministerio de Ciencia, Innovación y Universidades (FPU/17/01319). A.R.J. is the recipient of a Miguel Servet Research Contract by the Ministerio de Ciencia, Promoción y Universidades of Spain (CP18/00111).
Subjects: Population control, Veterinary medicine, Sus scrofa, España, medicine.disease_cause, Zoonosis, Virus de la hepatitis E, Hepatitis E virus, Long-term, Salud pública, Abundance (ecology), Health Care::Environment and Public Health::Public Health [Medical Subject Headings], SF600-1100, Organisms::Eukaryota::Animals [Medical Subject Headings], Tiempo, education.field_of_study, Public health, biology, National park, public health, shared infection, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Seroepidemiologic Studies [Medical Subject Headings], Sylvatic cycle, Phenomena and Processes::Biological Phenomena::Ecological and Environmental Phenomena::Environment::Climate::Seasons [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Artiodactyla::Swine::Sus scrofa [Medical Subject Headings], wild boar, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Demography::Population Dynamics::Population Control [Medical Subject Headings], Regulación de la población, Organisms::Viruses::Hepatitis Viruses::Hepatitis E virus [Medical Subject Headings], Population, Zoology, hepatitis E virus, Wild boar, Article, Shared infection, biology.animal, medicine, Seroprevalence, education, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], long-term, General Veterinary, zoonosis, Diseases::Virus Diseases::Zoonoses [Medical Subject Headings], medicine.disease, QL1-991, Spain, Animal Science and Zoology
Abstract: This article belongs to the Special Issue Wildlife Diseases., The hepatitis E virus (HEV) is an emerging zoonotic pathogen whose main reservoir is suids. Most of the ecological and epidemiological aspects of its sylvatic cycle remain unknown. Thus, in this work, we study the drivers of HEV exposure in the wild boar population of Doñana National Park (DNP, southwest Spain) operating in the medium and long-term (2005–2018). Anti-HEV antibodies are widely distributed throughout the wild boar (46.7 ± 3.8%, 327 out of 700 sampled), showing a statistically significant age-increasing pattern. The temporal pattern displayed important interannual fluctuations. This could be mediated by marked variations in the population control of the wild boar, and subsequent changes in abundance rates, and its interplay with climatic conditions; as wet years together with a low abundance of wild boar led to the lowest seroprevalence. The fact that seroprevalence is high during conditions of high abundance, and not affected by rainfall level, is probably due to the increased interactions among the animals, and possibly, the subsequent higher environmental contamination with HEV particles. The proximity to the marshland (the main water body of the study area) is associated with a higher risk of testing positive, which is probably mediated by the preferential use of this area during the dry season and the favourable environmental conditions for the survival of HEV particles. A deeper understanding of the epidemiology of HEV in host communities deserves future research concerning other susceptible species. Most importantly, wild boar population control remains a challenge at the international level, and an increase of shared pathogen-related conflicts associated with this species is expected, as exemplified by HEV. Therefore, surveillance of wild boar diseases, including integrated population monitoring and sustainable population control programmes, will be essential to control the associated risks., This research was funded by the Ministerio de Economía y Competitividad (MINECO; AEI/FEDER, UE; AGL2016-76358-R). S.J. is co-supported by the UCLM and the European Social Fund (2018/12504). J.C. received support from the Ministerio de Ciencia, Innovación y Universidades (FPU/17/01319). A.R.J. is the recipient of a Miguel Servet Research Contract by the Ministerio de Ciencia, Promoción y Universidades of Spain (CP18/00111).
Published: 2021

38. Positive psychological profiles based on perceived health clustering in patients with cardiovascular disease: a longitudinal study

Author: Pablo Perez-Martinez, Esther Cuadrado, Javier Delgado-Lista, Rosario Castillo-Mayén, Sebastián Jesús Rubio, Alicia Arenas, Carmen Tabernero, Bárbara Luque, Tamara Gutiérrez-Domingo, Universidad de Sevilla. Departamento de Psicología Social, Ministerio de Economía y Competitividad (MINECO). España, Ministerio de Ciencia, Innovación y Universidades (MICINN). España, [Castillo-Mayén,R, Luque,B, Rubio,SJ, Cuadrado,E, Gutiérrez-Domingo,T, Arenas,A, Delgado-Lista,J, Pérez-Martínez,P, Tabernero,C] Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. [Castillo-Mayén,R, Gutiérrez-Domingo,T] Department of Psychology, University of Cordoba, Córdoba, Spain. [Rubio,J] Department of Specific Didactics, University of Cordoba, Córdoba, Spain. [Arenas,A] Department of Social Psychology, University of Seville, Sevilla, Spain. [Delgado-Lista,J, Pérez-Martínez,P] Lipids and Atherosclerosis Unit, Department of Internal Medicine, Reina Sofia University Hospital, Córdoba, Spain. [Tabernero,C] Instituto de Neurociencias de Castilla y León, University of Salamanca, Salamanca, Spain, and This work was supported by the Spanish Ministry of Economy and Competitiveness under Grant number PSI2014-58609-R, in which CT is the principal investigator, and by the Spanish Ministry of Science, Innovation and Universities under Grant number PDI2019-107304RB-I00, in which BL and CT are the principal investigators
Subjects: Male, Longitudinal study, Calidad de vida, Health Status, Psychological intervention, Autoeficacia, 030204 cardiovascular system & hematology, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Depresión, Cluster Analysis, Longitudinal Studies, 030212 general & internal medicine, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Social Class [Medical Subject Headings], Persons::Persons::Age Groups::Infant [Medical Subject Headings], Depression, General Medicine, Cardiovascular disease, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Personal Satisfaction [Medical Subject Headings], Cardiovascular Diseases, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Quality of Life [Medical Subject Headings], cardiology, Socioeconomic status, Estado de salud, Medicine, Life satisfaction, Female, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Demography::Health Status [Medical Subject Headings], Public Health, Enfermedades cardiovasculares, Self-efficacy, Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospitals::Hospitals, Public [Medical Subject Headings], mental health, Clinical psychology, Employment, Quality of life, medicine.medical_specialty, Clase social, Check Tags::Male [Medical Subject Headings], Health Care::Population Characteristics::Socioeconomic Factors::Employment [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Cluster Analysis [Medical Subject Headings], preventive medicine, Health status, 03 medical and health sciences, Cluster analysis, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies [Medical Subject Headings], medicine, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Socioeconomic Factors [Medical Subject Headings], Humans, Diseases::Cardiovascular Diseases [Medical Subject Headings], Preventive healthcare, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Psychiatry and Psychology::Behavior and Behavior Mechanisms::Personality::Personality Development::Self Concept::Self Efficacy [Medical Subject Headings], business.industry, Public health, Infant, Análisis por conglomerados, Mental health, Cardiovascular health, Check Tags::Female [Medical Subject Headings], Spain, Public hospital, Quality of Life, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression [Medical Subject Headings], business, Empleo, Disciplines and Occupations::Natural Science Disciplines::Science::Research::Biomedical Research::Outcome Assessment (Health Care) [Medical Subject Headings]
Abstract: ObjectivesPsychological well-being and sociodemographic factors have been associated with cardiovascular health. Positive psychological well-being research is limited in the literature; as such, this study aimed to investigate how patients with cardiovascular disease could be classified according to their perceived mental and physical health, and to identify positive psychological profiles based on this classification and test their stability over time.Design and settingLongitudinal study with patients from a public hospital located in Córdoba (Spain).ParticipantsThis study comprised 379 cardiovascular patients (87.3% men) tested at three measurement points.Outcome measuresParticipants reported their sociodemographic variables (age, sex, educational level, employment and socioeconomic status) at phase 1, while their perceived health and variables relating to positive psychological well-being were tested at this and two subsequent time points (average interval time: 9 months).ResultsThe two-step cluster analysis classified participants into three groups according to their mental and physical health levels, pConclusionCardiovascular patients may differ in terms of their perceived health and, accordingly, in terms of other relevant variables. Perceived health clusters generated varying and generally stable psychological profiles based on positive psychological well-being variables. Psychological interventions should be adapted to patients’ requirements.
Published: 2021

39. High prevalence of obstructive sleep apnea syndrome in Spain’s Stroke Belt

Author: Ana Barragán-Prieto, Marta Ferrer, Pilar Algaba, Joan Montaner, Ana Domínguez-Mayoral, Reyes de Torres-Chacón, Carmen Yllera Gutierrez, José M. Benítez, Patricia Guerrero, Lidia Ruiz-Bayo, Soledad Pérez-Sánchez, Natalia Fouz-Rosón, María Aguilar, Miguel Ángel Gamero-García, Jesús Sanchez-Gómez, Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares (España), [Domínguez-Mayoral,A, Pérez-Sánchez,S, Gamero-García,MA, De Torres-Chacón,R, Barragán-Prieto,A, Ruiz-Bayo,L, Montaner,J] Stroke Unit, Neurology Department, Virgen Macarena University Hospital, Seville, Spain. [Sánchez-Gómez,J, Guerrero,P, Ferrer,M, Fouz-Rosón,N, Benítez,JM] Pneumology Department, Virgen Macarena University Hospital, Seville, Spain. [Gutiérrez,C, Aguilar,M] Neurophysiology Department, Virgen Macarena University Hospital, Seville, Spain. [Domínguez-Mayoral,A, Algaba,P, Montaner,J] Neurovascular Research Laboratory, Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain., and This work was supported by the Neurovascular Research Group, part of the Cooperative Cerebrovascular Disease Research Network (INVICTUS+) (RD16/0019/0015).
Subjects: Medicine (General), Prospective Clinical Research Report, Pediatrics, Estudios transversales, Diseases::Nervous System Diseases::Sleep Disorders::Dyssomnias::Sleep Disorders, Intrinsic::Sleep Apnea Syndromes::Sleep Apnea, Central [Medical Subject Headings], Polysomnography, Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity [Medical Subject Headings], Biochemistry, Brain Ischemia, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Prevalence, Medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings], Stroke, Tamizaje masivo, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospitals [Medical Subject Headings], Psychiatry and Psychology::Psychological Phenomena and Processes::Psychophysiology::Sleep [Medical Subject Headings], Sleep Apnea, Obstructive, Polisomnografía, Ischemic stroke, medicine.diagnostic_test, Atrial fibrillation, General Medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Spanish Stroke Belt, Obstructive sleep apnea–hypopnea syndrome, Hypertension, Screening, Parálisis facial, Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke [Medical Subject Headings], medicine.medical_specialty, Diseases::Nervous System Diseases::Neurologic Manifestations::Paralysis::Facial Paralysis [Medical Subject Headings], Polygraphy, Síndromes de la apnea del sueño, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings], Diseases::Cardiovascular Diseases::Heart Diseases::Arrhythmias, Cardiac::Atrial Fibrillation [Medical Subject Headings], Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension [Medical Subject Headings], R5-920, Diseases::Nervous System Diseases::Sleep Disorders::Dyssomnias::Sleep Disorders, Intrinsic::Sleep Apnea Syndromes::Sleep Apnea, Obstructive [Medical Subject Headings], Hipertensión, Humans, Accidente cerebrovascular isquémico, Stroke Belt, Aged, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Ischemic cardiomyopathy, Central Sleep Apnea Syndrome, business.industry, Biochemistry (medical), Apnea obstructiva del sueño, Andalucía, Cell Biology, medicine.disease, respiratory tract diseases, Obstructive sleep apnea, Cross-Sectional Studies, Spain, Diseases::Cardiovascular Diseases::Heart Diseases::Cardiomyopathies [Medical Subject Headings], Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Brain Ischemia [Medical Subject Headings], Prevalencia, business, Facial palsy, Body mass index, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Neuroimaging [Medical Subject Headings]
Abstract: [Objective] Spain’s so-called Stroke Belt is an area with high prevalence of vascular disease. We aimed to determine the prevalence of undetected obstructive sleep apnea–hypopnea syndrome (OSAHS) among patients with acute ischemic stroke (AIS) in southern Spain., [Methods] We conducted a cross-sectional study at the Virgen Macarena University Hospital Stroke Unit during 2018 to 2019. We included patients, [Results] Seventy-two patients were included. The median participant age was 72 years. Mean body mass index was 27.07 kg/m2, and 40.28% were daily alcohol drinkers. Hypertension, atrial fibrillation, ischemic cardiomyopathy, and previous stroke were detected in 63.9%, 11.1%, 15.3%, and 17.6% of patients, respectively. Polygraphy was feasible in 91.38% of patients. The prevalence of OSAHS was 84.72% (apnea–hypopnea index ≥5). Patients with moderate and severe OSAHS were more likely to be obese and to have a larger neck circumference and facial palsy. The diagnostic criteria of central sleep apnea syndrome were met in only 1.38% of patients., [Conclusions] The high prevalence of OSAHS found in the Spanish Stroke Belt justifies further investigation and development of a screening program as a strategy to identify patients with undetected OSAHS., The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by the Neurovascular Research Group, part of the Cooperative Cerebrovascular Disease Research Network (INVICTUS+) (RD16/0019/0015).
Published: 2021

40. Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review

Author: Camila A. Picchio, Sabela Lens, Manuel Hernandez-Guerra, Juan Arenas, Raúl J. Andrade, Javier Crespo, Javier García-Samaniego, Manuel Romero-Gómez, Juan Turnes, José Luis Calleja, Miguel Ángel Simón, Trenton M. White, Mar Riveiro-Barciela, Anna Pocurull, Dalia Morales-Arraez, Alexandra Gómez, Maria Buti, Jeffrey V. Lazarus, Ministerio de Ciencia, Innovación y Universidades (España), Generalitat de Catalunya, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, [Picchio,CA, White,TM, Lazarus,JV] Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain. [Lens,S, Pocurull,A] Liver Unit, Hospital Clinic, Universidad de Barcelona, Barcelona, Spain. [Lens,S, Pocurull,A] IDIBAPS, University of Barcelona, Barcelona, Spain. [Lens,S, Andrade,RJ, García‑Samaniego,J, Calleja,JL, Pocurull,A, Buti,M] CIBER Hepatic and Digestive Diseases (CIBERehd), Instituto Carlos III, Madrid, Spain. [Hernandez-Guerra,M, Morales-Arraez,D] Department of Gastroenterology, University Hospital of the Canary Islands, San Cristóbal de La Laguna, Spain. [Arenas,J, Gomez,A] Biodonostia, Liver Diseases Research Group, Osakidetza Basque Health Service, Donostia University Hospital, San Sebastián, Spain. [Andrade,RJ] Unidad de Gestión Clínica de Enfermedades Digestivas, Instituto de Investigación Biomédica de Málaga‑IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain. [Crespo,J] Gastroenterology and Hepatology Unit, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain. [García-Samaniego,J] Liver Unit, Department of Gastroenterology, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain. [Romero-Gómez,M] UCM Digestive Diseases, Hospital Universitario Virgen del Rocío, Institute of Biomedicine of Seville, Universidad de Sevilla, Seville, Spain. [Turnes,J] Complejo Hospitalario Universitario de Pontevedra, Instituto de Investigación Sanitaria Galicia Sur (IISGS), Pontevedra, Spain. [Calleja,JL] Gastroenterology and Hepatology Department, Hospital Universitario Puerta del Hierro de, Universidad Autónoma de Madrid, Madrid, Spain. [Simón,MA] Department of Digestive Diseases, Hospital Clínico de Zaragoza, Zaragoza, Spain. [Simón,MA] Instituto de Investigación Sanitario Aragón (IIS Aragón), Zaragoza, Spain. [Riveiro-Barciela,M, Buti,M] Liver Unit, Hospital Universitario Vall d’Hebron, Barcelona, Spain., CAP, TMW, JVL acknowledge support to ISGlobal from the Spanish Ministry of Science, Innovation and Universities through the 'Centro de Excelencia Severo Ochoa 2019–2023' Programme (CEX2018-000806-S), and support from the Government of Catalonia through the CERCA Programme. CAP acknowledges support from the Secretaria d’Universitats i Recerca de la Generalitat de Catalunya and the European Social Fund as an AGAUR-funded PhD fellow. The authors would like to thank those who contributed to data collection: From the Basque Country: Leire Samaniego, Maria Vaamonde, and Edurne Almandoz. From Madrid, Dr Yza Frias, and Ana Robles. From Málaga, Enrique del Campo Herrera. From Sevilla, and Bianca Sánchez-Barbero, Javier Ampuero.
Subjects: Male, Hepatitis C, chronic, Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C::Hepatitis C, Chronic [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings], Organisms::Viruses::Hepatitis Viruses::Hepacivirus [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Registries, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Multidisciplinary, Referral and consultation, Middle Aged, Hepatitis B, Hepatitis C, Health services, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Models [Medical Subject Headings], Diseases::Digestive System Diseases::Liver Diseases [Medical Subject Headings], Diseases::Virus Diseases::DNA Virus Infections::Hepadnaviridae Infections::Hepatitis B::Hepatitis B, Chronic [Medical Subject Headings], Medicine, Female, Liver disease, Hepatitis C crónica, Adult, Science, Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Academic Medical Centers::Hospitals, Teaching [Medical Subject Headings], Check Tags::Male [Medical Subject Headings], Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C [Medical Subject Headings], Health Care::Health Services Administration::Organization and Administration::Professional Practice::Referral and Consultation [Medical Subject Headings], Article, Hepatitis B, Chronic, Progresión de la enfermedad, Humans, Enfermedades hepáticas, Hospitals, Teaching, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis B [Medical Subject Headings], Aged, Retrospective Studies, Derivación y consulta, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Disease progression, Hepatology, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Hepatitis B, chronic, Hepatitis C, Chronic, Check Tags::Female [Medical Subject Headings], Spain, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], Hepatitis B crónica, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Registries [Medical Subject Headings]
Abstract: Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after significant disease progression face increased risk of severe liver complications and death. Data are scarce on the characteristics and risk factors of people who present late to care in Spain and globally. Data were collected from January 2018 to December 2019 to report late presentation (LP) to specialist care at 11 large university hospitals in Spain to assess related risk factors using a multivariable logistic regression model. 2290 (CHB = 505, CHC = 1785) patients were analysed, with 581 (25.2%) presenting late. Hepatitis C patients more frequently reported LP compared to hepatitis B patients (28.1% vs 15.0%; p, AP, TMW, JVL acknowledge support to ISGlobal from the Spanish Ministry of Science, Innovation and Universities through the “Centro de Excelencia Severo Ochoa 2019–2023” Programme (CEX2018-000806-S), and support from the Government of Catalonia through the CERCA Programme. CAP acknowledges support from the Secretaria d’Universitats i Recerca de la Generalitat de Catalunya and the European Social Fund as an AGAUR-funded PhD fellow.
Published: 2021

41. Social mobility and healthy behaviours from a gender perspective in the Spanish multicase-control study (MCC-Spain)

Author: Leire Gil-Majuelo, Tania Fernández-Villa, Nuria Aragonés, Pilar Amiano, Esther Gracia-Lavedan, Juan Alguacil, Inmaculada Salcedo-Bellido, A. Delgado-parrilla, Cristina O'Callaghan-Gordo, Virginia Lope, Maria Dolores Chirlaque, Marta Maria Rodriguez-Suarez, Rafael Marcos-Gragera, Marcela Guevara, Dolores Salas, Rosana Peiró-Pérez, Inés Gómez-Acebo, Gemma Castaño-Vinyals, Marina Pollán, Trinidad Dierssen-Sotos, M. Pinto-carbó, Manolis Kogevinas, Antonio J. Molina, Conchi Moreno-Iribas, Mercedes Vanaclocha-Espi, Beatriz Pérez-Gómez, Mireia Obón-Santacana, Ana Molina-Barceló, Universidad de Cantabria, Universitat Oberta de Catalunya (UOC), Universidad de Granada, Universidad de Huelva, Fundación para el Fomento de la Investigación Sanitaria y Biomédica (FISABIO), Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBEResp), Instituto de Salud Carlos III, European Regional Development Fund, Fundación Marqués de Valdecilla, International Cancer Genome Consortium, Ministerio de Economía y Competitividad (España), Red Temática de Investigación Cooperativa en Cáncer (España), Junta de Castilla y León (España), Regional Government of Andalusia (España), Generalitat Valenciana (España), Fundación La Caixa, Basque Government (España), Gobierno de Murcia, Unión Europea. Comisión Europea, Asociación Española Contra el Cáncer, Government of Catalonia (España), Fundación Caja de Ahorros de Asturias, University of Oviedo (España), [Pinto-Carbo,M, Molina-Barcelo,A, Vanaclocha-Espi,M, Salas,D] Cancer and Public Health Area, Foundation for the Promotion of the Research in Healthcare and Biomedicine (FISABIO-Salud Pública), Valencia, Valencian Community, Spain. [Peiró-Pérez,R] Inequalities Area, Foundation for the Promotion of the Research in Healthcare and Biomedicine (FISABIO-Salud Pública), Valencia, Valencian Community, Spain. [Peiró-Pérez,R, Salas,D] General Directorate of Public Health, Valencia, Valencian Community, Spain. [Peiró-Pérez,R, Alguacil,J, Castaño-Vinyals,G, O’Callaghan-Gordo,C, Gràcia-Lavedan,E, Pérez-Gómez,B, Lope,V, Aragonés,N, Amiano,P, Dierssen-Soto,T, Gómez-Acebo,I, Guevara,M, Obón-Santacana,M, Salcedo-Bellido,I, Marcos-Gragera,R, Chirlaque,MD, Kogevinas,M, Pollán,M, Salas,D] Consortium for Biomedical Research in Epidemiology and Public Health (CIBEResp), Madrid, Spain. [Alguacil,J, Delgado-Parrilla,A] Centre for Health and Environmental Research, Huelva University, Huelva, Andalucia, Spain. [Castaño-Vinyals,G, Kogevinas,M] Barcelona Institute for Global Health (ISGlobal), Barcelona, Catalonia, Spain. [Castaño-Vinyals,G, O’Callaghan-Gordo,G, Kogevinas,M] Universitat Pompeu Fabra, Plaça de la Mercè, Barcelona, Catalonia, Spain. [Castaño-Vinyals,G, Kogevinas,M] Hospital del Mar Medical Research Institute, Barcelona, Catalonia, Spain. [O’Callaghan-Gordo,C] Faculty of Health Science,Universitat Oberta de Catalunya, Barcelona, Catalonia, Spain. [Pérez-Gómez,B, Pollán,M] Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain. [Aragonés,N] Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain. [Molina,AJ, Fernández-Villa,T] The Research Group in Gene—Environment and Health Interactions, Institute of Biomedicine (IBIOMED), University of León, León, Castilla y León, Spain. [Gil-Majuelo,L, Amiano,P] Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Gipuzkoa, Spain. [Gil-Majuelo,L, Amiano,P] Biodonostia Health Research Institute, Group of Epidemiology of Chronic and Communicable Diseases, San Sebastián, Gipuzkoa, Spain. [Dierssen-Sotos,T, Gómez-Acebo,I] Cantabria University, Santander, Cantabria, Spain. [Guevara,M, Moreno-Iribas,C] Navarra Public Health Institute, Pamplona, Navarra, Spain. [Guevara,M, Moreno-Iribas,C] Navarra Institute for Health Research (IdiSNA), Pamplona, Navarra, Spain. [Obón-Santacana,M] Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), Barcelona, Catalonia, Spain. [Obón-Santacana,M] ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain. [Rodríguez-Suárez,MM] Preventive Medicine and Public Health Area, Oviedo University, Oviedo, Asturias, Spain. [Rodríguez-Suárez,MM] Central University Hospital of Asturias, Public Health Service of the Principe de Asturias, Oviedo, Asturias, Spain. [Salcedo-Bellido,I] Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Andalucia, Spain. [Salcedo-Bellido,I] Departamento de Medicina Preventiva y Salud Publica, Universidad de Granada, Granada, Andalucia, Spain. [Marcos-Gragera,R] Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona, Catalonia, Spain. [Marcos-Gragera,R] Descriptive Epidemiology, Genetics and Cancer Prevention Group [Girona Biomedical Research Institute], Girona, Catalonia, Spain. [Chirlaque,D] Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, El Palmar, Murcia, Spain., and This research was supported by the 'Acción Transversal del Cancer', approved by the Spanish Council of Ministers on 11th October 2007, by the Instituto de Salud Carlos III-FEDER [grant number:PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/ 01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI11/01810, PI14/01219, PI11/02213, PIE16/00049, PI17/01179, PI17-00092], by the Fundación Marqués de Valdecilla [grant number: API 10/09], by the ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII)), by the Red Temática de Investigación del Cáncer (RTICC) del ISCIII [grant number: RD12/0036/0036], by the Junta de Castilla y León [grant number: LE22A10-2], by the Consejería de Salud of the Junta de Andalucía [grant number: PI-0571-2009, PI-0306-2011, salud201200057018tra], by the Conselleria de Sanitat of the Generalitat Valenciana [grant number: AP_061/10], by the Recercaixa [grant number: 2010ACUP00310], by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission [grant number: FOOD-CT-2006-036224-HIWATE], by the Spanish Association Against Cancer (AECC) Scientific Foundation [grant number: GCTRA18022MORE], by the Catalan Government-Agency for Management of University and Research Grants (AGAUR) [grant number: 2014SGR647, 2014SGR850 and 2017SGR723], by the Fundación Caja de Ahorros de Asturias and by the University of Oviedo.
Subjects: Male, Behavioral and social aspects of health, Health Behavior, España, Social Sciences, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Tobacco Use::Smoking [Medical Subject Headings], Gender perspective, healthy behaviours, Hàbits sanitaris, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Movilidad social, Sociology, Social mobility, Medicine and Health Sciences, Socioeconomic aspects of health, Public and Occupational Health, European commission, Alcohol consumption, Salut, 030212 general & internal medicine, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Social Class [Medical Subject Headings], Perspectiva de género, Aged, 80 and over, Multidisciplinary, Estudios de casos y controles, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings], Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Sex Factors [Medical Subject Headings], multicase-control study, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Health Behavior [Medical Subject Headings], Middle Aged, Sexual and gender issues, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Social Class::Social Mobility [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Models [Medical Subject Headings], Health, language, Medicine, Female, 0305 other medical science, Persons::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings], Research Article, Adult, Science, Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Health Surveys::Nutrition Surveys::Diet Surveys [Medical Subject Headings], Healthy lifestyle, Clase social, Check Tags::Male [Medical Subject Headings], Genre studies, Education, socioeconomic status, 03 medical and health sciences, Young Adult, Sex Factors, Political science, Cancer genome, Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Sociology::Socioeconomic Factors [Medical Subject Headings], Humans, social mobility, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Health behavior, Exercise, Educational Attainment, Nutrition, Aged, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], 030505 public health, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys [Medical Subject Headings], Physical activity, Biology and Life Sciences, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Health Surveys, language.human_language, Diet, Health Care, Check Tags::Female [Medical Subject Headings], Social Class, Socioeconomic Factors, Estudis de gènere, Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over [Medical Subject Headings], Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity::Exercise [Medical Subject Headings], Spain, Case-Control Studies, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking [Medical Subject Headings], Catalan, Gender studies, Estilo de vida saludable, Humanities
Abstract: This research was supported by the “Acción Transversal del Cancer”, approved by the Spanish Council of Ministers on 11th October 2007, by the Instituto de Salud Carlos III-FEDER [grant number:PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/ 01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI11/01810, PI14/01219, PI11/02213, PIE16/00049, PI17/01179, PI17-00092], by the Fundación Marqués de Valdecilla [grant number: API 10/09], by the ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII)), by the Red Temática de Investigación del Cáncer (RTICC) del ISCIII [grant number: RD12/0036/0036], by the Junta de Castilla y León [grant number: LE22A10-2], by the Consejería de Salud of the Junta de Andalucía [grant number: PI-0571-2009, PI-0306-2011, salud201200057018tra], by the Conselleria de Sanitat of the Generalitat Valenciana [grant number: AP_061/10], by the Recercaixa [grant number: 2010ACUP00310], by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission [grant number: FOOD-CT-2006-036224-HIWATE], by the Spanish Association Against Cancer (AECC) Scientific Foundation [grant number: GCTRA18022MORE], by the Catalan Government-Agency for Management of University and Research Grants (AGAUR) [grant number: 2014SGR647, 2014SGR850 and 2017SGR723], by the Fundación Caja de Ahorros de Asturias and by the University of Oviedo. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript., There is evidence for the influence of socioeconomic status (SES) on healthy behaviours but the effect of social mobility (SM) is not yet well known. This study aims to analyse the influence of origin and destination SES (O-SES and D-SES) and SM on healthy behaviours and co-occurrence, from an integrated gender and age perspective. Data were obtained from the controls of MCC-Spain between 2008–2013 (3,606 participants). Healthy behaviours considered: healthy diet, moderate alcohol consumption, non-smoking and physical activity. SM was categorized as stable high, upward, stable medium, downward or stable low. Binary and multinomial logistic regression models were adjusted. Those aged, “Acción Transversal del Cancer” by the Spanish Council of Ministers, Instituto de Salud Carlos III-FEDER [grant number:PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/ 01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI11/01810, PI14/01219, PI11/02213, PIE16/00049, PI17/01179, PI17-00092, Fundación Marqués de Valdecilla [grant number: API 10/09], ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII)), Red Temática de Investigación del Cáncer (RTICC) del ISCIII [grant number: RD12/0036/0036], Junta de Castilla y León [grant number: LE22A10-2], Consejería de Salud of the Junta de Andalucía [grant number: PI-0571-2009, PI-0306-2011, salud201200057018tra], Conselleria de Sanitat of the Generalitat Valenciana [grant number: AP_061/10], Recercaixa [grant number: 2010ACUP00310], Regional Government of the Basque Country, Consejería de Sanidad de la Región de Murcia, European Commission [grant number: FOOD-CT-2006-036224-HIWATE], Spanish Association Against Cancer (AECC) Scientific Foundation [grant number: GCTRA18022MORE, Catalan Government-Agency for Management of University and Research Grants (AGAUR) [grant number: 2014SGR647, 2014SGR850 and 2017SGR723], Fundación Caja de Ahorros de Asturias, University of Oviedo
Published: 2021

42. Position statement on the definition of added sugars and their declaration on the labelling of foodstuffs in Spain

Author: Gil, Ángel, Urrialde de Andrés, Rafael, Varela-Moreiras, Gregorio, and [Gil,Á] Departamento de Bioquímica y Biología Molecular. Facultad de Farmacia. Instituto de Nutrición y Tecnología de los Alimentos 'José Mataix'. Centro de Investigación Biomédica. Universidad de Granada. Facultad de Farmacia. Granada. [Gil,Á] Instituto Biosanitario IBS Granada. Granada. [Gil,Á] Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN). Madrid. [Urrialde,R] Unidad Docente de Fisiología Vegetal. Departamento de Genética, Fisiología y Microbiología. Facultad de Ciencias Biológicas. Universidad Complutense de Madrid. Madrid. [Urrialde,R] Departamento de Nutrición y Dietética. Facultad de Enfermería. Universidad de Valladolid. Valladolid. [Varela-Moreiras,G] Departamento de Ciencias Farmacéuticas y de la Salud. Facultad de Farmacia. Universidad San Pablo-CEU. Alcorcón, Madrid.
Subjects: Chemicals and Drugs::Carbohydrates::Monosaccharides [Medical Subject Headings], España, Cantidad dietética recomendada, Free sugars, Added sugars, Dietética y nutrición, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Labelling, Information Science::Information Science::Communication::Language::Linguistics::Terminology as Topic [Medical Subject Headings], Geographical Locations::Geographic Locations::Historical Geographic Locations::European Union [Medical Subject Headings], Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Technology and Food and Beverages::Food and Beverages::Beverages [Medical Subject Headings], Geographical Locations::Geographic Locations::Americas::North America::United States [Medical Subject Headings], Azúcares añadidos, Disciplines and Occupations::Health Occupations::Nutritional Sciences [Medical Subject Headings], Technology and Food and Beverages::Technology, Industry, and Agriculture::Industry::Food Industry::Food Technology::Food Packaging::Food Labeling [Medical Subject Headings], Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutritional Requirements::Recommended Dietary Allowances [Medical Subject Headings], Geographical Locations::Geographic Locations::Americas::North America::Mexico [Medical Subject Headings], Spain, Bromatología, Azúcares, Etiquetado, Technology and Food and Beverages::Food and Beverages::Food [Medical Subject Headings], Azúcares libres, Disciplines and Occupations::Health Occupations::Nutritional Sciences::Dietetics [Medical Subject Headings], Sugars
Abstract: Introduction: there is currently great concern about the sugar content of food and beverages as excessive consumption is associated with a higher prevalence of chronic non-communicable diseases. In addition, there is a great deal of confusion both in published scientific data and in media reports about various concepts such as free sugars, intrinsic or endogenous sugars, and sugars added to food, as well as the type of monosaccharides and disaccharides that are part of them. The term "free sugars" refers to public health aspects whereas the term "added sugars" relates to the nutritional information included in the labelling covered by Regulation 1169/2011 as applicable to food information provided to the consumer. Material and methods: an analysis of the legislation in force in the European Union and Spain, as well as in the United States and Mexico, together with the position statements of the World Health Organization (WHO), the European Food Safety Authority (EFSA), and the Spanish Agency for Food Safety and Nutrition (AESAN), as well as their Scientific Committees on the definition and declaration of total sugars, free sugars, and added sugars. Results: added sugars are declared on the label in countries such as the United States and Mexico. In the case of the United States, there is a proposal to modify the percentage they should contribute to the diet from 10 % to 6 %. In the case of the European Union, only the reference intake for carbohydrates is established: 45-65 %, as has already been done by the Scientific Committee of AESAN. Only in the case of the ANIBES study is there an approximate figure for the consumption of added sugars by the Spanish population: 7.3 %. Conclusions: reference intakes for added sugars should be established and declared in the information provided on food product labels in order to work with reliable data in the food composition tables, and to assess their real intake by the Spanish population, and thus implement public health measures to reduce their intake in all food products containing them. Yes Introducción: actualmente existe una gran preocupación relacionada con el contenido de azúcares de los alimentos y bebidas ya que un consumo excesivo se asocia con una mayor prevalencia de enfermedades crónicas no transmisibles. Además, hay una gran confusión tanto en los datos científicos publicados como en las informaciones que aparecen en los medios de comunicación sobre diversos conceptos tales como azúcares libres, azúcares intrínsecos o endógenos y azúcares añadidos a los alimentos, así como sobre el tipo de monosacáridos y disacáridos que forman parte de ellos. El término azúcares libres se refiere a aspectos de salud pública mientras que el de azúcares añadidos se relaciona con la información nutricional incluida en el etiquetado regulado en el Reglamento 1169/2011, aplicable a la información alimentaria facilitada al consumidor. Material y métodos: análisis de la legislación vigente en la Unión Europea y en España, así como en Estados Unidos y México, junto con los posicionamientos de la Organización Mundial de la Salud (OMS), la European Food Safety Authority (EFSA) y la Agencia Española de Seguridad Alimentaria y Nutrición (AESAN), así como de sus comités científicos sobre la definición y declaración de azúcares totales, azúcares libres y azúcares añadidos. Resultados: los azúcares añadidos se declaran en el etiquetado en países como en Estados Unidos y México. En el caso de Estados Unidos hay una propuesta de modificación del porcentaje que deben contribuir a la dieta, pasando del 10 % al 6 %. En el caso de la Unión Europea solo está establecida la ingesta de referencia para los hidratos de carbono: 45-65 %, al igual que ya lo ha hecho el Comité Científico de la AESAN. Solo en el caso del estudio ANIBES hay un dato aproximado del consumo de azúcares añadidos para la población española: un 7,3 %.Conclusiones: se deben establecer ingestas de referencia para los azúcares añadidos y hacer que se declaren en la información del etiquetado de los productos alimenticios, para poder trabajar con datos fidedignos en las tablas de composición de alimentos, conocer la ingesta real por parte de la población española, y así implementar medidas de salud pública que permitan reducir la ingesta de los mismos en todos los productos alimenticios que los contengan.
Published: 2021

43. Evaluation of the gut microbiota after metformin intervention in children with obesity: A metagenomic study of a randomized controlled trial

Author: Javier Caballero-Villarraso, Raúl Hoyos, Miriam Latorre, Ramón Cañete, Rocío Vázquez-Cobela, María Dolores Cañete, Alejandro Egea-Zorrilla, Gloria Bueno, Concepción M. Aguilera, Julio Plaza-Díaz, Angel Gil, Rosaura Leis, Belén Pastor-Villaescusa, [Pastor-Villaescusa,B] Institute for Nutritional Medicine, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising Germany. [Pastor-Villaescusa,B, Plaza-Díaz,J, Gil,A, Aguilera,CM] Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain. [Pastor-Villaescusa,B, Egea-Zorrilla,A, Aguilera,CM] Institute of Nutrition and Food Technology 'José Mataix', Centre of Biomedical Research, University of Granada, Armilla, Granada, Spain. [Plaza-Díaz,J, Aguilera,CM] Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, Granada, Spain. [Leis,R, Bueno,G, Aguilera,CM] CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain. [Leis,R, Vázquez-Cobela,R] Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Paediatric Department, Clinic University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain. [Bueno,G, Latorre,M] Pediatric Department, Lozano Blesa University Clinical Hospital, University of Zaragoza, Zaragoza, Spain. [Hoyos,R] Pediatric Department, Virgen de Las Nieves University Hospital, Andalusian Health Service, Granada, Spain. [Latorre,M] Pediatric Department and Health Sciences Institute in Aragon, Zaragoza, Spain. [Cañete,MD, Cañete,R] PAIDI CTS-329, Maimonides Institute of Biomedical Research of Córdoba (IMIBIC), Córdoba, Spain. [Caballero-Villarraso,J] Clinical Analysis Services, IMIBIC/Reina Sofía Hospital, Córdoba University, Córdoba, Spain. [Latorre,M] Unit of Paediatric Endocrinology, Reina Sofia University Hospital, Córdoba, Spain, and The authors acknowledge the Spanish Ministry of Health, Social and Equality, General Department for Pharmacy and Health Products for financing this study and the Instituto de Salud Carlos III-Fondo de Investigación Sanitaria (FONDOS FEDER), Redes temáticas de investigación cooperativa RETIC (Red SAMID RD12/0026/0015).
Subjects: 0301 basic medicine, Male, Pediatric Obesity, Time Factors, Phenomena and Processes::Physical Phenomena::Time::Time Factors [Medical Subject Headings], Obesidad, Psychological intervention, Bacillus, Ensayo clínico controlado aleatorio, Organisms::Bacteria::Gram-Positive Bacteria::Actinobacteria [Medical Subject Headings], Gut flora, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Principal Component Analysis [Medical Subject Headings], law.invention, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Randomized controlled trial, law, Medicine, Child, biology, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Age Factors [Medical Subject Headings], Organisms::Bacteria::Verrucomicrobia [Medical Subject Headings], Microbiota, Age Factors, Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics::Metagenomics [Medical Subject Headings], General Medicine, Organisms::Bacteria::Bacteroidetes [Medical Subject Headings], Metformin, ddc, Actinobacteria, Intestines, Treatment Outcome, Niño, 030220 oncology & carcinogenesis, Chemicals and Drugs::Organic Chemicals::Amidines::Guanidines::Biguanides::Metformin [Medical Subject Headings], Female, Anatomy::Digestive System::Gastrointestinal Tract::Intestines [Medical Subject Headings], medicine.drug, medicine.medical_specialty, Microbioma gastrointestinal, Adolescent, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Sample Size [Medical Subject Headings], Publication Type::Study Characteristics::Clinical Trial::Randomized Controlled Trial [Medical Subject Headings], Healthy lifestyle, Firmicutes, Check Tags::Male [Medical Subject Headings], RM1-950, Gut microbiota, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior [Medical Subject Headings], Placebo, Persons::Persons::Age Groups::Adolescent [Medical Subject Headings], 03 medical and health sciences, Verrucomicrobia, Double-Blind Method, Intervention (counseling), Internal medicine, Humans, Hypoglycemic Agents, Persons::Persons::Age Groups::Child [Medical Subject Headings], Obesity, Metformina, Life Style, Organisms::Bacteria [Medical Subject Headings], Organisms::Bacteria::Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Rods::Bacillaceae::Bacillus [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings], Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Pharmacology, Bacteria, Bacteroidetes, business.industry, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology, Social::Life Style [Medical Subject Headings], biology.organism_classification, medicine.disease, Gastrointestinal Microbiome, Children population, Clinical trial, Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity::Pediatric Obesity [Medical Subject Headings], 030104 developmental biology, Pubertal stage, Check Tags::Female [Medical Subject Headings], Spain, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hypoglycemic Agents [Medical Subject Headings], Metagenome, Therapeutics. Pharmacology, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Double-Blind Method [Medical Subject Headings], Metagenomics, Estilo de vida saludable, business, Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Metagenome [Medical Subject Headings]
Abstract: Background: Metformin, a first-line oral antidiabetic agent that has shown promising results in terms of treating childhood and adolescent obesity, might influence the composition of the gut microbiota. We aimed to evaluate whether the gut microbiota of non-diabetic children with obesity changes after a metformin intervention. Methods: The study was a multicenter and double-blind randomized controlled trial in 160 children with obesity. Children were randomly assigned to receive either metformin (1 g/day) or placebo for 6 months in combination with healthy lifestyle recommendations in both groups. Then, we conducted a metagenomic analysis in a subsample obtained from 33 children (15 metformin, 18 placebo). A linear mixed-effects model (LMM) was used to determine the abundance changes from baseline to six months according to treatment. To analyze the data by clusters, a principal component analysis was performed to understand whether lifestyle habits have a different influence on the microbiota depending on the treatment group. Results: Actinobacteria abundance was higher after placebo treatment compared with metformin. However, the interaction time x treatment just showed a trend to be significant (4.6% to 8.1% after placebo vs. 3.8 % to 2.6 % after metformin treatment, p = 0.055). At genus level, only the abundance of Bacillus was significantly higher after the placebo intervention compared with metformin (2.5% to 5.7% after placebo vs. 1.5 % to 0.8 % after metformin treatment, p = 0.044). Furthermore, different ensembles formed by Firmicutes, Bacteroidetes, and Verrucomicrobia were found according to the interventions under a similar food consumption, Spanish Ministry of Health, Social and Equality, General Department for Pharmacy and Health Products, Instituto de Salud Carlos III-Fondo de Investigación Sanitaria (FONDOS FEDER), Redes temáticas de investigación cooperativa RETIC Red SAMID RD12/0026/0015
Published: 2020

44. Assessment of the quality of mobile applications (Apps) for management of low back pain using the mobile app rating scale (mars)

Author: Jaime Martin-Martin, Wen Tang, Antonio Cuesta-Vargas, Manuel González-Sánchez, Attila Biró, Cristina Roldán-Jiménez, Maria Ruiz-Muñoz, Adrian Escriche-Escuder, Antonio Muro-Culebras, Irene De-Torres, Fermin Mayoral-Cleries, Borjanka Nikolova, Alfredo Salvatore, [Escriche-Escuder,A, Roldán-Jiménez,C, Muro-Culebras,A, González-Sánchez,M, Cuesta-Vargas,AI] Department of Physiotherapy, University of Malaga, Málaga, Spain. [Escriche-Escuder,A, De-Torres,I, Martín-Martín,J, Ruiz-Muñoz,M, Mayoral-Cleries,F, Cuesta-Vargas,AI] Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [De-Torres,I] Physical Medicine and Rehabilitation Unit, Hospital Regional Universitario, Málaga, Spain. [Martín-Martín,J] Department of Human Anatomy, Legal Medicine and History of Science, University of Malaga, Málaga, Spain. [Ruiz-Muñoz,M] Department of Nursing and Podiatry, University of Malaga, Málaga, Spain. [Mayoral-Cleries,F] Mental Health Unit, Regional Universitary Hospital of Malaga, Málaga, Spain. [Biró,A] ITWare, Budapest, Hungary. [Tang,W] Faculty of Science and Technology, Bournemouth University, Bournemouth, UK. [Nikolova,B] Arthaus, Production Trade and Service Company, Skopje, Macedonia. [Salvatore,A] Sensor ID Snc, Boiano, Italy. [Cuesta-Vargas,AI] Faculty of Health Science, School of Clinical Science, Queensland University Technology, Brisbane, Australia., and This project has received funding from the European Union’s Horizon 2020 Research and Innovation programme under the Marie Sklodowska-Curie actions. Grant Agreement: 823871 (iGAME).
Subjects: 020205 medical informatics, Computer science, Health, Toxicology and Mutagenesis, Information Science::Information Science::Computing Methodologies::Software::Mobile Applications [Medical Subject Headings], Psychological intervention, lcsh:Medicine, 02 engineering and technology, computer.software_genre, Dolor de la región lumbar, App store, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, 0202 electrical engineering, electronic engineering, information engineering, Application (app), 030212 general & internal medicine, Mobile health, Android (operating system), mHealth, low back pain, Multimedia, Evaluación, exercise, Mobile apps, Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Thinking::Esthetics [Medical Subject Headings], Telemedicina, Low back pain, Mobile Applications, Ejercicio físico, Diseases::Nervous System Diseases::Neurologic Manifestations::Pain::Back Pain::Low Back Pain [Medical Subject Headings], 3. Good health, medicine.symptom, Geographical Locations::Geographic Locations::Europe::Great Britain [Medical Subject Headings], Assessment, Article, Mobile app rating scale (MARS), 03 medical and health sciences, Rating scale, mental disorders, medicine, Information Science::Information Science::Data Collection [Medical Subject Headings], Humans, Exercise, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], lcsh:R, Public Health, Environmental and Occupational Health, Aplicaciones móviles, Digital health, United Kingdom, Spain, Mobile App Rating Scale (MARS), computer, application (app)
Abstract: Digital health interventions may improve different behaviours. However, the rapid proliferation of technological solutions often does not allow for a correct assessment of the quality of the tools. This study aims to review and assess the quality of the available mobile applications (apps) related to interventions for low back pain. Two reviewers search the official stores of Android (Play Store) and iOS (App Store) for localisation in Spain and the United Kingdom, in September 2019, searching for apps related to interventions for low back pain. Seventeen apps finally are included. The quality of the apps is measured using the Mobile App Rating Scale (MARS). The scores of each section and the final score of the apps are retrieved and the mean and standard deviation obtained. The average quality ranges between 2.83 and 4.57 (mean 3.82) on a scale from 1 (inadequate) to 5 (excellent). The best scores are found in functionality (4.7), followed by aesthetic content (mean 4.1). Information (2.93) and engagement (3.58) are the worst rated items. Apps generally have good overall quality, especially in terms of functionality and aesthetics. Engagement and information should be improved in most of the apps. Moreover, scientific evidence is necessary to support the use of applied health tools.
Published: 2020

45. Is It Possible to Find Something Positive in Being Confined Due to COVID-19? Implications for Well-Being

Author: M. Dolores Merino, Coral Oliver-Hernández, M. Dolores Vallellano, Inmaculada Méndez Mateo, [Merino,MD, Oliver-Hernández,C, and Vallellano,MD] Departamento de Psicología Social, del Trabajo y Diferencial, Facultad de Psicología, Campus de Somosaguas, Universidad Complutense de Madrid, Madrid, Spain. [Mateo,I] Escuela Andaluza de Salud Pública, Granada, Spain. [Mateo,I] CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Subjects: Adult, Male, Coping (psychology), Health Care::Environment and Public Health::Public Health::Public Health Practice::Communicable Disease Control::Infection Control::Quarantine [Medical Subject Headings], Coronavirus disease 2019 (COVID-19), Health, Toxicology and Mutagenesis, Well-being, lcsh:Medicine, Check Tags::Male [Medical Subject Headings], negative affect, Logistic regression, Affect (psychology), Article, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 03 medical and health sciences, 0302 clinical medicine, Qualitative analysis, well-being, Adaptation, Psychological, Humans, Negative affect, 030212 general & internal medicine, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Pandemics, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], lcsh:R, Public Health, Environmental and Occupational Health, quarantine, Cuarentena, Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings], COVID-19, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Middle Aged, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Adaptation, Psychological [Medical Subject Headings], 030227 psychiatry, Spanish population, Mental Health, Positive affect, Check Tags::Female [Medical Subject Headings], Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Health [Medical Subject Headings], Spain, Thematic network, Quarantine, Female, Psychology, Social psychology, positive affect
Abstract: In relation to COVID-19, little research has focused on the study of variables that affect well-being during this pandemic. The purpose of this research is twofold: (1) to find out if people experiencing a quarantine are able to appreciate any positive aspects of it, and to analyze how these responses are categorized and (2) to check if there are differences in levels of well-being according to these categories. There were 243 representative participants of the Spanish population according to sex, age, and educational level. The methodology was mixed, qualitative for the first objective and quantitative for the second. The first used the Thematic Network, while the second used logistic regression. From the qualitative analysis, three major categories were extracted: intrinsic orientation, extrinsic orientation, and empty orientation. The quantitative results showed a clear advantage in well-being for the intrinsically oriented group. The group of intrinsic orientation presented a better coping ability while the group of extrinsic orientation was as little adaptive as the group of empty orientation. Recommendations are extracted from the results.
Published: 2020
Full Text: View/download PDF

46. High rate of major drug–drug interactions of lopinavir–ritonavir for COVID-19 treatment

Author: Anaïs Corma, Marta Trigo, Marta Fernandez-Fuertes, Alejandro González-Serna, Enrique Contreras-Macias, Antonio Gutiérrez-Pizarraya, Juan Macías, Luis Miguel Real, Francisco A. Lao-Dominguez, Juan A. Pineda, Ana Pinilla, Ramón Morillo-Verdugo, Instituto de Salud Carlos III, [Macías,J, Pinilla,A, Corma,A, González-Serna,A, Fernández-Fuertes,M, Trigo,M, Real,LM, Pineda,JA] Infectious Diseases and Microbiology Unit, Hospital Universitario Virgen de Valme, Seville, Spain. [Lao-Dominguez,FA, Contreras-Macias,E, Gutierrez-Pizarraya,A, and Morillo-Verdugo,R] Pharmacy, Hospital Universitario Virgen de Valme, Seville, Spain.
Subjects: Male, 0301 basic medicine, España, Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Lopinavir/ritonavir, Single Center, Lopinavir, Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Pharmacological Processes::Drug Interactions [Medical Subject Headings], Antimicrobial therapy, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, immune system diseases, Chemicals and Drugs::Pharmaceutical Preparations::Drug Combinations [Medical Subject Headings], Drug Interactions, heterocyclic compounds, 030212 general & internal medicine, Inhibidores de proteasas, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], media_common, High rate, Multidisciplinary, Drug combinations, virus diseases, Middle Aged, Drug Combinations, Interacciones farmacológicas, Female, medicine.drug, Drug, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiazoles::Ritonavir [Medical Subject Headings], media_common.quotation_subject, 030106 microbiology, Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidinones::Lopinavir [Medical Subject Headings], Check Tags::Male [Medical Subject Headings], Lower risk, Antiviral Agents, Article, 03 medical and health sciences, Internal medicine, parasitic diseases, medicine, Humans, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protease Inhibitors [Medical Subject Headings], Protease Inhibitors, Aged, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Ritonavir, Adverse effects, SARS-CoV-2, business.industry, COVID-19, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Odds ratio, biochemical phenomena, metabolism, and nutrition, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], Confidence interval, COVID-19 Drug Treatment, Cross-Sectional Studies, Antiviral agents, Check Tags::Female [Medical Subject Headings], Viral infection, Spain, Concomitant, Antivirales, Combinación de medicamentos, business
Abstract: The impact of drug–drug interactions (DDI) between ritonavir-boosted lopinavir (LPV-r) to treat patients with coronavirus disease 2019 (COVID-19) and commonly used drugs in clinical practice is not well-known. Thus, we evaluated the rate and severity of DDI between LPV-r for COVID-19 treatment and concomitant medications. This was a cross-sectional study including all individuals diagnosed of SARS-CoV-2 infection treated with LPV-r and attended at a single center in Southern Spain (March 1st to April 30th, 2020). The frequency [95% confidence interval (95% CI)] of potential and major DDI were calculated. Overall, 469 patients were diagnosed of COVID-19, 125 (27%) of them were prescribed LPV-r. LPV-r had potential DDI with concomitant medications in 97 (78%, 95% CI 69–85%) patients, and in 33 (26%, 95% CI 19–35%) individuals showed major DDI. Twelve (36%) patients with major DDI and 14 (15%) individuals without major DDI died (p = 0.010). After adjustment, only the Charlson index was independently associated with death [adjusted OR (95% CI) for Charlson index ≥ 5: 85 (10–731), p, This study has not been funded. J.A.P. is recipient of an intensification grant from the Instituto de Salud Carlos III (Grant number Programa-I3SNS).
Published: 2020

47. Association between mental health comorbidity and health outcomes in type 2 diabetes mellitus patients

Author: Ignatios Ioakeim-Skoufa, Antonio Gimeno-Miguel, Beatriz Poblador-Plou, Alexandra Prados-Torres, Maria João Forjaz, Luis Andrés Gimeno-Feliu, Inmaculada Guerrero-Fernández de Alba, Gemma Rojo-Martínez, [Guerrero Fernández de Alba,I] EpiChron Research Group, IIS Aragón, Teaching Unit of Preventive Medicine and Public Health, Zaragoza, Spain. [Gimeno-Miguel,A, Poblador-Plou,B, Prados-Torres,A] EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Health Services Research On Chronic Patients Network (REDISSEC), Miguel Servet University Hospital, Zaragoza, Spain. [Gimeno-Feliu,LA] EpiChron Research Group, IIS Aragón, REDISSEC, University of Zaragoza, Servicio Aragonés de Salud (SALUD), Primary Care Health Centre San Pablo, Zaragoza, Spain. [Ioakeim Skoufa,I] EpiChron Research Group, IIS Aragón, Zaragoza, Spain. [Rojo-Martínez,G] Regional University Hospital of Málaga, Endocrinology and Nutrition Department, IBIMA, University of Malaga, CIBERDEM, Málaga, Spain. [Forjaz,MJ] National Centre of Epidemiology, Institute of Health Carlos III, REDISSEC, Madrid, Spain., This work was supported by Gobierno de Aragón [B01_20R] and the European Regional Development Fund 'Construyendo Europa desde Aragón'., Gobierno de Aragón (España), and Gobierno de Aragón
Subjects: Male, endocrine system diseases, lcsh:Medicine, Diseases, Esquizofrenia, Comorbidity, Health administration, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Comorbidity [Medical Subject Headings], Prevalence, Medicine, 030212 general & internal medicine, lcsh:Science, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings], Depression (differential diagnoses), Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Aged, 80 and over, Multidisciplinary, Depression, Middle Aged, Comorbilidad, Substance abuse, Hospitalization, Mental Health, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization [Medical Subject Headings], Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Health [Medical Subject Headings], Schizophrenia, Trastornos relacionados con sustancias, Anxiety, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2 [Medical Subject Headings], Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Administration::Hospital Departments::Emergency Service, Hospital [Medical Subject Headings], Female, Mental health, medicine.symptom, Emergency Service, Hospital, Persons::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings], Substance-related disorders, Adult, medicine.medical_specialty, Adolescent, Substance-Related Disorders, Diabetes Mellitus tipo 2, Check Tags::Male [Medical Subject Headings], 030209 endocrinology & metabolism, Article, Persons::Persons::Age Groups::Adolescent [Medical Subject Headings], Salud mental, 03 medical and health sciences, Young Adult, Psychiatry and Psychology::Mental Disorders::Schizophrenia and Disorders with Psychotic Features::Schizophrenia [Medical Subject Headings], Humans, Psychiatry, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Aged, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, lcsh:R, Enfermedad crónica, Health care, Diabetes mellitus, type 2, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Odds ratio, medicine.disease, Diseases::Chemically-Induced Disorders::Substance-Related Disorders [Medical Subject Headings], Diabetes Mellitus, Type 2, Check Tags::Female [Medical Subject Headings], Spain, Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over [Medical Subject Headings], Chronic diseases, lcsh:Q, business, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression [Medical Subject Headings]
Abstract: Type 2 diabetes mellitus (T2D) is often accompanied by chronic diseases, including mental health problems. We aimed at studying mental health comorbidity prevalence in T2D patients and its association with T2D outcomes through a retrospective, observational study of individuals of the EpiChron Cohort (Aragón, Spain) with prevalent T2D in 2011 (n = 63,365). Participants were categorized as having or not mental health comorbidity (i.e., depression, anxiety, schizophrenia, and/or substance use disorder). We performed logistic regression models, controlled for age, sex and comorbidities, to analyse the likelihood of 4-year mortality, 1-year all-cause hospitalization, T2D-hospitalization, and emergency room visit. Mental health comorbidity was observed in 19% of patients. Depression was the most frequent condition, especially in women (20.7% vs. 7.57%). Mortality risk was higher in patients with mental health comorbidity (odds ratio 1.24; 95% confidence interval 1.16-1.31), especially in those with substance use disorder (2.18; 1.84-2.57) and schizophrenia (1.82; 1.50-2.21). Mental health comorbidity also increased the likelihood of all-cause hospitalization (1.16; 1.10-1.23), T2D-hospitalization (1.51; 1.18-1.93) and emergency room visit (1.26; 1.21-1.32). These results suggest that T2D healthcare management should include specific strategies for the early detection and treatment of mental health problems to reduce its impact on health outcomes. This work was supported by Gobierno de Aragón [B01_20R] and the European Regional Development Fund “Construyendo Europa desde Aragón”. The authors sincerely thank Eva Giménez Labrador for her statistical support. Sí
Published: 2020

48. Dietary Patterns and Their Association with Body Composition and Cardiometabolic Markers in Children and Adolescents: Genobox Cohort

Author: Rosaura Leis, Alba M Santaliestra-Pasías, Gloria Bueno, Mercedes Gil-Campos, Luis A. Moreno, Miriam Latorre-Millán, Esther M González-Gil, Angel Gil, Concepción M. Aguilera, Rocío Vázquez-Cobela, Azahara I. Rupérez, [Latorre-Millán,M, Rupérez,AI, González-Gil,EM, Santaliestra-Pasías,A, Moreno,LA, Bueno,G] GENUD Research group, Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Universidad de Zaragoza, Zaragoza, Spain. [Latorre-Millán,M, Bueno,G] Unidad de Endocrinología Pediátrica, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain. [Rupérez,AI, Bueno,G] Instituto Agroalimentario de Aragón (IA2), Zaragoza, Spain. [González-Gil,EM, Gil-Campos,M, Aguilera,CM, Gil,Á, Leis,R, Bueno,G] Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. [González-Gil,EM, Gil,Á] Departamento de Bioquímica y Biología Molecular II, Instituto de Nutrición y Tecnología de los Alimentos, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain. [Vázquez-Cobela,R, Leis,R] Unidad de Gastroenterología, Hepatología y Nutrición Pediátrica, Grupo de Investigación Nutrición Pediátrica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain. [Gil-Campos,M] Unidad de Metabolismo e Investigación Pediátrica, Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. [Aguilera,CM, Gil,Á] Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, Granada, Spain. [Leis,R] Unidad de Investigación en Nutrición, Crecimiento y Desarrollo Humano de Galicia (GALINUT), Universidad de Santiago de Compostela, Santiago de Compostela, Spain., This research was supported by the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I+D+I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) (PI05/1968, PI11/01425, PI11/02042, PI11/02059, PI16/01301, PI16/01205 and PI1600871), and CIBEROBN Network (CB15/00131,CB15/00043). E.M.G.-G. and A.I.R. were funded by a Juan de la Cierva-Formación stipend (FJCI-2017-34967 and FJCI-2014-19795, respectively) from the Spanish Government. Á.G. was co-financed by the Research Plan of the Vice-Rectorate of Research and Transfer of the University of Granada, Spain.
Subjects: Male, 0301 basic medicine, obesity, Análisis por grupos, Obesidad, Overweight, Body Mass Index, Cohort Studies, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Waist–hip ratio, cardiovascular disease, Surveys and Questionnaires, oxidative stress, Child, Phenomena and Processes::Metabolic Phenomena::Body Composition [Medical Subject Headings], Metabolic Syndrome, anthropometry, Nutrition and Dietetics, Anthropometry, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings], Estrés oxidativo, Cardiovascular disease, Cardiovascular diseases, Cardiovascular Diseases, Cohort, Body Composition, Female, Dieta, medicine.symptom, Enfermedades cardiovasculares, lcsh:Nutrition. Foods and food supply, Bioelectrical impedance analysis, Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, Pharmacological [Medical Subject Headings], medicine.medical_specialty, Waist, Adolescent, Conducta alimentaria, Check Tags::Male [Medical Subject Headings], lcsh:TX341-641, 030209 endocrinology & metabolism, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings], Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings], Disease cluster, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior [Medical Subject Headings], Article, Persons::Persons::Age Groups::Adolescent [Medical Subject Headings], 03 medical and health sciences, Cluster analysis, Internal medicine, medicine, Humans, Persons::Persons::Age Groups::Child [Medical Subject Headings], Obesity, Diseases::Cardiovascular Diseases [Medical Subject Headings], Inflammation, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], 030109 nutrition & dietetics, Inflamación, business.industry, Feeding Behavior, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases [Medical Subject Headings], medicine.disease, Diet, Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [Medical Subject Headings], Antropometría, Check Tags::Female [Medical Subject Headings], inflammation, Spain, Oxidative stress, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], diet, business, Biomarkers, cluster analysis, Food Science
Abstract: Diet is a key factor for obesity development; however, limited data are available on dietary cluster analysis in children with obesity. We aimed to assess the associations between dietary patterns and obesity and several cardiometabolic markers. Anthropometry, bioelectrical impedance, blood pressure and plasma biomarkers of oxidative stress, inflammation and endothelial damage were determined in 674 Caucasian children, aged 5–16, with normal or excess weight. Using a food frequency questionnaire and cluster analysis, two consistent dietary patterns were shown, labeled as health conscious (HC) and sweet and processed (SP). The HC pattern included a greater proportion of participants with overweight/obesity than the SP cluster (80.1% vs. 63.8%). However, children with obesity within the HC cluster, showed less abdominal fat, through waist to hip (0.93 vs. 0.94) and waist to height (0.61 vs. 0.63) indexes (p < 0.01). Univariate general models showed several additional di erences in cardiometabolic risk biomarkers in the global and stratified analyses, with a healthier profile being observed mainly in the HC cluster. However, multivariate models questioned these findings and pointed out the need for further studies in this field. Anyhow, our findings support the benefits of a healthy diet and highlight the importance of dietary patterns in the cardiometabolic risk assessment of children with overweight/obesity, beyond weight control., Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) PI05/1968 PI11/01425 PI11/02042 PI11/02059 PI16/01301 PI16/01205 PI1600871, CIBEROBN Network CB15/00131 CB15/00043, Juan de la Cierva-Formacion from the Spanish Government FJCI-2017-34967 FJCI-2014-19795, Vice-Rectorate of Research and Transfer of the University of Granada, Spain
Published: 2020

49. Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry

Author: Julio César Blázquez Encinar, Francisco Javier Martínez-Marcos, María Esther Guisado Espartero, J. Peña, Davide Luordo, Ricardo Gómez Huelgas, Carmen Suárez Fernández, Santiago Jesús Freire Castro, Jeffrey Oskar Magallanes Gamboa, Raquel Gómez Méndez, Natalia Vicente López, Carlos Jorge Ripper, Luis M. Pérez-Belmonte, Joaquim Fernández Sola, Andrés de la Peña Fernández, Jose Javier Napal Lecumberri, María Gloria Rojano Rivero, José Manuel Ramos Rincón, Paula Maria Pesqueira Fontan, Francisco Javier Carrasco-Sánchez, Mª Dolores López-Carmona, Verónica Buonaiuto, Berta Román Bernal, Francisco Amorós Martínez, Alicia Hidalgo-Jiménez, SEMI-COVID-19 Network, [Carrasco-Sánchez,FJ, Hidalgo-Jiménez,A] Internal Medicine Department, Juan Ramón Jiménez University Hospital, Huelva, Spain. [López-Carmona,MD, Pérez-Belmonte,LM, Buonaiuto,V, Gómez Huelgas,R] Internal Medicine Department, Málaga Regional University Hospital, Málaga, Spain. [Martínez-Marcos,FJ] Clinical Infectious Disease Unit, Juan Ramón Jiménez University Hospital, Huelva, Spain. [Suárez Fernández,C] Internal Medicine Department, La Princesa University Hospital, Madrid, Spain. [Freire Castro,SJ] Internal Medicine Department, A Coruña University Hospital, A Coruña, Spain. [Luordo,D] Internal Medicine Department, Infanta Cristina University Hospital, Parla, Spain. [Pesqueira Fontan,PM] Internal Medicine Department, Santiago Clinical Hospital, Santiago de Compostela, Santiago, Spain. [Blázquez Encinar,JC] Internal Medicine Department, Torrevieja University Hospital, Torrevieja, Spain. [Magallanes Gamboa,JO] Internal Medicine Department, Nuestra Señora del Prado Hospital, Talavera de la Reina, Spain. [de la Peña Fernández,A] Internal Medicine Department, Son Llàtzer University Hospital, Palma de Mallorca, Spain. [Torres Peña,JD] Lipis and Atherosclerosis Unit, Department of Interna Medicine, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Spain. [Torres Peña,JD] CIBER Fisiopatologia de la Obesidad y Nutrición (CIBEROBN), Insituto de Salud Carlos III, Córdoba, Spain. [Fernández Solà,J] Internal Medicine Department, Barcelona Clinical Hospital, Barcelona, Spain. [Napal Lecumberri,JJ] Internal Medicine Department, Marqués de Valdecilla University Hospital, Santander, Spain. [Amorós Martínez,F] Internal Medicine Department, Vinalopó University Hospital, Elche, Spain. [Guisado Espartero,ME] Internal Medicine Department, Infanta Margarita Hospital, Cabra, Spain. [Jorge Ripper,C] Internal Medicine Department, Insular de Gran Canaria Hospital, Las Palmas de Gran Canaria, Spain. [Gómez Méndez] Internal Medicine Department, Lucus Augusti University Hospital, Lugo, Spain. [Vicente López,N] Internal Medicine Department, Sureste University Hospital, Arganda del Rey, Spain. [Román Bernal,B] Internal Medicine Department, Doctor José Molina Orosa Hospital, Arrecife, Spain. [Rojano Rivero,MG] Internal Medicine Department, Infanta Elena Hospital, Huelva Hospital, Huelva, Spain. [Ramos Rincón,JM] Internal Medicine Department, Alicante General University Hospital, Alicante, Spain., and The study was completely support by the Spanish Federation of Internal Medicine.
Subjects: Blood Glucose, Male, sistema de registros, humanos, asistencia del enfermo crítico, pandemias, Diseases::Virus Diseases::Pneumonia, Viral [Medical Subject Headings], 030204 cardiovascular system & hematology, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Respiratory Therapy::Respiration, Artificial [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, duración de estancia hospitalaria, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization::Length of Stay [Medical Subject Headings], Pandemic, Medicine, Hyperglycaemia, Registries, 030212 general & internal medicine, Hiperglucemia, mediana edad, Aged, 80 and over, anciano, diabetes, Respiration, respiración, Diabetes, General Medicine, Middle Aged, Original Article, Female, Coronavirus Infections, infecciones por Coronavirus, Research Article, medicine.medical_specialty, 2019-20 coronavirus outbreak, glucosa sanguínea, Critical Care, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, 03 medical and health sciences, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Clinical Chemistry Tests::Blood Chemical Analysis [Medical Subject Headings], Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperglycemia [Medical Subject Headings], Internal medicine, Diabetes mellitus, Humans, In patient, Risk factor, Mortality, hiperglucemia, Pandemics, Aged, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, SARS-CoV-2, Diseases::Endocrine System Diseases::Diabetes Mellitus [Medical Subject Headings], Diabetes status, COVID-19, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality [Medical Subject Headings], Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings], neumonía, Pneumonia, Length of Stay, medicine.disease, mortality, Respiration, Artificial, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], Spain, Hyperglycemia, Mortalidad, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Registries [Medical Subject Headings], business, hyperglycaemia
Abstract: Background Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. Methods This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients were categorized into three groups according to admission BG levels: 180 mg/dL. The primary endpoint was all-cause in-hospital mortality. Results Of the 11,312 patients, only 2128 (18.9%) had diabetes and 2289 (20.4%) died during hospitalization. The in-hospital mortality rates were 15.7% (180 mg/dL), p.001. The cumulative probability of mortality was significantly higher in patients with hyperglycaemia compared to patients with normoglycaemia (log rank, p.001), independently of pre-existing diabetes. Hyperglycaemia (after adjusting for age, diabetes, hypertension and other confounding factors) was an independent risk factor of mortality (BG >180 mg/dL: HR 1.50; 95% confidence interval (CI): 1.31-1.73) (BG 140-180 mg/dL; HR 1.48; 95%CI: 1.29-1.70). Hyperglycaemia was also associated with requirement for mechanical ventilation, intensive care unit (ICU) admission and mortality. Conclusions Admission hyperglycaemia is a strong predictor of all-cause mortality in non-critically hospitalized COVID-19 patients regardless of prior history of diabetes. KEY MESSAGE Admission hyperglycaemia is a stronger and independent risk factor for mortality in COVID-19. Screening for hyperglycaemia, in patients without diabetes, and early treatment of hyperglycaemia should be mandatory in the management of patients hospitalized with COVID-19. Admission hyperglycaemia should not be overlooked in all patients regardless prior history of diabetes., The study was completely support by the Spanish Federation of Internal Medicine.
Published: 2020

50. Case fatality of COVID-19 in patients with neurodegenerative dementia

Author: P.J. Serrano-Castro, T. Ojea-Ortega, J.A. Reyes-Bueno, Natalia Mena-Vázquez, Pablo Cabezudo-García, M.M. Gonzalez-Sotomayor, N.L. Ciano-Petersen, G. Pons-Pons, M.V. Castro-Sánchez, [Reyes-Bueno,JA, Ojea-Ortega,T, Gonzalez-Sotomayor,MM, Cabezudo-Garcia,P, Ciano-Petersen,NL, Pons-Pons,G, Castro-Sánchez,MV, and Serrano-Castro,PJ] Unidad de Gestión Clínica de Neurociencias, Servicio de Neurología, Hospital Regional Universitario de Málaga, Málaga, España. [Mena-Vázquez,N] Unidad de Gestión Clínica de Reumatología, Hospital Regional Universitario de Málaga, Málaga, España.
Subjects: Lung Diseases, Male, Diseases::Virus Diseases::Pneumonia, Viral [Medical Subject Headings], Comorbidity, lcsh:RC346-429, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Demencias, 0302 clinical medicine, Risk Factors, Prevalence, Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer Disease [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings], Case fatality, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Aged, 80 and over, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings], Smoking, Neurodegenerative Diseases, Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Comorbidity [Medical Subject Headings], Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia [Medical Subject Headings], Cardiovascular Diseases, Female, Kidney Diseases, Coronavirus Infections, Pneumonia, Viral, Clinical Neurology, 03 medical and health sciences, Betacoronavirus, Alzheimer Disease, Diseases::Nervous System Diseases::Neurodegenerative Diseases [Medical Subject Headings], Diabetes Mellitus, Humans, Diseases::Cardiovascular Diseases [Medical Subject Headings], Pandemics, lcsh:Neurology. Diseases of the nervous system, Aged, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Diseases::Endocrine System Diseases::Diabetes Mellitus [Medical Subject Headings], SARS-CoV-2, Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings], COVID-19, Letalidad, Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings], Check Tags::Female [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over [Medical Subject Headings], Spain, Case-Control Studies, Dementia, Neurology (clinical), 030217 neurology & neurosurgery
Abstract: Introduction: The elderly population is the group most threatened by COVID-19, with the highest mortality rates. This study aims to analyse the case fatality of COVID-19 in a cohort of patients with degenerative dementia. Methods: We conducted a descriptive case-control study of a sample of patients diagnosed with primary neurodegenerative dementia. Results: Twenty-four of the 88 patients with COVID-19 included in the study died: 10/23 (43.4%) patients diagnosed with dementia and 14/65 (21.5%) controls; this difference was statistically significant. Discussion: Our results suggest that case fatality of COVID-19 is significantly higher among patients with primary degenerative dementia than in other patients with similar mean ages and comorbidities. Proyecto COV20/00157 financiado por fondo COVID-19 del Instituto de Salud Carlos III. España. Yes Introducción: La población anciana es la más amenazada por COVID-19, con mayores tasas de mortalidad. El objetivo de este trabajo es analizar la letalidad en una cohorte de pacientes de COVID-19 con demencia degenerativa. Métodos: Hicimos un estudio descriptivo de casos-control de una muestra de pacientes diagnosticados con demencias neurodegenerativas primarias. Resultados: De los 88 pacientes incluidos en el estudio, 24 pacientes con COVID-19 fallecieron: 10/23 (43,4%) eran pacientes con diagnóstico de demencia y 14/65 (21,5%) pacientes del grupo control, una diferencia estadísticamente significativa. Discusión: La letalidad por COVID-19 entre los pacientes con demencia degenerativa primaria es significativamente mayor en comparación con otros pacientes con edades medias y comorbilidades similares, según nuestro estudio.
Published: 2020
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Journal

Database

Publisher

114 results on '"Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources