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Introduction: recent studies in the field of infertility have showed the implications of immunologic substances in infertility and prenatal problems. These substances, including antisperm antibody (ASA), are the result of immune system reactions of male or his partner against sperms. Studies mentioned different mechanisms for production of these antibodies such as destruction of sperm-blood barrier in male or female body. It seems to be that these antibodies block sperms and decrease their motility and fertility potency. Dorr et al showed these antibodies are specific for each person. This paper aims to review current treatments in this field. If antisperm antibodies are causes of infertilities the costs of current infertility treatments can be hugely reduced. Materials and Methods: This study was written using relevant articles published during the period 2004-2013 in PubMed. Keywords including anti-sperm antibody abd infertility were used to find articles. Results: Studies indicated controversies regarding the implication of these antibodies. Zini et al in 2011 evaluated the effect of ASA on sperms in IVF and ICSI in vitro environment in Mc. Hill University. They reported no significant correlation between ASA level and spermatic motility factors, morphology and their fertility potency. Another study shows the same result in 2007. In 2010, Check examined the ASA effects on human body and reported decreasing fertility rate in sperms covered with ASA to one third. In 2008, Wlilliams found murine FA-1 antigen and YLP(12) in infertile women who were the cause of infertility. He suggested to produce a vaccine against these agents. Conclusion: Given the probable role of ASA in infertility, we could use simpler, cheaper methods to control this antibody in infertile couples instead of costly methods like IVF or IICSI. This method can even be used as a reliable contraceptive. Still, the results are shrouded in controversy and larger sample sizes are required. [ABSTRACT FROM AUTHOR]