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Introduction: Spinal cord injury (SCI) is a central nervous system injury that is primarily traumatic and manifests as motor, sensory, and autonomic dysfunction below the level of damage. Our previous studies confirmed the ability of zinc to protect mitochondria, protect neurons and promote spinal cord recovery. However, the role of zinc in Parthanatos is unknown., Aim: We investigated the effects of zinc in Parthanatos from oxidative stress and mitophagy. We elucidated the role of SIRT3 in providing new ideas for treating spinal cord injury., The Results: Zinc protected SCI mice by regulating Parthanatos. On the one hand, zinc eliminated ROS directly through SIRT3 deacetylation targeting SOD2 to alleviate Parthanatos. On the other hand, zinc eliminated ROS indirectly through SIRT3-mediated promotion of mitophagy to alleviate Parthanatos., Conclusion: Zinc defends against Parthanatos and promotes functional recovery after spinal cord injury through SIRT3-mediated anti-oxidative stress and mitophagy., (© 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)

Spinal cord injury (SCI) is very complex and causes complicated neurological disorders with serious socioeconomic implications. After SCI, some cells are seriously damaged and the lesion face physiological, anatomical, chemical, and immune system changes that hinder their attempts for recovering. Near-Infrared (NIR) light-assisted therapy for SCI treatment is quite limited, but the reported work has shown great promise to combat SCI, which particularly has more efficient anti-inflammation and tissue regeneration effects. To advance research on NIR adjuvant therapy for SCI, we summarized the reported strategies including the NIR light-assisted control-release system and NIR light-assisted photothermal therapy (NIR-PTT) to assist therapy of SCI. In addition, the prospect and challenges for widespread clinical implementation of NIR-assisted therapeutics are discussed. • Inhibition of secondary injury is an effective treatment for spinal cord injury. • At present, the commonly used clinical methods have great side effects. • NIR light-assisted therapy deserves deeper investigation for the therapy of spinal cord injury. • Using search tools with spinal cord injury NIR as the keyword to found some reports. • Facilitating the future advancement of NIR light-assisted therapy for spinal cord injury. [ABSTRACT FROM AUTHOR]