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Background. Leptin has an association with male infertility. However, only sporadic studies inconsistently reported the results. Aim and Objective. In this study, we aimed to perform a meta-analysis to investigate the relationship between leptin and male infertility. Methods. This study was performed based on published articles related to leptin and infertile males. PubMed, Web of Science, Google Scholar, Ovid + Cochrane Central Register of Controlled Trials, Wiley Online Library, Chinese CNKI, Chinese Chong Qing VIP, Chinese Wan Fang, and China Biology Medicine databases were searched to identify all relevant studies. All eligible works of literature were analyzed by the "meta" or "metan" command in STATA version 12.0 software. The standardized mean difference (SMD) of leptin concentration in serum or semen and 95% confidence intervals (CIs) were estimated for all studies. The heterogeneity was described with I2. The sources of heterogeneity were explored via metaregression, and stratified analyses, sensitivity analyses, and publication bias were performed. Results. Nineteen studies were included in the current meta-analysis, involving 1138 cases of infertile men and 756 controls. The SMD of leptin concentration in serum was 2.002 (95% CI: 1.086, 2.918), Z-test (z) z = 4.29; p < 0.001 , and I2 was 97.3%, p < 0.001. The SMD of leptin concentration in semen was 3.274 (95% CI: 2.137, 4.411), z = 5.64; p < 0.001 , and I2 was 98.2%, p < 0.001. Notably, serum follicle-stimulating hormone (FSH) was slightly higher in infertile men (SMD = 3.695, z = 2.33, p = 0.020 , I2 = 98.8%, p < 0.001). Other hormones, such as luteinizing hormone (LH) and testosterone, were also slightly higher, but the results were not statistically significant. In addition, sperm count (SMD = −4.533, 95% CI: −6.565, −2.501) and sperm motility (SMD = −7.894, 95% CI: −10.616, −5.172) inversely correlated with leptin levels in infertile males. Sperm abnormal forms did not show a statistically significant SMD of −0.076 (95% CI: −3.410, 3.258). Conclusion. Leptin plays a potential role in association with male infertility. This study may effectively reveal the relationship between leptin together with other hormones and its association with male infertility. These results may also provide opinions on precautionary measures. [ABSTRACT FROM AUTHOR]

Objective To investigate and understand the semen quality sitration of normal fertility men in the partial areas of Guangxi Zhuang Autonomous Region during 2011 by the multicenter cooperation. Methods To study semen quality of 965 fertility men from four reproduction medcine centers in Guang xi zhuang autonomous Region. Their basic examine include age, longth of penis, volume of testis and so on. Semen samples were compared with the World Health Organization criteria. Questionnaire were used by special trainer for all reproductive centers. The semen quality were compared among different ages groups, nation groups, rigion groups and culture groups. Results Sperm progressive motility and sperm morphology reached 61.7% , 73.5% of normal levels respectively. Others reached above 80.0%. Sperm motility and sperm progressive motility were (64.493± 17.199)%, (47.478±15.305)% in 18-<30 group respectively. Sperm density of Han group and sperm morphology of Zhuang group were best among all groups. Culture degree did not affect semen quality. Conclusions The sperm motility bias and sperm deformity degree in the partial areas of Guangxi Zhuang Autonomous Rigion are higher and have local difference, which needs to further perfect the inrestigation data and felermine the influencing factors. [ABSTRACT FROM AUTHOR]